5031252
doi
10.5281/zenodo.5031252
oai:zenodo.org:5031252
user-sgc-opennotebook
Schapira Matthieu
Are Enantiomer of Chemical Probes Good Negative Control?
Tang Shiting
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
Negative Control
<p>Chemical probes are drug-like compounds that bind potently and selectively to a protein target. When there is a chiral center in the compound, a common practice is to purify and test both enantiomers. Sometimes (often) enantiomer A is active and B is inactive or far less potent. When this is the case, enantiomer A is declared the chemical probe, while enantiomer B is used as a negative control . But if enantiomer A is active against unknown off-targets, enantiomer B may be inactive against these off-targets, which would be a serious problem. The project is to systematically evaluate how often enantiomer B is inactive against protein X if enantiomer A is active against the same target. </p>
Zenodo
2021-06-25
info:eu-repo/semantics/other
5031251
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https://zenodo.org/records/5031252/files/Are Enantiomers of Chemical Probes Good Negative Controls.docx
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