10.5281/zenodo.5636950
https://zenodo.org/records/5636950
oai:zenodo.org:5636950
Coreţchi Liuba
Coreţchi Liuba
National Agency for Public Health, Chișinău, Republic of Moldova
Overcenco Ala
Overcenco Ala
National Agency for Public Health, Chișinău, Republic of Moldova
Ababii Aurelia
Ababii Aurelia
National Agency for Public Health, Chișinău, Republic of Moldova
Bîlba Valeriu
Bîlba Valeriu
Oncology Institute, Chișinău, Republic of Moldova
STUDIES ON THE DEVELOPMENT OF A METHODOLOGY FOR STUDYING THE RADON X SMOKING INTERACTION AS A TRIGGER FACTOR IN THE OCCURRENCE OF BRONCHOPULMONARY CANCER
Zenodo
2021
radon
smoking
interaction
synergism
bronchopulmonary cancer
methodology
2021-11-01
ron
10.5281/zenodo.5636949
https://zenodo.org/communities/artamedica
Creative Commons Attribution 4.0 International
Objectives. Residential exposure to radon is the second risk factor for lung cancer triggering for smokers and the first – for non-smokers. The obtaining reliable result in this area requires large-scale epidemiological scientific studies with the appropriate patient samples, but the results of some studies are controversial. The synthetic analysis of the specialized literature served as a basis for the methodology development to study the interaction of radon x smoking as a trigger factor in the occurrence of lung cancer at smokers in the Republic of Moldova.
Material and methods. Global experience on the methodology for studying the interaction radon x smoking was examined about 30 publications on platforms of ResearchGate, Pubmed, BioMedCentral, RSCI, European Commission Webgate, WHO, AIEA, etc. A descriptive synthesis of current approaches to the development and implementation of research methods for studying the radon x smoking interaction on the triggering of bronchopulmonary cancer was performed.
Results. A few researches have focused on the study of the effect of synergic exposure of radon/smoke on the occurrence of lung cancer. A review showed that the main methods for studying this phenomenon are case-control and sociological. Combining the studied approaches and basing on the experience of international research, the methodology for estimating the interaction of radon x smoking on triggering the bronchopulmonary cancer was developed. Two directions are proposed in the research methods: (1) statistical with the use of smokers' data in the Republic of Moldova, radon concentration in dwellings and morbidity/mortality indices and (2) "case-control" with the use of the long-term study questionnaire in collaboration with the Institute of Oncology.
Conclusions. The development of a methodological approach to the study of the radon x smoking interaction on the occurrence of bronchopulmonary cancer will allow the Public Health System to develop tools to control/prevent/reduce this disease.