Physicochemical, computational and DNA cleavage studies of N'-[(1E)-1-(2,4- dihydroxyphenyl)ethylidene]benzenesulfonohydrazide and its metal complexes

Department of Chemistry, University College for Women, Osmania University, Hyderabad-500 005, India

Department of Chemistry, S. N. Vanitha Mahavidyalaya, Hyderabad-500 001, India

Department of Chemistry, University College of Science, Osmania University, Hyderabad-500 007, India

E-mail : dr_saraladevi@yahoo.com

Manuscript received online 05 June 2014, revised 10 July 2014, accepted 22 July 2014

Benzenesulfonohydrazides and their metal complexes are important compounds in medicinal chemistry. In the present investigation synthesis of N´-[(1E)-1-(2,4-dihydroxyphenyl)ethylidene]benzenesulfonohydrazide, its metal complexes and their structural properties have been investigated by various spectro-analytical and computational studies. Molecular orbital and Quantitative Structure Activity Relationship (QSAR) properties were computed by employing HyperChem 7.5 tools. The pH-metric studies indicated dibasic nature of compound with two corresponding pKa values. The pKa values were further compared with computed values derived by using ChemAxon tools. The interaction of metal ions with candidate compound was monitored by Job’s method of continuous variation and mole-ratio methods in ethanol-water medium. The solid metal complexes synthesized were investigated by various techniques viz. IR, UV-Visible, mass, ESR, SEM, TG, DTA and elemental analysis. The DNA cleavage studies carried out on the title compound and its metal complexes indicated that only copper complex has the property to cleave the super coiled DNA to linear form.