XPP model
This model was converted from XPP ode format to SBML using sbmlutils-0.1.5a6
.
# Cardiac ventricular action potential (Luo Rudy dynamic model) (Luo Rudy 1994) used # in (Wang et al 2006) # LRdt01.ode # # Initial Conditions init V=-85.2119207874627, Cai=0.000117482029668194 init m=0.00149183115674257, h=0.985596581239651, j=0.990898461370389 init d=5.82597094505446e-6 init f=0.997765362821995 init b=0.00136737866785149 init g=0.98881442877378 init xr=0.000204700363126417 init xs1=0.00660746743356887 init xs2=0.0303768241233812 init zdv=0.0144622472219576 init ydv=0.999945568566232 init Ca_JSR=1.12791401197882, Ca_NSR=1.76731003671612 init APtrack=9.65910542308504e-196, APtrack2=5.33944967562997e-195, APtrack3=0.000129515197402902 init CaFluxtr=2.69380318286645e-196 init O_track=0, O_track2=0, O_track3=0 init Na_i=13.3649235394859, Ki=141.056872392446 # Stimulation Protocol Par period=200 Par pulse=25.5 Par tf=0, tp=2, tstart=50 ts=t-tstart Iapp = -pulse*(heav(mod(ts,period)-tf)-heav(mod(ts,period)-(tf+tp))) # Constant Variables Number Rgas=8314, Temp=310, Fara=96485 Number delta_m=1e-5 Number gg_Nai=0.75, gg_Nao=0.75, gg_Ki=0.75, gg_Ko=0.75, gg_Cai=1, gg_Cao=0.341 Number Km_Ca=0.0006 Number g_CaT=0.05 Number K_mpCa=0.0005 Number I_pCa=1.15 Number II_NaK=2.25 Number K_mNai=10 Number K_mKo=1.5 Number K_m_ns_Ca=0.0012 Number A_cap=0.0001534 Number G_rel_max=60 Number Grelover=4 Number tau_tr=180 Number K_mrel=0.0008 Number delCaith=0.00018 Number CSQN_max=10 Number KmCSQN=0.8 Number K_mup=0.00092 Number Iup=0.00875 Number CaNSRmax=15 Number K_mTn=0.0005 Number KmCMDN=0.00238 Number Tn_max=0.07 Number CMDNmax=0.05 Number CSQN_Th=0.7, Log_Th=0.98 # Parameters Par tauT1=0.5, tauT2=0.5 Par GG_Kr=0.02614, GG_Ks=0.433 Par Nao=140, Ko=5.4, Cao=1.8 Par g_Na=16 Par P_Ca=0.00054, P_Na=6.75e-7, P_K=1.93e-7 Par PNaK=0.01833 Par GG_K1=0.75 Par g_Kp=0.00552 Par g_K_Na=0.12848 Par nKNa=2.8 Par kdKNa=66 Par iKATP_on=1 Par nATP=0.24 Par N_area=5e-5 Par ATPi=3 Par hATP=2 Par kATP=0.00025 Par g_Nab=0.004 Par g_Cab=0.003016 Par P_ns_Ca=1.75e-7 Par c1=0.00025, c2=0.0001, gamma=0.15 # Functions E_Na = Rgas*Temp/Fara*ln(Nao/Na_i) alpha_m=heav(abs(V+47.13)-delta_m)*(0.32*(V+47.13)/(1-exp(-0.1*(V+47.13))))+heav(delta_m-abs(V+47.13))*3.2 beta_m = 0.08*exp(-V/11) alpha_h=heav(-40-V)*(0.135*exp((80+V)/(-6.8)))+heav(V-(-40))*0 beta_h=heav(-40-V)*(3.56*exp(0.079*V)+310000*exp(0.35*V))+heav(V-(-40))*(1/(0.13*(1+exp((V+10.66)/(-11.1))))) alpha_j=heav(-40-V)*(-(127140*exp(0.2444*V)+3.474e-5*exp(-0.04391*V))*(V+37.78)/(1+exp(0.311*(V+79.23))))+heav(V-(-40))*0 beta_j= heav(-V-40)*((0.1212 * exp( - (0.01052 * V)) / (1.0 + exp( - (0.1378 * (40.14 + V)))))) + heav(V+40)*((0.3 * exp( - (2.535E-7 * V)) / (1.0 + exp( - (0.1 * (32.0 + V)))))) d_inf = 1/(1+exp(-(V+10)/6.24)) tau_d=heav(1e-5-abs(V+10))*1/(0.035*6.24*2)+heav(abs(V+10)-1e-5)*1*d_inf*(1-exp(-(V+10)/6.24))/(0.035*(V+10)) alpha_d = d_inf/tau_d beta_d = (1-d_inf)/tau_d f_inf = 1/(1+exp((V+35.06)/8.6))+0.6/(1+exp((50-V)/20)) tau_f = 1/(0.0197*exp(-(0.0337*(V+10))^2)+0.02) alpha_f = f_inf/tau_f beta_f = (1-f_inf)/tau_f f' = alpha_f*(1-f)-beta_f*f f_Ca = 1/(1+Cai/Km_Ca) b_inf = 1/(1+exp(-(V+14)/10.8)) tau_b = 3.7+6.1/(1+exp((V+25)/4.5)) b' = (b_inf-b)/tau_b g_inf = 1/(1+exp((V+60)/5.6)) tau_g=heav(0-V)*(-0.875*V+12)+heav(V-0)*12 g_Kr = GG_Kr*(Ko/5.4)^(0.5) Rect = 1/(1+exp((V+9)/22.4)) xr_inf = 1/(1+exp(-(V+21.5)/7.5)) tau_xr = 1/(0.00138*(V+14.2)/(1-exp(-0.123*(V+14.2)))+0.00061*(V+38.9)/(exp(0.145*(V+38.9))-1)) E_Ks = Rgas*Temp/Fara*ln((Ko+PNaK*Nao)/(Ki+PNaK*Na_i)) g_Ks = GG_Ks*(1+0.6/(1+((3.8e-5/Cai)^1.4))) xs1_inf = 1/(1+exp(-(V-1.5)/16.7)) tau_xs1 = 1/(7.19e-5*(V+30)/(1-exp(-0.148*(V+30)))+0.000131*(V+30)/(exp(0.0687*(V+30))-1)) xs2_inf = 1/(1+exp(-(V-1.5)/16.7)) tau_xs2 = 4/(7.19e-5*(V+30)/(1-exp(-0.148*(V+30)))+0.000131*(V+30)/(exp(0.0687*(V+30))-1)) g_K1 = GG_K1*(Ko/5.4)^(0.5) E_K = Rgas*Temp/Fara*ln(Ko/Ki) alpha_K1 = 1.02/(1+exp(0.2385*(V-E_K-59.215))) beta_K1 = 1*(0.49124*exp(0.08032*(V-E_K+5.476))+exp(0.06175*(V-E_K-594.31)))/(1+exp(-0.5143*(V-E_K+4.753))) K1_inf = alpha_K1/(alpha_K1+beta_K1) Kp = 1/(1+exp((7.488-V)/5.98)) i_Kp = g_Kp*Kp*(V-E_K) pona = 0.85/(1+((kdKNa/Na_i)^nKNa)) pov = 0.8-0.65/(1+exp((V+125)/15)) g_K_ATP = iKATP_on*0.000193/N_area pATP = 1/(1+((ATPi/kATP)^hATP)) GKbarT = g_K_ATP*pATP*((Ko/4)^nATP) g_to = 0*0.5 rvdv = exp(V/100) alpha_zdv = 10*exp((V-40)/25)/(1+exp((V-40)/25)) beta_zdv = 10*exp(-(V+90)/25)/(1+exp(-(V+90)/25)) tau_zdv = 1/(alpha_zdv+beta_zdv) zdv_ss = alpha_zdv/(alpha_zdv+beta_zdv) alpha_ydv = 0.015/(1+exp((V+60)/5)) beta_ydv = 0.1*exp((V+25)/5)/(1+exp((V+25)/5)) tau_ydv = 1/(alpha_ydv+beta_ydv) ydv_ss = alpha_ydv/(alpha_ydv+beta_ydv) E_Ca = Rgas*Temp/(2*Fara)*ln(Cao/Cai) sigma = 1/7*(exp(Nao/67.3)-1) f_NaK = 1/(1+0.1245*exp(-0.1*V*Fara/(Rgas*Temp))+0.0365*sigma*exp(-V*Fara/(Rgas*Temp))) Ins_Na = P_ns_Ca*(1^2)*V*(Fara^2)/(Rgas*Temp)*(gg_Nai*Na_i*exp(1*V*Fara/(Rgas*Temp))-gg_Nao*Nao)/(exp(1*V*Fara/(Rgas*Temp))-1) Ins_K = P_ns_Ca*(1^2)*V*(Fara^2)/(Rgas*Temp)*(gg_Ki*Ki*exp(1*V*Fara/(Rgas*Temp))-gg_Ko*Ko)/(exp(1*V*Fara/(Rgas*Temp))-1) Vmyo = 0.68*pi*0.1*(0.011^2) VJSR = 0.0048*pi*0.1*(0.011^2) VNSR = 0.0552*pi*0.1*(0.011^2) Kleak = Iup/CaNSRmax # Currents i_Na = g_Na*(m^3)*h*j*(V-E_Na) ICaCa = (P_Ca*(2^2)*V*(Fara^2)/(Rgas*Temp))*(gg_Cai*Cai*exp(2*V*Fara/(Rgas*Temp))-gg_Cao*Cao)/(exp(2*V*Fara/(Rgas*Temp))-1) ICaNa = P_Na*(1^2)*V*(Fara^2)/(Rgas*Temp)*(gg_Nai*Na_i*exp(1*V*Fara/(Rgas*Temp))-gg_Nao*Nao)/(exp(1*V*Fara/(Rgas*Temp))-1) ICaK = P_K*(1^2)*V*(Fara^2)/(Rgas*Temp)*(gg_Ki*Ki*exp(1*V*Fara/(Rgas*Temp))-gg_Ko*Ko)/(exp(1*V*Fara/(Rgas*Temp))-1) i_CaCa = d*f*f_Ca*ICaCa i_CaNa = d*f*f_Ca*ICaNa i_CaK = d*f*f_Ca*ICaK iCaL = i_CaCa+i_CaK+i_CaNa iCaT = g_CaT*b*b*g*(V-E_Ca) i_Kr = g_Kr*xr*Rect*(V-E_K) i_Ks = g_Ks*xs1*xs2*(V-E_Ks) i_K1 = g_K1*K1_inf*(V-E_K) iKNa = g_K_Na*pona*pov*(V-E_K) iKATP = GKbarT*(V-E_K) i_to = g_to*(zdv^3)*ydv*rvdv*(V-E_K) ipCa = I_pCa*Cai/(K_mpCa+Cai) i_Ca_b = g_Cab*(V-E_Ca) iNab = g_Nab*(V-E_Na) iNaK = II_NaK*f_NaK*1/(1+(K_mNai/Na_i)^2)*Ko/(Ko+K_mKo) i_NaCa = c1*exp((gamma-1)*V*Fara/(Rgas*Temp))*(exp(V*Fara/(Rgas*Temp))*(Na_i^3)*Cao-(Nao^3)*Cai)/(1+c2*exp((gamma-1)*V*Fara/(Rgas*Temp))*(exp(V*Fara/(Rgas*Temp))*(Na_i^3)*Cao+(Nao^3)*Cai)) insNa = Ins_Na*1/(1+((K_m_ns_Ca/Cai)^3)) insK = Ins_K*1/(1+((K_m_ns_Ca/Cai)^3)) insCa = insNa+insK i_rel = G_relVis*(Ca_JSR-Cai) i_up = Iup*Cai/(Cai+K_mup) i_leak = Kleak*Ca_NSR i_tr = (Ca_NSR-Ca_JSR)/tau_tr # Control of Calcium Fluxes During an Action Potential APtrack' = heav(dV_dt-150)*(100*(1-APtrack)-tauT1*APtrack)+ \ heav(150-dV_dt)*(-tauT2*APtrack) APtrack2' = heav(0.2-APtrack)*heav(APtrack-0.18)*(100*(1-APtrack2)-0.5*APtrack2)+heav(APtrack-0.2)*(-0.5*APtrack2)+heav(0.18-APtrack)*(-0.5*APtrack2) APtrack3' = heav(0.2-APtrack)*heav(APtrack-0.18)*(100*(1-APtrack3)-0.5*APtrack3)+heav(APtrack-0.2)*(-0.01*APtrack3)+heav(0.18-APtrack)*(-0.01*APtrack3) CaFluxtr'=heav(APtrack-0.2)*(-1*A_cap*(i_CaCa+iCaT-2*i_NaCa+ipCa+i_Ca_b)/(2*Vmyo*Fara))+heav(APtrack2-0.01)*heav(0.2-APtrack)*0+ \ heav(0.01-APtrack2)*(-0.5*CaFluxtr) O_track'=heav(1/(1+KmCSQN/Ca_JSR)-CSQN_Th)*heav(0.37-O_track3)*heav(0.37-APtrack3)*(50*(1-O_track))+ \ heav(CSQN_Th-1/(1+KmCSQN/Ca_JSR))*(-0.5*O_track)+heav(O_track3-0.37)*(-0.5*O_track)+heav(APtrack3-0.37)*(-0.5*O_track) O_track2'=heav(O_track - Log_Th)*heav(Log_Th- O_track2)*(50*(1-O_track2))+heav(Log_Th-O_track)*(-0.5*O_track2)+heav(O_track2-Log_Th)*(-0.5*O_track2) O_track3'=heav(O_track - Log_Th)*heav(Log_Th-O_track3)*(50*(1-O_track3))+heav(Log_Th-O_track)*(-0.01*O_track3)+heav(O_track3-Log_Th)*(-0.01*O_track3) G_relVis=heav(CaFluxtr-delCaith)*((G_rel_max*(CaFluxtr-delCaith)/(K_mrel+CaFluxtr-delCaith))*(1-APtrack2)*APtrack2)+ \ heav(delCaith-CaFluxtr)*heav(O_track2-0)*(Grelover*(1-O_track2)*O_track2)+heav(delCaith-CaFluxtr)*0+heav(CaFluxtr-delCaith)*0+heav(0-O_track2)*0 # Differential Wquations dV_dt = -(i_Na+iCaL+iCaT+i_Kr+i_Ks+iKNa+iKATP+i_to+i_K1+i_Kp+i_NaCa+ipCa+iNab+i_Ca_b+iNaK+insCa+Iapp) V' = dV_dt m' = alpha_m*(1-m)-beta_m*m h' = alpha_h*(1-h)-beta_h*h j' = alpha_j*(1-j)-beta_j*j d' = alpha_d*(1-d)-beta_d*d g' = (g_inf-g)/tau_g xr' = (xr_inf-xr)/tau_xr xs1' = (xs1_inf-xs1)/tau_xs1 xs2' = (xs2_inf-xs2)/tau_xs2 zdv' = (zdv_ss-zdv)/tau_zdv ydv' = (ydv_ss-ydv)/tau_ydv Cai' = 1/(1+CMDNmax*KmCMDN/(KmCMDN+Cai)^2+ \ Tn_max*K_mTn/(K_mTn+Cai)^2)*(-1*A_cap*(i_CaCa+iCaT-2*i_NaCa+ipCa+i_Ca_b)/(2*Vmyo*Fara)+i_rel*VJSR/Vmyo+(i_leak-i_up)*VNSR/Vmyo) Ca_JSR' = (1/(1+CSQN_max*KmCSQN/(KmCSQN+Ca_JSR)^2))*(i_tr-i_rel) Ca_NSR' = -i_tr*VJSR/VNSR-i_leak+i_up Na_i' = -1*(i_Na+i_CaNa+iNab+insNa+i_NaCa*3+iNaK*3)*A_cap/(Vmyo*Fara) Ki' = -1*(-Iapp+i_CaK+i_Kr+i_Ks+i_K1+i_Kp+iKNa+iKATP+i_to+insK+(-iNaK)*2)*A_cap/(Vmyo*Fara) aux ikr=i_Kr aux iks=i_Ks # only t, Ca_JSR, V # Numerical and plotting parameters for xpp @ method=euler, bounds=1000000, dt=0.01, maxstores=1000000, total=3000 @ ylo=-95, yhi=55, yp=V, xlo=0, xhi=3000, nout=1 done
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Model :
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type | FunctionDefinitions [4] | name | math | sbo | cvterm |
---|---|---|---|---|---|
FunctionDefinition | max
|
minimum | |||
FunctionDefinition | min
|
maximum | |||
FunctionDefinition | heav
|
heavyside | |||
FunctionDefinition | mod
|
modulo |
type | Parameters [189] | name | constant | value | unit | derived unit | sbo | cvterm |
---|---|---|---|---|---|---|---|---|
Parameter | v
|
v = -85.2119207874627 | F | -85.2119207874627 | None | |||
Parameter | cai
|
cai = 0.000117482029668194 | F | 0.000117482029668194 | None | |||
Parameter | m
|
m = 0.00149183115674257 | F | 0.00149183115674257 | None | |||
Parameter | h
|
h = 0.985596581239651 | F | 0.985596581239651 | None | |||
Parameter | j
|
j = 0.990898461370389 | F | 0.990898461370389 | None | |||
Parameter | d
|
d = 5.82597094505446e-6 | F | 5.82597094505446e-06 | None | |||
Parameter | f
|
f = 0.997765362821995 | F | 0.997765362821995 | None | |||
Parameter | b
|
b = 0.00136737866785149 | F | 0.00136737866785149 | None | |||
Parameter | g
|
g = 0.98881442877378 | F | 0.98881442877378 | None | |||
Parameter | xr
|
xr = 0.000204700363126417 | F | 0.000204700363126417 | None | |||
Parameter | xs1
|
xs1 = 0.00660746743356887 | F | 0.00660746743356887 | None | |||
Parameter | xs2
|
xs2 = 0.0303768241233812 | F | 0.0303768241233812 | None | |||
Parameter | zdv
|
zdv = 0.0144622472219576 | F | 0.0144622472219576 | None | |||
Parameter | ydv
|
ydv = 0.999945568566232 | F | 0.999945568566232 | None | |||
Parameter | ca_jsr
|
ca_jsr = 1.12791401197882 | F | 1.12791401197882 | None | |||
Parameter | ca_nsr
|
ca_nsr = 1.76731003671612 | F | 1.76731003671612 | None | |||
Parameter | aptrack
|
aptrack = 9.65910542308504e-196 | F | 9.65910542308504e-196 | None | |||
Parameter | aptrack2
|
aptrack2 = 5.33944967562997e-195 | F | 5.33944967562997e-195 | None | |||
Parameter | aptrack3
|
aptrack3 = 0.000129515197402902 | F | 0.000129515197402902 | None | |||
Parameter | cafluxtr
|
cafluxtr = 2.69380318286645e-196 | F | 2.69380318286645e-196 | None | |||
Parameter | o_track
|
o_track = 0 | F | 0.0 | None | |||
Parameter | o_track2
|
o_track2 = 0 | F | 0.0 | None | |||
Parameter | o_track3
|
o_track3 = 0 | F | 0.0 | None | |||
Parameter | na_i
|
na_i = 13.3649235394859 | F | 13.3649235394859 | None | |||
Parameter | ki
|
ki = 141.056872392446 | F | 141.056872392446 | None | |||
Parameter | period
|
period = 200 | F | 200.0 | None | |||
Parameter | pulse
|
pulse = 25.5 | F | 25.5 | None | |||
Parameter | tf
|
tf = 0 | F | 0.0 | None | |||
Parameter | tp
|
tp = 2 | F | 2.0 | None | |||
Parameter | tstart
|
tstart = 50 | F | 50.0 | None | |||
Parameter | rgas
|
rgas = 8314 | F | 8314.0 | None | |||
Parameter | temp
|
temp = 310 | F | 310.0 | None | |||
Parameter | fara
|
fara = 96485 | F | 96485.0 | None | |||
Parameter | delta_m
|
delta_m = 1e-5 | F | 1e-05 | None | |||
Parameter | gg_nai
|
gg_nai = 0.75 | F | 0.75 | None | |||
Parameter | gg_nao
|
gg_nao = 0.75 | F | 0.75 | None | |||
Parameter | gg_ki
|
gg_ki = 0.75 | F | 0.75 | None | |||
Parameter | gg_ko
|
gg_ko = 0.75 | F | 0.75 | None | |||
Parameter | gg_cai
|
gg_cai = 1 | F | 1.0 | None | |||
Parameter | gg_cao
|
gg_cao = 0.341 | F | 0.341 | None | |||
Parameter | km_ca
|
km_ca = 0.0006 | F | 0.0006 | None | |||
Parameter | g_cat
|
g_cat = 0.05 | F | 0.05 | None | |||
Parameter | k_mpca
|
k_mpca = 0.0005 | F | 0.0005 | None | |||
Parameter | i_pca
|
i_pca = 1.15 | F | 1.15 | None | |||
Parameter | ii_nak
|
ii_nak = 2.25 | F | 2.25 | None | |||
Parameter | k_mnai
|
k_mnai = 10 | F | 10.0 | None | |||
Parameter | k_mko
|
k_mko = 1.5 | F | 1.5 | None | |||
Parameter | k_m_ns_ca
|
k_m_ns_ca = 0.0012 | F | 0.0012 | None | |||
Parameter | a_cap
|
a_cap = 0.0001534 | F | 0.0001534 | None | |||
Parameter | g_rel_max
|
g_rel_max = 60 | F | 60.0 | None | |||
Parameter | grelover
|
grelover = 4 | F | 4.0 | None | |||
Parameter | tau_tr
|
tau_tr = 180 | F | 180.0 | None | |||
Parameter | k_mrel
|
k_mrel = 0.0008 | F | 0.0008 | None | |||
Parameter | delcaith
|
delcaith = 0.00018 | F | 0.00018 | None | |||
Parameter | csqn_max
|
csqn_max = 10 | F | 10.0 | None | |||
Parameter | kmcsqn
|
kmcsqn = 0.8 | F | 0.8 | None | |||
Parameter | k_mup
|
k_mup = 0.00092 | F | 0.00092 | None | |||
Parameter | iup
|
iup = 0.00875 | F | 0.00875 | None | |||
Parameter | cansrmax
|
cansrmax = 15 | F | 15.0 | None | |||
Parameter | k_mtn
|
k_mtn = 0.0005 | F | 0.0005 | None | |||
Parameter | kmcmdn
|
kmcmdn = 0.00238 | F | 0.00238 | None | |||
Parameter | tn_max
|
tn_max = 0.07 | F | 0.07 | None | |||
Parameter | cmdnmax
|
cmdnmax = 0.05 | F | 0.05 | None | |||
Parameter | csqn_th
|
csqn_th = 0.7 | F | 0.7 | None | |||
Parameter | log_th
|
log_th = 0.98 | F | 0.98 | None | |||
Parameter | taut1
|
taut1 = 0.5 | F | 0.5 | None | |||
Parameter | taut2
|
taut2 = 0.5 | F | 0.5 | None | |||
Parameter | gg_kr
|
gg_kr = 0.02614 | F | 0.02614 | None | |||
Parameter | gg_ks
|
gg_ks = 0.433 | F | 0.433 | None | |||
Parameter | nao
|
nao = 140 | F | 140.0 | None | |||
Parameter | ko
|
ko = 5.4 | F | 5.4 | None | |||
Parameter | cao
|
cao = 1.8 | F | 1.8 | None | |||
Parameter | g_na
|
g_na = 16 | F | 16.0 | None | |||
Parameter | p_ca
|
p_ca = 0.00054 | F | 0.00054 | None | |||
Parameter | p_na
|
p_na = 6.75e-7 | F | 6.75e-07 | None | |||
Parameter | p_k
|
p_k = 1.93e-7 | F | 1.93e-07 | None | |||
Parameter | pnak
|
pnak = 0.01833 | F | 0.01833 | None | |||
Parameter | gg_k1
|
gg_k1 = 0.75 | F | 0.75 | None | |||
Parameter | g_kp
|
g_kp = 0.00552 | F | 0.00552 | None | |||
Parameter | g_k_na
|
g_k_na = 0.12848 | F | 0.12848 | None | |||
Parameter | nkna
|
nkna = 2.8 | F | 2.8 | None | |||
Parameter | kdkna
|
kdkna = 66 | F | 66.0 | None | |||
Parameter | ikatp_on
|
ikatp_on = 1 | F | 1.0 | None | |||
Parameter | natp
|
natp = 0.24 | F | 0.24 | None | |||
Parameter | n_area
|
n_area = 5e-5 | F | 5e-05 | None | |||
Parameter | atpi
|
atpi = 3 | F | 3.0 | None | |||
Parameter | hatp
|
hatp = 2 | F | 2.0 | None | |||
Parameter | katp
|
katp = 0.00025 | F | 0.00025 | None | |||
Parameter | g_nab
|
g_nab = 0.004 | F | 0.004 | None | |||
Parameter | g_cab
|
g_cab = 0.003016 | F | 0.003016 | None | |||
Parameter | p_ns_ca
|
p_ns_ca = 1.75e-7 | F | 1.75e-07 | None | |||
Parameter | c1
|
c1 = 0.00025 | F | 0.00025 | None | |||
Parameter | c2
|
c2 = 0.0001 | F | 0.0001 | None | |||
Parameter | gamma
|
gamma = 0.15 | F | 0.15 | None | |||
Parameter | ts
|
F | 0.0 | dimensionless | None | |||
Parameter | iapp
|
F | 0.0 | dimensionless | None | |||
Parameter | e_na
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_m
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_m
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_h
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_h
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_j
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_j
|
F | 0.0 | dimensionless | None | |||
Parameter | d_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_d
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_d
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_d
|
F | 0.0 | dimensionless | None | |||
Parameter | f_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_f
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_f
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_f
|
F | 0.0 | dimensionless | None | |||
Parameter | f_ca
|
F | 0.0 | dimensionless | None | |||
Parameter | b_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_b
|
F | 0.0 | dimensionless | None | |||
Parameter | g_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_g
|
F | 0.0 | dimensionless | None | |||
Parameter | g_kr
|
F | 0.0 | dimensionless | None | |||
Parameter | rect
|
F | 0.0 | dimensionless | None | |||
Parameter | xr_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_xr
|
F | 0.0 | dimensionless | None | |||
Parameter | e_ks
|
F | 0.0 | dimensionless | None | |||
Parameter | g_ks
|
F | 0.0 | dimensionless | None | |||
Parameter | xs1_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_xs1
|
F | 0.0 | dimensionless | None | |||
Parameter | xs2_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_xs2
|
F | 0.0 | dimensionless | None | |||
Parameter | g_k1
|
F | 0.0 | dimensionless | None | |||
Parameter | e_k
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_k1
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_k1
|
F | 0.0 | dimensionless | None | |||
Parameter | k1_inf
|
F | 0.0 | dimensionless | None | |||
Parameter | kp
|
F | 0.0 | dimensionless | None | |||
Parameter | i_kp
|
F | 0.0 | dimensionless | None | |||
Parameter | pona
|
F | 0.0 | dimensionless | None | |||
Parameter | pov
|
F | 0.0 | dimensionless | None | |||
Parameter | g_k_atp
|
F | 0.0 | dimensionless | None | |||
Parameter | patp
|
F | 0.0 | dimensionless | None | |||
Parameter | gkbart
|
F | 0.0 | dimensionless | None | |||
Parameter | g_to
|
F | 0.0 | dimensionless | None | |||
Parameter | rvdv
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_zdv
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_zdv
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_zdv
|
F | 0.0 | dimensionless | None | |||
Parameter | zdv_ss
|
F | 0.0 | dimensionless | None | |||
Parameter | alpha_ydv
|
F | 0.0 | dimensionless | None | |||
Parameter | beta_ydv
|
F | 0.0 | dimensionless | None | |||
Parameter | tau_ydv
|
F | 0.0 | dimensionless | None | |||
Parameter | ydv_ss
|
F | 0.0 | dimensionless | None | |||
Parameter | e_ca
|
F | 0.0 | dimensionless | None | |||
Parameter | sigma
|
F | 0.0 | dimensionless | None | |||
Parameter | f_nak
|
F | 0.0 | dimensionless | None | |||
Parameter | ins_na
|
F | 0.0 | dimensionless | None | |||
Parameter | ins_k
|
F | 0.0 | dimensionless | None | |||
Parameter | vmyo
|
F | 0.0 | dimensionless | None | |||
Parameter | vjsr
|
F | 0.0 | dimensionless | None | |||
Parameter | vnsr
|
F | 0.0 | dimensionless | None | |||
Parameter | kleak
|
F | 0.0 | dimensionless | None | |||
Parameter | i_na
|
F | 0.0 | dimensionless | None | |||
Parameter | icaca
|
F | 0.0 | dimensionless | None | |||
Parameter | icana
|
F | 0.0 | dimensionless | None | |||
Parameter | icak
|
F | 0.0 | dimensionless | None | |||
Parameter | i_caca
|
F | 0.0 | dimensionless | None | |||
Parameter | i_cana
|
F | 0.0 | dimensionless | None | |||
Parameter | i_cak
|
F | 0.0 | dimensionless | None | |||
Parameter | ical
|
F | 0.0 | dimensionless | None | |||
Parameter | icat
|
F | 0.0 | dimensionless | None | |||
Parameter | i_kr
|
F | 0.0 | dimensionless | None | |||
Parameter | i_ks
|
F | 0.0 | dimensionless | None | |||
Parameter | i_k1
|
F | 0.0 | dimensionless | None | |||
Parameter | ikna
|
F | 0.0 | dimensionless | None | |||
Parameter | ikatp
|
F | 0.0 | dimensionless | None | |||
Parameter | i_to
|
F | 0.0 | dimensionless | None | |||
Parameter | ipca
|
F | 0.0 | dimensionless | None | |||
Parameter | i_ca_b
|
F | 0.0 | dimensionless | None | |||
Parameter | inab
|
F | 0.0 | dimensionless | None | |||
Parameter | inak
|
F | 0.0 | dimensionless | None | |||
Parameter | i_naca
|
F | 0.0 | dimensionless | None | |||
Parameter | insna
|
F | 0.0 | dimensionless | None | |||
Parameter | insk
|
F | 0.0 | dimensionless | None | |||
Parameter | insca
|
F | 0.0 | dimensionless | None | |||
Parameter | i_rel
|
F | 0.0 | dimensionless | None | |||
Parameter | i_up
|
F | 0.0 | dimensionless | None | |||
Parameter | i_leak
|
F | 0.0 | dimensionless | None | |||
Parameter | i_tr
|
F | 0.0 | dimensionless | None | |||
Parameter | g_relvis
|
F | 0.0 | dimensionless | None | |||
Parameter | dv_dt
|
F | 0.0 | dimensionless | None | |||
Parameter | ikr
|
F | 0.0 | dimensionless | None | |||
Parameter | iks
|
F | 0.0 | dimensionless | None | |||
Parameter | t
|
model time | F | 0.0 | dimensionless | None |
type | Rules [120] | assignment | name | derived units | sbo | cvterm | |
---|---|---|---|---|---|---|---|
Rule | d f/dt
|
= | None | ||||
Rule | d b/dt
|
= | None | ||||
Rule | d aptrack/dt
|
= | None | ||||
Rule | d aptrack2/dt
|
= | None | ||||
Rule | d aptrack3/dt
|
= | None | ||||
Rule | d cafluxtr/dt
|
= | None | ||||
Rule | d o_track/dt
|
= | None | ||||
Rule | d o_track2/dt
|
= | None | ||||
Rule | d o_track3/dt
|
= | None | ||||
Rule | d v/dt
|
= | None | ||||
Rule | d m/dt
|
= | None | ||||
Rule | d h/dt
|
= | None | ||||
Rule | d j/dt
|
= | None | ||||
Rule | d d/dt
|
= | None | ||||
Rule | d g/dt
|
= | None | ||||
Rule | d xr/dt
|
= | None | ||||
Rule | d xs1/dt
|
= | None | ||||
Rule | d xs2/dt
|
= | None | ||||
Rule | d zdv/dt
|
= | None | ||||
Rule | d ydv/dt
|
= | None | ||||
Rule | d cai/dt
|
= | None | ||||
Rule | d ca_jsr/dt
|
= | None | ||||
Rule | d ca_nsr/dt
|
= | None | ||||
Rule | d na_i/dt
|
= | None | ||||
Rule | d ki/dt
|
= | None | ||||
Rule | ts
|
= | None | ||||
Rule | iapp
|
= | None | ||||
Rule | e_na
|
= | None | ||||
Rule | alpha_m
|
= | None | ||||
Rule | beta_m
|
= | None | ||||
Rule | alpha_h
|
= | None | ||||
Rule | beta_h
|
= | None | ||||
Rule | alpha_j
|
= | None | ||||
Rule | beta_j
|
= | None | ||||
Rule | d_inf
|
= | None | ||||
Rule | tau_d
|
= | None | ||||
Rule | alpha_d
|
= | None | ||||
Rule | beta_d
|
= | None | ||||
Rule | f_inf
|
= | None | ||||
Rule | tau_f
|
= | None | ||||
Rule | alpha_f
|
= | None | ||||
Rule | beta_f
|
= | None | ||||
Rule | f_ca
|
= | None | ||||
Rule | b_inf
|
= | None | ||||
Rule | tau_b
|
= | None | ||||
Rule | g_inf
|
= | None | ||||
Rule | tau_g
|
= | None | ||||
Rule | g_kr
|
= | None | ||||
Rule | rect
|
= | None | ||||
Rule | xr_inf
|
= | None | ||||
Rule | tau_xr
|
= | None | ||||
Rule | e_ks
|
= | None | ||||
Rule | g_ks
|
= | None | ||||
Rule | xs1_inf
|
= | None | ||||
Rule | tau_xs1
|
= | None | ||||
Rule | xs2_inf
|
= | None | ||||
Rule | tau_xs2
|
= | None | ||||
Rule | g_k1
|
= | None | ||||
Rule | e_k
|
= | None | ||||
Rule | alpha_k1
|
= | None | ||||
Rule | beta_k1
|
= | None | ||||
Rule | k1_inf
|
= | None | ||||
Rule | kp
|
= | None | ||||
Rule | i_kp
|
= | None | ||||
Rule | pona
|
= | None | ||||
Rule | pov
|
= | None | ||||
Rule | g_k_atp
|
= | None | ||||
Rule | patp
|
= | None | ||||
Rule | gkbart
|
= | None | ||||
Rule | g_to
|
= | None | ||||
Rule | rvdv
|
= | None | ||||
Rule | alpha_zdv
|
= | None | ||||
Rule | beta_zdv
|
= | None | ||||
Rule | tau_zdv
|
= | None | ||||
Rule | zdv_ss
|
= | None | ||||
Rule | alpha_ydv
|
= | None | ||||
Rule | beta_ydv
|
= | None | ||||
Rule | tau_ydv
|
= | None | ||||
Rule | ydv_ss
|
= | None | ||||
Rule | e_ca
|
= | None | ||||
Rule | sigma
|
= | None | ||||
Rule | f_nak
|
= | None | ||||
Rule | ins_na
|
= | None | ||||
Rule | ins_k
|
= | None | ||||
Rule | vmyo
|
= | None | ||||
Rule | vjsr
|
= | None | ||||
Rule | vnsr
|
= | None | ||||
Rule | kleak
|
= | None | ||||
Rule | i_na
|
= | None | ||||
Rule | icaca
|
= | None | ||||
Rule | icana
|
= | None | ||||
Rule | icak
|
= | None | ||||
Rule | i_caca
|
= | None | ||||
Rule | i_cana
|
= | None | ||||
Rule | i_cak
|
= | None | ||||
Rule | ical
|
= | None | ||||
Rule | icat
|
= | None | ||||
Rule | i_kr
|
= | None | ||||
Rule | i_ks
|
= | None | ||||
Rule | i_k1
|
= | None | ||||
Rule | ikna
|
= | None | ||||
Rule | ikatp
|
= | None | ||||
Rule | i_to
|
= | None | ||||
Rule | ipca
|
= | None | ||||
Rule | i_ca_b
|
= | None | ||||
Rule | inab
|
= | None | ||||
Rule | inak
|
= | None | ||||
Rule | i_naca
|
= | None | ||||
Rule | insna
|
= | None | ||||
Rule | insk
|
= | None | ||||
Rule | insca
|
= | None | ||||
Rule | i_rel
|
= | None | ||||
Rule | i_up
|
= | None | ||||
Rule | i_leak
|
= | None | ||||
Rule | i_tr
|
= | None | ||||
Rule | g_relvis
|
= | None | ||||
Rule | dv_dt
|
= | None | ||||
Rule | ikr
|
= | None | ||||
Rule | iks
|
= | None | ||||
Rule | t
|
= | None |