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Published August 25, 2021 | Version v1
Journal article Open

A PROSPECTIVE OBSERVATIONAL STUDY ON APPRAISAL OF INCIDENCE, PREDISPOSING FACTORS AND CLINICAL OUTCOMES IN NEONATAL SEPSIS

Description

Neonatal sepsis is a most common and frequent cause of morbidity and mortality in neonates. This study was conducted to appraise the incidence, predisposing factors and clinical outcomes of neonatal sepsis. A non experimental prospective cross sectional study was conducted for a period of 6 months in Neonatal Intensive Care Unit and Sick Newborn Care Unit of tertiary care teaching hospital located in Guntur. Study was ethically approved from Institutional ethical committee. A total of 197 neonates with age 0-28 days with clinical sepsis and culture proved sepsis were included into the study. Among 197 neonates, 78.7% with clinical sepsis and 21.3% neonates with culture positive sepsis. 68.5% neonates were diagnosed with early onset neonatal sepsis and 31.5% with late onset neonatal sepsis. Low birth weight (56.3%) was the predominant risk factor for neonatal sepsis and incidence rate was 20.6%. Klebsiella pneumonia (43.9%) was most isolated microorganism. Neonatal septicemia is one of the leading causes of infant morbidity and mortality. Our study found that sepsis was predominantly found in female patients and inpatients whose mode of delivery is vaginal. Most common isolated organism in culture positive cases is Klebsiella pneumonia. EOS is predominantly seen in culture where as LOS in clinical sepsis.    

Keywords: sepsis, gasping, EOS, LOS, mortality 

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