Journal article Open Access

HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ITRACONAZOLE AND TERBINAFINE IN BULK AND PHARMACEUTICAL DOSAGE FORM

G. Indira Priyadarshini* Manchi venkata Chari


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.5687866", 
  "author": [
    {
      "family": "G. Indira Priyadarshini* Manchi venkata Chari"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2021, 
        11, 
        13
      ]
    ]
  }, 
  "abstract": "<p><em>A simple, Accurate, precise method was developed for the simultaneous estimation of the Terbinafine and Itraconazole in bulk and pharmaceutical dosage form. Chromatogram was run through phenomenex C18 150 x 4.6mm, 5.0</em><em>m</em><em>. Mobile phase containing Buffer 0.1%OPA: Methanol taken in the ratio 60:40v/v was pumped through column at a flow rate of 1.0ml/min. Temperature was maintained at 30&deg;C. Optimized wavelength selected was 245 nm. Retention time of Terbinafine and Itraconazole were found to be 2.331 min and 2.934 min. %RSD of the Terbinafine and Itraconazole were and found to be 0.4 and 0.9 respectively. %Recovery was obtained as 99.95% and 100.98% for Terbinafine and Itraconazole respectively. LOD, LOQ values obtained from regression equations of Terbinafine and Itraconazole were 0.94, 2.86 and 0.70, 2.13 respectively. Regression equation of Terbinafine is y =&nbsp; 6951.x + 2494., and y = 7657x + 2075. of Itraconazole Retention times were decreased and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.</em></p>\n\n<p><strong><em>Key Words: </em></strong><em>Terbinafine, Itraconazole, RP-HPLC</em></p>", 
  "title": "HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF ITRACONAZOLE AND TERBINAFINE IN BULK AND PHARMACEUTICAL DOSAGE FORM", 
  "type": "article-journal", 
  "id": "5687866"
}
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