5560273
doi
10.35940/ijeat.D7454.049420
oai:zenodo.org:5560273
Blue Eyes Intelligence Engineering & Sciences Publication(BEIESP)
Publisher
Yue Ling
Department of Mechanical Engineering, Baylor University, Waco, Texas, USA.
Seunghyun Kim
Department of Electrical and Computer Engineering, Baylor University, Waco, Texas, USA.
Numerical Analysis of a Trapezoidal Microchannel for Hydrodynamic Detachment of Cells
Jessanne Y. Lichtenberg,
Department of Electrical and Computer Engineering, Baylor University, Waco, Texas, USA.
issn:2249-8958
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
computational fluid dynamics, microchannel, microfluidics.
<p>Hydrodynamic shear force along the bottom microchannel wall has been utilized in cell adhesion studies to detach cells in microfluidic channels. Due to the small dimensions of microfluidic channels, the shear stress produced in a conventional microchannel is dependent mainly on the fluid velocity and channel height. The wall shear force magnitude increases as the channel height is reduced. However, a reduced channel height decreases the sample volume to be contained in the fluidic channel and also increases the pressure drop significantly which may fail the fluidic device. In this study, a novel microchannel with a trapezoidal structure was investigated using computational fluid dynamics simulations. The key fluidic properties, including wall shear stress, sample volume, and pressure drop of the trapezoidal microchannel are compared with those of a conventional straight channel with a reduced channel height. We found the trapezoidal structure produces a wall shear stress of 5 Pa in the region of interest similar to that of the straight channel with a small channel height (50 μm) while having less than 30 percent pressure drop. Additionally, the pressure drop can be reduced by modifying the geometry of the trapezoidal channel to minimize pressure loss.</p>
Zenodo
2020-04-30
info:eu-repo/semantics/article
5560272
1633960111.360928
926293
md5:813959a2fe70d3049ff018c752aa1a25
https://zenodo.org/records/5560273/files/D7454049420.pdf
public
2249-8958
Is cited by
issn
International Journal of Engineering and Advanced Technology (IJEAT)
9
4
1473-1477
2020-04-30