A PHARMACOKINETIC & PHARMACODYNAMIC INTERACTION BETWEEN MOMORDICA DIOICA FRUIT'S EXTRACT AND ORAL HYPOGLYCEMIC DRUG – METFORMIN IN HYPERGLYCEMIC RATS

Traditional medication obtained from the   medicated   herbal plants are used by about maximum percentage of world population for different chronic disease condition. Diabetes (Hyperglycaemia- high blood sugar level) is a very important metabolic disorder in different developed, developing countries including India. It providing to a very serious complications on health of human beings, especially in the rural and subrural areas. Momordica dioica is an annual herb that anti hyperglycemic activity. Other pharmacological properties such as anti inflammatory, antioxidant, anti microbial, antiviral, hypotensive, and hypercholesterolemia are also exhibited. However, the research  so   far on the hypoglycaemic effect of Momordica dioica   could’t establish the optimum dose-level for experimental subjects. Hence, the research studies required to be subjected to pharmacodynamic and pharmacokinetic studies in order to determine effect of Momordica dioica on the hyperglycemic patients who are taking the therapy with synthetic drugs. This research work was to identify the influence of Momordica dioica on the pharmacokinetic and pharmacodynamic of Metformin in rats. Results have proves the negative (decrease) effect of Momordica dioica on pharmacokinetics but positive (increase) effect on pharmacodynamics of Metformin.

Key words: Momordica dioica, Metformin, Oral hypoglycemic drugs.