FORMULATION AND DEVELOPMENT OF INDOMETHACIN POLYMERIC SUSTAIN RELEASE MICROSPONGES

The goal of the present study was to develop and evaluate polymeric microsponges for sustained release of Indomethacin were prepared by quasi emulsion solvent diffusion method.Prepeared microsponge was studied for Effect of drug polymer ratio on active drug content, particle size and entrapment efficiency were studied. Drug polymer ratio greatly affects properties (entrapment efficiency, active drug content, particle size) of microsponges. Indomethacin microsponges showed highest actual drug content, entrapment efficiency and smaller particle size, so 3:1 ratio of drug and polymer was selected for optimization study. The microsponges were characterized by FTIR, DSC and SEM studies followed by determination of total drug content and entrapment efficiency. Optimization study was carried out by taking internal phase volume, stirring rate, emulsifier concentration as independent variables and their effects on entrapment efficiency, particle size were studied. Morphology of obtained micro sponges was revealed by scanning electron microscope and was found to be porous and spherical. Optimized formulation of microsponge was evaluated for drug content, pH, viscosity and in vitro drug release. Release of drug was found to be sustained through microsponge as compared to marketed product and pure drug. Drug deposition was found to be satisfactory. Prepared polymeric microsponges could be a potential for sustained release drug delivery system in pain & inflammatory therapy.

Keywords: Microsponge, Optimization, Indomethacin, Quasi-emulsion solvent diffusion technique