THROMBOCYTOPENIA AND ITS ASSOCIATED ISSUES INCLUDING ISCHEMIC STROKES, CLOTS AND BLEEDING REPORTS IN DIFFERENT COUNTRIES IN PATIENTS WHO NEWLY GET ADENOVIRAL VECTOR-BASED COVID-19 VACCINE

Here we are elaborating the cases of a rare reaction of COVID-19 vaccine based on adenoviral (ChAdOx1) vector, the reactions include thrombocytopenia (low level of platelets count), rare type of blood clots, and ischemic strokes. The cases describe first a Pakistani 55 years old man who was hypertensive and diagnosed MI before 3 years, was on different medication, took first shot of vaccine (AZD1222) and felt little weakness including headache, after 3^rd day of shot a greater elevation in blood pressure was seen, later he fell unconscious and later on computer tomography scan on head showed clots in right hemisphere with acute cerebral edema, the patient was completely paralyzed on the left size, in the blood reports there was a rapid decline in platelets count from 110000 to 65000 per uL, patient had 2 cardiac strokes events on 7^th day of hospitalization with 2^nd cardiac stroke he passed away, with CT scan it showed clots in both hemisphere , and blood reports showed platelet factor (PE-4) reactive antibody, here we took a reference of Danish 60 years old woman who was diagnosed with same kind of events after receiving same vaccine first shot, she passed away on 6^th day of hospitalization. Her CT scan and MRI scan also showed acute cerebral edema, and blood reports revealed platelet factor (PF-4) reactive antibody, many countries also reported such cases, but no detailed information was provided. This can be novel immune response against specific type of vaccine, need to be evaluated further.

Keywords: Thrombocytopenia, Hemorrhage, Stroke, antibodies, vector, vaccines