Journal article Open Access

The Origins of SARS-CoV-2: A Critical Review

Holmes, Edward C; Goldstein, Stephen A; Rasmussen, Angela L; Robertson, David L; Crits-Christoph, Alexander; Wertheim, Joel O; Anthony, Simon J; Barclay, Wendy S; Boni, Maciej F; Doherty, Peter C; Farrar, Jeremy; Geoghegan, Jemma L; Jiang, Xiaowei; Leibowitz, Julian L; Neil, Stuart J D; Skern, Tim; Weiss, Susan R; Worobey, Michael; Andersen, Kristian G; Garry, Robert F; Rambaut, Andrew

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  <dc:creator>Holmes, Edward C</dc:creator>
  <dc:creator>Goldstein, Stephen A</dc:creator>
  <dc:creator>Rasmussen, Angela L</dc:creator>
  <dc:creator>Robertson, David L</dc:creator>
  <dc:creator>Crits-Christoph, Alexander</dc:creator>
  <dc:creator>Wertheim, Joel O</dc:creator>
  <dc:creator>Anthony, Simon J</dc:creator>
  <dc:creator>Barclay, Wendy S</dc:creator>
  <dc:creator>Boni, Maciej F</dc:creator>
  <dc:creator>Doherty, Peter C</dc:creator>
  <dc:creator>Farrar, Jeremy</dc:creator>
  <dc:creator>Geoghegan, Jemma L</dc:creator>
  <dc:creator>Jiang, Xiaowei</dc:creator>
  <dc:creator>Leibowitz, Julian L</dc:creator>
  <dc:creator>Neil, Stuart J D</dc:creator>
  <dc:creator>Skern, Tim</dc:creator>
  <dc:creator>Weiss, Susan R</dc:creator>
  <dc:creator>Worobey, Michael</dc:creator>
  <dc:creator>Andersen, Kristian G</dc:creator>
  <dc:creator>Garry, Robert F</dc:creator>
  <dc:creator>Rambaut, Andrew</dc:creator>
  <dc:description>The Origins of SARS-CoV-2: A Critical Review

Holmes et al.

Published online: 18-Aug-2021, Cell,

Since the first reports of a novel SARS-like coronavirus in December 2019 in Wuhan, China, there has been intense interest in understanding how SARS-CoV-2 emerged in the human population. Recent debate has coalesced around two competing ideas: a “laboratory escape” scenario and zoonotic emergence. Here, we critically review the current scientific evidence that may help clarify the origin of SARS-CoV-2.

Computer readable versions of data tables, SVG maps, and acknowledgements of sequence data used are available from:

  <dc:description>Authors' final peer-reviewed version. Published as:</dc:description>
  <dc:title>The Origins of SARS-CoV-2: A Critical Review</dc:title>
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