5074837
doi
10.5281/zenodo.5074837
oai:zenodo.org:5074837
user-fhtw
Santos da Costa, Joao Pedro
Barros, Nelson
Kolar, Radim
Forjan, Mathias
Patient–Ventilator Interaction Testing Using the Electromechanical Lung Simulator xPULMTM during V/A-C and PSV Ventilation Mode
Pasteka, Richard
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
<p>Abstract: During mechanical ventilation, a disparity between flow, pressure and volume demands<br>
of the patient and the assistance delivered by the mechanical ventilator often occurs. This paper<br>
introduces an alternative approach of simulating and evaluating patient–ventilator interactions<br>
with high fidelity using the electromechanical lung simulator xPULM™. The xPULM™ approximates<br>
respiratory activities of a patient during alternating phases of spontaneous breathing and<br>
apnea intervals while connected to a mechanical ventilator. Focusing on different triggering events,<br>
volume assist-control (V/A-C) and pressure support ventilation (PSV) modes were chosen to test<br>
patient–ventilator interactions. In V/A-C mode, a double-triggering was detected every third<br>
breathing cycle, leading to an asynchrony index of 16.67%, which is classified as severe. This asynchrony<br>
causes a significant increase of peak inspiratory pressure (7.966.38 vs. 11.090.49cmH2O,<br>
p < 0.01)) and peak expiratory flow (ô€€€25.578.93 vs. 32.900.54 L/min, p < 0.01) when compared<br>
to synchronous phases of the breathing simulation. Additionally, events of premature cycling were<br>
observed during PSV mode. In this mode, the peak delivered volume during simulated spontaneous<br>
breathing phases increased significantly (917.0945.74 vs. 468.4031.79 mL, p < 0.01)<br>
compared to apnea phases. Various dynamic clinical situations can be approximated using this<br>
approach and thereby could help to identify undesired patient–ventilation interactions in the future.<br>
Rapidly manufactured ventilator systems could also be tested using this approach.</p>
<p><br>
Keywords: biomedical engineering; breathing simulation; electromechanical lung simulator; patient–<br>
ventilator interactions; rapidly manufactured ventilator systems testing</p>
Zenodo
2021-04-21
info:eu-repo/semantics/article
5074836
user-fhtw
1625579299.282393
7519149
md5:165c3fde08e615f0660e02df18cf8e80
https://zenodo.org/records/5074837/files/Patient–Ventilator Interaction Testing.pdf
public
10.5281/zenodo.5074836
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doi