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", "type": { "id": "notes", "title": { "de": "Anmerkungen", "en": "Notes" } } } ], "creators": [ { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Bhagwandin", "given_name": "Candida", "name": "Bhagwandin, Candida", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Ashbeck", "given_name": "Erin L.", "name": "Ashbeck, Erin L.", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Whalen", "given_name": "Michael", "name": "Whalen, Michael", "type": "personal" } }, { "affiliations": [ { "name": "National Institutes of Health" } ], "person_or_org": { "family_name": "Bandola-Simon", "given_name": "Joanna", "name": "Bandola-Simon, Joanna", "type": "personal" } }, { "affiliations": [ { "name": "National Institutes of Health" } ], "person_or_org": { "family_name": "Roche", "given_name": "Paul A.", "name": "Roche, Paul A.", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Szajman", "given_name": "Adam", "name": "Szajman, Adam", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Truong", "given_name": "Sarah Mai", "name": "Truong, Sarah Mai", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Wertheim", "given_name": "Betsy C.", "name": "Wertheim, Betsy C.", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Klimentidis", "given_name": "Yann C.", "name": "Klimentidis, Yann C.", "type": "personal" } }, { "person_or_org": { "family_name": "Ishido", "given_name": "Satoshi", "name": "Ishido, Satoshi", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Renquist", "given_name": "Benjamin J.", "name": "Renquist, Benjamin J.", "type": "personal" } }, { "affiliations": [ { "name": "University of Arizona" } ], "person_or_org": { "family_name": "Lybarger", "given_name": "Lonnie", "name": "Lybarger, Lonnie", "type": "personal" } } ], "description": "Type 2 diabetes is typified by insulin-resistance in adipose tissue, skeletal muscle, and liver, leading to chronic hyperglycemia. Additionally, obesity and type 2 diabetes are characterized by chronic low-grade inflammation. Membrane-associated RING-CH-1 (MARCH1) is an E3 ubiquitin ligase best known for suppression of antigen presentation by dendritic and B cells. MARCH1 was recently found to negatively regulate the cell surface levels of the insulin receptor via ubiquitination. This, in turn, impaired insulin sensitivity in mouse models. Here, we report that MARCH1-deficient (knockout; KO) female mice exhibit excessive weight gain and excessive visceral adiposity when reared on standard chow diet, without increased inflammatory cell infiltration of adipose tissue. By contrast, male MARCH1 KO mice had similar weight gain and visceral adiposity to wildtype (WT) male mice. MARCH1 KO mice of both sexes were more glucose tolerant than WT mice. The levels of insulin receptor were generally higher in insulin-responsive tissues (especially the liver) from female MARCH1 KO mice compared to males, with the potential to account in part for the differences between male and female MARCH1 KO mice. We also explored a potential role for MARCH1 in human type 2 diabetes risk through genetic association testing in publicly-available datasets, and found evidence suggestive of association. Collectively, our data indicate an additional link between immune function and diabetes, specifically implicating MARCH1 as a regulator of lipid metabolism and glucose tolerance, whose function is modified by sex-specific factors.", "publication_date": "2018-11-07", "publisher": "Zenodo", "related_identifiers": [ { "identifier": "10.1371/journal.pone.0204898", "relation_type": { "id": "iscitedby", "title": { "de": "Wird zitiert von", "en": "Is cited by" } }, "scheme": "doi" } ], "resource_type": { "id": "dataset", "title": { "de": "Datensatz", "en": "Dataset" } }, "rights": [ { "description": { "en": "CC0 waives copyright interest in a work you've created and dedicates it to the world-wide public domain. Use CC0 to opt out of copyright entirely and ensure your work has the widest reach." }, "icon": "cc-cc0-icon", "id": "cc0-1.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/publicdomain/zero/1.0/legalcode" }, "title": { "en": "Creative Commons Zero v1.0 Universal" } } ], "title": "Data from: The E3 ubiquitin ligase MARCH1 regulates glucose-tolerance and lipid storage in a sex-specific manner" }, "parent": { "access": { "owned_by": { "user": 90070 } }, "communities": { "default": "734b6452-1f40-4db0-b218-08ab1d568b7f", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2020-02-04T14:03:17.992421+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "734b6452-1f40-4db0-b218-08ab1d568b7f", "links": {}, "metadata": { "curation_policy": "The Dryad collection in Zenodo contains datasets mirrored from the Dryad Digital Repository. If you want your dataset to appear here, submit it through https://datadryad.org. No other datasets will be accepted.
", "description": "Dryad is an international open-access repository of research data, especially data underlying scientific and medical publications. Dryad is a curated general-purpose repository that makes data discoverable, freely reusable, and citable.", "organizations": [ { "id": "00x6h5n95" } ], "page": "Dryad is a community-governed open data publishing and curation repository. Through Dryad and Zenodo's partnership, Zenodo hosts a preservation copy of Dryad datasets, available through this Zenodo Community. For more information or to access the original published datasets, visit https://datadryad.org.
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