Chaotic and Stochastic Dynamics of Epileptiform-Like Activities in Sclerotic Hippocampus Resected from Patients with Pharmacoresistant Epilepsy

This set contains 35 electrophysiological data recorded from slices of 12 human hippocampal specimens surgically resected from patients with pharmacoresistant temporal lobe epilepsy (TLE). The recordings were performed in the granule cell layer of the dentate gyrus (DG) and in the pyramidal cell layer of the CA1, CA2, CA3, CA4 and subiculum (SUB). The signals are organized in .txt files (which are easily importable), in terms of these hippocampal subfields and type of activity: interictal-like events (II) and periodic ictal spiking (PIS).

The study was approved by the Ethics Committee of Universidade Federal de São Paulo (CAAE 47551015.1.0000.5505 and / data processing: CAAE 7961030418) and written informed consent was obtained from all patients. The dataset available herein is part of the results submitted to PLOS Computationa Biology in order to meet the submission requirements. For further information, please contact: jeanfaber@gmail.com or ferres.brogin@unesp.br.

Below follows the order in which the electrophysiological recordings appear:

Interictal-like events:

1 = DG(II);
2 = DG(II);
3 = DG(II);
4 = DG(II);

5 = CA4(II);
6 = CA4(II);
7 = CA4(II);
8 = CA4(II);
9 = CA4(II);

10 = CA3(II);
11 = CA3(II);
12 = CA3(II);
13 = CA3(II);
14 = CA3(II);

15 = CA2(II);

16 = CA1(II);
17 = CA1(II);

18 = SUB(II);
19 = SUB(II);
20 = SUB(II);
21 = SUB(II);
22 = SUB(II);

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Periodic ictal spiking:

23 = DG(PIS);
24 = DG(PIS);
25 = DG(PIS);
26 = DG(PIS);
27 = DG(PIS);

28 = CA2(PIS);
29 = CA2(PIS);

30 = CA1(PIS);

31 = SUB(PIS);
32 = SUB(PIS);
33 = SUB(PIS);
34 = SUB(PIS);
35 = SUB(PIS);