Preprint Open Access

Fetal heart rate and nuchal translucency as first trimester markers of preterm birth

Morales-Roselló, José; Loscalzo, Gabriela; Perez, Gemma; Soriano Paya, Alicia; Jakaitė, Vaidilė; Perales Marín, Alfredo


MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">Preterm birth</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">fetal heart rate</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">first trimester screening</subfield>
  </datafield>
  <datafield tag="653" ind1=" " ind2=" ">
    <subfield code="a">nuchal translucency</subfield>
  </datafield>
  <controlfield tag="005">20210623134821.0</controlfield>
  <datafield tag="500" ind1=" " ind2=" ">
    <subfield code="a">This is an Author's Original Manuscript of an article published by Taylor &amp;amp; Francis in Journal of Maternal-Fetal and Neonatal Medicine on 22 February 2021, available at http://wwww.tandfonline.com/10.1080/14767058.2021.1887128.

Funding sources: Gabriela Loscalzo received funding from the European Union's Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant, agreement No 765274.</subfield>
  </datafield>
  <controlfield tag="001">5006140</controlfield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain</subfield>
    <subfield code="a">Loscalzo, Gabriela</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain</subfield>
    <subfield code="a">Perez, Gemma</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Servicio de Obstetricia y Ginecología, Hospital Francisco de Borja, Gandía, Valencia, Spain</subfield>
    <subfield code="a">Soriano Paya, Alicia</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain</subfield>
    <subfield code="a">Jakaitė, Vaidilė</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain; Departamento de Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain</subfield>
    <subfield code="a">Perales Marín, Alfredo</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">192748</subfield>
    <subfield code="z">md5:a509fc42f5224f7208b8c90223b621da</subfield>
    <subfield code="u">https://zenodo.org/record/5006140/files/Manuscript Morales-Rosello J Matern Fetal Neonatal Med 2021.pdf</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2021-02-22</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">openaire</subfield>
    <subfield code="p">user-iplacenta</subfield>
    <subfield code="o">oai:zenodo.org:5006140</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain;  Departamento de Pediatría, Obstetricia y Ginecología, Universidad de Valencia, Valencia, Spain</subfield>
    <subfield code="a">Morales-Roselló, José</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Fetal heart rate and nuchal translucency as first trimester markers of preterm birth</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-iplacenta</subfield>
  </datafield>
  <datafield tag="536" ind1=" " ind2=" ">
    <subfield code="c">765274</subfield>
    <subfield code="a">Innovation in modelling Placenta for Maternal and Fetal Health</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution 4.0 International</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Objective&lt;/p&gt;

&lt;p&gt;To evaluate whether first trimester fetal heart rate (FHR) and nuchal translucency (NT) associate with preterm birth (PTB).&lt;/p&gt;

&lt;p&gt;Methods&lt;/p&gt;

&lt;p&gt;This was a comparative case-control study of 518 normal pregnancies with no history of PTB of which 272 delivered at term (TB) and 246 progressed to spontaneous PTB prior to 37, 34, 32 and 28 weeks. Fetal heart rate (FHR) and nuchal translucency (NT) values at the first trimester scan were compared by means of univariable (Mann-Whitney) and multivariable logistic regression analysis considering hourglass membranes (HM) as the most severe PTB subgroup. Finally severity trends for both parameters were investigated using correlations with gestational age (GA) at delivery and Kruskal-Walls tests.&lt;/p&gt;

&lt;p&gt;Results&lt;/p&gt;

&lt;p&gt;Regardless of GA at delivery, pregnancies affected with PTB showed higher FHR and thicker NT at the first trimester scan. The association was confirmed by the multivariable analysis and the severity trends, which paired the highest FHR and NT values with the most severe cases of PTB (p&amp;lt;0.001) (p&amp;lt;0.0001).&lt;/p&gt;

&lt;p&gt;Conclusion&lt;/p&gt;

&lt;p&gt;Fetuses with subsequent late, early and very early PTB show higher values of NT and FHR at the first trimester scan.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="773" ind1=" " ind2=" ">
    <subfield code="n">doi</subfield>
    <subfield code="i">isVersionOf</subfield>
    <subfield code="a">10.5281/zenodo.5006139</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.5281/zenodo.5006140</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">preprint</subfield>
  </datafield>
</record>
12
7
views
downloads
All versions This version
Views 1212
Downloads 77
Data volume 1.3 MB1.3 MB
Unique views 1111
Unique downloads 77

Share

Cite as