Journal article Open Access

Synthesis, characterization and antimicrobial evaluation of some new substituted 1H-indole-2 carboxamide derivatives

Kamal A. Sweidan; Ala'a M. Al-Shamaileha; Mohammad K. Abu Sini; Rajendra Joshi


JSON-LD (schema.org) Export

{
  "inLanguage": {
    "alternateName": "eng", 
    "@type": "Language", 
    "name": "English"
  }, 
  "description": "<p>Department of Chemistry, The University of Jordan, Amman, 11942, Jordan</p>\n\n<p>Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, 11733, Jordan</p>\n\n<p>Department of Chemical Science and Engineering, School of Engineering, Kathmandu University, Nepal</p>\n\n<p>E-mail: rajendra.joshi@k.edu.np</p>\n\n<p>Manuscript received online 19 July 2020, accepted 28 August 2020</p>\n\n<p>A new series of 1H-indole-2-carboxamide derivatives has been prepared by simple procedures in good yields, followed by complete characterization using nuclear magnetic resonance, infrared spectroscopy, high resolution mass spectrometry and elemental analysis techniques. The prepared compounds have been tested as potential antifungal and anti-bacterial (Grampositive and Gram-negative) agents. The antifungal and antibacterial results indicated that carboxylic acid compounds exhibited a weak bioactivity; even with replacement of carboxylic acid group with ester, no significant difference in activities was observed relative to standard commercial drugs.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Kamal A. Sweidan"
    }, 
    {
      "@type": "Person", 
      "name": "Ala'a M. Al-Shamaileha"
    }, 
    {
      "@type": "Person", 
      "name": "Mohammad K. Abu Sini"
    }, 
    {
      "@type": "Person", 
      "name": "Rajendra Joshi"
    }
  ], 
  "headline": "Synthesis, characterization and antimicrobial evaluation of some new substituted 1H-indole-2 carboxamide derivatives", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2020-09-01", 
  "url": "https://zenodo.org/record/5657220", 
  "keywords": [
    "Antimicrobial", 
    "carboxamide", 
    "DEPT-NMR", 
    "indole", 
    "synthesis"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.5657220", 
  "@id": "https://doi.org/10.5281/zenodo.5657220", 
  "@type": "ScholarlyArticle", 
  "name": "Synthesis, characterization and antimicrobial evaluation of some new substituted 1H-indole-2 carboxamide derivatives"
}
32
18
views
downloads
All versions This version
Views 3232
Downloads 1818
Data volume 3.9 MB3.9 MB
Unique views 2323
Unique downloads 1818

Share

Cite as