Koenig Human Glucose Metabolism

Description

This is a metabolism model of Human glucose metabolism in SBML format.

This model is described in the article:

König M., Bulik S., Holzhütter HG.
PLoS Comput Biol. 2012;8(6)

Abstract:

Despite the crucial role of the liver in glucose homeostasis, a detailed mathematical model of human hepatic glucose metabolism is lacking so far. Here we present a detailed kinetic model of glycolysis, gluconeogenesis and glycogen metabolism in human hepatocytes integrated with the hormonal control of these pathways by insulin, glucagon and epinephrine. Model simulations are in good agreement with experimental data on (i) the quantitative contributions of glycolysis, gluconeogenesis, and glycogen metabolism to hepatic glucose production and hepatic glucose utilization under varying physiological states. (ii) the time courses of postprandial glycogen storage as well as glycogen depletion in overnight fasting and short term fasting (iii) the switch from net hepatic glucose production under hypoglycemia to net hepatic glucose utilization under hyperglycemia essential for glucose homeostasis (iv) hormone perturbations of hepatic glucose metabolism. Response analysis reveals an extra high capacity of the liver to counteract changes of plasma glucose level below 5 mM (hypoglycemia) and above 7.5 mM (hyperglycemia). Our model may serve as an important module of a whole-body model of human glucose metabolism and as a valuable tool for understanding the role of the liver in glucose homeostasis under normal conditions and in diseases like diabetes or glycogen storage diseases.

The content of this model has been carefully created in a manual research effort.
This file has been created by Matthias Koenig.

Terms of use

Copyright © 2016 Matthias Koenig.

Redistribution and use of any part of this model, with or without modification, are permitted provided that the following conditions are met:

  1. Redistributions of this SBML file must retain the above copyright notice, this list of conditions and the following disclaimer.
  2. Redistributions in a different form must reproduce the above copyright notice, this list of conditions and the following disclaimer in the documentation and/or other materials provided with the distribution.
This model is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.


Model : Hepatic_glucose_3

Creator
Matthias, Koenig, Humboldt-University Berlin, Institute for Theoretical Biology, konigmatt@googlemail.com
Created: 2016-10-05 14:32
Modified: 2016-10-05 14:32

id Hepatic_glucose_3 meta_ba33e19ea94d4f09b78beb5b55ad8b5b
nameHepatic_glucose_3
times
substancemole
extentmole
volumem3
aream2
lengthm
Access SBML model  L3V1 fbc-V2

FunctionDefinitions [2] name math sbo cvterm
max minimum of arguments x y x x y y
min maximum of arguments x y x x y y

UnitDefinitions [16] name units sbo cvterm
s s
kg kg
m m
m2 m 2
m3 m 3
per_s 1 s
min 60 s
s_per_min s 60 s
mM mole m 3
per_mM m 3 mole
mM2 mole 2 m 6
mole_per_s mole s
pmol 10 12 mole
pM 10 12 mole litre
mumol_per_min_kg 10 6 mole kg 60 s
s_per_min_kg s kg 60 s

Compartments [5] name size constant spatial dimensions units derived units sbo cvterm
ext meta_f08012973f5e42f7a9d796778cf458ea blood V_ext 3 m3 m 3
cyto meta_1edcfec978da48eea4f18b973b9ad6e6 cytosol V_cyto 3 m3 m 3
mito meta_ad8abb25ec2f494c80de21a0ab8b8180 mitochondrion V_mito 3 m3 m 3
pm meta_e76b305621064b4fa8844e665a4cd3ed plasma membrane 1 2 m2 m 2
mm meta_0de218213b3946e9899fd492fe6d8c55 mitochondrial membrane 1 2 m2 m 2

Species [49] name compartment boundary condition constant initial amount initial concentration conversion factor units substance units derived units sbo cvterm
atp meta_30adac61de9a4e01853cad35fc995a73 ATP
C10H12N5O13P3 (-4)
cyto 2.8 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:30616
BQB_IS_VERSION_OF
C00002
adp meta_2d6c1b8f2d6d4f7ea18fb363a22ccefe ADP
C10H12N5O10P2 (-3)
cyto 0.8 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:456216
BQB_IS_VERSION_OF
C00008
amp meta_7a9f9064bb7542a5ba0388db3f9fbdbc AMP
C10H12N5O7P (-2)
cyto 0.16 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:456215
BQB_IS_VERSION_OF
C00020
utp meta_caf82aad1d5e4390b53b7e9591946408 UTP
C9H11N2O15P3 (-4)
cyto 0.27 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:46398
BQB_IS_VERSION_OF
C00075
udp meta_f301e59aadb148bcb9a4f535adc5b608 UDP
C9H11N2O12P2 (-3)
cyto 0.09 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58223
BQB_IS_VERSION_OF
C00015
gtp meta_e0da1dea14ca40b58c9cbdf28b8701ef GTP
C10H12N5O14P3 (-4)
cyto 0.29 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:37565
BQB_IS_VERSION_OF
C00044
gdp meta_3b19085ef4504bf09031cc03fe07b71e GDP
C10H12N5O11P2 (-3)
cyto 0.1 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58189
BQB_IS_VERSION_OF
C00035
nad meta_e21b1c11f99a4c3d9a3b01c18cd15b8e NAD+
C21H26N7O14P2 (-1)
cyto 1.22 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:57540
BQB_IS_VERSION_OF
C00003
nadh meta_a124633781394749b0ce1b20a9dd8ef5 NADH
C21H27N7O14P2 (-2)
cyto 0.00056 mole mole mole m 3
phos meta_f98a1e1c4be04a06a6b9048b3eb5d864 phosphate
HO4P (-2)
cyto 5.0 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:43474
BQB_IS_VERSION_OF
C00009
pp meta_14f6468ca05841e5a886f9c160dd2e4c pyrophosphate
HO7P2 (-3)
cyto 0.008 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:33019
BQB_IS_VERSION_OF
C00013
co2 meta_a7c4ea2a645b4d849b9047ed1dbb9b5a CO2
CO2
cyto 5.0 mole mole mole m 3
h2o meta_dd9b514cd81f4b5f92e1f807ca8a955a H2O
H2O
cyto 0.0 mole mole mole m 3
h meta_92325fd074b8446fb2d48e70584d7a60 H+
H (1)
cyto 0.0 mole mole mole m 3
glc1p meta_14bdf79e0806430e9c81f1d68e0861a7 glucose-1 phosphate
C6H11O9P (-2)
cyto 0.012 mole mole mole m 3
udpglc meta_bc19915a517e4b2a9f7b636a425df34c UDP-glucose
C15H22N2O17P2 (-2)
cyto 0.38 mole mole mole m 3
glyglc meta_7c9ff0cd3bdb4652b1743bdfad72ac8d glycogen
C6H12O6
cyto 250.0 mole mole mole m 3
BQB_IS
SBO:0000247
BQB_IS_VERSION_OF
C00182; CHEBI:28087
glc meta_3fb11a55bd44461d9661f7345f7cdea3 glucose
C6H12O6
cyto 5.0 mole mole mole m 3
glc6p meta_61aa80f6510047f694a139fd16c0dc3e glucose-6 phosphate
C6H11O9P (-2)
cyto 0.12 mole mole mole m 3
fru6p meta_3360f52a781c40d8ac4cd6313195233d fructose-6 phosphate
C6H11O9P (-2)
cyto 0.05 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:57579
BQB_IS_VERSION_OF
C00085
fru16bp meta_9386761d87fd49c2b0c74b651091d106 fructose-16 bisphosphate
C6H10O12P2 (-4)
cyto 0.02 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:49299
BQB_IS_VERSION_OF
C00354
fru26bp meta_59a115e45529430bae69d647f93fded3 fructose-26 bisphosphate
C6H10O12P2 (-4)
cyto 0.004 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58579
BQB_IS_VERSION_OF
C00665
grap meta_4a9b5f8ee45c45809f6918fbc0428548 glyceraldehyde 3-phosphate
C3H5O6P (-2)
cyto 0.1 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:59776
BQB_IS_VERSION_OF
C00118
dhap meta_04fd18bf0446443db060503d4c9eb294 dihydroxyacetone phosphate
C3H5O6P (-2)
cyto 0.03 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:57642
BQB_IS_VERSION_OF
C00111
bpg13 meta_cdde408ba42b45bd95251b9b8ecfc03b 13-bisphospho-glycerate
C3H4O10P2 (-4)
cyto 0.3 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:57604
BQB_IS_VERSION_OF
C00236
pg3 meta_910a6794848a40fdbf2d1017eea5876b 3-phosphoglycerate
C3H4O7P (-3)
cyto 0.27 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58272
BQB_IS_VERSION_OF
C00197
pg2 meta_9c39119e54ae4c89a4d0e6d4d7c2a018 2-phosphoglycerate
C3H4O7P (-3)
cyto 0.03 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58289
BQB_IS_VERSION_OF
C00631
pep meta_aca24ba0a29247048aef9667ae412071 phosphoenolpyruvate
C3H2O6P (-3)
cyto 0.15 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58702
BQB_IS_VERSION_OF
C00074
pyr meta_9f33414948f0464f8d341fdabcfed96d pyruvate
C3H3O3 (-1)
cyto 0.1 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:15361
BQB_IS_VERSION_OF
C00022
oaa meta_67ebd001558d4bc2b5aa76cbf80ee251 oxaloacetate
C4H2O5 (-2)
cyto 0.01 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:16452
BQB_IS_VERSION_OF
C00036
lac meta_2a077c9bc6164d2e920d4b7567b1e138 lactate
C3H5O3 (-1)
cyto 0.5 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:16651
BQB_IS_VERSION_OF
C00186
glc_ext meta_51edb78d31b546f3bc9c6954386b7a09 glucose
C6H12O6
ext 3.0 mole mole mole m 3
lac_ext meta_40c5ebc9558145e9b2e0f6ff73b12107 lactate
C3H5O3 (-1)
ext 1.2 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:16651
BQB_IS_VERSION_OF
C00186
co2_mito meta_e1321f8dc319432eb371407c2ac685f6 CO2
CO2
mito 5.0 mole mole mole m 3
phos_mito meta_de6dc26cda7b46d4b0503887b7c460b3 phosphate
HO4P (-2)
mito 5.0 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:43474
BQB_IS_VERSION_OF
C00009
oaa_mito meta_d1c59ba0e463477fb109b37a0001cf0d oxaloacetate
C4H2O5 (-2)
mito 0.01 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:16452
BQB_IS_VERSION_OF
C00036
pep_mito meta_a155df7c52c94bf2b4147d75a25bd46e phosphoenolpyruvate
C3H2O6P (-3)
mito 0.15 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58702
BQB_IS_VERSION_OF
C00074
acoa_mito meta_1ede72cdc7a94215ad7896b194b7e4e8 acetyl-coenzyme A
C23H34N7O17P3S (-4)
mito 0.04 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:57288
BQB_IS_VERSION_OF
C00024
pyr_mito meta_981b13ae77674f1e9e5b2d7eb8803ff8 pyruvate
C3H3O3 (-1)
mito 0.1 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:15361
BQB_IS_VERSION_OF
C00022
cit_mito meta_af684a37c2fa4ec9a44c932e655cb99a citrate
C6H5O7 (-3)
mito 0.32 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:16947
BQB_IS_VERSION_OF
C00158
atp_mito meta_f96ddf3c29ac45de9e660a73d7eeba63 ATP
C10H12N5O13P3 (-4)
mito 2.8 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:30616
BQB_IS_VERSION_OF
C00002
adp_mito meta_9a15984b9e4a40e78148fa7b85c7f67b ADP
C10H12N5O10P2 (-3)
mito 0.8 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:456216
BQB_IS_VERSION_OF
C00008
gtp_mito meta_b010d94455dc44b8b6067dbd73d29171 GTP
C10H12N5O14P3 (-4)
mito 0.29 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:37565
BQB_IS_VERSION_OF
C00044
gdp_mito meta_16f8bcf3cd3f4233bb1155846dc6ac1b GDP
C10H12N5O11P2 (-3)
mito 0.1 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:58189
BQB_IS_VERSION_OF
C00035
coa_mito meta_94506773d69a46539e1867822e74dafc coenzyme A
C21H32N7O16P3S (-4)
mito 0.055 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:57287
BQB_IS_VERSION_OF
C00010
nadh_mito meta_4e2d61c5181b4ad3a52e8458ce577bcb NADH
C21H27N7O14P2 (-2)
mito 0.24 mole mole mole m 3
nad_mito meta_d8b0749a261141f795d43d7482c7f25d NAD+
C21H26N7O14P2 (-1)
mito 0.98 mole mole mole m 3
BQB_IS
SBO:0000247; CHEBI:57540
BQB_IS_VERSION_OF
C00003
h2o_mito meta_3b8fab25d61248d7a5d67dc12dd72f37 H20
H2O
mito 0.0 mole mole mole m 3
h_mito meta_c777da6ef46a48738842666fc8443026 H+
H (1)
mito 0.0 mole mole mole m 3

Parameters [258] name constant value unit derived unit sbo cvterm
V_cyto cytosolic volume 0.001 m3 m 3
f_ext external volume factor 10.0 dimensionless None
f_mito mitochondrial volume factor 0.2 dimensionless None
Vliver liver volume 0.0015 m3 m 3
fliver parenchymal fraction liver 0.583333333333334 dimensionless None
bodyweight bodyweight 70.0 kg kg
sec_per_min time conversion 60.0 s_per_min s 60 s
x_ins1 818.9 pM 10 12 mole litre
x_ins2 0.0 pM 10 12 mole litre
x_ins3 8.6 mM mole m 3
x_ins4 4.2 dimensionless None
x_glu1 190.0 pM 10 12 mole litre
x_glu2 37.9 pM 10 12 mole litre
x_glu3 3.01 mM mole m 3
x_glu4 6.4 dimensionless None
x_epi1 6090.0 pM 10 12 mole litre
x_epi2 100.0 pM 10 12 mole litre
x_epi3 3.1 mM mole m 3
x_epi4 8.4 dimensionless None
K_val 0.1 dimensionless None
epi_f 0.8 dimensionless None
V_ext external volume f_ext V_cyto m3 m 3
V_mito mitochondrial volume f_mito V_cyto m3 m 3
conversion_factor fliver Vliver V_cyto sec_per_min 1 3 bodyweight s_per_min_kg s kg 60 s
scale scaling factor rates 1 60 dimensionless None
f_gly scaling factor glycolysis scale dimensionless None
f_glyglc scaling factor glycogen metabolism scale dimensionless None
ins meta_1d72dbddbe7a40fc960fc456a795b8a3 insulin x_ins2 x_ins1 x_ins2 glc_ext x_ins4 glc_ext x_ins4 x_ins3 x_ins4 pM 10 12 mole litre
BQB_IS
C00723; P01308
ins_norm insulin normalized max 0 ins x_ins2 pM 10 12 mole litre
glu meta_0fc7b3a91c584a93b6ce70771c37bd91 glucagon x_glu2 x_glu1 x_glu2 1 glc_ext x_glu4 glc_ext x_glu4 x_glu3 x_glu4 pM 10 12 mole litre
BQB_IS
C01501; P01275
glu_norm glucagon normalized max 0 glu x_glu2 pM 10 12 mole litre
epi meta_8ef1ad13f19049f6878a62743255146a epinephrine x_epi2 x_epi1 x_epi2 1 glc_ext x_epi4 glc_ext x_epi4 x_epi3 x_epi4 pM 10 12 mole litre
epi_norm epinephrine normalized max 0 epi x_epi2 pM 10 12 mole litre
K_ins x_ins1 x_ins2 K_val pM 10 12 mole litre
K_glu x_glu1 x_glu2 K_val pM 10 12 mole litre
K_epi x_epi1 x_epi2 K_val pM 10 12 mole litre
gamma phosphorylation state 0.5 1 ins_norm ins_norm K_ins max glu_norm glu_norm K_glu epi_f epi_norm epi_norm K_epi dimensionless None
nadh_tot NADH balance nadh nad mM mole m 3
atp_tot ATP balance atp adp amp mM mole m 3
utp_tot UTP balance utp udp udpglc mM mole m 3
gtp_tot GTP balance gtp gdp mM mole m 3
nadh_mito_tot NADH mito balance nadh_mito nad_mito mM mole m 3
atp_mito_tot ATP mito balance atp_mito adp_mito mM mole m 3
gtp_mito_tot GTP mito balance gtp_mito gdp_mito mM mole m 3
HGP hepatic glucose production/utilization GLUT2 conversion_factor mumol_per_min_kg 10 6 mole kg 60 s
GNG gluconeogenesis/glycolysis GPI conversion_factor mumol_per_min_kg 10 6 mole kg 60 s
GLY glycogenolysis/glycogen synthesis G16PI conversion_factor mumol_per_min_kg 10 6 mole kg 60 s
GLUT2_keq meta_e097144762f34f8ea29a95f13ed89721 1.0 dimensionless None
GLUT2_k_glc meta_6a52d394cd7e4661b221bf08ccdda225 42.0 mM mole m 3
GLUT2_Vmax meta_925228a7c16e4b9ca7182d1009268f20 420.0 mole_per_s mole s
GK_n_gkrp 2.0 dimensionless None
GK_k_glc1 meta_dcc8f8df175e4211959569220aa560e3 15.0 mM mole m 3
GK_k_fru6p meta_edad1888770f46ad8fcd97c10fef4719 0.01 mM mole m 3
GK_b 0.7 dimensionless None
GK_n 1.6 dimensionless None
GK_k_glc meta_bf4bedd63a5e463ab493fd2e74c93799 7.5 mM mole m 3
GK_k_atp meta_c0c8a90ab8e243ac99467628154e3d4e 0.26 mM mole m 3
GK_Vmax meta_5ed3e72a140e4bbeb00f97c972942b66 25.2 mole_per_s mole s
GK_gc_free glc GK_n_gkrp glc GK_n_gkrp GK_k_glc1 GK_n_gkrp 1 GK_b fru6p fru6p GK_k_fru6p dimensionless None
G6PASE_k_glc6p meta_d9be195083014de3ad08f2a4f077c882 2.0 mM mole m 3
G6PASE_Vmax meta_a0ee26db60e545c68dc5543e166a142f 18.9 mole_per_s mole s
GPI_keq meta_1aa6e6b75aa14f1aa136ea2ffd2c8908 0.517060817492925 dimensionless None
GPI_k_glc6p meta_3fb8683155cf4abba3731a70c71c839a 0.182 mM mole m 3
GPI_k_fru6p meta_4597e08ecba44615b3f7c318388b903c 0.071 mM mole m 3
GPI_Vmax meta_d8770bbb21904cf9a4951810a5ff64b0 420.0 mole_per_s mole s
G16PI_keq meta_7fa1f847e95c4f6fbfad85d4d46d4ab1 15.7175540821514 dimensionless None
G16PI_k_glc6p meta_dd8277d68e424e8da0e9d2de01db1183 0.67 mM mole m 3
G16PI_k_glc1p meta_3b5b9f7ba0bf40c7a5af1c8804edca35 0.045 mM mole m 3
G16PI_Vmax meta_e1b0a6dc995845088c2e7111e911253b 100.0 mole_per_s mole s
UPGASE_keq meta_ac94cc28ab74443c85cd8d44df006558 0.312237619153088 dimensionless None
UPGASE_k_utp meta_ff565a1cd2e84dc6a682ae16933aca5f 0.563 mM mole m 3
UPGASE_k_glc1p meta_3004fb83c3d0454899070bfadc50d2c7 0.172 mM mole m 3
UPGASE_k_udpglc meta_27c418510b734f0c86745145037600a2 0.049 mM mole m 3
UPGASE_k_pp meta_c4ce382d509246f99a82e1562a913a2b 0.166 mM mole m 3
UPGASE_Vmax meta_2d087e18328c4edbbb2d1308c54563c4 80.0 mole_per_s mole s
PPASE_k_pp meta_233961cb25bf4bf59c3ca0836ce4e5ad 0.005 mM mole m 3
PPASE_Vmax meta_729d054ae6bd48f08603e016a2529cf5 2.4 mole_per_s mole s
GS_C 500.0 mM mole m 3
GS_k1_max 0.2 dimensionless None
GSn_k1 0.224 mM2 mole 2 m 6
GSp_k1 3.003 mM2 mole 2 m 6
GSn_k2 0.1504 mM mole m 3
GSp_k2 0.09029 mM mole m 3
GS_Vmax meta_319da5956f1548ec8c1570860f335c3f 13.2 mole_per_s mole s
GS_fs 1 GS_k1_max GS_C glyglc GS_C glyglc GS_k1_max GS_C dimensionless None
GSn_k_udpglc meta_205751e7d3014a8d8a99d5ff2d5e48b7 GSn_k1 glc6p GSn_k2 mM mole m 3
GSp_k_udpglc meta_deaf8ca255c348baa79b88c2cf490ccf GSp_k1 glc6p GSp_k2 mM mole m 3
GSn f_glyglc GS_Vmax GS_fs udpglc GSn_k_udpglc udpglc mole_per_s mole s
GSp f_glyglc GS_Vmax GS_fs udpglc GSp_k_udpglc udpglc mole_per_s mole s
GP_keq meta_777eecf3aa5b4fff8710b41676946f03 0.211826505793075 per_mM m 3 mole
GPn_k_glyglc meta_1da097271bb44ca3b32a7da88d7855f5 4.8 mM mole m 3
GPp_k_glyglc meta_fd4481106d92410fb9033688b59c8de2 2.7 mM mole m 3
GPn_k_glc1p meta_dbf0cadd8a69478495c154ebe24cb283 120.0 mM mole m 3
GPp_k_glc1p meta_12ba58e229be4c34b53ca19141194d0a 2.0 mM mole m 3
GPn_k_phos meta_2bf86f0e3a934c6694eb4a93cf2e3770 300.0 mM mole m 3
GPp_k_phos meta_05ff2dc33ba349c0a185dd5e89dc5b93 5.0 mM mole m 3
GPp_ki_glc meta_e37c1a6eb81044169b20f999c9480d94 5.0 mM mole m 3
GPn_ka_amp 1.0 mM mole m 3
GPn_base_amp 0.03 dimensionless None
GPn_max_amp 0.3 dimensionless None
GP_Vmax meta_dc6945c2c541486680e2e5f2f756550d 6.8 mole_per_s mole s
GP_fmax 1 GS_k1_max glyglc glyglc GS_k1_max GS_C dimensionless None
GPn_Vmax meta_c122f15108cd48c4bfeba307a1368d48 f_glyglc GP_Vmax GP_fmax GPn_base_amp GPn_max_amp GPn_base_amp amp amp GPn_ka_amp mole_per_s mole s
GPn GPn_Vmax GPn_k_glyglc GPn_k_phos glyglc phos glc1p GP_keq 1 glyglc GPn_k_glyglc 1 phos GPn_k_phos 1 glc1p GPn_k_glc1p 1 mole_per_s mole s
GPp_Vmax meta_74cf94e419614a4fab6ee19e17f1dfc3 f_glyglc GP_Vmax GP_fmax 10 2 GPp_ki_glc glc mole_per_s mole s
GPp GPp_Vmax GPp_k_glyglc GPp_k_phos glyglc phos glc1p GP_keq 1 glyglc GPp_k_glyglc 1 phos GPp_k_phos 1 glc1p GPp_k_glc1p 1 mole_per_s mole s
NDKGTP_keq meta_470603abbc46432d922b02dc409ee610 1.0 dimensionless None
NDKGTP_k_atp meta_361c37419643433b891ef0d8f24670ea 1.33 mM mole m 3
NDKGTP_k_adp meta_332b23de498c4b219563dc251f34d7ae 0.042 mM mole m 3
NDKGTP_k_gtp meta_398196b284694e4f8612010e7403fa40 0.15 mM mole m 3
NDKGTP_k_gdp meta_45502aa3795546b785bfbe7699d0bfe3 0.031 mM mole m 3
NDKGTP_Vmax meta_13d872a692994167b9d60ceaa8d0b6d5 0.0 mole_per_s mole s
NDKUTP_keq meta_af758987c2f94cb9a7cd5c67f9fccbe8 1.0 dimensionless None
NDKUTP_k_atp meta_f9be88d4a1c54e44b48e721e3900504b 1.33 mM mole m 3
NDKUTP_k_adp meta_5756f1208db24a94919908433ab893c0 0.042 mM mole m 3
NDKUTP_k_utp meta_cd33fc5e507b4d04afd73488b11baf1c 16.0 mM mole m 3
NDKUTP_k_udp meta_a1c1080d2e6d44939b45de10fc539d22 0.19 mM mole m 3
NDKUTP_Vmax meta_eef7d5668ee54be0afd1a85de449a9c9 2940.0 mole_per_s mole s
AK_keq meta_4101431556254b2b9745558bf02385da 0.247390074904985 dimensionless None
AK_k_atp meta_0ad947be373a4833a808ae8ec6b06096 0.09 mM mole m 3
AK_k_amp meta_7a7f59affe514305b6341c871e5ab76d 0.08 mM mole m 3
AK_k_adp meta_6666b2c7851b4584a2427c7c8d97f19e 0.11 mM mole m 3
AK_Vmax meta_2fd8311454964443b4ab7c9ea09182fd 0.0 mole_per_s mole s
PFK2n_n 1.3 dimensionless None
PFK2p_n 2.1 dimensionless None
PFK2n_k_fru6p meta_a08a9fe2357d47b0adb6130ade6062bb 0.016 mM mole m 3
PFK2p_k_fru6p meta_6ba7004b142742c4b4ed248f75c4d9bc 0.05 mM mole m 3
PFK2n_k_atp meta_8f8ba21a8d8c40769e5eafdff18e5e43 0.28 mM mole m 3
PFK2p_k_atp meta_0f0570a67a3b47928e8544cea50df6c1 0.65 mM mole m 3
PFK2_Vmax meta_461be80580b447a0a04b9ae4ffa781bf 0.0042 mole_per_s mole s
PFK2n f_gly PFK2_Vmax fru6p PFK2n_n fru6p PFK2n_n PFK2n_k_fru6p PFK2n_n atp atp PFK2n_k_atp mole_per_s mole s
PFK2p f_gly PFK2_Vmax fru6p PFK2p_n fru6p PFK2p_n PFK2p_k_fru6p PFK2p_n atp atp PFK2p_k_atp mole_per_s mole s
FBP2n_k_fru26bp meta_aaacab41ebe949008c4538c8c743f1fa 0.01 mM mole m 3
FBP2p_k_fru26bp meta_721d5893840741288238f807faa96b1e 0.0005 mM mole m 3
FBP2n_ki_fru6p meta_c1810032476147838bbb4b9150f735e1 0.0035 mM mole m 3
FBP2p_ki_fru6p meta_62e329609e1f4d19b38f1af9831d4bef 0.01 mM mole m 3
FBP2_Vmax meta_7e09a45c77df4099ab84c6534fefff11 0.126 mole_per_s mole s
FBP2n f_gly FBP2_Vmax 1 fru6p FBP2n_ki_fru6p fru26bp FBP2n_k_fru26bp fru26bp mole_per_s mole s
FBP2p f_gly FBP2_Vmax 1 fru6p FBP2p_ki_fru6p fru26bp FBP2p_k_fru26bp fru26bp mole_per_s mole s
PFK1_k_atp meta_3e3588576d7f41659d2a87996348e799 0.111 mM mole m 3
PFK1_k_fru6p meta_a6d1dfe661c54aa38e4f0a4a249474c2 0.077 mM mole m 3
PFK1_ki_fru6p meta_b76ffbb55ef242ef9bb4d8482f617964 0.012 mM mole m 3
PFK1_ka_fru26bp 0.001 mM mole m 3
PFK1_Vmax meta_25249c2375914ae0b846294e3e3ccb01 7.182 mole_per_s mole s
FBP1_ki_fru26bp meta_3f8c4a2660374ee2935254b3f9f1ab6a 0.001 mM mole m 3
FBP1_k_fru16bp meta_3b407e6d73c4443eb644c28015dea3c1 0.0013 mM mole m 3
FBP1_Vmax meta_5d192b459d1e4e42a4826559b878af38 4.326 mole_per_s mole s
ALD_keq meta_f44258397b8d476ca2eb21b1105136d4 9.76298897362969e-05 mM mole m 3
ALD_k_fru16bp meta_28d5e02b9bcd40c9b695c5b650add794 0.0071 mM mole m 3
ALD_k_dhap meta_079eb7f2b01f4d1abef33c31ebe9aaab 0.0364 mM mole m 3
ALD_k_grap meta_91b6605836184f9fb4810cfd11d5e295 0.0071 mM mole m 3
ALD_ki1_grap 0.0572 mM mole m 3
ALD_ki2_grap 0.176 mM mole m 3
ALD_Vmax meta_d8c8e0f6264a4777be470c3fdfbf7e6a 420.0 mole_per_s mole s
TPI_keq meta_abdda832f5484f3c8d56443915350a0b 0.054476985386756 dimensionless None
TPI_k_dhap meta_f7524d8d112048ac8d62f3a8ffcc682d 0.59 mM mole m 3
TPI_k_grap meta_fc799262b4fd4dae95e28b1ddf963a7a 0.42 mM mole m 3
TPI_Vmax meta_a3334fb52db542a29f995cb7adec9ba8 420.0 mole_per_s mole s
GAPDH_keq meta_3c6932eb3e564ec8975b9b1296c19492 0.086779866194594 per_mM m 3 mole
GAPDH_k_nad meta_fd12b8c72ce64d7eabf9e4886b4eddd3 0.05 mM mole m 3
GAPDH_k_grap meta_79163de6a15e4fb8b7de8b197c76a18a 0.005 mM mole m 3
GAPDH_k_phos meta_08aa3f078e9847dbbf80240eb7945bfa 3.9 mM mole m 3
GAPDH_k_nadh meta_3dad61c2c72e4f9a8d01e3afe1c2e820 0.0083 mM mole m 3
GAPDH_k_bpg13 meta_81738e0fc3d844dc93073d16caef6d0d 0.0035 mM mole m 3
GAPDH_Vmax meta_d60055615d7f4ef7acc7cfe54123d166 420.0 mole_per_s mole s
PGK_keq meta_3ccec785469c4c5d82c50718d1fa1ee2 6.95864405248854 dimensionless None
PGK_k_adp meta_853bf9f7c8314c21b423e2f0ca784da7 0.35 mM mole m 3
PGK_k_atp meta_73318af6f5f34686a08b152a66e5ec2f 0.48 mM mole m 3
PGK_k_bpg13 meta_64cef802898d4d8b82ddd9b78ea6c752 0.002 mM mole m 3
PGK_k_pg3 meta_4049ea8395b24930a0f1f72f148950de 1.2 mM mole m 3
PGK_Vmax meta_021572b467d342da844f43bc58414c9f 420.0 mole_per_s mole s
PGM_keq meta_6e90ed894cf14a7793e059b8bfb116c1 0.181375378837397 dimensionless None
PGM_k_pg3 meta_4068d25696cd46d4bc12de17e3b18e4a 5.0 mM mole m 3
PGM_k_pg2 meta_48235180384740e6986488f13912a188 1.0 mM mole m 3
PGM_Vmax meta_46d79518e89f478eb6e0f261d3eafe79 420.0 mole_per_s mole s
EN_keq meta_8f7596f8411e4bfe93f444665a86bc95 0.054476985386756 dimensionless None
EN_k_pep meta_794dd0e9e3fb4734bc64a4e0ebf93536 1.0 mM mole m 3
EN_k_pg2 meta_86582b79ba4a4a3387630498cb7adcb4 1.0 mM mole m 3
EN_Vmax meta_7f2bd8bbb66148d88d279589db1067b6 35.994 mole_per_s mole s
PKn_n 3.5 dimensionless None
PKp_n 3.5 dimensionless None
PKn_n_fbp 1.8 dimensionless None
PKp_n_fbp 1.8 dimensionless None
PKn_alpha 1.0 dimensionless None
PKp_alpha 1.1 dimensionless None
PKn_k_fbp meta_d6faa8876ccd49a4a9c8b40d9782bfe1 0.00016 mM mole m 3
PKp_k_fbp meta_e415762a6a714d269ea66d6f0e1711b3 0.00035 mM mole m 3
PKn_k_pep meta_1b3109d7ff454b0489ec4d938eb8618f 0.58 mM mole m 3
PKp_k_pep meta_84c455f1d7ec46348bf47a15923c4bf9 1.1 mM mole m 3
PKn_ba 0.08 dimensionless None
PKp_ba 0.04 dimensionless None
PK_ae 1.0 dimensionless None
PKn_k_pep_end meta_c8abaea00a024fb3829a462e88013631 0.08 mM mole m 3
PK_k_adp meta_66aab064f6174f4b8f6f1d39d2c81a26 2.3 mM mole m 3
PK_Vmax meta_3936104345264b6e931c9607085d5134 46.2 mole_per_s mole s
PKn_f fru16bp PKn_n_fbp PKn_k_fbp PKn_n_fbp fru16bp PKn_n_fbp dimensionless None
PKp_f fru16bp PKp_n_fbp PKp_k_fbp PKp_n_fbp fru16bp PKp_n_fbp dimensionless None
PKn_alpha_inp 1 PKn_f PKn_alpha PK_ae PK_ae dimensionless None
PKp_alpha_inp 1 PKp_f PKp_alpha PK_ae PK_ae dimensionless None
PKn_pep_inp 1 PKn_f PKn_k_pep PKn_k_pep_end PKn_k_pep_end mM mole m 3
PKp_pep_inp 1 PKp_f PKp_k_pep PKn_k_pep_end PKn_k_pep_end mM mole m 3
PKn f_gly PK_Vmax PKn_alpha_inp pep PKn_n PKn_pep_inp PKn_n pep PKn_n adp adp PK_k_adp PKn_ba 1 PKn_ba PKn_f mole_per_s mole s
PKp f_gly PK_Vmax PKp_alpha_inp pep PKp_n PKp_pep_inp PKp_n pep PKp_n adp adp PK_k_adp PKp_ba 1 PKp_ba PKp_f mole_per_s mole s
PEPCK_keq meta_2d8cf38db76440ed8a6d34ddb6606f51 336.956521586429 mM mole m 3
PEPCK_k_pep meta_0c20385efa214b889f31bbeab6e15c1d 0.237 mM mole m 3
PEPCK_k_gdp meta_5faf2f2cbf3e4548b163d31c5b9f8831 0.0921 mM mole m 3
PEPCK_k_co2 meta_4640e904f73c461dbfcd590416c34c1e 25.5 mM mole m 3
PEPCK_k_oaa meta_9b2dbce4e495453ea950792803016b79 0.0055 mM mole m 3
PEPCK_k_gtp meta_bca48e58ac0c41efbe4e44c6c8518aa5 0.0222 mM mole m 3
PEPCK_Vmax meta_4e31140df28844a6bc96cfeac421f332 0.0 mole_per_s mole s
PEPCKM_Vmax meta_1235e785a8804ce9b13e68be38a7eb32 546.0 mole_per_s mole s
PC_k_atp meta_453a2d6018894b8ebee58f48826818e6 0.22 mM mole m 3
PC_k_pyr meta_24caa50209f04367830b7f9baa6846d4 0.22 mM mole m 3
PC_k_co2 meta_7e4a6f640a794a4781f5405771fed956 3.2 mM mole m 3
PC_k_acoa meta_7e8deccfd18247da922780f9f441db31 0.015 mM mole m 3
PC_n 2.5 dimensionless None
PC_Vmax meta_8fec9d2a7b4a44d89289d21dcb4d7e3c 168.0 mole_per_s mole s
LDH_keq meta_ed5cc99aa0ba4490a4c74b8aa8cf6878 0.000278321076004752 dimensionless None
LDH_k_pyr meta_222dfa46cf9740bcb2587b2cea691df1 0.495 mM mole m 3
LDH_k_lac meta_42b26d793f3d47b4b5a47c45e9a56b42 31.98 mM mole m 3
LDH_k_nad meta_630cebc045854c93b2b4a7628942c223 0.984 mM mole m 3
LDH_k_nadh meta_8aaa9fd43d22424aa0523d8354445625 0.027 mM mole m 3
LDH_Vmax meta_a2248cc8404943ed947f6d255baabf2f 12.6 mole_per_s mole s
LACT_keq meta_0d11576865934290a95a861a78eaea56 1.0 dimensionless None
LACT_k_lac meta_061ed12ee480486d8cd4717a97927b48 0.8 mM mole m 3
LACT_Vmax meta_aca590d031784b8bb3e8e8cf09f48245 5.418 mole_per_s mole s
PYRTM_keq meta_b609795b4649458cabc8da67cbdf5f4f 1.0 dimensionless None
PYRTM_k_pyr meta_604d50771b8e48569df79514cf51489c 0.1 mM mole m 3
PYRTM_Vmax meta_1ab6cbfa23304682af19714b4a68595f 42.0 mole_per_s mole s
PEPTM_keq meta_5549c86f206a4d7b8d2afdc39fa96104 1.0 dimensionless None
PEPTM_k_pep meta_294089eb99b84f60a6860d7a2626c429 0.1 mM mole m 3
PEPTM_Vmax meta_f7b4c943bfda48a2b9c90f332ee73d93 33.6 mole_per_s mole s
PDH_k_pyr meta_003c65134a674ad0a6335dc3d6767888 0.025 mM mole m 3
PDH_k_coa meta_006b987f483645c498b20776429b8a90 0.013 mM mole m 3
PDH_k_nad meta_251f1c303c934fda824cc63161ce5dc3 0.05 mM mole m 3
PDH_ki_acoa meta_3b56b468e84d4a39a57105a446594b43 0.035 mM mole m 3
PDH_ki_nadh meta_c8bd71024dd342bca868fb3e9842c44f 0.036 mM mole m 3
PDHn_alpha 5.0 dimensionless None
PDHp_alpha 1.0 dimensionless None
PDH_Vmax meta_2e6bff1b10164bf886a97e81826372bf 13.44 mole_per_s mole s
PDH_base f_gly PDH_Vmax pyr_mito pyr_mito PDH_k_pyr nad_mito nad_mito PDH_k_nad 1 nadh_mito PDH_ki_nadh coa_mito coa_mito PDH_k_coa 1 acoa_mito PDH_ki_acoa mole_per_s mole s
PDHn PDH_base PDHn_alpha mole_per_s mole s
PDHp PDH_base PDHp_alpha mole_per_s mole s
CS_keq meta_21c5e753574141f9ab57c86e82b88069 266599.030842759 dimensionless None
CS_k_oaa meta_9fe6f533444d405e95b16bafbe0e6fa0 0.002 mM mole m 3
CS_k_acoa meta_7bd6dd90fe8a461e984e37c11e03b16f 0.016 mM mole m 3
CS_k_cit meta_082a66e64b7e46b0a52d175563f54f6e 0.42 mM mole m 3
CS_k_coa meta_eccab28f2b384535a314d1092245c9bf 0.07 mM mole m 3
CS_Vmax meta_c978d887e2eb4fd191152fe164b54836 4.2 mole_per_s mole s
NDKGTPM_keq meta_4c03222af0084efd87b73d5b4dd61b27 1.0 dimensionless None
NDKGTPM_k_atp meta_fd7856783cd64f10b54b1fe70a3c19ad 1.33 mM mole m 3
NDKGTPM_k_adp meta_9592bfb8c1c84945bb4e1d21a6032a3f 0.042 mM mole m 3
NDKGTPM_k_gtp meta_e6377382d30d432c81e92595416a6959 0.15 mM mole m 3
NDKGTPM_k_gdp meta_79a26e19d3444a02af89d57c8e1656c1 0.031 mM mole m 3
NDKGTPM_Vmax meta_5fee90f9ce1b437497796397b290bf2a 420.0 mole_per_s mole s
OAAFLX_Vmax meta_820f800730f9494e8dfc32830bbb0bec 0.0 mole_per_s mole s
ACOAFLX_Vmax meta_94dc473ae9294fa3a75e1be33298757e 0.0 mole_per_s mole s
CITFLX_Vmax meta_c392c70ea4404aa789d82d0b5e914c28 0.0 mole_per_s mole s

InitialAssignments [8] name assignment derived units sbo cvterm
pm = 1 m 2
mm = 1 m 2
V_ext = f_ext V_cyto m 3
V_mito = f_mito V_cyto m 3
conversion_factor = fliver Vliver V_cyto sec_per_min 1 3 bodyweight 1 59.9999999999999 kg
scale = 1 60 None
f_gly = scale None
f_glyglc = scale None

Rules [49]   assignment name derived units sbo cvterm
ext = V_ext m 3
cyto = V_cyto m 3
mito = V_mito m 3
ins = x_ins2 x_ins1 x_ins2 glc_ext x_ins4 glc_ext x_ins4 x_ins3 x_ins4 10 12 mole litre
ins_norm = max 0 ins x_ins2 10 12 mole litre
glu = x_glu2 x_glu1 x_glu2 1 glc_ext x_glu4 glc_ext x_glu4 x_glu3 x_glu4 10 12 mole litre
glu_norm = max 0 glu x_glu2 10 12 mole litre
epi = x_epi2 x_epi1 x_epi2 1 glc_ext x_epi4 glc_ext x_epi4 x_epi3 x_epi4 10 12 mole litre
epi_norm = max 0 epi x_epi2 10 12 mole litre
K_ins = x_ins1 x_ins2 K_val 10 12 mole litre
K_glu = x_glu1 x_glu2 K_val 10 12 mole litre
K_epi = x_epi1 x_epi2 K_val 10 12 mole litre
gamma = 0.5 1 ins_norm ins_norm K_ins max glu_norm glu_norm K_glu epi_f epi_norm epi_norm K_epi None
nadh_tot meta_4fd016d1f69c4059984c438a25d93779 = nadh nad mole m 3
atp_tot meta_c0c4a3f29ad1462e9069418e568abc23 = atp adp amp mole m 3
utp_tot meta_fc2021dcbf604c40b5eb191564eca230 = utp udp udpglc mole m 3
gtp_tot meta_09e3a68118fa4f5c99348c24d5da773e = gtp gdp mole m 3
nadh_mito_tot meta_4f58fd6e7cfc45408135e98374016eed = nadh_mito nad_mito mole m 3
atp_mito_tot meta_c6299ae28c4746b8b22a7a393be83f05 = atp_mito adp_mito mole m 3
gtp_mito_tot meta_99a80cd7754e41e59ed392270e5d7ddf = gtp_mito gdp_mito mole m 3
HGP = GLUT2 conversion_factor mole 59.9999999999999 kg s
GNG = GPI conversion_factor mole 59.9999999999999 kg s
GLY = G16PI conversion_factor mole 59.9999999999999 kg s
GK_gc_free = glc GK_n_gkrp glc GK_n_gkrp GK_k_glc1 GK_n_gkrp 1 GK_b fru6p fru6p GK_k_fru6p None
GS_fs = 1 GS_k1_max GS_C glyglc GS_C glyglc GS_k1_max GS_C None
GSn_k_udpglc = GSn_k1 glc6p GSn_k2 mole m 3
GSp_k_udpglc = GSp_k1 glc6p GSp_k2 mole m 3
GSn = f_glyglc GS_Vmax GS_fs udpglc GSn_k_udpglc udpglc mole s
GSp = f_glyglc GS_Vmax GS_fs udpglc GSp_k_udpglc udpglc mole s
GP_fmax = 1 GS_k1_max glyglc glyglc GS_k1_max GS_C None
GPn_Vmax = f_glyglc GP_Vmax GP_fmax GPn_base_amp GPn_max_amp GPn_base_amp amp amp GPn_ka_amp mole s
GPn = GPn_Vmax GPn_k_glyglc GPn_k_phos glyglc phos glc1p GP_keq 1 glyglc GPn_k_glyglc 1 phos GPn_k_phos 1 glc1p GPn_k_glc1p 1 mole s
GPp_Vmax = f_glyglc GP_Vmax GP_fmax 10 2 GPp_ki_glc glc mole s
GPp = GPp_Vmax GPp_k_glyglc GPp_k_phos glyglc phos glc1p GP_keq 1 glyglc GPp_k_glyglc 1 phos GPp_k_phos 1 glc1p GPp_k_glc1p 1 mole s
PFK2n = f_gly PFK2_Vmax fru6p PFK2n_n fru6p PFK2n_n PFK2n_k_fru6p PFK2n_n atp atp PFK2n_k_atp mole 0 s
PFK2p = f_gly PFK2_Vmax fru6p PFK2p_n fru6p PFK2p_n PFK2p_k_fru6p PFK2p_n atp atp PFK2p_k_atp mole s
FBP2n = f_gly FBP2_Vmax 1 fru6p FBP2n_ki_fru6p fru26bp FBP2n_k_fru26bp fru26bp mole s
FBP2p = f_gly FBP2_Vmax 1 fru6p FBP2p_ki_fru6p fru26bp FBP2p_k_fru26bp fru26bp mole s
PKn_f = fru16bp PKn_n_fbp PKn_k_fbp PKn_n_fbp fru16bp PKn_n_fbp None
PKp_f = fru16bp PKp_n_fbp PKp_k_fbp PKp_n_fbp fru16bp PKp_n_fbp None
PKn_alpha_inp = 1 PKn_f PKn_alpha PK_ae PK_ae None
PKp_alpha_inp = 1 PKp_f PKp_alpha PK_ae PK_ae None
PKn_pep_inp = 1 PKn_f PKn_k_pep PKn_k_pep_end PKn_k_pep_end mole m 3
PKp_pep_inp = 1 PKp_f PKp_k_pep PKn_k_pep_end PKn_k_pep_end mole m 3
PKn = f_gly PK_Vmax PKn_alpha_inp pep PKn_n PKn_pep_inp PKn_n pep PKn_n adp adp PK_k_adp PKn_ba 1 PKn_ba PKn_f mole s
PKp = f_gly PK_Vmax PKp_alpha_inp pep PKp_n PKp_pep_inp PKp_n pep PKp_n adp adp PK_k_adp PKp_ba 1 PKp_ba PKp_f mole s
PDH_base = f_gly PDH_Vmax pyr_mito pyr_mito PDH_k_pyr nad_mito nad_mito PDH_k_nad 1 nadh_mito PDH_ki_nadh coa_mito coa_mito PDH_k_coa 1 acoa_mito PDH_ki_acoa mole s
PDHn = PDH_base PDHn_alpha mole s
PDHp = PDH_base PDHp_alpha mole s

Reactions [36] name equation modifiers kinetic law derived units sbo cvterm
GLUT2 meta_22ca43bd7a2545028a6085b60b551ba7 GLUT2 glucose transporter
glc_ext ⇆ glc f_gly GLUT2_Vmax GLUT2_k_glc glc_ext glc GLUT2_keq 1 glc_ext GLUT2_k_glc glc GLUT2_k_glc mole s
GK meta_560cdcc124cf45c1b3b3f455e7561b0e Glucokinase
glc + atp ➞ glc6p + adp + h glc1p
fru6p
f_gly GK_Vmax GK_gc_free atp GK_k_atp atp glc GK_n glc GK_n GK_k_glc GK_n mole s
G6PASE meta_61a6571784ec450a917238d3b42a3ccd D-Glucose-6-phosphate Phosphatase
glc6p + h2o ➞ glc + phos f_gly G6PASE_Vmax glc6p G6PASE_k_glc6p glc6p mole s
GPI meta_1f8257e0d9334adbb540b363007b4d4a D-Glucose-6-phosphate Isomerase
glc6p ⇆ fru6p f_gly GPI_Vmax GPI_k_glc6p glc6p fru6p GPI_keq 1 glc6p GPI_k_glc6p fru6p GPI_k_fru6p mole s
G16PI meta_4f230843c6b548939ac75b5ea0f30c70 Glucose 1-phosphate 1,6-phosphomutase
glc1p ⇆ glc6p f_glyglc G16PI_Vmax G16PI_k_glc1p glc1p glc6p G16PI_keq 1 glc1p G16PI_k_glc1p glc6p G16PI_k_glc6p mole s
UPGASE meta_9fd0ef886b77400cb02cce15b64b5c5e UTP:Glucose-1-phosphate uridylyltransferase
glc1p + h + utp ⇆ pp + udpglc f_glyglc UPGASE_Vmax UPGASE_k_utp UPGASE_k_glc1p utp glc1p udpglc pp UPGASE_keq 1 utp UPGASE_k_utp 1 glc1p UPGASE_k_glc1p 1 udpglc UPGASE_k_udpglc 1 pp UPGASE_k_pp 1 mole s
PPASE meta_136770feabb54ae3933a16385e60902a Pyrophosphate phosphohydrolase
pp + h2o ➞ h + 2.0 phos f_glyglc PPASE_Vmax pp pp PPASE_k_pp mole s
GS meta_6e1c8137d18f44c6a45019b1efb17f7f Glycogen synthase
udpglc + h2o ➞ udp + h + glyglc glc6p 1 gamma GSn gamma GSp mole s
BQB_IS
SBO:0000176; P54840
BQB_IS_VERSION_OF
R00292; 18552
GP meta_e11b9bd9c2e94442abf904add157ee64 Glycogen-Phosphorylase
glyglc + phos ⇆ glc1p + h2o phos
amp
glc
1 gamma GPn gamma GPp mole s
BQB_IS
SBO:0000176; P06737
BQB_IS_VERSION_OF
41732; R01821
NDKGTP meta_e28964a7b1084d37893ae35835ef29a3 Nucleoside-diphosphate kinase (ATP, GTP)
atp + gdp ⇆ adp + gtp f_gly NDKGTP_Vmax NDKGTP_k_atp NDKGTP_k_gdp atp gdp adp gtp NDKGTP_keq 1 atp NDKGTP_k_atp 1 gdp NDKGTP_k_gdp 1 adp NDKGTP_k_adp 1 gtp NDKGTP_k_gtp 1 mole s
NDKUTP meta_5a8b50018e9f4afb9640ad61140ebc14 Nucleoside-diphosphate kinase (ATP, UTP)
atp + udp ⇆ adp + utp f_glyglc NDKUTP_Vmax NDKUTP_k_atp NDKUTP_k_udp atp udp adp utp NDKUTP_keq 1 atp NDKUTP_k_atp 1 udp NDKUTP_k_udp 1 adp NDKUTP_k_adp 1 utp NDKUTP_k_utp 1 mole s
AK meta_356ebf930a0943aa88e0df5944ecdbd5 ATP:AMP phosphotransferase (Adenylatkinase)
amp + atp ⇆ 2.0 adp f_gly AK_Vmax AK_k_atp AK_k_amp atp amp adp adp AK_keq 1 atp AK_k_atp 1 amp AK_k_amp 1 adp AK_k_adp 1 adp AK_k_adp 1 mole s
PFK2 meta_86d1e4ff2822414b9b8bc5a851c006cc ATP:D-fructose-6-phosphate 2-phosphotransferase
fru6p + atp ➞ fru26bp + adp + h 1 gamma PFK2n gamma PFK2p mole s
FBP2 meta_a9a3ebe5b3f64cbc848fc835dc99bc85 D-Fructose-2,6-bisphosphate 2-phosphohydrolase
fru26bp + h2o ➞ fru6p + phos 1 gamma FBP2n gamma FBP2p mole s
PFK1 meta_528d7c511dff4400a4aeb63532249d1b ATP:D-fructose-6-phosphate 1-phosphotransferase
fru6p + atp ➞ fru16bp + adp + h fru26bp f_gly PFK1_Vmax 1 1 1 fru26bp PFK1_ka_fru26bp fru6p atp PFK1_ki_fru6p PFK1_k_atp PFK1_k_fru6p atp PFK1_k_atp fru6p atp fru6p mole s
FBP1 meta_b1b91f1555614a24bf9805ea59d49b68 D-Fructose-1,6-bisphosphate 1-phosphohydrolase
fru16bp + h2o ➞ fru6p + phos fru26bp f_gly FBP1_Vmax 1 fru26bp FBP1_ki_fru26bp fru16bp fru16bp FBP1_k_fru16bp mole s
ALD meta_14268c7ae34f42b9900233354364cf10 Aldolase
fru16bp ⇆ grap + dhap f_gly ALD_Vmax ALD_k_fru16bp fru16bp grap dhap ALD_keq 1 fru16bp ALD_k_fru16bp grap ALD_ki1_grap dhap grap ALD_k_grap ALD_k_dhap ALD_ki1_grap fru16bp grap ALD_k_fru16bp ALD_ki2_grap mole s
TPI meta_6340c27ac1ce4919804c18b11df6c027 Triosephosphate Isomerase
dhap ⇆ grap f_gly TPI_Vmax TPI_k_dhap dhap grap TPI_keq 1 dhap TPI_k_dhap grap TPI_k_grap mole s
GAPDH meta_7067d7523d994e07a8a3faa87edadd6d D-Glyceraldehyde-3-phosphate:NAD+ oxidoreductase
grap + nad + phos ⇆ bpg13 + nadh + h f_gly GAPDH_Vmax GAPDH_k_nad GAPDH_k_grap GAPDH_k_phos nad grap phos bpg13 nadh GAPDH_keq 1 nad GAPDH_k_nad 1 grap GAPDH_k_grap 1 phos GAPDH_k_phos 1 nadh GAPDH_k_nadh 1 bpg13 GAPDH_k_bpg13 1 mole s
PGK meta_1fc282a4548c4963b4f84e0f597c5972 Phosphoglycerate Kinase
adp + bpg13 ⇆ atp + pg3 f_gly PGK_Vmax PGK_k_adp PGK_k_bpg13 adp bpg13 atp pg3 PGK_keq 1 adp PGK_k_adp 1 bpg13 PGK_k_bpg13 1 atp PGK_k_atp 1 pg3 PGK_k_pg3 1 mole s
BQB_IS
SBO:0000176; 2.7.2.3; R01512; P00558
BQB_IS_VERSION_OF
14804
PGM meta_11be42c3881c485c8713fec7c9f58235 2-Phospho-D-glycerate 2,3-phosphomutase
pg3 ⇆ pg2 f_gly PGM_Vmax pg3 pg2 PGM_keq pg3 PGM_k_pg3 1 pg2 PGM_k_pg2 mole s
BQB_IS
SBO:0000176; 5.4.2.1; R01518; P18669
BQB_IS_VERSION_OF
15904
EN meta_b15bd3db5c164bae99e51b039e7e1551 2-Phospho-D-glucerate hydro-lyase (enolase)
pg2 ⇆ h2o + pep f_gly EN_Vmax pg2 pep EN_keq pg2 EN_k_pg2 1 pep EN_k_pep mole s
PK meta_7b1853d5e1184d629fe981f440ff195f Pyruvatkinase
pep + adp + h ➞ pyr + atp fru16bp 1 gamma PKn gamma PKp mole s
PEPCK meta_162e1bf01c724d0b9a2f4ce0a225295a PEPCK cyto
gtp + oaa ⇆ co2 + gdp + pep f_gly PEPCK_Vmax PEPCK_k_oaa PEPCK_k_gtp oaa gtp pep gdp co2 PEPCK_keq 1 oaa PEPCK_k_oaa 1 gtp PEPCK_k_gtp 1 pep PEPCK_k_pep 1 gdp PEPCK_k_gdp 1 co2 PEPCK_k_co2 1 mole s
PEPCKM meta_13135b3bc29e4ae18039ba6cc29b64ec PEPCK mito
gtp_mito + oaa_mito ⇆ co2_mito + gdp_mito + pep_mito f_gly PEPCKM_Vmax PEPCK_k_oaa PEPCK_k_gtp oaa_mito gtp_mito pep_mito gdp_mito co2_mito PEPCK_keq 1 oaa_mito PEPCK_k_oaa 1 gtp_mito PEPCK_k_gtp 1 pep_mito PEPCK_k_pep 1 gdp_mito PEPCK_k_gdp 1 co2_mito PEPCK_k_co2 1 mole s
PC meta_d6597e7449ab48e2a3b627edc0e92411 Pyruvate Carboxylase
atp_mito + pyr_mito + co2_mito + h2o_mito ➞ adp_mito + oaa_mito + phos_mito + 2.0 h acoa_mito f_gly PC_Vmax atp_mito PC_k_atp atp_mito pyr_mito PC_k_pyr pyr_mito co2_mito PC_k_co2 co2_mito acoa_mito PC_n acoa_mito PC_n PC_k_acoa PC_n mole s
BQB_IS
SBO:0000176; 6.4.1.1; R00344; P11498
BQB_IS_VERSION_OF
20847
LDH meta_551d79dffaf74569881915ae14274a09 Lactate Dehydrogenase
pyr + nadh + h ⇆ lac + nad f_gly LDH_Vmax LDH_k_pyr LDH_k_nadh pyr nadh lac nad LDH_keq 1 nadh LDH_k_nadh 1 pyr LDH_k_pyr 1 lac LDH_k_lac 1 nad LDH_k_nad 1 mole s
LACT meta_96b62460d8ed4288a467107d28357deb Lactate transport (import)
lac_ext ⇆ lac f_gly LACT_Vmax LACT_k_lac lac_ext lac LACT_keq 1 lac_ext LACT_k_lac lac LACT_k_lac mole s
PYRTM meta_02f8c3be7c5e4a3bbb2aeb318ec86639 Pyruvate transport (mito)
pyr ⇆ pyr_mito f_gly PYRTM_Vmax PYRTM_k_pyr pyr pyr_mito PYRTM_keq 1 pyr PYRTM_k_pyr pyr_mito PYRTM_k_pyr mole s
PEPTM meta_b2615383c9d84753afa383a5a7a2d1d6 PEP Transport (export mito)
pep_mito ⇆ pep f_gly PEPTM_Vmax PEPTM_k_pep pep_mito pep PEPTM_keq 1 pep PEPTM_k_pep pep_mito PEPTM_k_pep mole s
PDH meta_c98332bcc65546c59f745d63ce5ac1e2 Pyruvate Dehydrogenase
pyr_mito + coa_mito + nad_mito ➞ acoa_mito + co2_mito + nadh_mito 1 gamma PDHn gamma PDHp mole s
CS meta_27329c61aea3449b85566f3b081fa742 Citrate Synthase
acoa_mito + oaa_mito + h2o_mito ⇆ cit_mito + coa_mito + h_mito f_gly CS_Vmax CS_k_oaa CS_k_acoa acoa_mito oaa_mito cit_mito coa_mito CS_keq 1 acoa_mito CS_k_acoa 1 oaa_mito CS_k_oaa 1 cit_mito CS_k_cit 1 coa_mito CS_k_coa 1 mole s
NDKGTPM meta_8a94238f3219471eb74c0f9d9b2e5fd9 Nucleoside-diphosphate kinase (ATP, GTP) mito
atp_mito + gdp_mito ⇆ adp_mito + gtp_mito f_gly NDKGTPM_Vmax NDKGTPM_k_atp NDKGTPM_k_gdp atp_mito gdp_mito adp_mito gtp_mito NDKGTPM_keq 1 atp_mito NDKGTPM_k_atp 1 gdp_mito NDKGTPM_k_gdp 1 adp_mito NDKGTPM_k_adp 1 gtp_mito NDKGTPM_k_gtp 1 mole s
OAAFLX oxalacetate influx
➞ oaa_mito f_gly OAAFLX_Vmax mole s
ACOAFLX acetyl-coa efflux
acoa_mito ➞ f_gly ACOAFLX_Vmax mole s
CITFLX citrate efflux
cit_mito ➞ f_gly CITFLX_Vmax mole s