Condition of pro-oxidant and antioxidant systems in guinea pigs' lungs under the condition of immobilization stress

Kryvko Yurij, Soguiko Yurij, Hot Iryna, Antonenko Yuliia, Baida Mariana, Kovalska Marta. Condition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress. Journal of Education, Health and Sport. 2021;11(05): 319-324. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2021.11.05.033

https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2021.11.05.033

https://zenodo.org/record/5559664

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© The Authors 2021;

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Received: 15.05.2021. Revised: 21.05.2021. Accepted: 28.05.2021.

UDC: 616.24-002-008.6-056.3-092: 612.24.015.11

сondition of pro-oxidant and antioxidant systems in guinea pigs’ lungs under the condition of immobilization stress

Yurij Kryvko1, Yurij Soguiko1, Iryna Hot¹, Yuliia Antonenko¹, Mariana Baida,

Marta Kovalska

Danylo Halytsky Lviv National Medical University, Lviv

1Andrei Krupynskyi Lviv Medical Academy, Lviv

dr.kowalska.marta@gmail.com

Abstract

We have investigated the results of alterations in indices of pro-oxidant (conjugated diene and malondialdehyde) and antioxidant (superoxide dismutase, ceruloplasmin, catalase) systems in guinea pigs’ lungs under the conditions of immobilization stress. The experiment was conducted on 40 female guinea pigs weighing 0.18-0.20 kg. The animals were divided into 4 groups, each contained 10 guinea pigs: I – intact guinea pigs (control), II–guinea pigs with model of IS on1st day of experiment;Ш–animals on 2nd  day of experiment;IV- group of animals on 34th day of experimental model of IS.

The results of our experimental work showed a significant accumulation of lipid peroxidation products in the lung`s tissure in different periods (on 1st, 2nd and 34th days) of immobilization stress. The state of antioxidant defence was characterized by moderate decrease of inzymes activity (superoxide dismutase, catalase and ceruloplasmin). disorders of balance between pro-oxidant and antioxidant systems couse oxidative stress development.

Key words: immobilization stress; peroxide lipid oxidation; antioxidant system.