FORMULATION & EVALUATION OF FLOATING MICOSPHERE OF RANITIDINE HYDROCHLORIDE

The present study was to formulation & evaluation of floating microsphere of ranitidine hydrochloride. The physical characteristic like organoleptic properties of drug sample was performed and it was found to be bitter in taste, colour was white crystalline powder and was odourless. And hence the drug sample was found to be as per specifications. The quantitative solubility of drug was determined and it was found that drug freely soluble in methanol and ethanol, sparingly soluble in chloroform and slightly soluble in water. And this result indicated that the drug is poorly water soluble and soluble in organic solvents like methanol and ethanol. The partition coefficient of drug was determined as per procedure. It was found to be 2.50 that indicated that the drug was portioning maximum in lipophillic phase and hence it was found that drug was lipophilic in nature. Identification and authentication of drug sample was done by infrared spectroscopy. The IR spectra showed the presence of principal groups like at 756 o- disubstituted benzene; 1279 C-N; 1458 & 1479 CH3; 1531 C=C aromatic; 1638 C=N, C=O ring and at 3410 H2O. The principal groups of infrared spectroscopies showed that the drug sample was authenticated. Identification and authentication of drug sample was done by ultraviolet spectroscopy and it was scanned in the range of 200-400 nm. Drug absorption maximum λmax was found to be at 310 nm. Absorption maximum showed that drug sample was authenticated. Melting point was also determined by melting point apparatus. The melting point was found in the range between 2267⁰-237⁰C which meets as per specification. The melting point showed that drug sample was authenticated.

Keywords: Microsphere, dosage form, drug delivery, design, bioavailability