ATP5O Hypo-crotonylation is a Primary Detrimental Factor for Abnormal Lipid Metabolism under Chronic Resistant Stress
Creators
- 1. State Key Lab of Reproductive Medicine, Nanjing Medical University
Description
Supplementary dataset 1
This file corresponds to Fig. 2L–N. Label-free crotonylome was employed to identify all crotonylated sites & proteins from control or CRS mouse ovaries, two repeats each. This file includes two sheets. " All Site_quant Normalized" sheet include all identified crotonylated sites, normalized by gross protein level; "Stress vs control > 1.3 or < 0.77" sheet includes all crotonylated sites that were 1.3-fold upregulated or 0.77 fold downregulated in stress group in contrast to control.
Supplementary dataset 2
This file corresponds to Fig. 4A–D. Full-spectrum metabolome was employed to identify all types of metabolites from control or CRS mice (six repeats each). This file includes two sheets. "All data" sheet include all identified metabolites; " S vs C > 2 or < 0.5" sheet includes all metabolites that were 2 fold upregulated or 0.5 fold downregulated in CRS group in contrast to control.
Supplementary dataset 3
This file corresponds to Fig. 6A–C. TMT-labeled quantitative phosphoproteome was employed to identify all phosphorylated sites & proteins from control or CRS mouse ovaries, two repeats each. This file includes two sheets. " All Site_quant Normalized" sheet include all identified phosphorylated sites, normalized by gross protein level; "Stress vs control >1.2 or < 0.833" sheet includes all phosphorylated sites that were 1.2 fold upregulated or 0.833 fold downregulated in stress group in contrast to control.
Supplementary dataset 4
This file corresponds to Fig. 7D–F. Lipid metabolome was employed to identify all lipid metabolites from control, CRS, or CRS+THP-treated mice (six repeats each). This file includes two sheets. "ALL_DATA" sheet includes all identified lipid metabolites; "S vs SH >1.5 or <0.67" sheet includes all lipid metabolites that were 1.5 fold upregulated or 0.67 downregulated in CRS+THP group in contrast to CRS group and meanwhile close to control group.
Supplementary dataset 5
This file corresponds to Fig. 8F-H. Lipid metabolome was employed to identify all lipid metabolites of human serum from control (C), stress-prone (SP), or stress (S) groups (ten repeats each). This file includes two sheets. "ALL_DATA" sheet includes all identified lipid metabolites; " HCRS vs HC > 1.5 or < 0.67" sheet includes all lipid metabolites that were 1.5 fold upregulated or 0.67 fold downregulated in S (HCRS) group in contrast to control.