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The Association between Vitamin D and Zinc Status with the Disease Onset and Progression of Clinical Symptoms among Outpatients Infected with COVID-19 and Non-Infected Participants: A Cross-Sectional Study

Sahar Golabi; Maryam Adelipour; Sara Mobarak; Maghsud Piri; Maryam Seyedtabib; Reza Bagheri; Katsuhiko Suzuki; Damoon Ashtari Larki; Fatemeh Maghsoudi; Mahshid Naghashpour


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<oai_dc:dc xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:oai_dc="http://www.openarchives.org/OAI/2.0/oai_dc/" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.openarchives.org/OAI/2.0/oai_dc/ http://www.openarchives.org/OAI/2.0/oai_dc.xsd">
  <dc:creator>Sahar Golabi</dc:creator>
  <dc:creator>Maryam Adelipour</dc:creator>
  <dc:creator>Sara Mobarak</dc:creator>
  <dc:creator>Maghsud Piri</dc:creator>
  <dc:creator>Maryam Seyedtabib</dc:creator>
  <dc:creator>Reza Bagheri</dc:creator>
  <dc:creator>Katsuhiko Suzuki</dc:creator>
  <dc:creator>Damoon Ashtari Larki</dc:creator>
  <dc:creator>Fatemeh Maghsoudi</dc:creator>
  <dc:creator>Mahshid Naghashpour</dc:creator>
  <dc:date>2021-08-26</dc:date>
  <dc:description>Background: Vitamin D and zinc are important components of nutritional immunity. This study compared the serum concentrations of vitamin D and zinc in COVID-19 outpatients with those of non-infected participants. Clinical symptoms and associations with vitamin D and zinc status were also examined. Methods: A checklist and laboratory examination were applied to collect data in a health service center-based descriptive-analytical cross-sectional study conducted on 53 infected outpatients with COVID-19 and 53 non-infected participants of both sexes. Results: Lower serum concentration of total 25-hydroxyvitamin D [25(OH)D] were observed in patients with moderate illness (18.9±11.5 ng/mL) than in patients with asymptomatic or mild illness (29.2±18.3 ng/mL) (p=0.054). Also, infected patients (100.6±17.8 µg/dL) showed lower serum concentration of zinc than non-infected participants (113.8±13.4 µg/dL) (p=0.013). Patients with normal and insufficient vitamin D status at the time of admission had decreased odds ratios of general symptoms of COVID-19 (odds ratio, 0.19; p≤0.001 for normal and odds ratio, 0.3; p=0.007 for insufficient vitamin D status) compared to patients with vitamin D deficiency. Conclusion: This study revealed the importance of 25(OH)D measurement as a relatively easy option to predict the progression of general and pulmonary symptoms. Also, this study showed that a poor zinc status of the outpatients might affect the disease onset of COVID-19.</dc:description>
  <dc:identifier>https://zenodo.org/record/5266352</dc:identifier>
  <dc:identifier>10.5281/zenodo.5266352</dc:identifier>
  <dc:identifier>oai:zenodo.org:5266352</dc:identifier>
  <dc:relation>doi:10.5281/zenodo.5266351</dc:relation>
  <dc:relation>url:https://zenodo.org/communities/covid-19</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:subject>Clinical symptoms</dc:subject>
  <dc:subject>Vitamin D status</dc:subject>
  <dc:subject>Zinc status</dc:subject>
  <dc:subject>Sunlight exposure</dc:subject>
  <dc:subject>COVID-19</dc:subject>
  <dc:title>The Association between Vitamin D and Zinc Status with the Disease Onset and Progression of Clinical Symptoms among Outpatients Infected with COVID-19 and Non-Infected Participants: A Cross-Sectional Study</dc:title>
  <dc:type>info:eu-repo/semantics/article</dc:type>
  <dc:type>publication-article</dc:type>
</oai_dc:dc>
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