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HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ITRACONAZOLE AND TERBINAFINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

G. Indira Priyadarshini* Manchi venkata Chari


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    <subfield code="a">&lt;p&gt;&lt;em&gt;A simple, Accurate, precise method was developed for the simultaneous estimation of the Terbinafine and Itraconazole in bulk and pharmaceutical dosage form. Chromatogram was run through phenomenex C18 150 x 4.6mm, 5.0&lt;/em&gt;&lt;em&gt;m&lt;/em&gt;&lt;em&gt;. Mobile phase containing Buffer 0.1%OPA: Methanol taken in the ratio 60:40v/v was pumped through column at a flow rate of 1.0ml/min. Temperature was maintained at 30&amp;deg;C. Optimized wavelength selected was 245 nm. Retention time of Terbinafine and Itraconazole were found to be 2.331 min and 2.934 min. %RSD of the Terbinafine and Itraconazole were and found to be 0.4 and 0.9 respectively. %Recovery was obtained as 99.95% and 100.98% for Terbinafine and Itraconazole respectively. LOD, LOQ values obtained from regression equations of Terbinafine and Itraconazole were 0.94, 2.86 and 0.70, 2.13 respectively. Regression equation of Terbinafine is y =&amp;nbsp; 6951.x + 2494., and y = 7657x + 2075. of Itraconazole Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.&lt;/em&gt;&lt;/p&gt;

&lt;p&gt;&lt;strong&gt;&lt;em&gt;Key Words: &lt;/em&gt;&lt;/strong&gt;&lt;em&gt;Terbinafine, Itraconazole, RP-HPLC&lt;/em&gt;&lt;/p&gt;</subfield>
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