Data from: Profile of and risk factors for post-stroke cognitive impairment in diverse ethno-regional groups
Creators
- Lo, Jessica W1
- Crawford, John D1
- Desmond, David W2
- Godefroy, Olivier3
- Jokinen, Hanna4
- Mahinrad, Simin5
- Bae, Hee-Joon6
- Köhler, Sebastian7
- Douven, Elles7
- Staals, Julie8
- Chen, Christopher9
- Xu, Xin9
- Chong, Eddie J9
- Akinyemi, Rufus O10
- Kalaria, Rajesh N11
- Ogunniyi, Adesola10
- Barbay, Mélanie3
- Roussel, Martine3
- Lee, Byung-Chul12
- Srikanth, Velandai K13
- Moran, Christopher13
- Kandiah, Nagaendran14
- Chander, Russell J1
- Sabayan, Behnam15
- Jukema, J. Wouter5
- Melkas, Susanna4
- Erkinjuntti, Timo4
- Brodaty, Henry1
- Bordet, Régis16
- Bombois, Stéphanie16
- Hénon, Hilde16
- Lipnicki, Darren M1
- Kochan, Nicole A1
- Lim, Jae-Sung12
- Sachdev, Perminder S1
- 1. University of New South Wales
- 2. ,
- 3. Centre Hospitalier Universitaire D' Amiens
- 4. University of Helsinki
- 5. Leiden University Medical Center
- 6. Seoul National University Bundang Hospital
- 7. Maastricht University
- 8. Maastricht University Medical Centre
- 9. National University of Singapore
- 10. University of Ibadan
- 11. Newcastle University
- 12. Hallym University Sacred Heart Hospital
- 13. Monash University
- 14. National Neuroscience Institute
- 15. Northwestern University
- 16. University of Lille
Description
OBJECTIVE: To address the variability in prevalence estimates and inconsistencies in potential risk factors for post-stroke cognitive impairment (PSCI) using a standardised approach and individual participant data (IPD) from international cohorts in the STROKOG consortium. METHODS: We harmonised data from thirteen studies based in eight countries. Neuropsychological test scores 2 to 6 months after stroke or TIA and appropriate normative data were used to calculate standardised cognitive domain scores. Domain-specific impairment was based on percentile cut-offs from normative groups, and associations between domain scores and risk factors were examined using one-stage IPD meta-analysis. RESULTS: In a combined sample of 3,146 participants admitted to hospital for stroke (97%) or TIA (3%), 44% were impaired in global cognition and 30–35% in individual domains 2 to 6 months after the index event. Diabetes and a history of past stroke were strongly associated with poorer cognitive function after covariate adjustments; hypertension, smoking and atrial fibrillation had weaker domain-specific associations. While there were no significant differences in domain impairment among ethno-racial groups, some inter-ethnic differences were found in the effects of risk factors on cognition. CONCLUSIONS: This paper confirms the high prevalence of PSCI in diverse populations, highlights common risk factors, in particular diabetes, and points to ethno-racial differences which warrant attention in the development of prevention strategies.
Notes
Files
Files
(368.4 kB)
Name | Size | Download all |
---|---|---|
md5:b1da23fa9ce8ccc5f495b4f5d6ed7d15
|
368.4 kB | Download |
Additional details
Related works
- Is cited by
- 10.1212/WNL.0000000000008612 (DOI)