[
  {"_key":"60c20a727723bebd86645338","_id":"documents/60c20a727723bebd86645338","_rev":"_cfFhA8i---","file_name":"000q5l5n.pdf","md5":"CEA8FEEE5CA332CF63F04EECC1E4205E","id":"000q5l5n","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/0q/5l/5n/000q5l5n/000q5l5n.pdf","date":"2021-06-10T12:49+0000","metadata":{"alternative-id":["ani9050228"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1557446400000,"date-time":"2019-05-10T00:00:00Z","date-parts":[[2019,5,10]]}}],"volume":"9","pmid":"31083284","has_valid_tei":false,"URL":"http://dx.doi.org/10.3390/ani9050228","DOI":"10.3390/ani9050228","original-title":[],"title":["Seroprevalence of Rodent Pathogens in Wild Rats from the Island of St. Kitts, West Indies"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":16,"page":"228","type":"journal-article","issued":{"date-parts":[[2019,5,10]]},"publisher":"MDPI AG","id":"000q5l5n","short-title":[],"pmcid":"PMC6562389","has_valid_oa_url":true,"deposited":{"timestamp":1561645867000,"date-time":"2019-06-27T14:31:07Z","date-parts":[[2019,6,27]]},"indexed":{"timestamp":1586920788693,"date-time":"2020-04-15T03:19:48Z","date-parts":[[2020,4,15]]},"is-referenced-by-count":0,"short-container-title":["Animals"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/83/58/PMC6562389.tar.gz","has_valid_thumbnail":false,"ISSN":["2076-2615"],"references-count":16,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"issn-type":[{"value":"2076-2615","type":"electronic"}],"container-title":["Animals"],"published-online":{"date-parts":[[2019,5,10]]},"issue":"5","member":"1968","abstract":"SIMPLE SUMMARY: The role of rodents in the transmission of many diseases is widely known. Wild rats abundant in urban environments may transmit diseases to humans and other animals, including laboratory rodents used for biomedical research in research facilities, possibly compromising research data. In order to gather information about the various diseases present around such facilities, it is important to conduct routine surveillance of wild rodents in the area. In this pilot study, we surveyed 22 captured wild rats (Rattus norvegicus and Rattus rattus) from the Caribbean island of St. Kitts for 19 microorganisms. Information gained from such surveillance data would be beneficial in assessing regional public health risks and when implementing routine laboratory rodent health monitoring protocols. ABSTRACT: A pilot seroprevalence study was conducted to document exposure to selected pathogens in wild rats inhabiting the Caribbean island of St. Kitts. Serum samples collected from 22 captured wild rats (Rattus norvegicus and Rattus rattus) were tested for the presence of antibodies to various rodent pathogens using a rat MFI2 serology panel. The samples were positive for cilia-associated respiratory bacillus (13/22; 59.1%), Clostridium piliforme (4/22; 18.2%), Mycoplasma pulmonis (4/22; 18.2%), Pneumocystis carinii (1/22; 4.5%), mouse adenovirus type 2 (16/22; 72.7%), Kilham rat virus (15/22; 68.2%), reovirus type 3 (9/22; 40.9%), rat parvovirus (4/22; 18.2%), rat minute virus (4/22; 18.2%), rat theilovirus (2/22; 9.1%), and infectious diarrhea of infant rats strain of group B rotavirus (rat rotavirus) (1/22; 4.5%). This study provides the first evidence of exposure to various rodent pathogens in wild rats on the island of St. Kitts. Periodic pathogen surveillance in the wild rat population would be beneficial in assessing potential regional zoonotic risks as well as in enhancing the current knowledge when implementing routine animal health monitoring protocols in facilities with laboratory rodent colonies.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Kenneth","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6329-2333","family":"Boey","affiliation":[]},{"sequence":"additional","family":"Shiokawa","given":"Kanae","affiliation":[]},{"sequence":"additional","family":"Avsaroglu","given":"Harutyun","affiliation":[]},{"sequence":"additional","family":"Rajeev","given":"Sreekumari","affiliation":[]}],"link":[{"URL":"https://www.mdpi.com/2076-2615/9/5/228/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1557734227000,"date-time":"2019-05-13T07:57:07Z","date-parts":[[2019,5,13]]},"language":"en","score":1,"source":"Crossref","cord_sha":"3442b139e80c8351c89a9398709090db63edb8fe"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":3943},
  {"_key":"60c20a747723bebd8664533d","_id":"documents/60c20a747723bebd8664533d","_rev":"_cfFhA8u---","file_name":"000tfenb.pdf","md5":"BBA7AF8FCA8C673549201DBE93F0974D","id":"000tfenb","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/0t/fe/nb/000tfenb/000tfenb.pdf","date":"2021-06-10T12:49+0000","metadata":{"alternative-id":["896"],"published-print":{"date-parts":[[2017,12]]},"article-number":"230","language":"en","volume":"14","pmid":"29166910","journal-issue":{"published-print":{"date-parts":[[2017,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1186/s12985-017-0896-0","original-title":[],"title":["Prevalence and genetic diversity analysis of human coronaviruses among cross-border children"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"type":"journal-article","issued":{"date-parts":[[2017,11,22]]},"prefix":"10.1186","publisher":"Springer Science and Business Media LLC","id":"000tfenb","reference-count":26,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/9d/45/PMC5700739.tar.gz","pmcid":"PMC5700739","has_valid_oa_url":true,"deposited":{"timestamp":1511353070000,"date-time":"2017-11-22T12:17:50Z","date-parts":[[2017,11,22]]},"indexed":{"timestamp":1615368233019,"date-time":"2021-03-10T09:23:53Z","date-parts":[[2021,3,10]]},"is-referenced-by-count":15,"short-container-title":["Virol J"],"funder":[{"doi-asserted-by":"publisher","award":["K16026"],"DOI":"10.13039/501100001809","name":"National Natural Science Foundation of China"},{"award":["2016YFF0203203 and 2016YFC1201404"],"name":"National Key Research and Development Plan of China"},{"award":["No. JCYJ20140419151618022, No. JCYJ20150330102720128 No. CXZZ20150504163004339, No. JCYJ20170307104024209, No. JCYJ20160427151920801"],"name":"Shenzhen Science and Technology Foundation"},{"award":["SZ2014101"],"name":"Science and Technology Foundation of Shenzhen Enter-exit Inspection and Quarantine Bureau"},{"award":["No. 2016A020219005, No. 20160223, No. CXZZ20150504163004339, No. 2016A020247001, No. 2016A020223001"],"name":"Guangdong Science and Technology Foundation"}],"published-online":{"date-parts":[[2017,11,22]]},"has_valid_thumbnail":false,"references-count":26,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12985-017-0896-0","short-title":[],"issn-type":[{"value":"1743-422X","type":"electronic"}],"container-title":["Virology Journal"],"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND: More than a decade after the outbreak of human coronaviruses (HCoVs) SARS in Guangdong province and Hong Kong SAR of China in 2002, there is still no reoccurrence, but the evolution and recombination of the coronaviruses in this region are still unknown. Therefore, surveillance on the prevalence and the virus variation of HCoVs circulation in this region is conducted. METHODS: A total of 3298 nasopharyngeal swabs samples were collected from cross-border children (<6 years, crossing border between Southern China and Hong Kong SAR) showing symptoms of respiratory tract infection, such as fever (body temperature > 37.5 °C), from 2014 May to 2015 Dec. Viral nucleic acids were analyzed and sequenced to study the prevalence and genetic diversity of the four human coronaviruses. The statistical significance of the data was evaluated with Fisher chi-square test. RESULTS: 78 (2.37%; 95%CI 1.8-2.8%) out of 3298 nasopharyngeal swabs specimens were found to be positive for OC43 (36;1.09%), HKU1 (34; 1.03%), NL63 (6; 0.18%) and 229E (2;0.01%). None of SARS or MERS was detected. The HCoVs predominant circulating season was in transition of winter to spring, especially January and February and NL63 detected only in summer and fall. Complex population with an abundant genetic diversity of coronaviruses was circulating and they shared homology with the published strains (99-100%). Besides, phylogenetic evolutionary analysis indicated that OC43 coronaviruses were clustered into three clades (B,D,E), HKU1 clustered into two clades(A,B) and NL63 clustered into two clades(A,B). Moreover, several novel mutations including nucleotides substitution and the insertion of spike of the glycoprotein on the viral surface were discovered. CONCLUSIONS: The detection rate and epidemic trend of coronaviruses were stable and no obvious fluctuations were found. The detected coronaviruses shared a conserved gene sequences in S and RdRp. However, mutants of the epidemic strains were detected, suggesting continuous monitoring of the human coronaviruses is in need among cross-border children, who are more likely to get infected and transmit the viruses across the border easily, in addition to the general public.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Liu","given":"Peilin","affiliation":[]},{"sequence":"additional","family":"Shi","given":"Lei","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Wei","affiliation":[]},{"sequence":"additional","family":"He","given":"Jianan","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Chunxiao","affiliation":[]},{"sequence":"additional","family":"Zhao","given":"Chunzhong","affiliation":[]},{"sequence":"additional","family":"Kong","given":"Siu Kai","affiliation":[]},{"sequence":"additional","given":"Jacky Fong Chuen","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-0355-8865","family":"Loo","affiliation":[]},{"sequence":"additional","family":"Gu","given":"Dayong","affiliation":[]},{"sequence":"additional","family":"Hu","given":"Longfei","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12985-017-0896-0.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1511353026000,"date-time":"2017-11-22T12:17:06Z","date-parts":[[2017,11,22]]},"ISSN":["1743-422X"],"score":1,"source":"Crossref","cord_sha":"c890cb0b691543c29b35b5a1351ff8c990739fe2"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":6057},
  {"_key":"60c20a757723bebd86645340","_id":"documents/60c20a757723bebd86645340","_rev":"_cfFhA86---","file_name":"0012g4t9.pdf","md5":"249D53A1F05C9A22F1C1EED4C5C01EA4","id":"0012g4t9","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/12/g4/t9/0012g4t9/0012g4t9.pdf","date":"2021-06-10T12:49+0000","metadata":{"alternative-id":["S0022395620309870"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1609459200000,"date-time":"2021-01-01T00:00:00Z","date-parts":[[2021,1,1]]}}],"volume":"132","pmid":"33038563","has_valid_tei":false,"DOI":"10.1016/j.jpsychires.2020.09.021","original-title":[],"published-print":{"date-parts":[[2021,1]]},"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Biological Psychiatry","Psychiatry and Mental health"],"page":"32-37","type":"journal-article","issued":{"date-parts":[[2021,1]]},"funder":[{"award":["2020-0162"],"name":"FIPE-HCPA GPPG"}],"publisher":"Elsevier BV","id":"0012g4t9","reference-count":23,"title":["COVID-19 and mental health in Brazil: Psychiatric symptoms in the general population"],"pmcid":"PMC7527181","has_valid_oa_url":true,"deposited":{"timestamp":1607260091000,"date-time":"2020-12-06T13:08:11Z","date-parts":[[2020,12,6]]},"indexed":{"timestamp":1613565832700,"date-time":"2021-02-17T12:43:52Z","date-parts":[[2021,2,17]]},"is-referenced-by-count":4,"short-container-title":["Journal of Psychiatric Research"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/84/20/PMC7527181.tar.gz","has_valid_thumbnail":false,"ISSN":["0022-3956"],"references-count":23,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.jpsychires.2020.09.021","short-title":[],"issn-type":[{"value":"0022-3956","type":"print"}],"container-title":["Journal of Psychiatric Research"],"score":1,"has_valid_ref_annotation":false,"member":"78","abstract":"Public health interventions at general population level are imperative in order to decrease the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), but they may contribute to widespread emotional distress and increased risk for psychiatric illnesses. We report on the results of an investigation into the occurrence and determinants of psychiatric symptoms among the Brazilian general population (N=1996). We assessed sociodemographic variables and general mental health (DSM-5 Self-Rated Level 1 Cross-Cutting Symptom Measure), depression (PROMIS depression v.8a), anxiety (PROMIS anxiety v.8a), and post-traumatic stress symptoms (Impact of Event Scale-IES-R scale) using an online web-based survey. Anxiety (81.9%), depression (68%), anger (64.5%), somatic symptoms (62.6%) and sleep problems (55.3%) were the most common psychiatric symptoms. Younger age, female gender, low income, lower level of education, longer period of social distancing, and self-reported history of previous psychiatric illness were strongly associated with higher severity of symptoms. Our results support the negative impact of the COVID-19 pandemic on the mental health of the Brazilian population. The high prevalence of psychiatric symptoms observed in our sample indicates that the mental health impact of the COVID-19 pandemic should be considered a public health problem in Brazil. The health systems and individual clinicians must be prepared to offer and implement specific interventions in order to identify and treat psychiatric issues.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Goularte","given":"Jeferson Ferraz","affiliation":[]},{"sequence":"additional","given":"Silvia Dubou","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7673-2676","family":"Serafim","affiliation":[]},{"sequence":"additional","family":"Colombo","given":"Rafael","affiliation":[]},{"sequence":"additional","given":"Bridget","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-2405-0593","family":"Hogg","affiliation":[]},{"sequence":"additional","given":"Marco Antonio","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-4355-9547","family":"Caldieraro","affiliation":[]},{"sequence":"additional","family":"Rosa","given":"Adriane Ribeiro","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S0022395620309870?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0022395620309870?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1601503293000,"date-time":"2020-09-30T22:01:33Z","date-parts":[[2020,9,30]]},"language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"COVID-19 and mental health in Brazil: Psychiatric symptoms in the general population","label":"Article Title","name":"articletitle"},{"value":"Journal of Psychiatric Research","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.jpsychires.2020.09.021","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 Elsevier Ltd. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"f78a19404a7bc2d7a6aaf48370dc867a1043cf9e"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":7398},
  {"_key":"60c20a787723bebd86645342","_id":"documents/60c20a787723bebd86645342","_rev":"_cfFhA9G---","file_name":"0014ih0d.pdf","md5":"ADA903815E4242C7563D74528075B37F","id":"0014ih0d","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/14/ih/0d/0014ih0d/0014ih0d.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["S0887618520301432"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1609459200000,"date-time":"2021-01-01T00:00:00Z","date-parts":[[2021,1,1]]}}],"article-number":"102329","language":"en","volume":"77","pmid":"33190017","has_valid_tei":false,"DOI":"10.1016/j.janxdis.2020.102329","original-title":[],"published-print":{"date-parts":[[2021,1]]},"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Clinical Psychology","Psychiatry and Mental health"],"page":"102329","issued":{"date-parts":[[2021,1]]},"publisher":"Elsevier BV","id":"0014ih0d","reference-count":46,"title":["Obsessive-compulsive disorder during COVID-19: Turning a problem into an opportunity?"],"pmcid":"PMC7644184","has_valid_oa_url":true,"deposited":{"timestamp":1615188143000,"date-time":"2021-03-08T07:22:23Z","date-parts":[[2021,3,8]]},"indexed":{"timestamp":1618452543383,"date-time":"2021-04-15T02:09:03Z","date-parts":[[2021,4,15]]},"is-referenced-by-count":4,"short-container-title":["Journal of Anxiety Disorders"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/82/7a/PMC7644184.tar.gz","has_valid_thumbnail":false,"ISSN":["0887-6185"],"references-count":46,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.janxdis.2020.102329","short-title":[],"issn-type":[{"value":"0887-6185","type":"print"}],"container-title":["Journal of Anxiety Disorders"],"score":1,"has_valid_ref_annotation":false,"member":"78","abstract":"The COVID-19 pandemic has prompted global measures to prevent infection. Experts assume that it is particularly affecting people with obsessive-compulsive disorder (OCD), especially those with washing compulsions. Data, however, are currently lacking. 394 participants with OCD (n = 223 washers) participated in an online survey. Change in severity of OCD symptoms, reasons participants reported for the change (e.g., reduced mobility, reduced availability of cleaning products, economic factors, interpersonal conflicts), as well as participants’ beliefs and experience associated with COVID-19 were assessed. 72% of the participants reported an increase in OCD. This increase was significantly stronger in washers compared to non-washers. The worsening of symptoms was primarily associated with reduced mobility and interpersonal conflicts. Dysfunctional hygiene-related beliefs were significantly higher in washers than non-washers and were associated with greater symptom progression. Washers were more confident than non-washers about providing other people with helpful advice related to infection preventions. Washers, however, received more negative feedback from others in response to the advice they provided than non-washers. The majority of participants with OCD were negatively affected by the COVID-19 pandemic, and the negative effects were more pronounced in washers than in non-washers. Rapid interventions for OCD should be implemented to prevent long-term deterioration.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Lena","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5292-350X","family":"Jelinek","affiliation":[]},{"sequence":"additional","given":"Steffen","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8601-0143","family":"Moritz","affiliation":[]},{"sequence":"additional","family":"Miegel","given":"Franziska","affiliation":[]},{"sequence":"additional","family":"Voderholzer","given":"Ulrich","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S0887618520301432?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0887618520301432?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1604615256000,"date-time":"2020-11-05T22:27:36Z","date-parts":[[2020,11,5]]},"type":"journal-article","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Obsessive-compulsive disorder during COVID-19: Turning a problem into an opportunity?","label":"Article Title","name":"articletitle"},{"value":"Journal of Anxiety Disorders","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.janxdis.2020.102329","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 Elsevier Ltd. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"524778797ba0ae602b02a6debc9d8d2239bf2589"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":10256},
  {"_key":"60c20a7b7723bebd86645345","_id":"documents/60c20a7b7723bebd86645345","_rev":"_cfFhA9S---","file_name":"001njzrs.pdf","md5":"B12AA512259D3514315A382792138215","id":"001njzrs","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/1n/jz/rs/001njzrs/001njzrs.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["10.1021/acs.jproteome.0c00674"],"published-print":{"date-parts":[[2020,11,6]]},"volume":"19","pmid":"33090795","journal-issue":{"published-print":{"date-parts":[[2020,11,6]]},"issue":"11"},"has_valid_tei":false,"DOI":"10.1021/acs.jproteome.0c00674","original-title":[],"title":["Perspective on Proteomics for Virus Detection in Clinical Samples"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":63,"page":"4380-4388","type":"journal-article","issued":{"date-parts":[[2020,10,22]]},"prefix":"10.1021","publisher":"American Chemical Society (ACS)","id":"001njzrs","short-title":[],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/04/82/PMC7640980.tar.gz","pmcid":"PMC7640980","has_valid_oa_url":true,"deposited":{"timestamp":1605309035000,"date-time":"2020-11-13T23:10:35Z","date-parts":[[2020,11,13]]},"indexed":{"timestamp":1617091583439,"date-time":"2021-03-30T08:06:23Z","date-parts":[[2021,3,30]]},"is-referenced-by-count":4,"short-container-title":["J. Proteome Res."],"funder":[{"doi-asserted-by":"publisher","award":["MU 4430/2-1"],"DOI":"10.13039/501100001659","name":"Deutsche Forschungsgemeinschaft"}],"published-online":{"date-parts":[[2020,10,22]]},"has_valid_thumbnail":false,"references-count":63,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1021/acs.jproteome.0c00674","ISSN":["1535-3893","1535-3907"],"issn-type":[{"value":"1535-3893","type":"print"},{"value":"1535-3907","type":"electronic"}],"container-title":["Journal of Proteome Research"],"has_valid_ref_annotation":false,"issue":"11","member":"316","abstract":"[Image: see text] One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Marica","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-9369-8203","family":"Grossegesse","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Highly Pathogenic Viruses (ZBS 1), Robert Koch Institute, Seestr. 10, Berlin 13353, Germany"}]},{"sequence":"additional","family":"Hartkopf","given":"Felix","affiliation":[{"name":"Microbial Genomics (NG 1), Robert Koch Institute, Berlin 13353, Germany"},{"name":"Section eScience (S.3), Federal Institute for Materials Research and Testing, Unter den Eichen 87, Berlin 12205, Germany"}]},{"sequence":"additional","family":"Nitsche","given":"Andreas","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Highly Pathogenic Viruses (ZBS 1), Robert Koch Institute, Seestr. 10, Berlin 13353, Germany"}]},{"sequence":"additional","family":"Schaade","given":"Lars","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin 13353, Germany"}]},{"sequence":"additional","given":"Joerg","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-8309-082X","family":"Doellinger","affiliation":[{"name":"Centre for Biological Threats and Special Pathogens, Proteomics and Spectroscopy (ZBS 6), Robert Koch Institute, Berlin 13353, Germany"}]},{"sequence":"additional","given":"Thilo","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-8304-2684","family":"Muth","affiliation":[{"name":"Section eScience (S.3), Federal Institute for Materials Research and Testing, Unter den Eichen 87, Berlin 12205, Germany"}]}],"subject":["Biochemistry","General Chemistry"],"link":[{"URL":"https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.0c00674","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1603394380000,"date-time":"2020-10-22T19:19:40Z","date-parts":[[2020,10,22]]},"language":"en","score":1,"source":"Crossref","cord_sha":"17cd5bb7030dca4c2334599c51bbfc813fc68b87"},"application":"software-mentions","pages":[{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362},{"page_width":625.436,"page_height":818.362}],"runtime":11796},
  {"_key":"60c20a7b7723bebd8664534f","_id":"documents/60c20a7b7723bebd8664534f","_rev":"_cfFhA9e---","file_name":"002psmxf.pdf","md5":"9F82E88184F106CFDFABB5586221E4A0","id":"002psmxf","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/2p/sm/xf/002psmxf/002psmxf.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["26574"],"volume":"37","pmid":"33598077","author":[{"sequence":"first","family":"Karim","given":"Syed Irfan","affiliation":[]},{"sequence":"additional","family":"Irfan","given":"Farhana","affiliation":[]},{"sequence":"additional","family":"Batais","given":"Mohammed","affiliation":[]}],"DOI":"10.11604/pamj.2020.37.262.26574","license-simplified":"cc-by","original-title":[],"title":["Becoming virtual: a preliminary experience of outpatient primary care during COVID-19 pandemic"],"content-domain":{"domain":["panafrican-med-journal.com"],"crossmark-restriction":true},"subject":["General Medicine"],"type":"journal-article","issued":{"date-parts":[[2020]]},"publisher":"Pan African Medical Journal","id":"002psmxf","reference-count":0,"pmcid":"PMC7864278","has_valid_oa_url":true,"deposited":{"timestamp":1606205532000,"date-time":"2020-11-24T08:12:12Z","date-parts":[[2020,11,24]]},"indexed":{"timestamp":1606210007688,"date-time":"2020-11-24T09:26:47Z","date-parts":[[2020,11,24]]},"is-referenced-by-count":0,"short-container-title":["Pan Afr Med J"],"prefix":"10.11604","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/ca/41/PMC7864278.tar.gz","has_valid_thumbnail":false,"ISSN":["1937-8688"],"references-count":0,"published-online":{"date-parts":[[2020]]},"subtitle":[],"URL":"http://dx.doi.org/10.11604/pamj.2020.37.262.26574","short-title":[],"issn-type":[{"value":"1937-8688","type":"electronic"}],"container-title":["Pan African Medical Journal"],"has_valid_ref_annotation":false,"member":"4870","abstract":"The World Health Organization (WHO) has declared COVID-19 outbreak as a pandemic. This pandemic is transforming the world and has posed exceptional challenges to health care delivery. Saudi Arabia has exerted unprecedented efforts and measures to fight the pandemic. Appreciating the value of primary health care during this crisis the family and community medicine department reorganized the services. We discuss the problems faced, solutions and lessons learned in the hope others may find it helpful.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.11604/pamj.2016.07.30.0001","relation":{},"created":{"timestamp":1606205531000,"date-time":"2020-11-24T08:12:11Z","date-parts":[[2020,11,24]]},"language":"en","score":1,"source":"Crossref","cord_sha":"473e04a044265ee62d57f87666ee5764e80743fe"},"application":"software-mentions","pages":[{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92}],"runtime":3189},
  {"_key":"60c20a817723bebd86645352","_id":"documents/60c20a817723bebd86645352","_rev":"_cfFhA9q---","file_name":"002czx8v.pdf","md5":"D97D9378D025826FAF8AD65D699634C7","id":"002czx8v","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/2c/zx/8v/002czx8v/002czx8v.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["963"],"published-print":{"date-parts":[[2020,12]]},"article-number":"106","language":"en","volume":"20","pmid":"32380951","journal-issue":{"published-print":{"date-parts":[[2020,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1186/s12874-020-00963-7","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1588809600000,"date-time":"2020-05-07T00:00:00Z","date-parts":[[2020,5,7]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","type":"journal-article","issued":{"date-parts":[[2020,5,7]]},"funder":[{"doi-asserted-by":"publisher","award":["UM1 AI068619"],"DOI":"10.13039/100000060","name":"National Institute of Allergy and Infectious Diseases"}],"publisher":"Springer Science and Business Media LLC","id":"002czx8v","reference-count":49,"title":["Psychometric properties of measures of substance use: a systematic review and meta-analysis of reliability, validity and diagnostic test accuracy"],"oaLink":"https://bmcmedresmethodol.biomedcentral.com/track/pdf/10.1186/s12874-020-00963-7","has_valid_oa_url":true,"deposited":{"timestamp":1588829703000,"date-time":"2020-05-07T05:35:03Z","date-parts":[[2020,5,7]]},"indexed":{"timestamp":1588831854319,"date-time":"2020-05-07T06:10:54Z","date-parts":[[2020,5,7]]},"is-referenced-by-count":0,"short-container-title":["BMC Med Res Methodol"],"prefix":"10.1186","published-online":{"date-parts":[[2020,5,7]]},"has_valid_thumbnail":false,"references-count":49,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12874-020-00963-7","short-title":[],"issn-type":[{"value":"1471-2288","type":"electronic"}],"container-title":["BMC Medical Research Methodology"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND Synthesis of psychometric properties of substance use measures to identify patterns of use and substance use disorders remains limited. To address this gap, we sought to systematically evaluate the psychometric properties of measures to detect substance use and misuse. METHODS We conducted a systematic review and meta-analysis of literature on measures of substance classes associated with HIV risk (heroin, methamphetamine, cocaine, ecstasy, alcohol) that were published in English before June 2016 that reported at least one of the following psychometric outcomes of interest: internal consistency (alpha), test-retest/inter-rater reliability (kappa), sensitivity, specificity, positive predictive value, and negative predictive value. We used meta-analytic techniques to generate pooled summary estimates for these outcomes using random effects and hierarchical logistic regression models. RESULTS Findings across 387 paper revealed that overall, 65% of pooled estimates for alpha were in the range of fair-to-excellent; 44% of estimates for kappa were in the range of fair-to-excellent. In addition, 69, 97, 37 and 96% of pooled estimates for sensitivity, specificity, positive predictive value, and negative predictive value, respectively, were in the range of moderate-to-excellent. CONCLUSION We conclude that many substance use measures had pooled summary estimates that were at the fair/moderate-to-excellent range across different psychometric outcomes. Most scales were conducted in English, within the United States, highlighting the need to test and validate these measures in more diverse settings. Additionally, the majority of studies had high risk of bias, indicating a need for more studies with higher methodological quality.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Santos","given":"Glenn-Milo","affiliation":[]},{"sequence":"additional","family":"Strathdee","given":"Steffanie A.","affiliation":[]},{"sequence":"additional","family":"El-Bassel","given":"Nabila","affiliation":[]},{"sequence":"additional","family":"Patel","given":"Poonam","affiliation":[]},{"sequence":"additional","family":"Subramanian","given":"Divya","affiliation":[]},{"sequence":"additional","family":"Horyniak","given":"Danielle","affiliation":[]},{"sequence":"additional","family":"Cook","given":"Ryan R.","affiliation":[]},{"sequence":"additional","family":"McCullagh","given":"Charlotte","affiliation":[]},{"sequence":"additional","family":"Marotta","given":"Phillip","affiliation":[]},{"sequence":"additional","family":"Choksi","given":"Foram","affiliation":[]},{"sequence":"additional","family":"Kang","given":"Brian","affiliation":[]},{"sequence":"additional","family":"Allen","given":"Isabel","affiliation":[]},{"sequence":"additional","family":"Shoptaw","given":"Steven","affiliation":[]}],"subject":["Health Informatics","Epidemiology"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12874-020-00963-7.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s12874-020-00963-7/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s12874-020-00963-7.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1588829694000,"date-time":"2020-05-07T05:34:54Z","date-parts":[[2020,5,7]]},"ISSN":["1471-2288"],"assertion":[{"order":1,"value":"22 July 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"30 March 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"7 May 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"This study involved only analysis of data from published scientific literature; we did not collect any primary data.","group":{"label":"Ethics approval and consent to participate","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Not applicable.","group":{"label":"Consent for publication","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":11714},
  {"_key":"60c20a827723bebd86645355","_id":"documents/60c20a827723bebd86645355","_rev":"_cfFhA96---","file_name":"003r4sjl.pdf","md5":"F2CE05723196C9428A73F9F93929DAB8","id":"003r4sjl","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/3r/4s/jl/003r4sjl/003r4sjl.pdf","date":"2021-06-10T12:50+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-51825-7_34","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"492-500","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"003r4sjl","reference-count":15,"title":["SAT Solving with Fragmented Hamiltonian Path Constraints for Wire Arc Additive Manufacturing"],"pmcid":"PMC7326536","has_valid_oa_url":true,"deposited":{"timestamp":1596827951000,"date-time":"2020-08-07T19:19:11Z","date-parts":[[2020,8,7]]},"indexed":{"timestamp":1596829254520,"date-time":"2020-08-07T19:40:54Z","date-parts":[[2020,8,7]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,6,26]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030518240","type":"print"},{"value":"9783030518257","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/e7/61/PMC7326536.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-51825-7_34","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Theory and Applications of Satisfiability Testing – SAT 2020","Lecture Notes in Computer Science"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"In Wire Arc Additive Manufactoring (WAAM), an object is welded from scratch. Finding feasible welding paths that make use of the potential of the technology is a computationally complex problem as it requires planning paths in 3D. All parts of the object to be manufactured have to be visited in few welding paths. The search for such welding paths in 3D can be mapped to searching for a fragmented Hamiltonian path in a mathematical graph. We propose a SAT-based approach to finding such fragmented Hamiltonian paths that is suitable for planning WAAM paths. We show how to encode the search for such paths as a mix of SAT clauses and one non-clausal constraint that can be integrated into the SAT solver itself. The reasoning power of the solver enables us to impose additional constraints coming from the application domain on the planned paths, and we show experimentally that in this way, we can find welding paths for relatively complex object geometries.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Ehlers","given":"Rüdiger","affiliation":[]},{"sequence":"additional","family":"Treutler","given":"Kai","affiliation":[]},{"sequence":"additional","family":"Wesling","given":"Volker","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030518240","9783030518257"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-51825-7_34","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1593558013000,"date-time":"2020-06-30T23:00:13Z","date-parts":[[2020,6,30]]},"references-count":15,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"26 June 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"SAT","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"International Conference on Theory and Applications of Satisfiability Testing","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Alghero","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"Italy","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"3 July 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"10 July 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"23","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"sat2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"http://sat2020.idea-researchlab.org/","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Single-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"69","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"25","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"9","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"36% - 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  {"_key":"60c20a877723bebd8664535a","_id":"documents/60c20a877723bebd8664535a","_rev":"_cfFhB-W---","file_name":"005b2j4b.pdf","md5":"F97A5B9414AD142BA053863D6D27DF41","id":"005b2j4b","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/5b/2j/4b/005b2j4b/005b2j4b.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["10.1086/382892"],"published-print":{"date-parts":[[2004,5]]},"language":"en","volume":"189","pmid":"15116304","has_valid_tei":false,"DOI":"10.1086/382892","original-title":[],"title":["Monophyletic Relationship between Severe Acute Respiratory Syndrome Coronavirus and Group 2 Coronaviruses"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":0,"page":"1676-1678","type":"journal-article","issued":{"date-parts":[[2004,5]]},"publisher":"Oxford University Press (OUP)","id":"005b2j4b","short-title":[],"pmcid":"PMC7109970","has_valid_oa_url":true,"deposited":{"timestamp":1503496751000,"date-time":"2017-08-23T13:59:11Z","date-parts":[[2017,8,23]]},"indexed":{"timestamp":1595823829615,"date-time":"2020-07-27T04:23:49Z","date-parts":[[2020,7,27]]},"is-referenced-by-count":8,"short-container-title":["J INFECT DIS"],"prefix":"10.1093","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/83/20/PMC7109970.tar.gz","has_valid_thumbnail":false,"references-count":0,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1086/382892","ISSN":["0022-1899","1537-6613"],"issn-type":[{"value":"0022-1899","type":"print"},{"value":"1537-6613","type":"electronic"}],"container-title":["The Journal of Infectious Diseases"],"has_valid_ref_annotation":false,"issue":"9","member":"286","abstract":"Although primary genomic analysis has revealed that severe acute respiratory syndrome coronavirus (SARS CoV) is a new type of coronavirus, the different protein trees published in previous reports have provided no conclusive evidence indicating the phylogenetic position of SARS CoV. To clarify the phylogenetic relationship between SARS CoV and other coronaviruses, we compiled a large data set composed of 7 concatenated protein sequences and performed comprehensive analyses, using the maximum-likelihood, Bayesian-inference, and maximum-parsimony methods. All resulting phylogenetic trees displayed an identical topology and supported the hypothesis that the relationship between SARS CoV and group 2 CoVs is monophyletic. Relationships among all major groups were well resolved and were supported by all statistical analyses.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Zhu","given":"Guan","affiliation":[]},{"sequence":"additional","family":"Chen","given":"Hsuan‐Wien","affiliation":[]}],"subject":["Immunology and Allergy","Infectious Diseases"],"link":[{"URL":"http://academic.oup.com/jid/article-pdf/189/9/1676/2593894/189-9-1676.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{},"created":{"timestamp":1082559867000,"date-time":"2004-04-21T15:04:27Z","date-parts":[[2004,4,21]]},"journal-issue":{"published-print":{"date-parts":[[2004,5]]},"issue":"9"},"score":1,"source":"Crossref","cord_sha":"4a0de3f874ad61c102ddb195fc10aa721d9f5b85"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":2443},
  {"_key":"60c20a8a7723bebd86645360","_id":"documents/60c20a8a7723bebd86645360","_rev":"_cfFhB-q---","file_name":"0053p2ji.pdf","md5":"0FE834C8CA24C314A8EC23CAE7F77DAC","id":"0053p2ji","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/53/p2/ji/0053p2ji/0053p2ji.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["1658"],"published-print":{"date-parts":[[2018,12]]},"article-number":"333","language":"en","volume":"14","pmid":"30404648","journal-issue":{"published-print":{"date-parts":[[2018,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1186/s12917-018-1658-y","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1541548800000,"date-time":"2018-11-07T00:00:00Z","date-parts":[[2018,11,7]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","type":"journal-article","issued":{"date-parts":[[2018,11,7]]},"funder":[{"award":["N.A."],"name":"stichting Diergeneeskundig Onderzoek Gezelschapsdieren"}],"publisher":"Springer Science and Business Media LLC","id":"0053p2ji","reference-count":47,"title":["A laparoscopic approach for removal of ovarian remnant tissue in 32 dogs"],"oaLink":"https://bmcvetres.biomedcentral.com/track/pdf/10.1186/s12917-018-1658-y","has_valid_oa_url":true,"deposited":{"timestamp":1573085359000,"date-time":"2019-11-07T00:09:19Z","date-parts":[[2019,11,7]]},"indexed":{"timestamp":1610687409996,"date-time":"2021-01-15T05:10:09Z","date-parts":[[2021,1,15]]},"is-referenced-by-count":4,"short-container-title":["BMC Vet Res"],"prefix":"10.1186","published-online":{"date-parts":[[2018,11,7]]},"has_valid_thumbnail":false,"references-count":47,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12917-018-1658-y","short-title":[],"issn-type":[{"value":"1746-6148","type":"electronic"}],"container-title":["BMC Veterinary Research"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND Surgical treatment of ovarian remnant syndrome (ORS) in dogs usually necessitates large celiotomies and considerable manipulation of organs because of the relatively deep position of ovarian remnant tissue, large patient size, and often encountered adhesions. In women, laparoscopic treatment of ORS is successful and has significant advantages over laparotomy. Since laparoscopic ovariectomy has significant advantages over open ovariectomy in dogs, including reduced surgical stress and postoperative pain and shorter convalescence period, the rationale for a laparoscopic approach of canine ORS is evident. Feasibility and efficacy of a laparoscopic approach for treatment of ORS in dogs was prospectively evaluated using a standardized protocol for diagnosis, treatment, and follow-up. Treatment success was evaluated by histology of removed tissues, postoperative hormone testing, and long-term clinical follow-up. RESULTS Thirty-two client-owned predominantly medium and large breed dogs diagnosed with ORS underwent abdominal ultrasound for ovarian remnant localization prior to laparoscopic surgery for removal of ovarian remnants. Tissue dissection and excision was performed using a vessel sealing forceps. Laparoscopy subjectively enabled detailed visibility and facilitated detection and removal of suspected ovarian tissue in all cases. Histology confirmed ovarian origin of removed tissue in all dogs. Additionally, a GnRH stimulation test was performed in fourteen dogs after a median follow-up of 10.5 months, which verified absence of residual functional ovarian remnant tissue in all dogs. Median surgery duration was 97.5 min and mean total convalescence duration, subjectively scored by owners, was 1.5 ± 0.7 days. No major complications occurred. Adhesions were observed in 79% of the dogs, complicated the surgical approach, and significantly affected surgery duration (85 versus 109 min; p = 0.03). Minor hemorrhage occurred in 12% and significantly increased surgery duration (95.5 versus 128 min; p = 0.02). Trendelenburg position and lateral tilting of the patient were essential for proper access to ovarian remnants. GnRH stimulation test results and/or absence of clinical signs indicative of ORS after a median follow-up period of 22.5 months confirmed treatment efficacy in all dogs. CONCLUSION Laparoscopic surgery for ORS in dogs is effective with minimal complications and short convalescence and can successfully replace the conventional, more invasive open surgical procedure.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Sebastiaan A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-5366-0120","family":"van Nimwegen","affiliation":[]},{"sequence":"additional","family":"Van Goethem","given":"Bart","affiliation":[]},{"sequence":"additional","family":"de Gier","given":"Jeffrey","affiliation":[]},{"sequence":"additional","family":"Kirpensteijn","given":"Jolle","affiliation":[]}],"subject":["General Veterinary","General Medicine"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12917-018-1658-y.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s12917-018-1658-y/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s12917-018-1658-y.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1541595743000,"date-time":"2018-11-07T13:02:23Z","date-parts":[[2018,11,7]]},"ISSN":["1746-6148"],"assertion":[{"order":1,"value":"13 October 2017","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"19 October 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"7 November 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"The study and associated protocol was approved by the local Ethical Committee of the Department of Clinical Sciences of Companion Animals, Utrecht University. Dog owners gave their verbal informed consent when choosing the option of laparoscopic surgery instead of a standard celiotomy approach for ovarian remnant removal. Participation in postoperative GnRH stimulation testing was only possible after full consent and cooperation by the dog owners.","group":{"label":"Ethics approval and consent to participate","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Not applicable.","group":{"label":"Consent for publication","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"},{"order":4,"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","group":{"label":"Publisher’s Note","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":7124},
  {"_key":"60c20a8c7723bebd86645362","_id":"documents/60c20a8c7723bebd86645362","_rev":"_cfFhB_----","file_name":"0055i5f4.pdf","md5":"F7D32B358EE443F9D2FDBB0CA7207D98","id":"0055i5f4","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/55/i5/f4/0055i5f4/0055i5f4.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["ijerph18041813"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1613088000000,"date-time":"2021-02-12T00:00:00Z","date-parts":[[2021,2,12]]}}],"volume":"18","pmid":"33673375","has_valid_tei":false,"URL":"http://dx.doi.org/10.3390/ijerph18041813","DOI":"10.3390/ijerph18041813","original-title":[],"title":["“Stay-at-Home” Lifestyle Effect on Weight Gain during the COVID-19 Outbreak Confinement in China"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":48,"page":"1813","type":"journal-article","issued":{"date-parts":[[2021,2,12]]},"publisher":"MDPI AG","id":"0055i5f4","short-title":[],"pmcid":"PMC7918476","has_valid_oa_url":true,"deposited":{"timestamp":1613984396000,"date-time":"2021-02-22T08:59:56Z","date-parts":[[2021,2,22]]},"indexed":{"timestamp":1613987545149,"date-time":"2021-02-22T09:52:25Z","date-parts":[[2021,2,22]]},"is-referenced-by-count":0,"short-container-title":["IJERPH"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/cd/0f/PMC7918476.tar.gz","has_valid_thumbnail":false,"ISSN":["1660-4601"],"references-count":48,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,2]]}},"issn-type":[{"value":"1660-4601","type":"electronic"}],"container-title":["International Journal of Environmental Research and Public Health"],"published-online":{"date-parts":[[2021,2,12]]},"issue":"4","member":"1968","abstract":"In February 2020, a novel coronavirus (SARS-COV2) broke out in Wuhan city of China. The Chinese government decisively imposed nationwide confinement. This study comprised a structured, online questionnaire, based on 40 items inquiring about socio-demographic information and anthropometric data (reporting weight and height), as well as changes in food intake, physical activity, and sleep during the COVID-19 outbreak. Questionnaires were distributed to residents of Jiangsu and other provinces from 29 March to 5 April. A total of 889 respondents were included, aged between 16 and 70 years (61% females). There was a significant increase in total food intake by 9.8% and a slight increase by 29.2% of respondents, and a significant decrease in physical activity by 31.5% and a slight decrease by 23.4% of respondents, especially in snacks and drinks, and outdoor activities. The rate of weight gain in the total population was 30.6% and the average weight gain was 0.5 ± 2.8 kg. The main factors contributing to weight gain were increased food intake and reduced physical activity. Additionally, normal-weight people were more likely to gain weight than people with overweight/obesity during the COVID-19 confinement. This study provided a good warning and educational reference value on lifestyle changes during the COVID-19 confinement.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Qi","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7047-5760","family":"Zhu","affiliation":[]},{"sequence":"additional","family":"Li","given":"Min","affiliation":[]},{"sequence":"additional","family":"Ji","given":"Yu","affiliation":[]},{"sequence":"additional","family":"Shi","given":"Youpeng","affiliation":[]},{"sequence":"additional","family":"Zhou","given":"Jie","affiliation":[]},{"sequence":"additional","family":"Li","given":"Qianyue","affiliation":[]},{"sequence":"additional","family":"Qin","given":"Ruoyu","affiliation":[]},{"sequence":"additional","family":"Zhuang","given":"Xun","affiliation":[]}],"link":[{"URL":"https://www.mdpi.com/1660-4601/18/4/1813/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1613187685000,"date-time":"2021-02-13T03:41:25Z","date-parts":[[2021,2,13]]},"language":"en","score":1,"source":"Crossref","cord_sha":"df0ff1c47db53b81d7642ed6e7fd2d378a01d31e"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":7890},
  {"_key":"60c20a977723bebd86645364","_id":"documents/60c20a977723bebd86645364","_rev":"_cfFhB_K---","file_name":"005u3n17.pdf","md5":"BC27803093A6C72147734A5D3062F540","id":"005u3n17","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/5u/3n/17/005u3n17/005u3n17.pdf","date":"2021-06-10T12:50+0000","metadata":{"is-referenced-by-count":0,"short-container-title":["Sisli Etfal"],"prefix":"10.14744","original-title":[],"pmid":"33312030","published-online":{"date-parts":[[2020]]},"has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.14744/semb.2020.06887","references-count":0,"license-simplified":"cc-by-nc","subtitle":[],"title":["Randomized prospective comparison of glidescope video laringoscope with macintosh laringoscope in adult who underwent thyroid or parathyroid surgery using neuromonitorization"],"content-domain":{"domain":[],"crossmark-restriction":false},"short-title":[],"issued":{"date-parts":[[2020]]},"issn-type":[{"value":"1302-7123","type":"print"}],"container-title":["SiSli Etfal Hastanesi Tip Bulteni / The Medical Bulletin of Sisli Hospital"],"has_valid_oa_url":true,"has_valid_ref_annotation":false,"publisher":"Kare Publishing","member":"5966","abstract":"Objectives The present study aims to compare the effects of Glidescope Video Laryngoscope (GVL) and Machintosh Laryngoscope (ML) on the hemodynamic response, intubation time and mucosal damage in adult patients who underwent thyroid or parathyroid surgery using neuromonitorization. Methods In this study, 180 patients, aged between 22 and 65 classified as Class I-II in ASA (American Society of Anesthesiologists) and operated under elective conditions were included. Patients were assigned into two groups: Patients intubated with GVL Group G (n=90) and patients intubated with ML Group M (n=90). In both groups, intubation time and the number of trials were recorded. HR (Heart Rate), SpO2 (Peripheral Capillary Oxygen Saturation), SBP (Systolic Blood Pressure), DBP (Diastolic Blood Pressure) and MBP (Mean Blood Pressure) scores were recorded at preinduction, post-induction, post-intubation and three minutes after intubation. Post-operative intubation-associated complications were recorded. Results Post intubation HR, DBP and MBP scores were found to be significantly higher in Group M than Group G (p=0,006, p=0.013, p=0.011). Intubation time was found to be significantly higher in Group G than in group M (35.3±10.3, 22.1±7.7 sec). There was no significant difference between the groups' number of trials and intubation-associated complications. Conclusion Despite its long intubation time, we believe that GVL may be the first choice laryngoscopy method in the thyroid or parathyroid cases that intubated with a low dose muscle relaxant for neuromonitoring since it has a slight effect than ML on hemodynamism it does not increase mucosal damage and has improved visibility.","source":"Crossref","published-print":{"date-parts":[[2020]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Güneş","given":"Murat","affiliation":[]}],"DOI":"10.14744/semb.2020.06887","reference-count":0,"relation":{},"created":{"timestamp":1593689672000,"date-time":"2020-07-02T11:34:32Z","date-parts":[[2020,7,2]]},"oaLink":"https://jag.journalagent.com/z4/download_fulltext.asp?pdir=sislietfaltip&ppdf=2&plng=eng&un=SETB-06887","id":"005u3n17","ISSN":["1302-7123"],"score":1,"deposited":{"timestamp":1593689675000,"date-time":"2020-07-02T11:34:35Z","date-parts":[[2020,7,2]]},"indexed":{"timestamp":1593691866639,"date-time":"2020-07-02T12:11:06Z","date-parts":[[2020,7,2]]},"type":"journal-article","cord_sha":""},"application":"software-mentions","pages":[{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701}],"runtime":15924},
  {"_key":"60c20a997723bebd86645367","_id":"documents/60c20a997723bebd86645367","_rev":"_cfFhB_W---","file_name":"00622vnt.pdf","md5":"8E5B134BBD6082919FE8DFA3F945EF7D","id":"00622vnt","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/62/2v/nt/00622vnt/00622vnt.pdf","date":"2021-06-10T12:50+0000","metadata":{"is-referenced-by-count":1,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,10,27]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.10.25.20219071","group-title":"Psychiatry and Clinical Psychology","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/10/27/2020.10.25.20219071.full.pdf","original-title":[],"title":["Causes of death in mental health service users during the first wave of the COVID-19 pandemic: South London and Maudsley data from March to June 2020, compared with 2015-2019"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":10,"short-title":[],"issued":{"date-parts":[[2020,10,27]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,10,27]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"The COVID-19 pandemic is likely to have had a particularly high impact on the health and wellbeing of people with pre-existing mental disorders. This may include higher than expected mortality rates due to severe infections themselves, due to other comorbidities, or through increased suicide rates during lockdown. However, there has been very little published information to date on causes of death in mental health service users. Taking advantage of a large mental healthcare database linked to death registrations, we describe numbers of deaths within specific underlying-cause-of-death groups for the period from 1st March to 30th June in 2020 and compare these with the same four-month periods in 2015-2019. In past and current service users, there were 2561 deaths in March-June 2020, compared to an average of 1452 for the same months in 2015-19: an excess of 1109. The 708 deaths with COVID-19 as the underlying cause in 2020 accounted for 63.8% of that excess. The remaining excess was accounted for by unnatural/unexplained deaths and by deaths recorded as due to neurodegenerative conditions, with no excess in those attributed to cancer, circulatory disorders, digestive disorders, respiratory disorders, or other disease codes. Of 295 unexplained deaths in 2020 with missing data on cause, 162 (54.9%) were awaiting a formal death notice (i.e. the group that included deaths awaiting a coroner inquest), an excess of 129 compared to the average of previous years, accounting for 11.6% of the excess in total deaths.","deposited":{"timestamp":1604017584000,"date-time":"2020-10-30T00:26:24Z","date-parts":[[2020,10,30]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Robert","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-4435-6397","family":"Stewart","affiliation":[]},{"sequence":"additional","family":"Jewell","given":"Amelia","affiliation":[]},{"sequence":"additional","family":"Broadbent","given":"Matthew","affiliation":[]},{"sequence":"additional","family":"Bakolis","given":"Ioannis","affiliation":[]},{"sequence":"additional","family":"Das-Munshi","given":"Jayati","affiliation":[]}],"DOI":"10.1101/2020.10.25.20219071","reference-count":10,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.10.25.20219071","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1603827624000,"date-time":"2020-10-27T19:40:24Z","date-parts":[[2020,10,27]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"00622vnt","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1612355212808,"date-time":"2021-02-03T12:26:52Z","date-parts":[[2021,2,3]]},"cord_sha":""},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":792,"page_height":612},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":792,"page_height":612}],"runtime":13282},
  {"_key":"60c20a9c7723bebd86645369","_id":"documents/60c20a9c7723bebd86645369","_rev":"_cfFhB_i---","file_name":"0065qkn2.pdf","md5":"E68B8DBD9C9646977D3832D7ED8BA231","id":"0065qkn2","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/65/qk/n2/0065qkn2/0065qkn2.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["928"],"published-print":{"date-parts":[[2020,12]]},"volume":"11","pmid":"32421107","journal-issue":{"published-print":{"date-parts":[[2020,12]]},"issue":"12"},"author":[{"sequence":"first","family":"Mitrović","given":"Tatjana","affiliation":[]},{"sequence":"additional","family":"Tomić","given":"Nataša","affiliation":[]},{"sequence":"additional","family":"Djukić-Vuković","given":"Aleksandra","affiliation":[]},{"sequence":"additional","family":"Dohčević-Mitrović","given":"Zorana","affiliation":[]},{"sequence":"additional","given":"Saša","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-1696-9134","family":"Lazović","affiliation":[]}],"DOI":"10.1007/s12649-019-00928-y","original-title":[],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1578441600000,"date-time":"2020-01-08T00:00:00Z","date-parts":[[2020,1,8]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1578441600000,"date-time":"2020-01-08T00:00:00Z","date-parts":[[2020,1,8]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":62,"page":"6841-6854","type":"journal-article","issued":{"date-parts":[[2020,1,8]]},"funder":[{"doi-asserted-by":"publisher","award":["III43007, OI171032, Bilateral No.39 Serbia/Slovenia"],"DOI":"10.13039/501100004564","name":"Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja"}],"publisher":"Springer Science and Business Media LLC","id":"0065qkn2","short-title":[],"title":["Atmospheric Plasma Supported by TiO2 Catalyst for Decolourisation of Reactive Orange 16 Dye in Water"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/c6/6e/PMC7224158.tar.gz","pmcid":"PMC7224158","has_valid_oa_url":true,"deposited":{"timestamp":1609981566000,"date-time":"2021-01-07T01:06:06Z","date-parts":[[2021,1,7]]},"indexed":{"timestamp":1609983647578,"date-time":"2021-01-07T01:40:47Z","date-parts":[[2021,1,7]]},"is-referenced-by-count":1,"short-container-title":["Waste Biomass Valor"],"prefix":"10.1007","published-online":{"date-parts":[[2020,1,8]]},"has_valid_thumbnail":false,"references-count":62,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1007/s12649-019-00928-y","ISSN":["1877-2641","1877-265X"],"issn-type":[{"value":"1877-2641","type":"print"},{"value":"1877-265X","type":"electronic"}],"subject":["Renewable Energy, Sustainability and the Environment","Environmental Engineering","Waste Management and Disposal"],"container-title":["Waste and Biomass Valorization"],"score":1,"has_valid_ref_annotation":false,"issue":"12","member":"297","abstract":"PURPOSE: Every advanced oxidation process (AOP) has its limitations in water purification. Novel designs with simultaneous application of different AOPs can offer better solutions for cleaner water. METHODS: We have comparatively studied two advanced oxidation processes (AOPs) on decolourisation of Reactive Orange 16 (RO 16) azo dye pollutant from water: gas plasma treatment by low power atmospheric pressure plasma using novel plasma needle configuration, and semiconductor heterogeneous photocatalysis using titanium dioxide (TiO(2)) nanopowders. Additionally, simultaneous application of two advanced oxidation processes on azo dye decolourisation was studied. RESULTS: It was found that plasma treatment is very efficient system for the dye removal even for low flow rates (1 slm) of the Ar as feed gas. The presence of 10% of O(2) in Ar flow intensified dye oxidation process and shortened required time for total decolourisation. When plasma and catalyst were simultaneously applied, TiO(2) was activated with a few Watts plasma source as well as 300 W UV lamp source. The synergic effect of two AOPs was more pronounced for higher feed gas flow rates, resulting in improved decolourisation efficiency. CONCLUSION: Plasma needle can efficiently remove Reactive Orange 16 azo dye from water with a power consumption of only few Watts. With the addition of TiO(2) the removal efficiency is significantly improved. GRAPHIC ABSTRACT: [Image: see text]","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s12649-019-00928-y.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s12649-019-00928-y/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s12649-019-00928-y.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1578470561000,"date-time":"2020-01-08T08:02:41Z","date-parts":[[2020,1,8]]},"language":"en","assertion":[{"order":1,"value":"8 July 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"30 December 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"8 January 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with Ethical Standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The authors declare that they have no conflict of interest.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"7b1ceb8014ffb7e2682ce94c9134d658432a34a4"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":14217},
  {"_key":"60c20aa07723bebd8664536b","_id":"documents/60c20aa07723bebd8664536b","_rev":"_cfFhB_u---","file_name":"007qk8nv.pdf","md5":"9B55F4AF67FA1B71F9D2A5948D31DDED","id":"007qk8nv","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/7q/k8/nv/007qk8nv/007qk8nv.pdf","date":"2021-06-10T12:50+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-49076-8_14","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"139-148","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"007qk8nv","reference-count":13,"title":["A Novel Set of Moment Invariants for Pattern Recognition Applications Based on Jacobi Polynomials"],"pmcid":"PMC7297594","has_valid_oa_url":true,"deposited":{"timestamp":1592352212000,"date-time":"2020-06-17T00:03:32Z","date-parts":[[2020,6,17]]},"indexed":{"timestamp":1592354449104,"date-time":"2020-06-17T00:40:49Z","date-parts":[[2020,6,17]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,6,17]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030490751","type":"print"},{"value":"9783030490768","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/48/49/PMC7297594.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-49076-8_14","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Lecture Notes in Computer Science","Pattern Recognition"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"A novel set of moment invariants for pattern recognition applications, which are based on Jacobi polynomials, are presented. These moment invariants are constructed for digital images by means of a combination with geometric moments, and are invariant in the face of affine geometric transformations such as rotation, translation and scaling, on the image plane. This invariance is tested on a sample of the MPEG-7 CE-Shape-1 dataset. The results presented show that the low-order moment invariants indeed possess low variance between images that are affected by the mentioned geometric transformations.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Rocha Angulo","given":"Rafael Augusto","affiliation":[]},{"sequence":"additional","given":"Juan Martín","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1191-2676","family":"Carpio","affiliation":[]},{"sequence":"additional","given":"Alfonso","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-1818-4162","family":"Rojas-Domínguez","affiliation":[]},{"sequence":"additional","family":"Ornelas-Rodríguez","given":"Manuel","affiliation":[]},{"sequence":"additional","given":"Héctor","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1315-1436","family":"Puga","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030490751","9783030490768"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-49076-8_14","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1592348692000,"date-time":"2020-06-16T23:04:52Z","date-parts":[[2020,6,16]]},"references-count":13,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"17 June 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"MCPR","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"Mexican Conference on Pattern Recognition","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Morelia","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"Mexico","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"24 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"27 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"12","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"mcpr22020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"http://ccc.inaoep.mx/~mcpr2020/index.html","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Single-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"67","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"31","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"0","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"46% - The value is computed by the equation \"Number of Full Papers Accepted / Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Acceptance Rate of Full Papers","name":"acceptance_rate_of_full_papers"},{"order":7,"value":"2.05","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Reviews per Paper","name":"average_number_of_reviews_per_paper"},{"order":8,"value":"2.79","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Papers per Reviewer","name":"average_number_of_papers_per_reviewer"},{"order":9,"value":"Yes","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"External Reviewers Involved","name":"external_reviewers_involved"},{"order":10,"value":"The conference was held virtually due to the COVID-19 pandemic.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Additional Info on Review Process","name":"additional_info_on_review_process"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"cf5ccb74db20270fa577e384170b4ecd152d1520"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":6609},
  {"_key":"60c20aa37723bebd8664536d","_id":"documents/60c20aa37723bebd8664536d","_rev":"_cfFhB_6---","file_name":"009sah0e.pdf","md5":"516F7C88B1016D075BC90140666F3AC5","id":"009sah0e","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/9s/ah/0e/009sah0e/009sah0e.pdf","date":"2021-06-10T12:50+0000","metadata":{"published-print":{"date-parts":[[2013,10,1]]},"volume":"58","pmid":"23533295","author":[{"sequence":"first","family":"Dai","given":"B.","affiliation":[]},{"sequence":"additional","family":"Kang","given":"J.","affiliation":[]},{"sequence":"additional","family":"Yu","given":"N.","affiliation":[]},{"sequence":"additional","family":"Tan","given":"W.","affiliation":[]},{"sequence":"additional","family":"Zhao","given":"H.-W.","affiliation":[]}],"DOI":"10.4187/respcare.02172","license-simplified":"unk","original-title":[],"title":["Oxygen Injection Site Affects FIO2 During Noninvasive Ventilation"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":0,"page":"1630-1636","type":"journal-article","issued":{"date-parts":[[2013,3,26]]},"publisher":"Daedalus Enterprises","id":"009sah0e","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1380011189000,"date-time":"2013-09-24T08:26:29Z","date-parts":[[2013,9,24]]},"indexed":{"timestamp":1595925874244,"date-time":"2020-07-28T08:44:34Z","date-parts":[[2020,7,28]]},"is-referenced-by-count":2,"short-container-title":["Respiratory Care"],"prefix":"10.4187","published-online":{"date-parts":[[2013,3,26]]},"has_valid_thumbnail":false,"ISSN":["0020-1324","1943-3654"],"references-count":0,"oaLink":"http://rc.rcjournal.com/content/respcare/58/10/1630.full.pdf","subtitle":[],"URL":"http://dx.doi.org/10.4187/respcare.02172","journal-issue":{"published-print":{"date-parts":[[2013,10,1]]},"issue":"10","published-online":{"date-parts":[[2013,9,23]]}},"issn-type":[{"value":"0020-1324","type":"print"},{"value":"1943-3654","type":"electronic"}],"container-title":["Respiratory Care"],"has_valid_ref_annotation":false,"issue":"10","member":"2694","abstract":"BACKGROUND Most portable bi-level positive airway pressure devices are not equipped with air-oxygen blenders for precisely regulating oxygen concentrations, and supplemental oxygen must be added to increase the F(IO2). Very few studies have investigated the factors that affect F(IO2), and their conclusions have been inconsistent. We investigated in vitro noninvasive ventilation (NIV) parameters and their effects on F(IO2), particularly the effect of the oxygen injection site. METHODS NIV was simulated with a test lung and manikin setup. F(IO2) was measured with 4 oxygen injection sites (mask, in front of the exhalation valve, at the humidifier outlet, and proximal to the ventilator), with 3 exhalation valve types, with 2 oxygen flows, and with 4 combinations of inspiratory and expiratory pressure. RESULTS Oxygen flow, inspiratory and expiratory pressure, and exhalation valve type all affected F(IO2). For a given oxygen flow, the oxygen injection site was the most important factor that affected F(IO2). The oxygen injection site that was closest to the patient (on the mask) had the higher F(IO2) (P < .001). CONCLUSIONS The oxygen injection site had the greatest effect on F(IO2) during NIV.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Critical Care and Intensive Care Medicine","Pulmonary and Respiratory Medicine","General Medicine"],"relation":{},"created":{"timestamp":1364357426000,"date-time":"2013-03-27T04:10:26Z","date-parts":[[2013,3,27]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":5289},
  {"_key":"60c20aa77723bebd8664536f","_id":"documents/60c20aa77723bebd8664536f","_rev":"_cfFhBAG---","file_name":"008rd8bh.pdf","md5":"ADBF609F4F7EBF5DFA214365BF0CE4DC","id":"008rd8bh","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/8r/d8/bh/008rd8bh/008rd8bh.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["14"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1613692800000,"date-time":"2021-02-19T00:00:00Z","date-parts":[[2021,2,19]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1613692800000,"date-time":"2021-02-19T00:00:00Z","date-parts":[[2021,2,19]]}}],"author":[{"sequence":"first","given":"Anna","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7105-794X","family":"Lips","affiliation":[]}],"URL":"http://dx.doi.org/10.1007/s41255-021-00014-3","DOI":"10.1007/s41255-021-00014-3","original-title":[],"title":["The Situation of Young People at Home During COVID-19 Pandemic"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":38,"issued":{"date-parts":[[2021,2,19]]},"funder":[{"award":[],"name":"Projekt DEAL"}],"publisher":"Springer Science and Business Media LLC","id":"008rd8bh","short-title":[],"pmcid":"PMC7893129","has_valid_oa_url":true,"deposited":{"timestamp":1613770196000,"date-time":"2021-02-19T21:29:56Z","date-parts":[[2021,2,19]]},"indexed":{"timestamp":1613772944882,"date-time":"2021-02-19T22:15:44Z","date-parts":[[2021,2,19]]},"is-referenced-by-count":0,"short-container-title":["Childhood Vulnerability"],"prefix":"10.1007","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/0e/0f/PMC7893129.tar.gz","has_valid_thumbnail":false,"ISSN":["2520-8071","2520-808X"],"references-count":38,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"type":"journal-article","issn-type":[{"value":"2520-8071","type":"print"},{"value":"2520-808X","type":"electronic"}],"container-title":["Childhood Vulnerability Journal"],"score":1,"published-online":{"date-parts":[[2021,2,19]]},"member":"297","abstract":"The political restrictions imposed by the COVID-19 pandemic affect all population groups. However, they are of particular importance for those, whose current phase of life is mainly shaped by social life in public space – adolescents and young adults. The (at least temporary) closure of schools and universities, youth facilities, sports grounds, and pubs as well as contact restrictions changed the living conditions of young people. Life shifted mainly to the home environment and young people are obliged to deal with the people they are living with more than before. The Germany-wide survey “JuCo – Experiences and Perspectives of Young People during the COVID-19 Pandemic” asked young people about their well-being, worries and experiences during the time of lockdown. This article presents results on the situation at home and the well-being of adolescents and young adults of n = 5,520 respondents. Regression analysis is used to determine which influencing factors (e.g. money worries) affect well-being at home during the COVID-19 pandemic. Results show that different factors are influencing youth’s well being at home during the lockdown. Especially the emotional and social nature of their home environment has a very significant impact on how young respondents experience it during lockdown as well as their possibility to go outside.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s41255-021-00014-3.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s41255-021-00014-3/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s41255-021-00014-3.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1613768968000,"date-time":"2021-02-19T21:09:28Z","date-parts":[[2021,2,19]]},"language":"en","assertion":[{"order":1,"value":"8 January 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":2,"value":"19 February 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with Ethical Standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee. The vote of the ethics committee of Goethe University Frankfurt was approved before starting the survey.","group":{"label":"Ethical Approval on Research Involving Human Participants","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"Informed consent was obtained from the participants.","group":{"label":"Informed Consent","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"6fcad62f83ba5cd34e181df9901e788accced8af"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":9880},
  {"_key":"60c20aae7723bebd86645371","_id":"documents/60c20aae7723bebd86645371","_rev":"_cfFhBAO---","file_name":"00a19z5i.pdf","md5":"4F1EFF5C63F729EF9BE6FBDAFEF71DCC","id":"00a19z5i","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/a1/9z/5i/00a19z5i/00a19z5i.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["S0042682205005283"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1136073600000,"date-time":"2006-01-01T00:00:00Z","date-parts":[[2006,1,1]]}},{"URL":"https://www.elsevier.com/open-access/userlicense/1.0/","content-version":"vor","delay-in-days":2790,"start":{"timestamp":1377129600000,"date-time":"2013-08-22T00:00:00Z","date-parts":[[2013,8,22]]}}],"volume":"344","pmid":"16226781","has_valid_tei":false,"DOI":"10.1016/j.virol.2005.08.044","original-title":[],"short-container-title":["Virology"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":71,"page":"453-467","type":"journal-article","issued":{"date-parts":[[2006,1]]},"publisher":"Elsevier BV","id":"00a19z5i","short-title":[],"pmcid":"PMC7111807","has_valid_oa_url":true,"deposited":{"timestamp":1586509510000,"date-time":"2020-04-10T09:05:10Z","date-parts":[[2020,4,10]]},"indexed":{"timestamp":1615994633585,"date-time":"2021-03-17T15:23:53Z","date-parts":[[2021,3,17]]},"is-referenced-by-count":33,"title":["Testing the modularity of the N-terminal amphipathic helix conserved in picornavirus 2C proteins and hepatitis C NS5A protein"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/8b/b5/PMC7111807.tar.gz","has_valid_thumbnail":false,"ISSN":["0042-6822"],"references-count":71,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.virol.2005.08.044","journal-issue":{"published-print":{"date-parts":[[2006,1]]},"issue":"2"},"issn-type":[{"value":"0042-6822","type":"print"}],"container-title":["Virology"],"has_valid_ref_annotation":false,"issue":"2","member":"78","abstract":"The N-terminal region of the picornaviral 2C protein is predicted to fold into an amphipathic α-helix that is responsible for the protein's association with membranes in the viral RNA replication complex. We have identified a similar sequence in the N-terminal region of NS5A of hepaciviruses that was recently shown to form an amphipathic α-helix. The conservation of the N-terminal region in two apparently unrelated proteins of two different RNA virus families suggested that this helix might represent an independent module. To test this hypothesis, we constructed chimeric poliovirus (PV) genomes in which the sequence encoding the N-terminal 2C amphipathic helix was replaced by orthologous sequences from other picornaviral genomes or a similar sequence from NS5A of HCV. Effects of the mutations were assessed by measuring the accumulation of viable virus and viral RNA in HeLa cells after transfection, examining membrane morphology in cells expressing chimeric proteins and by in vitro analysis of RNA translation, protein processing and negative strand RNA synthesis in HeLa cell extracts. The chimeras manifested a wide range of growth and RNA synthesis phenotypes. The results are compatible with our hypothesis, although they demonstrate that helix exchangeability may be restricted due to requirements for interactions with other viral components involved in virus replication.","published-print":{"date-parts":[[2006,1]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Teterina","given":"Natalya L.","affiliation":[]},{"sequence":"additional","family":"Gorbalenya","given":"Alexander E.","affiliation":[]},{"sequence":"additional","family":"Egger","given":"Denise","affiliation":[]},{"sequence":"additional","family":"Bienz","given":"Kurt","affiliation":[]},{"sequence":"additional","family":"Rinaudo","given":"Mario S.","affiliation":[]},{"sequence":"additional","family":"Ehrenfeld","given":"Ellie","affiliation":[]}],"subject":["Virology"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0042682205005283?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0042682205005283?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1129374654000,"date-time":"2005-10-15T11:10:54Z","date-parts":[[2005,10,15]]},"language":"en","score":1,"source":"Crossref","cord_sha":"8e3673efd4b53eabbbe603faddc34a111de80484"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794}],"runtime":13871},
  {"_key":"60c20ab17723bebd86645378","_id":"documents/60c20ab17723bebd86645378","_rev":"_cfFhBAa---","file_name":"00b1qn29.pdf","md5":"698EB36C5CB42C4EEA8F4629DD7E6EB4","id":"00b1qn29","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/b1/qn/29/00b1qn29/00b1qn29.pdf","date":"2021-06-10T12:50+0000","metadata":{"alternative-id":["10.3389/fimmu.2020.607918"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1608681600000,"date-time":"2020-12-23T00:00:00Z","date-parts":[[2020,12,23]]}}],"volume":"11","pmid":"33424856","author":[{"sequence":"first","family":"Steiner","given":"Sophie","affiliation":[]},{"sequence":"additional","family":"Sotzny","given":"Franziska","affiliation":[]},{"sequence":"additional","family":"Bauer","given":"Sandra","affiliation":[]},{"sequence":"additional","family":"Na","given":"Il-Kang","affiliation":[]},{"sequence":"additional","family":"Schmueck-Henneresse","given":"Michael","affiliation":[]},{"sequence":"additional","family":"Corman","given":"Victor M.","affiliation":[]},{"sequence":"additional","family":"Schwarz","given":"Tatjana","affiliation":[]},{"sequence":"additional","family":"Drosten","given":"Christian","affiliation":[]},{"sequence":"additional","family":"Wendering","given":"Désirée J.","affiliation":[]},{"sequence":"additional","family":"Behrends","given":"Uta","affiliation":[]},{"sequence":"additional","family":"Volk","given":"Hans-Dieter","affiliation":[]},{"sequence":"additional","family":"Scheibenbogen","given":"Carmen","affiliation":[]},{"sequence":"additional","family":"Hanitsch","given":"Leif G.","affiliation":[]}],"DOI":"10.3389/fimmu.2020.607918","license-simplified":"cc-by","original-title":[],"short-container-title":["Front. Immunol."],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"type":"journal-article","issued":{"date-parts":[[2020,12,23]]},"publisher":"Frontiers Media SA","id":"00b1qn29","reference-count":30,"pmcid":"PMC7785785","has_valid_oa_url":true,"deposited":{"timestamp":1608701828000,"date-time":"2020-12-23T05:37:08Z","date-parts":[[2020,12,23]]},"indexed":{"timestamp":1616509433173,"date-time":"2021-03-23T14:23:53Z","date-parts":[[2021,3,23]]},"is-referenced-by-count":2,"title":["HCoV- and SARS-CoV-2 Cross-Reactive T Cells in CVID Patients"],"prefix":"10.3389","published-online":{"date-parts":[[2020,12,23]]},"has_valid_thumbnail":false,"references-count":30,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/68/dd/PMC7785785.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.3389/fimmu.2020.607918","short-title":[],"issn-type":[{"value":"1664-3224","type":"electronic"}],"container-title":["Frontiers in Immunology"],"has_valid_ref_annotation":false,"member":"1965","abstract":"The inability of patients with CVID to mount specific antibody responses to pathogens has raised concerns on the risk and severity of SARS-CoV-2 infection, but there might be a role for protective T cells in these patients. SARS-CoV-2 reactive T cells have been reported for SARS-CoV-2 unexposed healthy individuals. Until now, there is no data on T cell immunity to SARS-CoV-2 infection in CVID. This study aimed to evaluate reactive T cells to human endemic corona viruses (HCoV) and to study pre-existing SARS-CoV-2 reactive T cells in unexposed CVID patients. We evaluated SARS-CoV-2- and HCoV-229E and –OC43 reactive T cells in response to seven peptide pools, including spike and nucleocapsid (NCAP) proteins, in 11 unexposed CVID, 12 unexposed and 11 post COVID-19 healthy controls (HC). We further characterized reactive T cells by IFNγ, TNFα and IL-2 profiles. SARS-CoV-2 spike-reactive CD4+ T cells were detected in 7 of 11 unexposed CVID patients, albeit with fewer multifunctional (IFNγ/TNFα/IL-2) cells than unexposed HC. CVID patients had no SARS-CoV-2 NCAP reactive CD4+ T cells and less reactive CD8+ cells compared to unexposed HC. We observed a correlation between T cell reactivity against spike of SARS-CoV-2 and HCoVs in unexposed, but not post COVID-19 HC, suggesting cross-reactivity. T cell responses in post COVID-19 HC could be distinguished from unexposed HC by higher frequencies of triple-positive NCAP reactive CD4+ T cells. Taken together, SARS-CoV-2 reactive T cells are detectable in unexposed CVID patients albeit with lower recognition frequencies and polyfunctional potential. Frequencies of triple-functional reactive CD4+ cells might provide a marker to distinguish HCoV cross-reactive from SARS-CoV-2 specific T cell responses. Our data provides evidence, that anti-viral T cell immunity is not relevantly impaired in most CVID patients.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.3389/crossmark-policy","link":[{"URL":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.607918/full","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1608701826000,"date-time":"2020-12-23T05:37:06Z","date-parts":[[2020,12,23]]},"ISSN":["1664-3224"],"score":1,"source":"Crossref","cord_sha":"3645dbeb6f1de0f0f01d4f1e54bab7f667c40510"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":779.528,"page_height":595.276},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528}],"runtime":9991},
  {"_key":"60c20ab67723bebd8664537a","_id":"documents/60c20ab67723bebd8664537a","_rev":"_cfFhBAm---","file_name":"00cqv16h.pdf","md5":"27898018D4CBE300D16637FCBA654BE9","id":"00cqv16h","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/cq/v1/6h/00cqv16h/00cqv16h.pdf","date":"2021-06-10T12:51+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-42266-0_14","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"178-187","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"00cqv16h","reference-count":31,"title":["A Topological Data Analysis Approach on Predicting Phenotypes from Gene Expression Data"],"pmcid":"PMC7197058","has_valid_oa_url":true,"deposited":{"timestamp":1588597506000,"date-time":"2020-05-04T13:05:06Z","date-parts":[[2020,5,4]]},"indexed":{"timestamp":1591769301009,"date-time":"2020-06-10T06:08:21Z","date-parts":[[2020,6,10]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,4,3]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030422653","type":"print"},{"value":"9783030422660","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/f0/bd/PMC7197058.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-42266-0_14","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Algorithms for Computational Biology","Lecture Notes in Computer Science"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"The goal of this study was to investigate if gene expression measured from RNA sequencing contains enough signal to separate healthy and afflicted individuals in the context of phenotype prediction. We observed that standard machine learning methods alone performed somewhat poorly on the disease phenotype prediction task; therefore we devised an approach augmenting machine learning with topological data analysis. We describe a framework for predicting phenotype values by utilizing gene expression data transformed into sample-specific topological signatures by employing feature subsampling and persistent homology. The topological data analysis approach developed in this work yielded improved results on Parkinson’s disease phenotype prediction when measured against standard machine learning methods. This study confirms that gene expression can be a useful indicator of the presence or absence of a condition, and the subtle signal contained in this high dimensional data reveals itself when considering the intricate topological connections between expressed genes.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Sayan","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-0861-6905","family":"Mandal","affiliation":[]},{"sequence":"additional","given":"Aldo","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2725-621X","family":"Guzmán-Sáenz","affiliation":[]},{"sequence":"additional","given":"Niina","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-8663-1019","family":"Haiminen","affiliation":[]},{"sequence":"additional","given":"Saugata","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-2441-0915","family":"Basu","affiliation":[]},{"sequence":"additional","given":"Laxmi","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7872-5074","family":"Parida","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030422653","9783030422660"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-42266-0_14","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1584972181000,"date-time":"2020-03-23T14:03:01Z","date-parts":[[2020,3,23]]},"references-count":31,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"3 April 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"AlCoB","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"International Conference on Algorithms for Computational Biology","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Missoula, MT","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"USA","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"13 April 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"15 April 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"7","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"alcob2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"https://alcob2020.irdta.eu/","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Single-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"24","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"15","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"0","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"63% - The value is computed by the equation \"Number of Full Papers Accepted / Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Acceptance Rate of Full Papers","name":"acceptance_rate_of_full_papers"},{"order":7,"value":"3","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Reviews per Paper","name":"average_number_of_reviews_per_paper"},{"order":8,"value":"3","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Papers per Reviewer","name":"average_number_of_papers_per_reviewer"},{"order":9,"value":"Yes","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"External Reviewers Involved","name":"external_reviewers_involved"},{"order":10,"value":"The conference was postponed to be held together with AlCoB 2021 due to the coronavirus pandemic.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Additional Info on Review Process","name":"additional_info_on_review_process"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"b9cd5d9c6a936f02c70d005b7f1c8403a565ac29"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":4500},
  {"_key":"60c20ab77723bebd8664537e","_id":"documents/60c20ab77723bebd8664537e","_rev":"_cfFhBAy---","file_name":"00cl7q1q.pdf","md5":"A2EFCD68AEA21006484514FD6910A8B9","id":"00cl7q1q","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/cl/7q/1q/00cl7q1q/00cl7q1q.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["S003257911942422X"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1264982400000,"date-time":"2010-02-01T00:00:00Z","date-parts":[[2010,2,1]]}},{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","content-version":"vor","delay-in-days":3544,"start":{"timestamp":1571184000000,"date-time":"2019-10-16T00:00:00Z","date-parts":[[2019,10,16]]}}],"volume":"89","pmid":"20075272","has_valid_tei":false,"DOI":"10.3382/ps.2009-00424","original-title":[],"short-container-title":["Poultry Science"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":36,"page":"217-226","type":"journal-article","issued":{"date-parts":[[2010,2]]},"publisher":"Elsevier BV","id":"00cl7q1q","short-title":[],"pmcid":"PMC7107190","has_valid_oa_url":true,"deposited":{"timestamp":1576078280000,"date-time":"2019-12-11T15:31:20Z","date-parts":[[2019,12,11]]},"indexed":{"timestamp":1586882285459,"date-time":"2020-04-14T16:38:05Z","date-parts":[[2020,4,14]]},"is-referenced-by-count":54,"title":["Detection and molecular characterization of enteric viruses from poult enteritis syndrome in turkeys"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/09/5b/PMC7107190.tar.gz","has_valid_thumbnail":false,"ISSN":["0032-5791"],"references-count":36,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.3382/ps.2009-00424","journal-issue":{"published-print":{"date-parts":[[2010,2]]},"issue":"2"},"issn-type":[{"value":"0032-5791","type":"print"}],"container-title":["Poultry Science"],"has_valid_ref_annotation":false,"issue":"2","member":"78","abstract":"This study was conducted to detect and characterize enteric viruses [rotavirus, turkey astrovirus-2 (TAstV-2), reovirus, and turkey coronavirus] from cases of poult enteritis syndrome (PES) in Minnesota turkeys. Of the intestinal contents collected from 43 PES cases, 25 were positive for rotavirus and 13 for small round viruses by electron microscopy (EM). Of the enteric virus-positive cases by EM (n = 27), 16 cases had rotavirus or small round viruses alone and the remaining 11 cases had both viruses. None of the cases were positive for reovirus or coronavirus by EM. However, with reverse transcription-PCR (RT-PCR), 40 cases (93%) were positive for rotavirus, 36 (84%) for TAstV-2, and 17 (40%) for reovirus. None of the cases were positive for turkey coronavirus by RT-PCR. The viruses from all cases were detected either alone or in combination of 2 or 3 by RT-PCR. Thus, 8 (19%) cases were positive for a single virus, whereas a combination of viruses was detected in the remaining 35 (81%) cases. The rota-TAstV-2 combination was the most predominant (n = 18 cases). Fifteen cases were positive for all 3 viruses. The rotaviruses had sequence homology of 89.8 to 100% with previously published sequences of turkey rotaviruses at the nucleotide level. The TAstV-2 had sequence homology of 84.6 to 98.7% with previously published TAstV-2, whereas reoviruses had sequence homology of 91.6 to 99.3% with previously published sequences of turkey reoviruses. Phylogenetic analysis revealed that rota- and reoviruses clustered in a single group, whereas TAstV-2 clustered in 2 different groups. In conclusion, a larger number of PES cases was positive for rotavirus, TAstV-2, and reovirus by RT-PCR than with EM. The presence of more than one virus and changes at the genetic level in a virus may affect the severity of PES in turkey flocks.","published-print":{"date-parts":[[2010,2]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Jindal","given":"N.","affiliation":[]},{"sequence":"additional","family":"Patnayak","given":"D.P.","affiliation":[]},{"sequence":"additional","family":"Chander","given":"Y.","affiliation":[]},{"sequence":"additional","family":"Ziegler","given":"A.F.","affiliation":[]},{"sequence":"additional","family":"Goyal","given":"S.M.","affiliation":[]}],"subject":["Animal Science and Zoology","General Medicine"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S003257911942422X?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S003257911942422X?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"},{"URL":"http://academic.oup.com/ps/article-pdf/89/2/217/4422120/poultrysci89-0217.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1263501870000,"date-time":"2010-01-14T20:44:30Z","date-parts":[[2010,1,14]]},"language":"en","score":1,"source":"Crossref","cord_sha":"4558c3716d4845efd52e95ebbad843f05bacf107; 0fec669a006d58bac228aaf94f0f760ebda30f45"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":5714},
  {"_key":"60c20ab97723bebd86645382","_id":"documents/60c20ab97723bebd86645382","_rev":"_cfFhBB----","file_name":"00bwhaga.pdf","md5":"333844DD4F7A69AE0590145A9D71ED01","id":"00bwhaga","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/bw/ha/ga/00bwhaga/00bwhaga.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["S0921448819301816"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1572566400000,"date-time":"2019-11-01T00:00:00Z","date-parts":[[2019,11,1]]}}],"volume":"180","pmid":"32288211","has_valid_tei":false,"DOI":"10.1016/j.smallrumres.2019.09.021","original-title":[],"published-print":{"date-parts":[[2019,11]]},"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Food Animals","Animal Science and Zoology"],"page":"27-34","type":"journal-article","issued":{"date-parts":[[2019,11]]},"funder":[{"doi-asserted-by":"crossref","award":["116O587)"],"DOI":"10.13039/501100004410","name":"Türkiye Bilimsel ve Teknolojik Araştirma Kurumu"}],"publisher":"Elsevier BV","id":"00bwhaga","reference-count":32,"title":["The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis"],"pmcid":"PMC7135297","has_valid_oa_url":true,"deposited":{"timestamp":1593225648000,"date-time":"2020-06-27T02:40:48Z","date-parts":[[2020,6,27]]},"indexed":{"timestamp":1593236467768,"date-time":"2020-06-27T05:41:07Z","date-parts":[[2020,6,27]]},"is-referenced-by-count":0,"short-container-title":["Small Ruminant Research"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/79/0a/PMC7135297.tar.gz","has_valid_thumbnail":false,"ISSN":["0921-4488"],"references-count":32,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.smallrumres.2019.09.021","short-title":[],"issn-type":[{"value":"0921-4488","type":"print"}],"container-title":["Small Ruminant Research"],"score":1,"has_valid_ref_annotation":false,"member":"78","abstract":"Abstract In this study, it was aimed to investigate the efficacy of chitosan oligosaccharide administrations in different doses of experimental infected lambs with Cryptosporidium parvum. 32 male lambs were used in the study and the lambs were divided into 4 groups with 8 lambs in each group. Groups 1, 2 and 3, twice a day, were administered chitosan oligosaccharide at a dose of 100, 500, and 1000 mg/kg for 7 days, respectively, with milk replacer. In group 4, lambs with cryptosporidiosis were subjected to normal feeding as control without drug administration. Clinical examinations of lambs were made before treatment (day 0) and on days 1, 3, 5 and 7 after treatment and 5 ml of blood was collected from vena jugularis for blood analysis of all lambs. Weight changes of lambs were recorded at 0, 7, 14, and 21 days. Stool specimens were collected pre-treatment (day 0) and on days 1, 3, 5, 7, 14 and 21 post-treatment to determine oocyst excretion of lambs with cryptosporidiosis. Lambs with a mean oocyte counts >10 after stool examination were included to the treatment. Changes in clinical hematology, blood gases and biochemical parameters were observed during the course of treatment, but these changes were limited. Weight loss was observed at 7th day according to 0th day the lambs with experimental cryptosporidiosis but gradually weight increase was observed at 14th and 21st days and these changes were similar in all groups. Oocyst excretion decreased in all groups during treatment. According to 0th day, there was a significant (p < 0.05) decrease in oocyte excretions in the third day in group 1 and 2, and in day 5 in the group 3 and 4. Significant changes (p < 0.05) were observed in oocyst excretions on the third and fifth days among the groups. As a result, in lambs with experimental cryptosporidiosis, chitosan oligosaccharide improved in clinical signs and stool character shorter than the positive control group and the administration of chitosan oligosaccharide at doses of 100, 500 and 1000 mg/kg for 7 days significantly reduced oocyst excretion but not enough to remove cryptosporidiosis completely.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Aydogdu","given":"Ugur","affiliation":[]},{"sequence":"additional","family":"Coskun","given":"Alparslan","affiliation":[]},{"sequence":"additional","family":"Atas","given":"Ahmet Duran","affiliation":[]},{"sequence":"additional","family":"Basbug","given":"Onur","affiliation":[]},{"sequence":"additional","family":"Agaoglu","given":"Zahid Tevfik","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S0921448819301816?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0921448819301816?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1569598456000,"date-time":"2019-09-27T15:34:16Z","date-parts":[[2019,9,27]]},"language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"The determination of treatment effect of chitosan oligosaccharide in lambs with experimentally cryptosporidiosis","label":"Article Title","name":"articletitle"},{"value":"Small Ruminant Research","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.smallrumres.2019.09.021","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2019 Elsevier B.V. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"cc0b240ce6015c9bc86ef54a44416c52f5ab27a6"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":7623},
  {"_key":"60c20abd7723bebd86645384","_id":"documents/60c20abd7723bebd86645384","_rev":"_cfFhBBK---","file_name":"00cdyxue.pdf","md5":"4EBA1EF790F234039AB8084E73DB8B2D","id":"00cdyxue","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/cd/yx/ue/00cdyxue/00cdyxue.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["S0102-311X2021000105001"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1609459200000,"date-time":"2021-01-01T00:00:00Z","date-parts":[[2021,1,1]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"am","delay-in-days":0,"start":{"timestamp":1609459200000,"date-time":"2021-01-01T00:00:00Z","date-parts":[[2021,1,1]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1609459200000,"date-time":"2021-01-01T00:00:00Z","date-parts":[[2021,1,1]]}}],"volume":"37","pmid":"33440409","author":[{"sequence":"first","given":"Mateus Luz","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6188-620X","family":"Levandowski","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil; Universidade Federal do Rio Grande,  Brazil"}]},{"sequence":"additional","given":"Douglas Nunes","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6871-4355","family":"Stahnke","affiliation":[{"name":"Universidade do Vale do Rio dos Sinos,  Brazil"}]},{"sequence":"additional","given":"Tiago N.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-1281-9542","family":"Munhoz","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil; Universidade Federal do Rio Grande,  Brazil; Universidade Federal de Pelotas,  Brazil"}]},{"sequence":"additional","given":"Jean Von","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7414-5312","family":"Hohendorff","affiliation":[{"name":"Faculdade Meridional (IMED),  Brazil"}]},{"sequence":"additional","given":"Roberta","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7729-7928","family":"Salvador-Silva","affiliation":[{"name":"Universidade Federal de Pelotas,  Brazil"}]}],"DOI":"10.1590/0102-311x00140020","license-simplified":"unk","original-title":[],"short-container-title":["Cad. Saúde Pública"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":49,"type":"journal-article","issued":{"date-parts":[[2021]]},"publisher":"FapUNIFESP (SciELO)","id":"00cdyxue","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1611336339000,"date-time":"2021-01-22T17:25:39Z","date-parts":[[2021,1,22]]},"indexed":{"timestamp":1611337336893,"date-time":"2021-01-22T17:42:16Z","date-parts":[[2021,1,22]]},"is-referenced-by-count":0,"title":["Impacto do distanciamento social nas notificações de violência contra crianças e adolescentes no Rio Grande do Sul, Brasil"],"prefix":"10.1590","published-online":{"date-parts":[[2021]]},"has_valid_thumbnail":false,"references-count":49,"oaLink":"http://www.scielo.br/pdf/csp/v37n1/1678-4464-csp-37-01-e00140020.pdf","subtitle":[],"URL":"http://dx.doi.org/10.1590/0102-311x00140020","ISSN":["1678-4464","0102-311X"],"issn-type":[{"value":"0102-311X","type":"print"},{"value":"1678-4464","type":"electronic"}],"container-title":["Cadernos de Saúde Pública"],"has_valid_ref_annotation":false,"issue":"1","member":"530","abstract":"This study aimed to analyze the rates of reports of violence against children and adolescents in the state of Rio Grande do Sul, Brazil, from 2015 to 2020, and the changes in trends by period due to the novel coronavirus pandemic (COVID-19). This is an ecological time series study with secondary data obtained from the Bi Saúde Portal in the panel on Interpersonal Violence and Suicide. The study collected reports on violence in individuals 0 to 19 years of age in the months of March and April each year, stratified by sex, age bracket, race/color, and type of violence. Prais-Winsten regression was used to analyze the time trend. Of the 7,718 reports analyzed, there was a drop of 54% in the year 2020 compared to the same period in 2019. The analysis of the trend until 2019 indicated an increase in the reporting rates (2.04, 95%CI: 1.01; 3.07, p = 0.002), but with the inclusion of the year 2020 in the time series, the direction of the trends in reporting rates was reversed to negative, losing statistical significance (-0.39, 95%CI: -1.16; 2.14, p = 0.632). The study concludes that social distancing due to the pandemic reduced the reporting rates of violence against children and adolescents due to underreporting, thus requiring strategies to improve the identification of suspected cases of violence during the pandemic. This highlights the need for inter-sector planning and rapid and specific actions (health, social protection, justice, and public security) in order to guarantee the rights of children and adolescents.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Public Health, Environmental and Occupational Health"],"link":[{"URL":"http://www.scielo.br/pdf/csp/v37n1/1678-4464-csp-37-01-e00140020.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1610592132000,"date-time":"2021-01-14T02:42:12Z","date-parts":[[2021,1,14]]},"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021]]}},"score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":11885},
  {"_key":"60c20ac67723bebd86645389","_id":"documents/60c20ac67723bebd86645389","_rev":"_cfFhBBW---","file_name":"00dxpxox.pdf","md5":"57A43A4B45EA2C5C861EDE00AF0F7715","id":"00dxpxox","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/dx/px/ox/00dxpxox/00dxpxox.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["S1388198118302294"],"published-print":{"date-parts":[[2019,6]]},"volume":"1864","pmid":"30905350","journal-issue":{"published-print":{"date-parts":[[2019,6]]},"issue":"6"},"author":[{"sequence":"first","family":"Nikolaou","given":"Aikaterini","affiliation":[]},{"sequence":"additional","family":"Kokotou","given":"Maroula G.","affiliation":[]},{"sequence":"additional","family":"Vasilakaki","given":"Sofia","affiliation":[]},{"sequence":"additional","family":"Kokotos","given":"George","affiliation":[]}],"created":{"timestamp":1535025645000,"date-time":"2018-08-23T12:00:45Z","date-parts":[[2018,8,23]]},"DOI":"10.1016/j.bbalip.2018.08.009","original-title":[],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1559347200000,"date-time":"2019-06-01T00:00:00Z","date-parts":[[2019,6,1]]}}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Cell Biology","Molecular Biology"],"page":"941-956","type":"journal-article","issued":{"date-parts":[[2019,6]]},"funder":[{"doi-asserted-by":"publisher","award":["13300"],"DOI":"10.13039/501100005187","name":"National and Kapodistrian University of Athens"}],"publisher":"Elsevier BV","id":"00dxpxox","short-title":[],"title":["Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2"],"pmcid":"PMC7106526","has_valid_oa_url":true,"deposited":{"timestamp":1565293482000,"date-time":"2019-08-08T19:44:42Z","date-parts":[[2019,8,8]]},"indexed":{"timestamp":1617825494867,"date-time":"2021-04-07T19:58:14Z","date-parts":[[2021,4,7]]},"is-referenced-by-count":24,"short-container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a1/d5/PMC7106526.tar.gz","has_valid_thumbnail":false,"references-count":142,"license-simplified":"no-cc","subtitle":[],"reference-count":142,"ISSN":["1388-1981"],"issn-type":[{"value":"1388-1981","type":"print"}],"container-title":["Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"],"score":1,"has_valid_ref_annotation":false,"issue":"6","member":"78","abstract":"Phospholipase A(2) (PLA(2)) enzymes are involved in various inflammatory pathological conditions including arthritis, cardiovascular and autoimmune diseases. The regulation of their catalytic activity is of high importance and a great effort has been devoted in developing synthetic inhibitors. We summarize the most important small-molecule synthetic PLA(2) inhibitors developed to target each one of the four major types of human PLA(2) (cytosolic cPLA(2), calcium-independent iPLA(2,) secreted sPLA(2,) and lipoprotein-associated LpPLA(2)). We discuss recent applications of inhibitors to understand the role of each PLA(2) type and their therapeutic potential. Potent and selective PLA(2) inhibitors have been developed. Although some of them have been evaluated in clinical trials, none reached the market yet. Apart from their importance as potential medicinal agents, PLA(2) inhibitors are excellent tools to unveil the role that each PLA(2) type plays in cells and in vivo. Modern medicinal chemistry approaches are expected to generate improved PLA(2) inhibitors as new agents to treat inflammatory diseases.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S1388198118302294?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1388198118302294?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1016/j.bbalip.2018.08.009","language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Small-molecule inhibitors as potential therapeutics and as tools to understand the role of phospholipases A2","label":"Article Title","name":"articletitle"},{"value":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.bbalip.2018.08.009","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2018 Elsevier B.V. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"8b0b2f1e4cfec5b7ad397ef4fb09dc83ee0a3e1c"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":15365},
  {"_key":"60c20aca7723bebd8664538c","_id":"documents/60c20aca7723bebd8664538c","_rev":"_cfFhBBi---","file_name":"00epw4i0.pdf","md5":"5B9F7645CABCDF743560F88E04ABD1A8","id":"00epw4i0","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/ep/w4/i0/00epw4i0/00epw4i0.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["10.1111/jocn.15469"],"published-print":{"date-parts":[[2020,11]]},"volume":"29","pmid":"32860287","journal-issue":{"published-print":{"date-parts":[[2020,11]]},"issue":"21-22"},"author":[{"sequence":"first","given":"María Dolores","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6454-4723","family":"Ruiz‐Fernández","affiliation":[{"name":"Department of Nursing, Physiotherapy and Medicine University of Almería  Almería Spain"}]},{"sequence":"additional","given":"Juan Diego","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6207-8490","family":"Ramos‐Pichardo","affiliation":[{"name":"Department of Nursing University of Huelva  Huelva Spain"}]},{"sequence":"additional","given":"Olivia","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6798-3553","family":"Ibáñez‐Masero","affiliation":[{"name":"Department of Nursing University of Huelva  Huelva Spain"},{"name":"Huelva‐Costa Health District Andalusian Health Service  Huelva Spain"}]},{"sequence":"additional","family":"Cabrera‐Troya","given":"José","affiliation":[{"name":"AGS Sevilla Sur Andalusian Health Service  Sevilla Spain"}]},{"sequence":"additional","family":"Carmona‐Rega","given":"María Inés","affiliation":[{"name":"Granada Metropolitan District Andalusian Health Service  Granada Spain"}]},{"sequence":"additional","given":"Ángela María","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5073-0499","family":"Ortega‐Galán","affiliation":[{"name":"Department of Nursing University of Huelva  Huelva Spain"}]}],"URL":"http://dx.doi.org/10.1111/jocn.15469","DOI":"10.1111/jocn.15469","original-title":[],"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","content-version":"vor","delay-in-days":0,"start":{"timestamp":1600128000000,"date-time":"2020-09-15T00:00:00Z","date-parts":[[2020,9,15]]}},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1600128000000,"date-time":"2020-09-15T00:00:00Z","date-parts":[[2020,9,15]]}}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"subject":["General Nursing","General Medicine"],"page":"4321-4330","type":"journal-article","issued":{"date-parts":[[2020,9,15]]},"funder":[{"doi-asserted-by":"publisher","award":["AP‐0100‐2016"],"DOI":"10.13039/100009647","name":"Ministry of Health"}],"publisher":"Wiley","id":"00epw4i0","reference-count":49,"title":["Compassion fatigue, burnout, compassion satisfaction and perceived stress in healthcare professionals during the COVID‐19 health crisis in Spain"],"oaLink":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/jocn.15469","has_valid_oa_url":true,"deposited":{"timestamp":1602551128000,"date-time":"2020-10-13T01:05:28Z","date-parts":[[2020,10,13]]},"indexed":{"timestamp":1615441160344,"date-time":"2021-03-11T05:39:20Z","date-parts":[[2021,3,11]]},"is-referenced-by-count":18,"short-container-title":["J. Creat. Behav."],"prefix":"10.1111","license-simplified":"unk","has_valid_thumbnail":false,"ISSN":["0962-1067","1365-2702"],"references-count":49,"published-online":{"date-parts":[[2020,9,15]]},"subtitle":[],"archive":["Portico"],"short-title":[],"issn-type":[{"value":"0962-1067","type":"print"},{"value":"1365-2702","type":"electronic"}],"container-title":["Journal of Clinical Nursing"],"score":1,"has_valid_ref_annotation":false,"issue":"21-22","member":"311","abstract":"AIMS AND OBJECTIVES To evaluate compassion fatigue, burnout, compassion satisfaction, and perceived stress in healthcare professionals during the COVID-19 health crisis in Spain. BACKGROUND Spain has been one of the countries hardest hit by the health crisis caused by the COVID-19 pandemic. Healthcare professionals have had to deal with traumatic and complex situations in the work context. In these particularly stressful situations, many professionals may develop compassion fatigue or burnout, which puts them at risk for mental health problems. DESIGN Cross-sectional online survey. METHODS A total of 506 healthcare professionals (physicians and nurses) who were working in healthcare centres during the COVID-19 pandemic participated. Compassion fatigue, compassion satisfaction, and burnout were assessed with the Professional Quality of Life Questionnaire (ProQoL), and perceived stress was measured with the Perceived Stress Scale (PSS-14). Socio-demographic and occupational variables were also analysed. Data were collected during the period of the highest incidence of cases and highest mortality rates due to COVID-19 in Spain. This article adheres to the STROBE guidelines for the reporting of observational studies. RESULTS Physicians had higher compassion fatigue and burnout scores, while nurses had higher compassion satisfaction scores. Perceived stress scores were similar in both occupations. Professionals working in specific COVID-19 units and in emergency departments had higher compassion fatigue and burnout scores, while levels of compassion satisfaction and perceived stress were similar regardless of the workplace. RELEVANCE TO CLINICAL PRACTICE Despite the health crisis situation and its implications for healthcare professionals, the levels of compassion fatigue and burnout have remained moderate/high. However, compassion satisfaction seems to be increasing, especially among nurses, possibly due to their motivation to relieve suffering and due to their perceived social recognition. It is necessary to implement interventions that help improve compassion satisfaction and prevent burnout and compassion fatigue among professionals in the long term.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1002/crossmark_policy","link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocn.15469","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/jocn.15469","content-version":"vor","intended-application":"text-mining","content-type":"application/xml"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/jocn.15469","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1598674023000,"date-time":"2020-08-29T04:07:03Z","date-parts":[[2020,8,29]]},"language":"en","assertion":[{"order":0,"value":"2020-05-29","group":{"label":"Publication History","name":"publication_history"},"label":"Received","name":"received"},{"order":1,"value":"2020-08-13","group":{"label":"Publication History","name":"publication_history"},"label":"Accepted","name":"accepted"},{"order":2,"value":"2020-09-15","group":{"label":"Publication History","name":"publication_history"},"label":"Published","name":"published"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362}],"runtime":13550},
  {"_key":"60c20ad27723bebd8664538e","_id":"documents/60c20ad27723bebd8664538e","_rev":"_cfFhBBq---","file_name":"00giq6r4.pdf","md5":"76721341E5556CE5100CE243E122341C","id":"00giq6r4","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/gi/q6/r4/00giq6r4/00giq6r4.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["2516"],"published-print":{"date-parts":[[2020,10]]},"volume":"29","pmid":"32388786","journal-issue":{"published-print":{"date-parts":[[2020,10]]},"issue":"10"},"author":[{"sequence":"first","given":"Angela S.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-0047-7103","family":"Labberton","affiliation":[]},{"sequence":"additional","given":"Liv Ariane","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3330-5081","family":"Augestad","affiliation":[]},{"sequence":"additional","family":"Thommessen","given":"Bente","affiliation":[]},{"sequence":"additional","given":"Mathias","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-0022-4042","family":"Barra","affiliation":[]}],"created":{"timestamp":1589004143000,"date-time":"2020-05-09T06:02:23Z","date-parts":[[2020,5,9]]},"DOI":"10.1007/s11136-020-02516-3","original-title":[],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1588982400000,"date-time":"2020-05-09T00:00:00Z","date-parts":[[2020,5,9]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1588982400000,"date-time":"2020-05-09T00:00:00Z","date-parts":[[2020,5,9]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Public Health, Environmental and Occupational Health"],"page":"2679-2693","type":"journal-article","issued":{"date-parts":[[2020,5,9]]},"funder":[{"doi-asserted-by":"publisher","award":["237809","196454"],"DOI":"10.13039/501100005416","name":"Norges Forskningsråd"}],"publisher":"Springer Science and Business Media LLC","id":"00giq6r4","short-title":[],"title":["The association of stroke severity with health-related quality of life in survivors of acute cerebrovascular disease and their informal caregivers during the first year post stroke: a survey study"],"oaLink":"https://link.springer.com/content/pdf/10.1007/s11136-020-02516-3.pdf","has_valid_oa_url":true,"deposited":{"timestamp":1602785655000,"date-time":"2020-10-15T18:14:15Z","date-parts":[[2020,10,15]]},"indexed":{"timestamp":1602787356879,"date-time":"2020-10-15T18:42:36Z","date-parts":[[2020,10,15]]},"is-referenced-by-count":0,"short-container-title":["Qual Life Res"],"prefix":"10.1007","published-online":{"date-parts":[[2020,5,9]]},"has_valid_thumbnail":false,"references-count":48,"license-simplified":"cc-by","subtitle":[],"reference-count":48,"ISSN":["0962-9343","1573-2649"],"issn-type":[{"value":"0962-9343","type":"print"},{"value":"1573-2649","type":"electronic"}],"container-title":["Quality of Life Research"],"score":1,"has_valid_ref_annotation":false,"issue":"10","member":"297","abstract":"PURPOSE To describe the health-related quality of life (HRQoL) of caregivers and survivors of transient ischaemic attack (TIA) and stroke during one year post discharge in comparison to age- and sex-matched population norms; and to analyse the association of initial stroke severity, measured by a routinely used stroke-specific scale, on subsequent HRQoL of caregivers and survivors. METHODS Cohort of hospitalized patients with TIA and stroke discharged alive from a large university hospital in Norway, and their informal caregivers. Questionnaires at 3 and 12 months post discharge were filled out by caregivers (n = 320 and n = 326, respectively) and survivors (n = 368 and n = 383, respectively). Multivariable linear regression analyses tested associations between initial stroke severity (National Institutes of Health Stroke Scale, NIHSS) and HRQoL (EQ-5D-3L) in caregivers and survivors. RESULTS Caregivers of survivors with TIA or stroke did not report lower HRQoL than matched norms. There was some evidence of an association of the NIHSS with caregiver HRQoL at 3 months only (age-sex-adjusted coefficient - 0.01, p = 0.008), however, this was attenuated after additional adjustments. Survivors with stroke, but not TIA, reported lower HRQoL than population norms at both time points. There was a negative association between higher NIHSS scores and survivors' HRQoL; fully adjusted coefficient - 0.01 at both time points (p = 0.001). CONCLUSION The informal caregivers and survivors with TIA did not report lower than expected HRQoL. Increasing stroke severity was associated with decreasing HRQoL among survivors, but had limited predictive value among caregivers. Other factors may therefore be better indicators of 'at risk' caregivers.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s11136-020-02516-3.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s11136-020-02516-3/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s11136-020-02516-3.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1007/s11136-020-02516-3","language":"en","assertion":[{"order":1,"value":"24 April 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":2,"value":"9 May 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with ethical standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"LAA is a member of the EuroQol Group. The authors declare that they have no other conflicts of interest.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":11657},
  {"_key":"60c20ad67723bebd86645393","_id":"documents/60c20ad67723bebd86645393","_rev":"_cfFhBB2---","file_name":"00gtpho6.pdf","md5":"58B96D8CD13DD8FE05A9D24E88028329","id":"00gtpho6","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/gt/ph/o6/00gtpho6/00gtpho6.pdf","date":"2021-06-10T12:51+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2021,1,14]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2021.01.10.21249550","group-title":"Endocrinology (including Diabetes Mellitus and Metabolic Disease)","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2021/01/14/2021.01.10.21249550.full.pdf","original-title":[],"title":["Acute Metabolic Emergencies in Diabetes and COVID-19: a systematic review and meta-analysis of case reports"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":95,"short-title":[],"issued":{"date-parts":[[2021,1,11]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2021,1,11]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Introduction: COVID-19 is associated with DKA (Diabetic Ketoacidosis), HHS (Hyperglycaemic Hyperosmolar State) and EDKA (Euglycaemic DKA). High mortality has been observed in COVID-19-related diabetic ketoacidosis; however, evidence is scarce. Patients and Methods: A systematic literature review was conducted using EMBASE, PubMed/Medline, and Google Scholar from January to December 2020 to identify all case reports describing DKA, HHS, and EDKA, in COVID-19 patients. The Joanna Briggs Institute critical appraisal checklist for case reports was used for quality assessment. Univariate and multivariate analysis assessed correlations of study origin, combined DKA/HHS, age, BMI, HbA1c, administered antidiabetics, comorbidities, symptoms onset, disease status, CRP, ferritin, d-dimers, glucose, osmolarity, pH, bicarbonates, ketones, lactates, {beta}-hydroxybutyric acid, anion gap, and acute kidney injury (AKI) with outcome. Results: From 312 identified publications, 41 including 71 cases analyzed qualitatively and quantitatively. Multivariate analysis demonstrated that COVID-19 disease status 4 (P<0.001), AKI (P<0.001), pH [≤]7.12 (P=0.032), and osmolarity [≥]324 (P=0.034), are all independently correlated with death. COVID-19 Disease Status 4 (P=3x10-8), combined DKA/HHS (P=0.021), and AKI (P=0.037) are independently correlated with death. Conclusion: COVID-19 intertwines with acute metabolic emergencies in diabetes leading to increased mortality; key determinants are critical COVID-19 illness, co-presence of ketoacidosis and hyperosmosis and AKI.","deposited":{"timestamp":1610789753000,"date-time":"2021-01-16T09:35:53Z","date-parts":[[2021,1,16]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Vasileios","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-4188-9518","family":"Papadopoulos","affiliation":[]},{"sequence":"additional","given":"Marios-Vasileios","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3264-5415","family":"Koutroulos","affiliation":[]},{"sequence":"additional","given":"Dimitra-Georgia","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3890-9776","family":"Zikoudi","affiliation":[]},{"sequence":"additional","given":"Stefania-Aspasia","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6238-3161","family":"Bakola","affiliation":[]},{"sequence":"additional","given":"Peny","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2493-3596","family":"Avramidou","affiliation":[]},{"sequence":"additional","given":"Ntilara","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3209-5927","family":"Touzlatzi","affiliation":[]},{"sequence":"additional","given":"Dimitrios K.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5410-3046","family":"Filippou","affiliation":[]}],"DOI":"10.1101/2021.01.10.21249550","reference-count":95,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2021.01.10.21249550","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1610512485000,"date-time":"2021-01-13T04:34:45Z","date-parts":[[2021,1,13]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"00gtpho6","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1610792032538,"date-time":"2021-01-16T10:13:52Z","date-parts":[[2021,1,16]]},"cord_sha":"5413e665ebd0a3ae4d2dce8b9ad5d5f58f15f966"},"application":"software-mentions","pages":[{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92}],"runtime":10565},
  {"_key":"60c20ad67723bebd86645396","_id":"documents/60c20ad67723bebd86645396","_rev":"_cfFhBCC---","file_name":"00h9pm1s.pdf","md5":"BE171C94C210F2915C3630517BE17FF4","id":"00h9pm1s","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/h9/pm/1s/00h9pm1s/00h9pm1s.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["1899"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1588550400000,"date-time":"2020-05-04T00:00:00Z","date-parts":[[2020,5,4]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1588550400000,"date-time":"2020-05-04T00:00:00Z","date-parts":[[2020,5,4]]}}],"language":"en","volume":"57","has_valid_tei":false,"DOI":"10.1007/s13312-020-1899-2","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020,7]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","page":"678-679","type":"journal-article","issued":{"date-parts":[[2020,5,4]]},"publisher":"Springer Science and Business Media LLC","id":"00h9pm1s","reference-count":10,"title":["Medical Education During the COVID-19 Pandemic: A Single Institution Experience"],"pmcid":"PMC7387263","has_valid_oa_url":true,"deposited":{"timestamp":1596000666000,"date-time":"2020-07-29T05:31:06Z","date-parts":[[2020,7,29]]},"indexed":{"timestamp":1617637446891,"date-time":"2021-04-05T15:44:06Z","date-parts":[[2021,4,5]]},"is-referenced-by-count":30,"short-container-title":["Indian Pediatr"],"prefix":"10.1007","published-online":{"date-parts":[[2020,5,4]]},"has_valid_thumbnail":false,"references-count":10,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/b2/77/PMC7387263.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s13312-020-1899-2","ISSN":["0019-6061","0974-7559"],"issn-type":[{"value":"0019-6061","type":"print"},{"value":"0974-7559","type":"electronic"}],"container-title":["Indian Pediatrics"],"score":1,"has_valid_ref_annotation":false,"issue":"7","member":"297","short-title":[],"has_valid_pdf":true,"author":[{"sequence":"first","family":"Singh","given":"Kuldeep","affiliation":[]},{"sequence":"additional","family":"Srivastav","given":"Shival","affiliation":[]},{"sequence":"additional","family":"Bhardwaj","given":"Abhishek","affiliation":[]},{"sequence":"additional","family":"Dixit","given":"Abhinav","affiliation":[]},{"sequence":"additional","family":"Misra","given":"Sanjeev","affiliation":[]}],"subject":["Pediatrics, Perinatology, and Child Health"],"abstract":"Social distancing to curb the COVID-19 pandemic has caused suspension of classroom teaching in all educational institutions. We implemented a novel online classroom platform at our institute to continue medical education. The program attracted encouraging feedback from the students. It may serve as a model for uninterrupted teaching and training during times of crisis.","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s13312-020-1899-2.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s13312-020-1899-2/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s13312-020-1899-2.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1595998891000,"date-time":"2020-07-29T05:01:31Z","date-parts":[[2020,7,29]]},"journal-issue":{"published-print":{"date-parts":[[2020,7]]},"issue":"7"},"assertion":[{"order":1,"value":"4 May 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"<i>Competing interest</i>: None stated.","group":{"label":"Ethics","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"42d8193383619af6cd843305499fe50446662092"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":7938},
  {"_key":"60c20ae07723bebd86645399","_id":"documents/60c20ae07723bebd86645399","_rev":"_cfFhBCO---","file_name":"00j26ca7.pdf","md5":"CF8520A49A7CEFCF214182B5B3BE56D1","id":"00j26ca7","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/j2/6c/a7/00j26ca7/00j26ca7.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["S0950268820001831"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":231,"start":{"timestamp":1597795200000,"date-time":"2020-08-19T00:00:00Z","date-parts":[[2020,8,19]]}}],"article-number":"e184","volume":"148","pmid":"32811577","has_valid_tei":false,"DOI":"10.1017/s0950268820001831","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"subject":["Epidemiology","Infectious Diseases"],"type":"journal-article","issued":{"date-parts":[[2020]]},"publisher":"Cambridge University Press (CUP)","id":"00j26ca7","reference-count":30,"title":["COVID-19: relationship between atmospheric temperature and daily new cases growth rate"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/51/6c/PMC7463156.tar.gz","pmcid":"PMC7463156","has_valid_oa_url":true,"deposited":{"timestamp":1616953237000,"date-time":"2021-03-28T17:40:37Z","date-parts":[[2021,3,28]]},"indexed":{"timestamp":1616955077164,"date-time":"2021-03-28T18:11:17Z","date-parts":[[2021,3,28]]},"is-referenced-by-count":4,"short-container-title":["Epidemiol. Infect."],"prefix":"10.1017","published-online":{"date-parts":[[2020,8,19]]},"has_valid_thumbnail":false,"ISSN":["0950-2688","1469-4409"],"references-count":30,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1017/s0950268820001831","short-title":[],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"container-title":["Epidemiology and Infection"],"score":1,"has_valid_ref_annotation":false,"member":"56","abstract":"Purpose: The novel coronavirus (severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)) first appeared in Wuhan, China, in December 2019, and rapidly spread across the globe. Since most respiratory viruses are known to show a seasonal pattern of infection, it has been hypothesised that SARS-CoV-2 may be seasonally dependent as well. The present study looks at a possible effect of atmospheric temperature, which is one of the suspected factors influencing seasonality, on the evolution of the pandemic. Basic procedures: Since confirming a seasonal pattern would take several more months of observation, we conducted an innovative day-to-day micro-correlation analysis of nine outbreak locations, across four continents and both hemispheres, in order to examine a possible relationship between atmospheric temperature (used as a proxy for seasonality) and outbreak progression. Main findings: There was a negative correlation between atmospheric temperature variations and daily new cases growth rates, in all nine outbreaks, with a median lag of 10 days. Principal conclusions: The results presented here suggest that high temperatures might dampen SARS-CoV-2 propagation, while lower temperatures might increase its transmission. Our hypothesis is that this could support a potential effect of atmospheric temperature on coronavirus disease progression, and potentially a seasonal pattern for this virus, with a peak in the cold season and rarer occurrences in the summer. This could guide government policy in both the Northern and Southern hemispheres for the months to come.","has_valid_pdf":true,"author":[{"sequence":"first","given":"A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-1098-6611","family":"Rouen","affiliation":[]},{"sequence":"additional","family":"Adda","given":"J.","affiliation":[]},{"sequence":"additional","family":"Roy","given":"O.","affiliation":[]},{"sequence":"additional","family":"Rogers","given":"E.","affiliation":[]},{"sequence":"additional","family":"Lévy","given":"P.","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1017/policypage","link":[{"URL":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0950268820001831","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1597807322000,"date-time":"2020-08-19T03:22:02Z","date-parts":[[2020,8,19]]},"language":"en","assertion":[{"value":"Copyright © The Author(s), 2020. Published by Cambridge University Press","group":{"label":"Copyright and Licensing","name":"copyright_and_licensing"},"label":"Copyright","name":"copyright"},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","group":{"label":"Copyright and Licensing","name":"copyright_and_licensing"},"label":"License","name":"license"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"5e7c54f8125702bdd4f77ae9715a7267fd046e9f"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":6576},
  {"_key":"60c20ae27723bebd8664539c","_id":"documents/60c20ae27723bebd8664539c","_rev":"_cfFhBCa---","file_name":"00j50rls.pdf","md5":"E62785408D9901D43F56C5A6BCE977D1","id":"00j50rls","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/j5/0r/ls/00j50rls/00j50rls.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["10.1080/15265161.2020.1782529"],"published-print":{"date-parts":[[2020,7,2]]},"volume":"20","pmid":"32716772","has_valid_tei":false,"DOI":"10.1080/15265161.2020.1782529","short-title":[],"original-title":[],"title":["A Novel Approach Using Social Media to Solve Medical Ethical Dilemmas and Legal Risks in the Emergencies of COVID-19"],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1080/tandf_crossmark_01","page":"W12-W14","type":"journal-article","issued":{"date-parts":[[2020,7,2]]},"publisher":"Informa UK Limited","id":"00j50rls","reference-count":9,"has_valid_oa_url":true,"deposited":{"timestamp":1599574431000,"date-time":"2020-09-08T14:13:51Z","date-parts":[[2020,9,8]]},"indexed":{"timestamp":1599576045790,"date-time":"2020-09-08T14:40:45Z","date-parts":[[2020,9,8]]},"is-referenced-by-count":0,"published-online":{"date-parts":[[2020,7,27]]},"short-container-title":["The American Journal of Bioethics"],"prefix":"10.1080","oaLink":"https://www.tandfonline.com/doi/pdf/10.1080/15265161.2020.1782529?needAccess=true","has_valid_thumbnail":false,"ISSN":["1526-5161","1536-0075"],"references-count":9,"license-simplified":"unk","subtitle":[],"URL":"http://dx.doi.org/10.1080/15265161.2020.1782529","journal-issue":{"published-print":{"date-parts":[[2020,7,2]]},"issue":"7"},"issn-type":[{"value":"1526-5161","type":"print"},{"value":"1536-0075","type":"electronic"}],"container-title":["The American Journal of Bioethics"],"score":1,"has_valid_ref_annotation":false,"issue":"7","member":"301","has_valid_pdf":true,"author":[{"sequence":"first","family":"Wan","given":"Jing","affiliation":[{"name":"Zhongnan Hospital of Wuhan University"}]},{"sequence":"additional","family":"Huang","given":"Yuqiong","affiliation":[{"name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"}]},{"sequence":"additional","family":"Aljaafreh","given":"Amaneh Abdel Hafez A.","affiliation":[{"name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"}]},{"sequence":"additional","family":"Dong","given":"Dandan","affiliation":[{"name":"Wuhan No. 7 Hospital"}]},{"sequence":"additional","given":"Yali","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8036-0054","family":"Cong","affiliation":[{"name":"Peking University Health Science Centre"}]},{"sequence":"additional","family":"Lin","given":"Jun","affiliation":[{"name":"Zhongnan Hospital of Wuhan University"}]},{"sequence":"additional","family":"Chen","given":"Hongxiang","affiliation":[{"name":"Union Hospital, Tongji Medical College, Huazhong University of Science and Technology"},{"name":"Huazhong University of Science and Technology Union Shenzhen Hospital"}]}],"subject":["Health Policy","Issues, ethics and legal aspects"],"link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/15265161.2020.1782529","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1595867813000,"date-time":"2020-07-27T16:36:53Z","date-parts":[[2020,7,27]]},"language":"en","assertion":[{"order":1,"value":"The publishing and review policy for this title is described in its Aims & Scope.","label":"Peer Review Statement","name":"peerreview_statement"},{"order":2,"URL":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=uajb20","value":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=uajb20","label":"Aim & Scope","name":"aims_and_scope_url"},{"order":3,"value":"2020-07-27","group":{"label":"Publication History","name":"publication_history"},"label":"Published","name":"published"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":634.32,"page_height":833.04},{"page_width":593.858,"page_height":792},{"page_width":593.858,"page_height":792},{"page_width":593.858,"page_height":792}],"runtime":7180},
  {"_key":"60c20ae57723bebd8664539e","_id":"documents/60c20ae57723bebd8664539e","_rev":"_cfFhBCm---","file_name":"00icjjip.pdf","md5":"157DCCE46BC95E133950201DE791D206","id":"00icjjip","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/ic/jj/ip/00icjjip/00icjjip.pdf","date":"2021-06-10T12:51+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,3,31]]},"license-simplified":"biorxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.03.31.018457","group-title":"Evolutionary Biology","oaLink":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0231683&type=printable","original-title":[],"title":["Hidden biodiversity in Neotropical streams: DNA barcoding uncovers high endemicity of freshwater macroinvertebrates at small spatial scales"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":73,"short-title":[],"issued":{"date-parts":[[2020,3,31]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,3,31]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Aquatic macroinvertebrates play a crucial role in freshwater ecosystems, but their diversity remains poorly known, particularly in the tropics. This “taxonomic void” represents limits our understanding of biodiversity patterns and processes in freshwater ecosystems, and the scale at which they operate. We used DNA barcoding to estimate lineage diversity (and the diversity of unique haplotypes) in 224 specimens of freshwater macroinvertebrates at a small spatial scale within the Panama Canal Watershed (PCW). In addition, we compiled available barcoding data to assess macroinvertebrate diversity at a broader spatial scale spanning the Isthmus of Panama. Consistently across two species delimitation algorithms (i.e., ABGD and GMYC), we found high lineage diversity within the PCW, with ~ 100-106 molecular operational taxonomic units (MOTUs at 2% sequence divergence) across 168 unique haplotypes. We also found a high lineage diversity along the Isthmus of Panama, but this diversity peaked within the PCW. However, our rarefaction/extrapolation approach showed that this diversity remains under sampled. As expected, these results indicate that the diversity of Neotropical freshwater macroinvertebrates is higher than previously thought, with the possibility of high endemicity even at narrow spatial scales. Geographic isolation is likely a main factor shaping these patterns of diversity. However, local disturbances such as the rupture of the continental divide due to the construction of the Panama Canal might be reshaping these patterns of diversity at a local scale. Although further work is needed to better understand the processes driving diversification in freshwater macroinvertebrates, we suggest that Neotropical streams represent continental islands of diversity. Understanding these islands of diversity is crucial in the face of increasing human disturbance.","deposited":{"timestamp":1606848699000,"date-time":"2020-12-01T18:51:39Z","date-parts":[[2020,12,1]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Luis F.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9317-420X","family":"De León","affiliation":[]},{"sequence":"additional","given":"Aydeé","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6789-5847","family":"Cornejo","affiliation":[]},{"sequence":"additional","given":"Ronnie G.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-1437-5607","family":"Gavilán","affiliation":[]},{"sequence":"additional","given":"Celestino","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-1627-0374","family":"Aguilar","affiliation":[]}],"DOI":"10.1101/2020.03.31.018457","reference-count":73,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.03.31.018457","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[],"is-preprint-of":[{"id":"10.1371/journal.pone.0231683","id-type":"doi","asserted-by":"subject"}]},"created":{"timestamp":1585740940000,"date-time":"2020-04-01T11:35:40Z","date-parts":[[2020,4,1]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"bioRxiv"},"id":"00icjjip","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1606850219724,"date-time":"2020-12-01T19:16:59Z","date-parts":[[2020,12,1]]},"cord_sha":"204020507c227cf6f02ed17eaa9916099ff42c5e"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":14770},
  {"_key":"60c20ae77723bebd866453b7","_id":"documents/60c20ae77723bebd866453b7","_rev":"_cfFhBCy---","file_name":"00j8iq73.pdf","md5":"19673DBC4175BEB76C0653C1F54C6019","id":"00j8iq73","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/j8/iq/73/00j8iq73/00j8iq73.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["10.1128/AAC.01407-13"],"published-print":{"date-parts":[[2014,1]]},"volume":"58","pmid":"24145548","journal-issue":{"published-print":{"date-parts":[[2014,1]]},"issue":"1","published-online":{"date-parts":[[2013,12,20]]}},"has_valid_tei":false,"DOI":"10.1128/aac.01407-13","license-simplified":"unk","original-title":[],"title":["Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":41,"page":"120-127","type":"journal-article","issued":{"date-parts":[[2013,10,21]]},"publisher":"American Society for Microbiology","id":"00j8iq73","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1589383491000,"date-time":"2020-05-13T15:24:51Z","date-parts":[[2020,5,13]]},"indexed":{"timestamp":1613702630631,"date-time":"2021-02-19T02:43:50Z","date-parts":[[2021,2,19]]},"is-referenced-by-count":64,"short-container-title":["Antimicrob. Agents Chemother."],"prefix":"10.1128","oaLink":"https://aac.asm.org/content/aac/58/1/120.full.pdf","has_valid_thumbnail":false,"references-count":41,"published-online":{"date-parts":[[2013,10,21]]},"subtitle":[],"URL":"http://dx.doi.org/10.1128/aac.01407-13","ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"has_valid_ref_annotation":false,"issue":"1","member":"235","abstract":"Griffithsin (GRFT) is a red-alga-derived lectin that binds the terminal mannose residues of N-linked glycans found on the surface of human immunodeficiency virus type 1 (HIV-1), HIV-2, and other enveloped viruses, including hepatitis C virus (HCV), severe acute respiratory syndrome coronavirus (SARS-CoV), and Ebola virus. GRFT displays no human T-cell mitogenic activity and does not induce production of proinflammatory cytokines in treated human cell lines. However, despite the growing evidence showing the broad-spectrum nanomolar or better antiviral activity of GRFT, no study has reported a comprehensive assessment of GRFT safety as a potential systemic antiviral treatment. The results presented in this work show that minimal toxicity was induced by a range of single and repeated daily subcutaneous doses of GRFT in two rodent species, although we noted treatment-associated increases in spleen and liver mass suggestive of an antidrug immune response. The drug is systemically distributed, accumulating to high levels in the serum and plasma after subcutaneous delivery. Further, we showed that serum from GRFT-treated animals retained antiviral activity against HIV-1-enveloped pseudoviruses in a cell-based neutralization assay. Overall, our data presented here show that GRFT accumulates to relevant therapeutic concentrations which are tolerated with minimal toxicity. These studies support further development of GRFT as a systemic antiviral therapeutic agent against enveloped viruses, although deimmunizing the molecule may be necessary if it is to be used in long-term treatment of chronic viral infections.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Barton","given":"Christopher","affiliation":[]},{"sequence":"additional","family":"Kouokam","given":"J. Calvin","affiliation":[]},{"sequence":"additional","family":"Lasnik","given":"Amanda B.","affiliation":[]},{"sequence":"additional","family":"Foreman","given":"Oded","affiliation":[]},{"sequence":"additional","family":"Cambon","given":"Alexander","affiliation":[]},{"sequence":"additional","family":"Brock","given":"Guy","affiliation":[]},{"sequence":"additional","family":"Montefiori","given":"David C.","affiliation":[]},{"sequence":"additional","family":"Vojdani","given":"Fakhrieh","affiliation":[]},{"sequence":"additional","family":"McCormick","given":"Alison A.","affiliation":[]},{"sequence":"additional","family":"O'Keefe","given":"Barry R.","affiliation":[]},{"sequence":"additional","family":"Palmer","given":"Kenneth E.","affiliation":[]}],"subject":["Pharmacology (medical)","Pharmacology","Infectious Diseases"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1128/AAC.01407-13","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1382409674000,"date-time":"2013-10-22T02:41:14Z","date-parts":[[2013,10,22]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":10397},
  {"_key":"60c20aeb7723bebd866453ba","_id":"documents/60c20aeb7723bebd866453ba","_rev":"_cfFhBC6---","file_name":"00kt3xof.pdf","md5":"18B835585A63E98E7F03C16F3B78ABE8","id":"00kt3xof","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/kt/3x/of/00kt3xof/00kt3xof.pdf","date":"2021-06-10T12:51+0000","metadata":{"is-referenced-by-count":0,"short-container-title":["ijph"],"prefix":"10.18502","pmcid":"PMC7548487","original-title":[],"pmid":"33083287","published-online":{"date-parts":[[2020,7,6]]},"has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.18502/ijph.v49i7.3574","references-count":0,"license-simplified":"cc-by","subtitle":[],"title":["Factors Associated with Mortality in COVID-19 Patients: A Systematic Review and Meta-Analysis"],"content-domain":{"domain":[],"crossmark-restriction":false},"short-title":[],"issued":{"date-parts":[[2020,7,6]]},"issn-type":[{"value":"2251-6085","type":"print"},{"value":"2251-6093","type":"electronic"}],"container-title":["Iranian Journal of Public Health"],"has_valid_oa_url":true,"has_valid_ref_annotation":false,"publisher":"Knowledge E","member":"7770","abstract":"BACKGROUND: The current study aimed to identify effective factors on the death among COVID-19 patients. METHODS: All articles published in the period Jan 1, 2020, to Mar 23, 2020, written in English and reporting factors associated with COVID-19 mortality were reviewed. The random-effects model with 95% CI was used to calculate the pooled Odds Ratio (OR) and Hazard Ratio (HR). Data were analyzed using Stata ver.11.0. RESULTS: The older age OR: 1.21(1.10–1.33) and male gender OR: 1.41(1.04–1.89) were most prone to death due to COVID-19. The Comorbidity with some chronic diseases such as Diabetes type2 OR: 2.42(1.06–5.52), Hypertension OR: 2.54(1.21–5.32), Kidney disorder OR: 2.61(1.22–5.60), Respiratory disorder 3.09 (1.39–6.88) and Heart diseases OR: 4.37 (1.13–16.90) can increase the risk of COVID19 mortality. CONCLUSION: Infection with COVID-19 is associated with substantial mortality mainly in older patients with comorbidities. We found the significant effect of age, gender and comorbidities such as Diabetes Mellitus, Hypertension, Kidney disorders and Heart diseases on the risk of death in patients with COVID-19. The factors associated with mortality found in this research can help to recognize patients with COVID-19 who are at higher risk of a poor prognosis. Monitoring these factors can serve to give early warning for the appropriate interventions.","source":"Crossref","has_valid_pdf":true,"author":[{"sequence":"first","family":"SEPANDI","given":"Mojtaba","affiliation":[]},{"sequence":"additional","family":"TAGHDIR","given":"Maryam","affiliation":[]},{"sequence":"additional","family":"ALIMOHAMADI","given":"Yousef","affiliation":[]},{"sequence":"additional","family":"AFRASHTEH","given":"Sima","affiliation":[]},{"sequence":"additional","family":"HOSAMIRUDSARI","given":"Hadiseh","affiliation":[]}],"DOI":"10.18502/ijph.v49i7.3574","reference-count":0,"relation":{},"created":{"timestamp":1594105402000,"date-time":"2020-07-07T07:03:22Z","date-parts":[[2020,7,7]]},"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/72/a2/PMC7548487.tar.gz","id":"00kt3xof","ISSN":["2251-6093","2251-6085"],"score":1,"deposited":{"timestamp":1596356981000,"date-time":"2020-08-02T08:29:41Z","date-parts":[[2020,8,2]]},"indexed":{"timestamp":1596359970542,"date-time":"2020-08-02T09:19:30Z","date-parts":[[2020,8,2]]},"type":"journal-article","cord_sha":"f8db50b2ad8aec2b553b22f3b3fb7d1c05f6c24b"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":6365},
  {"_key":"60c20aed7723bebd866453bd","_id":"documents/60c20aed7723bebd866453bd","_rev":"_cfFhBDG---","file_name":"00l2apsc.pdf","md5":"B7A1F90CA14069BC34A55142BF4375A7","id":"00l2apsc","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/l2/ap/sc/00l2apsc/00l2apsc.pdf","date":"2021-06-10T12:51+0000","metadata":{"alternative-id":["S1063458412008436"],"published-print":{"date-parts":[[2012,9]]},"volume":"20","pmid":"22698444","journal-issue":{"published-print":{"date-parts":[[2012,9]]},"issue":"9"},"has_valid_tei":false,"DOI":"10.1016/j.joca.2012.05.014","original-title":[],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1346457600000,"date-time":"2012-09-01T00:00:00Z","date-parts":[[2012,9,1]]}},{"URL":"https://www.elsevier.com/open-access/userlicense/1.0/","content-version":"vor","delay-in-days":534,"start":{"timestamp":1392595200000,"date-time":"2014-02-17T00:00:00Z","date-parts":[[2014,2,17]]}}],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":48,"page":"974-981","type":"journal-article","issued":{"date-parts":[[2012,9]]},"funder":[{"award":[],"name":"participants"},{"award":[],"name":"Dynamics of Human Movement group"}],"publisher":"Elsevier BV","id":"00l2apsc","short-title":[],"title":["Knee effusion affects knee mechanics and muscle activity during gait in individuals with knee osteoarthritis"],"has_valid_oa_url":true,"deposited":{"timestamp":1561833325000,"date-time":"2019-06-29T18:35:25Z","date-parts":[[2019,6,29]]},"indexed":{"timestamp":1614576262101,"date-time":"2021-03-01T05:24:22Z","date-parts":[[2021,3,1]]},"is-referenced-by-count":21,"short-container-title":["Osteoarthritis and Cartilage"],"prefix":"10.1016","oaLink":"http://www.oarsijournal.com/article/S1063458412008436/pdf","has_valid_thumbnail":false,"references-count":48,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.joca.2012.05.014","ISSN":["1063-4584"],"issn-type":[{"value":"1063-4584","type":"print"}],"container-title":["Osteoarthritis and Cartilage"],"has_valid_ref_annotation":false,"issue":"9","member":"78","abstract":"OBJECTIVE To test the hypothesis that knee effusion presence in those with knee osteoarthritis (OA) alters knee joint muscle activation patterns and sagittal plane mechanics during gait. METHODS Thirty-five patients with medial compartment knee OA were assessed for the presence of effusion using a brush test. Based on the results, they were assigned to the knee effusion (n = 17) and no knee effusion (n = 18) groups. Electromyograms from seven lower extremity muscles (lateral and medial gastrocnemius, vastus lateralis and medialis, rectus femoris and the lateral and medial hamstrings), leg motion and ground reaction forces were recorded during self-selected walking. Isometric knee extensor, plantar flexor and knee flexor strength were measured. Discrete measures from angular knee motion and net external moment of force waveforms were identified. Principal component analysis extracted electromyographic waveform features. Analysis of variance models tested for main effects (group, muscle) and interactions (α = 0.05). Bonferroni post-hoc testing was employed. RESULTS No differences in age, body mass index, knee pain, Western Ontario McMaster Osteoarthritis Index scores, gait velocity and muscle strength were found between groups (P > 0.05). Individuals with effusion had a greater overall quadriceps activation and prolonged hamstring activation into mid-stance (P < 0.05). Knee joint flexion angles were higher (P < 0.05) and net external knee extension (KE) moments in mid to late stance lower in the effusion group. CONCLUSION Quadriceps and hamstrings activation during walking were altered when effusions were present. Increased knee flexion (KF) angles and decreased KE moment in mid-late stance provide a mechanical explanation for the effect of joint effusion on muscle activation in those with knee OA.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Rutherford","given":"D.J.","affiliation":[]},{"sequence":"additional","family":"Hubley-Kozey","given":"C.L.","affiliation":[]},{"sequence":"additional","family":"Stanish","given":"W.D.","affiliation":[]}],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S1063458412008436?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1063458412008436?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1339514179000,"date-time":"2012-06-12T15:16:19Z","date-parts":[[2012,6,12]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":7653},
  {"_key":"60c20af57723bebd866453c0","_id":"documents/60c20af57723bebd866453c0","_rev":"_cfFhBDS---","file_name":"00l8cic5.pdf","md5":"950B7F217F59E66E07FC77FDB6E9F42C","id":"00l8cic5","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/l8/ci/c5/00l8cic5/00l8cic5.pdf","date":"2021-06-10T12:52+0000","metadata":{"alternative-id":["10.1021/acs.jpclett.0c02397"],"published-print":{"date-parts":[[2021,2,11]]},"volume":"12","pmid":"33508197","journal-issue":{"published-print":{"date-parts":[[2021,2,11]]},"issue":"5"},"has_valid_tei":false,"DOI":"10.1021/acs.jpclett.0c02397","original-title":[],"title":["On Drug-Membrane Permeability of Antivirals for SARS-CoV-2"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":24,"page":"1384-1389","type":"journal-article","issued":{"date-parts":[[2021,1,28]]},"prefix":"10.1021","publisher":"American Chemical Society (ACS)","id":"00l8cic5","short-title":[],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/fc/19/PMC7860140.tar.gz","pmcid":"PMC7860140","has_valid_oa_url":true,"deposited":{"timestamp":1613170825000,"date-time":"2021-02-12T23:00:25Z","date-parts":[[2021,2,12]]},"indexed":{"timestamp":1613175709234,"date-time":"2021-02-13T00:21:49Z","date-parts":[[2021,2,13]]},"is-referenced-by-count":0,"short-container-title":["J. Phys. Chem. Lett."],"funder":[{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100007270","name":"University of Michigan"}],"published-online":{"date-parts":[[2021,1,28]]},"has_valid_thumbnail":false,"references-count":24,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1021/acs.jpclett.0c02397","ISSN":["1948-7185","1948-7185"],"issn-type":[{"value":"1948-7185","type":"print"},{"value":"1948-7185","type":"electronic"}],"container-title":["The Journal of Physical Chemistry Letters"],"has_valid_ref_annotation":false,"issue":"5","member":"316","abstract":"[Image: see text] One of the key parameters required to identify effective drugs is membrane permeability, as a compound intended for an intracellular target with poor permeability will have low efficacy. In this paper, we leverage a computational approach recently developed by our group to study the interactions between nanoparticles and mammalian membranes to study the time of entry of a variety of drugs into the viral envelope of coronavirus as well as cellular organelles. Using a combination of all-atoms molecular dynamics simulations and statistical analysis, we consider both drug characteristics and membrane properties to determine the behavior of 79 drugs and their interactions with the viral envelope, composed of the membrane and spike protein, as well as five other membranes that correspond to various mammalian compartments (lysosome, plasma, Golgi, mitochondrial, and endoplasmic reticulum membranes). The results highlight important trends that can be exploited for drug design, from the relatively high permeability of the viral envelope and the effect of transmembrane proteins, to the differences in permeability between organelles. When compared with bioavailability data present in the literature, the model results suggest a negative correlation between time of permeation and bioavailability of promising drugs. The method is general and flexible and can be employed for a variety of molecules, from small drugs to small nanoparticles, as well to a variety of biological membranes. Overall, the results indicate that this model can contribute to the identification of successful drugs as it predicts the ability of compounds to reach both intended and unintended intracellular targets.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Changjiang","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-3272-0689","family":"Liu","affiliation":[{"name":"Biophysics Program, University of Michigan, Ann Arbor, Michigan 48109-2125, United States"}]},{"sequence":"additional","family":"Elvati","given":"Paolo","affiliation":[{"name":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125, United States"}]},{"sequence":"additional","given":"Angela","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-9517-668X","family":"Violi","affiliation":[{"name":"Biophysics Program, University of Michigan, Ann Arbor, Michigan 48109-2125, United States"},{"name":"Department of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125, United States"},{"name":"Department of Chemical Engineering, University of Michigan, Ann Arbor, Michigan 48109-2125, United States"}]}],"subject":["General Materials Science"],"link":[{"URL":"https://pubs.acs.org/doi/pdf/10.1021/acs.jpclett.0c02397","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1611882361000,"date-time":"2021-01-29T01:06:01Z","date-parts":[[2021,1,29]]},"language":"en","score":1,"source":"Crossref","cord_sha":"1af1e6ba46a1d097e266ff3d9451e64a7f06642b; 9f9121570e9b6daf363db479f87d3b14b2ac4ad0"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":7825},
  {"_key":"60c20b017723bebd866453c6","_id":"documents/60c20b017723bebd866453c6","_rev":"_cfFhBDe---","file_name":"00o8pkyk.pdf","md5":"35AEA227C266A582FDA58A7148060D07","id":"00o8pkyk","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/o8/pk/yk/00o8pkyk/00o8pkyk.pdf","date":"2021-06-10T12:52+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,9,23]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.08.18.20173500","group-title":"Epidemiology","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/09/23/2020.08.18.20173500.full.pdf","original-title":[],"title":["The Mental Health of Healthcare Staff during the COVID-19 Pandemic: It Depends on How Much They Work and Their Age"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":31,"short-title":[],"issued":{"date-parts":[[2020,8,21]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,8,21]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Background: Healthcare staff are the forefront of fight against COVID-19 and they are under enormous pressure due to the fast growth in the number and severity of infected cases. This creates their mental issues such as distress, depression and anxiety. Exploring healthcare staff's mental health during the pandemic contributes to improving their persistence in the growing challenges created by COVID-19 and enabling effective management of their mental health. Methods: An online survey of 280 healthcare staff in all the 31 provinces of Iran was conducted during April 5 to 20, 2020. The survey assessed staff's distress, depression and anxiety in the COVID-19 pandemic. Results: Nearly a third of healthcare staff suffered from distress, depression and anxiety. Females and more educated healthcare staff were more likely to experience distress. Compared to personnel who did not have COVID-19, those who were unsure whether they had COVID-19 were more likely to experience distress and depression. The number of COVID-19 cases among the staff's colleagues or friends positively predicted their anxiety. Compared to radio technologists, doctors were less likely to experience distress and anxiety. Technicians and obstetrics experienced less anxiety. Analysis the interaction between weekly working days and age of the staff indicated the chance of experiencing distress and depression varied greatly by working days among younger but not older healthcare staff. Conclusion: Exploring the potential predictors of mental health issues assists healthcare organizations to develop approaches to prevent and decrease the issues among staff and improve their task performance in sever crises such as COVID-19, so they can stay motivated in the COVID-19 pandemic. It is useful to identify more working characteristic predictors for healthcare staff at different ages.","deposited":{"timestamp":1613359859000,"date-time":"2021-02-15T03:30:59Z","date-parts":[[2021,2,15]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Xu","given":"Xingzi","affiliation":[]},{"sequence":"additional","given":"Stephen X.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6123-1193","family":"Zhang","affiliation":[]},{"sequence":"additional","family":"Jahanshahi","given":"Asghar Afshar","affiliation":[]},{"sequence":"additional","family":"Li","given":"Jizhen","affiliation":[]},{"sequence":"additional","family":"Bagheri","given":"Afsaneh","affiliation":[]},{"sequence":"additional","family":"Nawaser","given":"Khaled","affiliation":[]}],"DOI":"10.1101/2020.08.18.20173500","reference-count":31,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.08.18.20173500","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1598041517000,"date-time":"2020-08-21T20:25:17Z","date-parts":[[2020,8,21]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"00o8pkyk","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1613362495427,"date-time":"2021-02-15T04:14:55Z","date-parts":[[2021,2,15]]},"cord_sha":"15cbb2e066fb67d49eaf04a229becfa42bc32ebf"},"application":"software-mentions","pages":[{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":841.92,"page_height":595.32},{"page_width":841.92,"page_height":595.32},{"page_width":841.92,"page_height":595.32},{"page_width":841.92,"page_height":595.32}],"runtime":13455},
  {"_key":"60c20b047723bebd866453c8","_id":"documents/60c20b047723bebd866453c8","_rev":"_cfFhBDq---","file_name":"00objxul.pdf","md5":"D8221CBFC21337E6FD7DB9B3FBBCE3EE","id":"00objxul","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/ob/jx/ul/00objxul/00objxul.pdf","date":"2021-06-10T12:52+0000","metadata":{"alternative-id":["S1677-55382020000700156"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1593561600000,"date-time":"2020-07-01T00:00:00Z","date-parts":[[2020,7,1]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"am","delay-in-days":0,"start":{"timestamp":1593561600000,"date-time":"2020-07-01T00:00:00Z","date-parts":[[2020,7,1]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1593561600000,"date-time":"2020-07-01T00:00:00Z","date-parts":[[2020,7,1]]}}],"volume":"46","pmid":"32618462","has_valid_tei":false,"DOI":"10.1590/s1677-5538.ibju.2020.s119","license-simplified":"cc-by","original-title":[],"short-container-title":["Int. braz j urol."],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":13,"page":"156-164","type":"journal-article","issued":{"date-parts":[[2020,7]]},"publisher":"FapUNIFESP (SciELO)","id":"00objxul","short-title":[],"pmcid":"PMC7719987","has_valid_oa_url":true,"deposited":{"timestamp":1611442712000,"date-time":"2021-01-23T22:58:32Z","date-parts":[[2021,1,23]]},"indexed":{"timestamp":1611445472563,"date-time":"2021-01-23T23:44:32Z","date-parts":[[2021,1,23]]},"is-referenced-by-count":0,"title":["Exploring Urological Experience in the COVID-19 Outbreak: American Confederation of Urology (CAU) Survey"],"prefix":"10.1590","published-online":{"date-parts":[[2020,7]]},"has_valid_thumbnail":false,"references-count":13,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a9/3e/PMC7719987.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1590/s1677-5538.ibju.2020.s119","ISSN":["1677-6119","1677-5538"],"issn-type":[{"value":"1677-5538","type":"print"},{"value":"1677-6119","type":"electronic"}],"container-title":["International braz j urol"],"has_valid_ref_annotation":false,"issue":"suppl 1","member":"530","abstract":"PURPOSE: To explore the current situation faced by Latin American urology departments during the COVID-19 Outbreak in terms of knowledge, actions, prioritization of urology practices, and implementation of internal clinical management protocols for inpatients and outpatients. MATERIAL AND METHODS: A non-validated, structured, self-administered, electronic survey with 35 closed multiple choice questions was conducted in Spanish, Portuguese, Italian, and English and Deutsch versions from April 1st to April 30th, 2020. The survey was distributed through social networks and the official American Confederation of Urology (CAU) website. It was anonymous, mainly addressed to Latin American urologists and urology residents. It included 35 questions exploring different aspects: 1) Personal Protective Equipment (PPE) and internal management protocols for healthcare providers; 2) Priority surgeries and urological urgencies and 3) Inpatient and outpatient care. RESULTS: Of 864 surveys received, 846 had at least 70% valid responses and were included in the statistical analyses. Surveys corresponded to South America in 62% of the cases, Central America and North America in 29.7%. 12.7% were residents. Regarding to PPE and internal management protocols, 88% confirmed the implementation of specific protocols and 45.4% have not received training to perform a safe clinical practice; only 2.3% reported being infected with COVID-19. 60.9% attended urgent surgeries. The following major uro-oncologic surgeries were reported as high priority: Radical Nephrectomy (RN) 58.4%, and Radical Cystectomy (RC) 57.3%. When we associate the capacity of hospitalization (urologic beds available) and percentage of high-priority surgery performed, we observed that centers with fewer urological beds (10-20) compared to centers with more urological beds (31-40) performed more frequently major urologic cancer surgeries: RN 54.5% vs 60.8% (p=0.0003), RC 53.1% vs 64.9% (p=0.005) respectively. CONCLUSIONS: At the time of writing (May 13th 2020) our data represents a snapshot of COVID-19 outbreak in Latin American urological practices. Our findings have practical implications and should be contextualized considering many factors related to patients and urological care: The variability of health care scenarios, institutional capacity, heterogeneity and burden of urologic disease, impact of surgical indications and decision making when prioritizing and scheduling surgeries in times of COVID-19 pandemic.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Ana María","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-4961-5669","family":"Autrán-Gómez","affiliation":[{"name":"University Hospital Fundación Jiménez Díaz,  Spain"}]},{"sequence":"additional","family":"Tobia","given":"Ignacio","affiliation":[{"name":"Hospital Italiano de Buenos Aires,  Argentina"}]},{"sequence":"additional","family":"Molina","given":"Ricardo Castillejos","affiliation":[{"name":"Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,  Mexico"}]},{"sequence":"additional","family":"Covarrubias","given":"Francisco Rodríguez","affiliation":[{"name":"Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán,  Mexico"}]},{"sequence":"additional","family":"Benzing","given":"Frank","affiliation":[{"name":"Brandenburg Medical School University Hospital Brandenburg der Havel,  Germany"}]},{"sequence":"additional","family":"Maruccia","given":"Serena","affiliation":[{"name":"Institute Zucchi,  Italy"}]},{"sequence":"additional","family":"Reis","given":"Leonardo de O.","affiliation":[{"name":"Universidade Estadual de Campinas - Unicamp,  Brasil"}]},{"sequence":"additional","family":"Lay","given":"Ramón Rodríguez","affiliation":[{"name":"Complejo Hospitalario Metropolitano,  Panama"}]},{"sequence":"additional","family":"Reza","given":"Marcelo Torrico De la","affiliation":[{"name":"San Simón Higher University Cochabamba,  Bolivia"}]},{"sequence":"additional","family":"Torres","given":"Felix Santaella","affiliation":[{"name":"Hospital de Especialidades - Instituto Mexicano del Seguro Social Mexico,  Mexico"}]},{"sequence":"additional","family":"Porras","given":"Andrés Hernández","affiliation":[{"name":"Hospital Angeles Tiujana,  Mexico"}]},{"sequence":"additional","family":"Rodríguez","given":"Alejandro","affiliation":[{"name":"Rochester General Hospital,  US"}]}],"subject":["Urology"],"link":[{"URL":"http://www.scielo.br/pdf/ibju/v46s1/1677-6119-ibju-46-s01-0156.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1595879783000,"date-time":"2020-07-27T19:56:23Z","date-parts":[[2020,7,27]]},"journal-issue":{"issue":"suppl 1","published-online":{"date-parts":[[2020,7]]}},"score":1,"source":"Crossref","cord_sha":"f7b6967481cc5225c0225305bc37532de5048cdf"},"application":"software-mentions","pages":[{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37},{"page_width":598.11,"page_height":799.37}],"runtime":14589},
  {"_key":"60c20b057723bebd866453ca","_id":"documents/60c20b057723bebd866453ca","_rev":"_cfFhBD2---","file_name":"00od3ff9.pdf","md5":"4EE2D79E184966CA4EAB0B77F20B24C6","id":"00od3ff9","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/od/3f/f9/00od3ff9/00od3ff9.pdf","date":"2021-06-10T12:52+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-49076-8_5","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"45-56","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"00od3ff9","reference-count":11,"title":["Analysis of Repair Costs of Scholar Buildings Affected by Earthquakes Using Data Mining. Case Study: Earthquakes of 2017 in Mexico"],"pmcid":"PMC7297593","has_valid_oa_url":true,"deposited":{"timestamp":1592352161000,"date-time":"2020-06-17T00:02:41Z","date-parts":[[2020,6,17]]},"indexed":{"timestamp":1592354450801,"date-time":"2020-06-17T00:40:50Z","date-parts":[[2020,6,17]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,6,17]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030490751","type":"print"},{"value":"9783030490768","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/78/ef/PMC7297593.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-49076-8_5","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Lecture Notes in Computer Science","Pattern Recognition"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"Earthquakes are events that cannot be predicted. However, when they occur, devastating consequences are shown in economic, social and structural areas, among others. In this paper, the mining of association rules is carried out in order to estimate the repair cost required by schools affected during the earthquakes of September 7th and 19th, of 2017 in Mexico. For that, we use the public data collected by the Mexican FONDEN.","has_valid_pdf":true,"author":[{"sequence":"first","family":"García-Rueda","given":"Graciela","affiliation":[]},{"sequence":"additional","family":"Valdovinos","given":"Rosa M.","affiliation":[]},{"sequence":"additional","family":"Valdés-González","given":"Jesús","affiliation":[]},{"sequence":"additional","family":"Alejo","given":"Roberto","affiliation":[]},{"sequence":"additional","family":"González-Ruiz","given":"J. Leonardo","affiliation":[]},{"sequence":"additional","family":"Marcial-Romero","given":"José R.","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030490751","9783030490768"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-49076-8_5","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1592348692000,"date-time":"2020-06-16T23:04:52Z","date-parts":[[2020,6,16]]},"references-count":11,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"17 June 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"MCPR","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"Mexican Conference on Pattern Recognition","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Morelia","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"Mexico","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"24 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"27 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"12","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"mcpr22020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"http://ccc.inaoep.mx/~mcpr2020/index.html","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Single-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"67","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"31","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"0","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"46% - The value is computed by the equation \"Number of Full Papers Accepted / Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Acceptance Rate of Full Papers","name":"acceptance_rate_of_full_papers"},{"order":7,"value":"2.05","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Reviews per Paper","name":"average_number_of_reviews_per_paper"},{"order":8,"value":"2.79","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Papers per Reviewer","name":"average_number_of_papers_per_reviewer"},{"order":9,"value":"Yes","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"External Reviewers Involved","name":"external_reviewers_involved"},{"order":10,"value":"The conference was held virtually due to the COVID-19 pandemic.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Additional Info on Review Process","name":"additional_info_on_review_process"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"7469a5c9557e501ec689aa18d9e6a3572014df95"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":10372},
  {"_key":"60c20b067723bebd866453cc","_id":"documents/60c20b067723bebd866453cc","_rev":"_cfFhBEG---","file_name":"00odvrxr.pdf","md5":"F0B317CF7FE285A2D4E53FF059846B07","id":"00odvrxr","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/od/vr/xr/00odvrxr/00odvrxr.pdf","date":"2021-06-10T12:52+0000","metadata":{"alternative-id":["5883"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1613433600000,"date-time":"2021-02-16T00:00:00Z","date-parts":[[2021,2,16]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1613433600000,"date-time":"2021-02-16T00:00:00Z","date-parts":[[2021,2,16]]}}],"article-number":"180","language":"en","volume":"21","pmid":"33593280","journal-issue":{"published-print":{"date-parts":[[2021,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1186/s12879-021-05883-5","license-simplified":"cc-by","original-title":[],"published-print":{"date-parts":[[2021,12]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Infectious Diseases"],"type":"journal-article","issued":{"date-parts":[[2021,2,16]]},"publisher":"Springer Science and Business Media LLC","id":"00odvrxr","reference-count":33,"title":["Pseudomonas aeruginosa device associated – healthcare associated infections and its multidrug resistance at intensive care unit of University Hospital: polish, 8.5-year, prospective, single-centre study"],"pmcid":"PMC7885137","has_valid_oa_url":true,"deposited":{"timestamp":1613582604000,"date-time":"2021-02-17T17:23:24Z","date-parts":[[2021,2,17]]},"indexed":{"timestamp":1613584238019,"date-time":"2021-02-17T17:50:38Z","date-parts":[[2021,2,17]]},"is-referenced-by-count":0,"short-container-title":["BMC Infect Dis"],"prefix":"10.1186","published-online":{"date-parts":[[2021,2,16]]},"has_valid_thumbnail":false,"references-count":33,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/24/c6/PMC7885137.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12879-021-05883-5","short-title":[],"issn-type":[{"value":"1471-2334","type":"electronic"}],"container-title":["BMC Infectious Diseases"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND: Pseudomonas aeruginosa has recently shown to be one of the most important strains of bacteria and alert pathogens in Europe among Intensive Care Unit patients that provide serious therapeutic problems because of its multidrug resistance. METHODS: The purpose of this microbiological study was data analysis of device associated- healthcare associated infections (DA-HAIs) in an ICU in terms of the incidents of P.aeruginosa strain infections and its susceptibility within an 8.5-year observation. RESULTS: Among 919 isolated strains responsible for 799 DA-HAIs (17,62 ± 1,98/1000 patient-days) in 4010 ICU patients P.aeruginosa was the pathogen in 108/799 (13.52%) cases. Incidence rate (density) of: VAP/1000 MV- days, UTI /1000 UC- days and CLA-BSI/1000 CL- days were 11,15 ± 2.5, 6.82 ± 0.81, 2.35 ± 1.54.respectivelly. P.aeruginosa was the pathogen most frequently responsible for VAP 69/108 (63.88%). Mean frequency of VAP, UTI and CLA-BSI with P.aeruginosa etiology was 69/493 (14.28%), 32/299 (11.1%) and 7/127 (5.77%) respectively. The mean density of P.aeruginosa infection amounted to 2.43/1000 patient-days. The decrease was observed in the total number of DA-HAIs caused by the P.aeruginosa from 15.75% and 3.23/1000 patient-days in 2011 to 5.0% and 1.17/1000 in 2016 (p = 0.0104, p = 0.0348). Starting from 2016 to 2019 incidence and density of P.aeruginosa DA-HAIs increased to 12.33% and 2.63/1000 (p = 0.1388, p = 0.0818). P.aeruginosa was susceptible to ceftazidime, cefepime, amikacin, meropenem, ciprofloxacin, colistin, in 55.55, 58.33, 70.37, 53.73, 50, and 100% respectively. MDR characterised it in 40% in 2011 and 66.7% in 2019, (p = 0.177). CONCLUSIONS: The study revealed a changeable prevalence of P. aeruginosa strain infections; however their frequency was never highest in our ICU patients as it presented in the last years in Europe. The study showed a significant decrease in 2016 and increase in 2019, a nearly 3-fold increase of P.aeruginosa infections among Gram-negative strain infections, and a 2-fold increase of the P.aeruginosa DA-HAIs frequency between 2016 and 2019 as well as an increased resistance. Microbiological analysis of DA-HAIs in each hospital should be a standard method used in hospital infection control and antibiotic policy. In the case of P.aeruginosa, in order to minimize transmission, preventive infection methods should be assessed mainly in case of VAP.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Agnieszka","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1614-4522","family":"Litwin","affiliation":[]},{"sequence":"additional","given":"Stanislaw","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-7817-3751","family":"Rojek","affiliation":[]},{"sequence":"additional","given":"Waldemar","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8668-1641","family":"Gozdzik","affiliation":[]},{"sequence":"additional","given":"Wieslawa","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-5880-4904","family":"Duszynska","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12879-021-05883-5.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s12879-021-05883-5/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s12879-021-05883-5.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1613582496000,"date-time":"2021-02-17T17:21:36Z","date-parts":[[2021,2,17]]},"ISSN":["1471-2334"],"assertion":[{"order":1,"value":"16 June 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"9 February 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"16 February 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"Approval of this study (KB-579/2016) was given by the Bioethics Committee of the Wroclaw Medical University (Wroclaw, Poland). The study was based on the anonymous data including laboratory results which had been collected during routine patients care. The local Bioethics Committee of Wroclaw Medical University consent included approval for publication of the data without need of statement or consent from participants.","group":{"label":"Ethics approval and consent to participate","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Not applicable.","group":{"label":"Consent for publication","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"aef3612a0b5314a2925b0255a104db0655879e78"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":10397},
  {"_key":"60c20b0b7723bebd866453ce","_id":"documents/60c20b0b7723bebd866453ce","_rev":"_cfFhBES---","file_name":"00pvg49w.pdf","md5":"B3C39EEED2DDE0679BCF6002B01DEC2A","id":"00pvg49w","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/pv/g4/9w/00pvg49w/00pvg49w.pdf","date":"2021-06-10T12:52+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1599523200000,"date-time":"2020-09-08T00:00:00Z","date-parts":[[2020,9,8]]}}],"language":"en","volume":"15","pmid":"32898179","has_valid_tei":false,"created":{"timestamp":1599586070000,"date-time":"2020-09-08T17:27:50Z","date-parts":[[2020,9,8]]},"DOI":"10.1371/journal.pone.0238759","license-simplified":"cc-by","original-title":[],"short-container-title":["PLoS ONE"],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1371/journal.pone.corrections_policy","page":"e0238759","type":"journal-article","issued":{"date-parts":[[2020,9,8]]},"publisher":"Public Library of Science (PLoS)","id":"00pvg49w","short-title":[],"editor":[{"sequence":"first","family":"Simmen","given":"Hans-Peter","affiliation":[]}],"pmcid":"PMC7478708","has_valid_oa_url":true,"deposited":{"timestamp":1599586087000,"date-time":"2020-09-08T17:28:07Z","date-parts":[[2020,9,8]]},"indexed":{"timestamp":1605599073918,"date-time":"2020-11-17T07:44:33Z","date-parts":[[2020,11,17]]},"is-referenced-by-count":1,"title":["Collateral effect of COVID-19 on orthopedic and trauma surgery"],"prefix":"10.1371","published-online":{"date-parts":[[2020,9,8]]},"has_valid_thumbnail":false,"references-count":23,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/f9/86/PMC7478708.tar.gz","subtitle":[],"reference-count":23,"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"container-title":["PLOS ONE"],"has_valid_ref_annotation":false,"issue":"9","member":"340","abstract":"OBJECTIVES: The purpose of this study was to assess the impact of the COVID-19 pandemic on orthopedic and trauma surgery in private practices and hospitals in Germany. DESIGN: In this cross-sectional study, an online-based anonymous survey was conducted from April 2th to April 16(th) 2020. SETTING: The survey was conducted among 15.0000 of 18.000 orthopedic and trauma surgeons in Germany, both in private practices and hospitals. PARTICIPANTS: All members of the German Society of Orthopedic and Trauma Surgery (DGOU) and the Professional Association for Orthopedic and Trauma Surgery (BVOU). were invited by e-mail to participate in the survey. MAIN OUTCOME MEASURES: Out of 50 questions 42 were designed to enquire a certain dimension of the pandemic impact and contribute to one of six indices, namely “Preparedness”, “Resources”, “Reduction”, “Informedness”, “Concern”, and “Depletion”. Data was analyzed in multiple stepwise regression, aiming to identify those factors that independently influenced the indices. RESULTS: 858 orthopedic and trauma surgeons participated in the survey throughout Germany. In the multiple regression analysis, being employed at a hospital was identified as an independent positive predictor in the indices for “Preparedness”, “Resources”, and “Informedness” and an independent negative predictor regarding “Depletion”. Self-employment was found to be an independent positive predictor of the financial index “Depletion”. Female surgeons were identified as an independent variable for a higher level of “Concern”. CONCLUSIONS: The study confirms a distinct impact of the COVID-19 pandemic on orthopedic and trauma surgery in Germany. The containment measures are largely considered appropriate despite severe financial constraints. A substantial lack of personal protective equipment (PPE) is reported. The multiple regression analysis shows that self-employed surgeons are more affected by this shortage as well as by the financial consequences than surgeons working in hospitals. WHAT ARE THE NEW FINDINGS: The COVID-19 pandemic has a profound impact on orthopedic and trauma surgery as an unrelated specialty. Self-employed surgeons are affected especially by a shortage of PPE and financial consequences. HOW MIGHT IT IMPACT ON CLINICAL PRACTICE IN THE NEAR FUTURE: Political and financial support can now be applied more focused to subgroups in the field of orthopedics and trauma surgery with an increased demand for support. A special emphasis should be set on the support of self-employed surgeons which are a more affected by the shortage of PPE and financial consequences than surgeons working in hospitals.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Thomas M.","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-5224-9639","family":"Randau","affiliation":[]},{"sequence":"additional","given":"Max","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-5998-0224","family":"Jaenisch","affiliation":[]},{"sequence":"additional","family":"Haffer","given":"Henryk","affiliation":[]},{"sequence":"additional","family":"Schömig","given":"Friederike","affiliation":[]},{"sequence":"additional","family":"Kasapovic","given":"Adnan","affiliation":[]},{"sequence":"additional","family":"Olejniczak","given":"Katharina","affiliation":[]},{"sequence":"additional","family":"Flechtenmacher","given":"Johannes","affiliation":[]},{"sequence":"additional","family":"Perka","given":"Carsten","affiliation":[]},{"sequence":"additional","family":"Wirtz","given":"Dieter C.","affiliation":[]},{"sequence":"additional","given":"Matthias","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-0885-7370","family":"Pumberger","affiliation":[]}],"subject":["General Biochemistry, Genetics and Molecular Biology","General Agricultural and Biological Sciences","General Medicine"],"link":[{"URL":"https://dx.plos.org/10.1371/journal.pone.0238759","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1371/journal.pone.0238759","journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,8]]}},"score":1,"source":"Crossref","cord_sha":"01e11b9877183c83fadc5c62e1f0c3087e56bf54"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":7037},
  {"_key":"60c20b127723bebd866453d5","_id":"documents/60c20b127723bebd866453d5","_rev":"_cfFhBEe---","file_name":"00qqpkfd.pdf","md5":"9A0C0A124D91061CA6227C095CE20A44","id":"00qqpkfd","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/qq/pk/fd/00qqpkfd/00qqpkfd.pdf","date":"2021-06-10T12:52+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,9,23]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.09.17.20195867","group-title":"Intensive Care and Critical Care Medicine","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/09/23/2020.09.17.20195867.full.pdf","original-title":[],"title":["Dosing Of Thromboprophylaxis And Mortality In Critically Ill Covid-19 Patients"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":26,"short-title":[],"issued":{"date-parts":[[2020,9,23]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,9,23]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Background: A substantial proportion of critically ill COVID-19 patients develop thromboembolic complications, but it is unclear whether higher doses of thromboprophylaxis are associated with lower mortality rates. The purpose of the study was to evaluate the association of initial dosing strategy of thromboprophylaxis in critically ill COVID-19 patients and the risk of death, thromboembolism, and bleeding. Method: All critically ill COVID-19 patients admitted to two intensive care units in March and April 2020 were eligible. Patients were categorized into three groups according to initial daily dose of thromboprophylaxis: low (2500-4500 IU tinzaparin or 2500-5000 IU dalteparin), medium (>4500 IU but <175 IU/kilogram, kg, of body weight tinzaparin or >5000 IU but <200 IU/kg of body weight dalteparin), and high dose ([≥] 175 IU/kg of body weight tinzaparin or [≥]200 IU/kg of body weight dalteparin). Thromboprophylaxis dosage was based on local standardized recommendations, not on degree of critical illness or risk of thrombosis. Cox proportional hazards regression was used to estimate hazard ratios with corresponding 95% confidence intervals of death within 28 days from ICU admission. Multivariable models were adjusted for sex, age, body-mass index, Simplified Acute Physiology Score III, invasive respiratory support, and initial dosing strategy of thromboprophylaxis. Results: A total of 152 patients were included; 67 received low, 48 medium, and 37 high dose thromboprophylaxis. Baseline characteristics did not differ between groups. Mortality was lower in high (13.5%) vs medium (25.0%) and low dose thromboprophylaxis (38.8%) groups, p{equiv}0.02. The hazard ratio of death was 0.33 (95% confidence intervals 0.13 - 0.87) among those who received high dose, respectively 0.88 (95% confidence intervals 0.43 - 1.83) among those who received medium dose, as compared with those who received low dose thromboprophylaxis. There were fewer thromboembolic events in the high (2.7%) vs medium (18.8%) and low dose thromboprophylaxis (17.9%) groups, p{equiv}0.04, but no difference in the proportion of bleeding events, p{equiv}0.16. Conclusions: Among critically ill COVID-19 patients with respiratory failure, high dose thromboprophylaxis was associated with a lower risk of death and a lower cumulative incidence of thromboembolic events compared with lower doses.","deposited":{"timestamp":1613614612000,"date-time":"2021-02-18T02:16:52Z","date-parts":[[2021,2,18]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Jonmarker","given":"Sandra","affiliation":[]},{"sequence":"additional","family":"Hollenberg","given":"Jacob","affiliation":[]},{"sequence":"additional","family":"Dahlberg","given":"Martin","affiliation":[]},{"sequence":"additional","family":"Stackelberg","given":"Otto","affiliation":[]},{"sequence":"additional","family":"Litorell","given":"Jacob","affiliation":[]},{"sequence":"additional","family":"Everhov","given":"Åsa H","affiliation":[]},{"sequence":"additional","family":"Järnbert-Pettersson","given":"Hans","affiliation":[]},{"sequence":"additional","family":"Söderberg","given":"Mårten","affiliation":[]},{"sequence":"additional","family":"Grip","given":"Jonathan","affiliation":[]},{"sequence":"additional","family":"Schandl","given":"Anna","affiliation":[]},{"sequence":"additional","family":"Günther","given":"Mattias","affiliation":[]},{"sequence":"additional","family":"Cronhjort","given":"Maria","affiliation":[]}],"DOI":"10.1101/2020.09.17.20195867","reference-count":26,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.09.17.20195867","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1600895432000,"date-time":"2020-09-23T21:10:32Z","date-parts":[[2020,9,23]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"00qqpkfd","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1613616511917,"date-time":"2021-02-18T02:48:31Z","date-parts":[[2021,2,18]]},"cord_sha":"0a14f8858d2dcc80897aa3010fb20b7bf9bf67c0"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":384,"page_height":91},{"page_width":566,"page_height":1984},{"page_width":612,"page_height":792}],"runtime":13149},
  {"_key":"60c20b167723bebd866453d7","_id":"documents/60c20b167723bebd866453d7","_rev":"_cfFhBEq---","file_name":"00r6tzap.pdf","md5":"94023AAC4D28BBD7A9E0DAAB0402B581","id":"00r6tzap","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/r6/tz/ap/00r6tzap/00r6tzap.pdf","date":"2021-06-10T12:52+0000","metadata":{"alternative-id":["nu13020445"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1611878400000,"date-time":"2021-01-29T00:00:00Z","date-parts":[[2021,1,29]]}}],"volume":"13","pmid":"33572879","has_valid_tei":false,"created":{"timestamp":1611930322000,"date-time":"2021-01-29T14:25:22Z","date-parts":[[2021,1,29]]},"DOI":"10.3390/nu13020445","original-title":[],"title":["Do Chefs Value Health in Their Olive Oil Purchasing Decisions?"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":53,"page":"445","type":"journal-article","issued":{"date-parts":[[2021,1,29]]},"publisher":"MDPI AG","id":"00r6tzap","short-title":[],"pmcid":"PMC7912701","has_valid_oa_url":true,"deposited":{"timestamp":1612535970000,"date-time":"2021-02-05T14:39:30Z","date-parts":[[2021,2,5]]},"indexed":{"timestamp":1612567304410,"date-time":"2021-02-05T23:21:44Z","date-parts":[[2021,2,5]]},"is-referenced-by-count":0,"short-container-title":["Nutrients"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/5e/2b/PMC7912701.tar.gz","has_valid_thumbnail":false,"ISSN":["2072-6643"],"references-count":53,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,2]]}},"issn-type":[{"value":"2072-6643","type":"electronic"}],"container-title":["Nutrients"],"published-online":{"date-parts":[[2021,1,29]]},"issue":"2","member":"1968","abstract":"Amidst the public’s growing preoccupation with healthy eating, both inside and outside the home; an increase in people eating out; and the importance that olive oil has acquired in the markets due to its health benefits, the aim of this study is to find out whether health is also a relevant criterion for chefs in their olive oil purchase decisions. To this end, a survey was conducted of 400 chefs in Spain belonging to the international chefs’ association Euro-Toques. The results show that only 2% of the sample consider health to be a relevant criterion in the purchase of olive oils and that the attribute of “health” is not used by restaurants as an element of differentiation by which to position themselves in the market. These results lead us to conclude that the consumer demand for healthy foods (in this case, olive oils) is not being met by the restaurant sector. Moreover, this raises the question as to whether chefs actually make good opinion leaders, with all that this social role implies.","has_valid_pdf":true,"author":[{"sequence":"first","given":"María","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-8874-8069","family":"Gutierrez-Salcedo","affiliation":[]},{"sequence":"additional","family":"Parras-Rosa","given":"Manuel","affiliation":[]},{"sequence":"additional","given":"Francisco José","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-9832-1691","family":"Torres-Ruiz","affiliation":[]},{"sequence":"additional","given":"Manuela","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3934-9480","family":"Vega-Zamora","affiliation":[]}],"subject":["Food Science"],"link":[{"URL":"https://www.mdpi.com/2072-6643/13/2/445/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.3390/nu13020445","language":"en","score":1,"source":"Crossref","cord_sha":"60c8e73e27561c3e4302bab09d806ea000d0602e; c0e96eb0d6cdaace266508d0ce35cecd6cae42c9"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":16173},
  {"_key":"60c20b1e7723bebd866453da","_id":"documents/60c20b1e7723bebd866453da","_rev":"_cfFhBE2---","file_name":"00s2pabm.pdf","md5":"EE4B24E3DC393DE0828CDC92CFD8E23E","id":"00s2pabm","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/s2/pa/bm/00s2pabm/00s2pabm.pdf","date":"2021-06-10T12:52+0000","metadata":{"alternative-id":["42240"],"published-print":{"date-parts":[[2019,12]]},"article-number":"5681","language":"en","volume":"9","pmid":"30952938","journal-issue":{"published-print":{"date-parts":[[2019,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1038/s41598-019-42240-8","original-title":[],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1554422400000,"date-time":"2019-04-05T00:00:00Z","date-parts":[[2019,4,5]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","type":"journal-article","issued":{"date-parts":[[2019,4,5]]},"funder":[{"doi-asserted-by":"publisher","award":["2016R1D1A1B03931830"],"DOI":"10.13039/501100003725","name":"National Research Foundation of Korea"}],"publisher":"Springer Science and Business Media LLC","id":"00s2pabm","reference-count":29,"title":["Optimal blood pressure after reperfusion therapy in patients with acute ischemic stroke"],"oaLink":"https://www.nature.com/articles/s41598-019-42240-8.pdf","has_valid_oa_url":true,"deposited":{"timestamp":1585955935000,"date-time":"2020-04-03T23:18:55Z","date-parts":[[2020,4,3]]},"indexed":{"timestamp":1600005824057,"date-time":"2020-09-13T14:03:44Z","date-parts":[[2020,9,13]]},"is-referenced-by-count":1,"short-container-title":["Sci Rep"],"prefix":"10.1038","published-online":{"date-parts":[[2019,4,5]]},"has_valid_thumbnail":false,"references-count":29,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1038/s41598-019-42240-8","short-title":[],"issn-type":[{"value":"2045-2322","type":"electronic"}],"container-title":["Scientific Reports"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"We investigated the relationship between the mean blood pressure (BP) at 24-72 h and the clinical outcomes after acute ischemic stroke (AIS) in patients treated with reperfusion therapy. The primary outcome was measured using the modified Rankin Scale (mRS) at 3 months after AIS, and was based on the mean systolic BP at 24-72 h post-AIS. Favorable outcome was defined as mRS scores of 0-2. A total of 1,540 patients treated with reperfusion therapy were enrolled in the study. Favorable outcomes occurred more frequently in patients with BP ≤ 130/80 mmHg, and the risks of symptomatic intracranial hemorrhage and early neurological deterioration were lower in this optimal BP group. Multivariable analysis showed a significant association between mean BP ≤ 130/80 mmHg at 24-72 h and favorable outcomes at 3 months after AIS (odds ratio 2.95, 95% confidence interval 2.32-3.77, p < 0.001). Prespecified subgroup analyses showed that BP ≤ 130/80 mmHg had a more significant impact on clinical outcome in patients with recanalization than in those without recanalization. These data indicate that a mean BP of ≤ 130/80 mmHg at 24-72 h post-AIS is independently associated with favorable outcomes in patients treated with reperfusion therapy, particularly in those with recanalization.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Choi","given":"Kang-Ho","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Jae-Myung","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Ja-Hae","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Joon-Tae","affiliation":[]},{"sequence":"additional","family":"Park","given":"Man-Seok","affiliation":[]},{"sequence":"additional","family":"Choi","given":"Seong-Min","affiliation":[]},{"sequence":"additional","family":"Lee","given":"Seung-Han","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Byeong C.","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Myeong-Kyu","affiliation":[]},{"sequence":"additional","family":"Cho","given":"Ki-Hyun","affiliation":[]}],"subject":["Multidisciplinary"],"link":[{"URL":"http://www.nature.com/articles/s41598-019-42240-8.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://www.nature.com/articles/s41598-019-42240-8","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://www.nature.com/articles/s41598-019-42240-8.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1554458576000,"date-time":"2019-04-05T10:02:56Z","date-parts":[[2019,4,5]]},"ISSN":["2045-2322"],"assertion":[{"order":1,"value":"24 October 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"26 March 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"5 April 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"K.-H. Choi’s work has been funded by a National Research Foundation of Korea grant funded by the Korean government (NRF-2019M3A9E8020261). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. J.-M. Kim, J.-H. Kim, J.-T. Kim, M.-S. Park, S.-M. Choi, S.-H. Lee, B.-C. Kim, M.-K. Kim, and K.-H. Cho. declare no competing interests.","group":{"label":"Competing Interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362}],"runtime":7845},
  {"_key":"60c20b207723bebd866453dc","_id":"documents/60c20b207723bebd866453dc","_rev":"_cfFhBFC---","file_name":"00s30a1k.pdf","md5":"C7B65148B39A53D65E177F8C04D2B08F","id":"00s30a1k","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/s3/0a/1k/00s30a1k/00s30a1k.pdf","date":"2021-06-10T12:52+0000","metadata":{"alternative-id":["10.1080/09603123.2020.1831446"],"pmid":"33090891","author":[{"sequence":"first","given":"Malay","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7085-1236","family":"Pramanik","affiliation":[{"name":"Department of Development and Sustainability, School of Environment, Resources and Development,  Asian Institute of Technology (AIT) , PO. 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The results, based on the application of a Boosted Regression Tree algorithm method, show that average temperature and average relative humidity explain significant variations in COVID-19 transmission across temperate and subtropical regions, whereas in the tropical region, the average diurnal temperature range and temperature seasonality significantly predict the infection outbreak. The number of positive cases showed a decrease sharply above an average temperature of 10°C in the cities of France, Turkey, the US, the UK, and Germany. Among the tropical countries, COVID-19 in Indian cities is most affected by mean diurnal temperature, and those in Brazil by temperature seasonality. The findings have implications on public health interventions, and contribute to the ongoing scientific and policy discourse on the complex interplay of climatic factors determining the risks of COVID-19 transmission.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1080/tandf_crossmark_01","link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/09603123.2020.1831446","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1603394555000,"date-time":"2020-10-22T19:22:35Z","date-parts":[[2020,10,22]]},"language":"en","assertion":[{"order":1,"value":"The publishing and review policy for this title is described in its Aims & Scope.","label":"Peer Review Statement","name":"peerreview_statement"},{"order":2,"URL":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=cije20","value":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=cije20","label":"Aim & Scope","name":"aims_and_scope_url"},{"order":0,"value":"2020-08-02","group":{"label":"Publication History","name":"publication_history"},"label":"Received","name":"received"},{"order":2,"value":"2020-09-28","group":{"label":"Publication History","name":"publication_history"},"label":"Accepted","name":"accepted"},{"order":3,"value":"2020-10-22","group":{"label":"Publication History","name":"publication_history"},"label":"Published","name":"published"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":634.32,"page_height":833.04},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992},{"page_width":493.228,"page_height":702.992}],"runtime":8000},
  {"_key":"60c20b257723bebd866453de","_id":"documents/60c20b257723bebd866453de","_rev":"_cfFhBFO---","file_name":"00sospz3.pdf","md5":"29EB9EED8EFA25987B84E8AF42A128C8","id":"00sospz3","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/so/sp/z3/00sospz3/00sospz3.pdf","date":"2021-06-10T12:52+0000","metadata":{"published-print":{"date-parts":[[2017]]},"volume":"21","pmid":"29026282","author":[{"sequence":"first","family":"Seifarth","given":"Federico G.","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Michael H.","affiliation":[]},{"sequence":"additional","family":"Ayala","given":"Dimaris","affiliation":[]},{"sequence":"additional","family":"Worley","given":"Sarah","affiliation":[]},{"sequence":"additional","family":"Moslim","given":"Maitham A.","affiliation":[]}],"DOI":"10.4293/jsls.2017.00031","original-title":[],"short-container-title":["JSLS"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":0,"page":"e2017.00031","type":"journal-article","issued":{"date-parts":[[2017]]},"publisher":"The Society of Laparoendoscopic Surgeons","id":"00sospz3","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1507878014000,"date-time":"2017-10-13T07:00:14Z","date-parts":[[2017,10,13]]},"indexed":{"timestamp":1596367026396,"date-time":"2020-08-02T11:17:06Z","date-parts":[[2020,8,2]]},"is-referenced-by-count":2,"title":["Hybrid Single-Port Cholecystectomy Vs Four-Port Cholecystectomy in Children"],"prefix":"10.4293","oaLink":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617561/pdf/e2017.00031.pdf","has_valid_thumbnail":false,"references-count":0,"license-simplified":"cc-by-nc-nd","subtitle":[],"URL":"http://dx.doi.org/10.4293/jsls.2017.00031","ISSN":["1086-8089","1938-3797"],"issn-type":[{"value":"1086-8089","type":"print"},{"value":"1938-3797","type":"electronic"}],"container-title":["JSLS : Journal of the Society of Laparoendoscopic Surgeons"],"has_valid_ref_annotation":false,"issue":"3","member":"2844","abstract":"BACKGROUND AND OBJECTIVES Evidence is increasing that single-port or single-incision laparoscopic cholecystectomy is a safe and feasible alternative for cholecystectomy in children. In this study, we sought to compare the single-port hybrid technique, which we originally reported in 2012, with the conventional 4-port approach, in regards of complications, outcome, operative time and cost. METHODS A retrospective, single-center comparison of hybrid single-port versus conventional 4-port laparoscopic cholecystectomy was performed in 98 consecutive pediatric patients between January 2010 and October 2014. Patient characteristics, intra- and postoperative outcomes, operative costs, and total hospitalization costs were compared between the 2 approaches using univariate and multivariate analyses. RESULTS The single-port technique was utilized in 56 (57%) pediatric patients who underwent laparoscopic cholecystectomy. The operative time for single-port procedures was shorter than that of the conventional technique (median, 85 minutes vs 114 minutes; P = .003). Patients with single-port procedures were less likely to have a cholangiogram compared to patients who underwent 4-port cholecystectomy. (9% vs 40%; P < .001). No statistically significant differences between the 2 cohorts were observed for intra- or postoperative outcomes. Although the 2 groups shared nearly the same median duration of hospitalization (22 hours vs 21 hours; P = .70), the single-port group demonstrated a lower total cost of hospitalization (median cost, $7438 vs $8783; P = .030) and lower operative cost (median, $3918 vs $4647; P < .001). CONCLUSION Hybrid single-port laparoscopic cholecystectomy in children with uncomplicated gallbladder disease is feasible and equally safe, with similar intra- and postoperative outcomes compared with the conventional 4-port approach. It can contribute to global cost reduction because of lower operative and total hospitalization costs.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Surgery"],"link":[{"URL":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617561/","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{},"created":{"timestamp":1507878014000,"date-time":"2017-10-13T07:00:14Z","date-parts":[[2017,10,13]]},"journal-issue":{"published-print":{"date-parts":[[2017]]},"issue":"3"},"score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783}],"runtime":5729},
  {"_key":"60c20b287723bebd866453e0","_id":"documents/60c20b287723bebd866453e0","_rev":"_cfFhBFa---","file_name":"00qriy55.pdf","md5":"AB882DA43C75F676127F0F167DC0CA2C","id":"00qriy55","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/qr/iy/55/00qriy55/00qriy55.pdf","date":"2021-06-10T12:52+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,11,6]]},"license-simplified":"biorxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.11.04.358739","group-title":"Molecular Biology","oaLink":"https://www.biorxiv.org/content/biorxiv/early/2020/11/06/2020.11.04.358739.full.pdf","original-title":[],"title":["Human Chr18: “Stakhanovite” Genes, Missing and uPE1 Proteins in Liver Tissue and HepG2 Cells"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":55,"short-title":[],"issued":{"date-parts":[[2020,11,4]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,11,4]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Missing (MP) and functionally uncharacterized proteins (uPE1) comprise less than 5% of the total number of human Chr18 genes. Within half a year, since the January 2020 version of NextProt, the number of entries in the MP+uPE1 datasets has changed, mainly due to the achievements of antibody-based proteomics. Assuming that the proteome is closely related to the transcriptome scaffold, quantitative PCR, Illumina HiSeq, and Oxford Nanopore Technology were applied to characterize the liver samples of three male donors compared with the HepG2 cell line. The data mining of Expression Atlas (EMBL-EBI) and the profiling of our biospecimens using orthogonal methods of transcriptome analysis have shown that in HepG2 cells and the liver, the genes encoding functionally uncharacterized proteins (uPE1) are expressed as low as for the missing proteins (less than 1 copy per cell), except for selected cases of HSBP1L1, TMEM241, C18orf21, and KLHL14. The initial expectation that uPE1 genes might be expressed at higher levels than MP genes, was compromised by severe discrepancies in our semi-quantitative gene expression data and in public databanks. Such discrepancy forced us to revisit the transcriptome of Chr18, the target of Russian C-HPP Consortia. Tanglegram of highly expressed genes and further correlation analysis have shown the severe dependencies on the mRNA extraction method and analytical platform. Targeted gene expression analysis by quantitative PCR (qPCR) and high-throughput transcriptome profiling (Illumina HiSeq and ONT MinION) for the same set of samples from normal liver tissue and HepG2 cells revealed the detectable expression of 250+ (92%) protein-coding genes of Chr18 (at least one method). The expression of slightly more than 50% protein-coding genes was detected simultaneously by all three methods. Correlation analysis of the gene expression profiles showed that the grouping of the datasets depended almost equally on both the type of biological material and the experimental method, particularly cDNA/mRNA isolation and library preparation. The dependence on the choice of bioinformatics analysis pipeline was also noticeable but significantly less. Furthermore, the combination of Illumina HiSeq and ONT MinION sequencing to validate proteotypic peptides of missing and uPE1 proteins was performed for the heat-shock factor binding protein HSBP1L1 (missing protein, recently transferred to PE1 category) and uncharacterized protein C18orf21 (uPE1). We observed that a nonsynonymous SNP led to the loss of the site of trypsinolysis in HSBP1L1. The modified version of HSBP1L1 was included in the sequence database and searched against the MS/MS dataset from Kulak, Geyer & Mann (2017), but delivered no significant identification. Thus, HSBP1L1 is still missing for the MS-pillar of C-HPP, although its existence at the protein level has been confirmed.","deposited":{"timestamp":1605024984000,"date-time":"2020-11-10T16:16:24Z","date-parts":[[2020,11,10]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Krasnov","given":"George S.","affiliation":[]},{"sequence":"additional","family":"Radko","given":"Sergey P.","affiliation":[]},{"sequence":"additional","family":"Ptitsyn","given":"Konstantin G.","affiliation":[]},{"sequence":"additional","family":"Shapovalova","given":"Valeriya V.","affiliation":[]},{"sequence":"additional","family":"Timoshenko","given":"Olga S.","affiliation":[]},{"sequence":"additional","family":"Khmeleva","given":"Svetlana A.","affiliation":[]},{"sequence":"additional","family":"Kurbatov","given":"Leonid K.","affiliation":[]},{"sequence":"additional","family":"Kiseleva","given":"Yana Y.","affiliation":[]},{"sequence":"additional","family":"Ilgisonis","given":"Ekaterina V.","affiliation":[]},{"sequence":"additional","family":"Pyatnitskiy","given":"Mikhail A.","affiliation":[]},{"sequence":"additional","family":"Poverennaya","given":"Ekaterina V.","affiliation":[]},{"sequence":"additional","family":"Kiseleva","given":"Olga I.","affiliation":[]},{"sequence":"additional","family":"Vakhrushev","given":"Igor V.","affiliation":[]},{"sequence":"additional","family":"Tsvetkova","given":"Anastasia V.","affiliation":[]},{"sequence":"additional","family":"Buromski","given":"Ivan V.","affiliation":[]},{"sequence":"additional","family":"Markin","given":"Sergey S.","affiliation":[]},{"sequence":"additional","family":"Zgoda","given":"Victor G.","affiliation":[]},{"sequence":"additional","family":"Archakov","given":"Alexander I.","affiliation":[]},{"sequence":"additional","family":"Lisitsa","given":"Andrey V.","affiliation":[]},{"sequence":"additional","family":"Ponomarenko","given":"Elena A.","affiliation":[]}],"DOI":"10.1101/2020.11.04.358739","reference-count":55,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.11.04.358739","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1604559618000,"date-time":"2020-11-05T07:00:18Z","date-parts":[[2020,11,5]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"bioRxiv"},"id":"00qriy55","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1605026634001,"date-time":"2020-11-10T16:43:54Z","date-parts":[[2020,11,10]]},"cord_sha":"0bc3644e8877888dd776644dad4d9568688927eb"},"application":"software-mentions","pages":[{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04},{"page_width":594.96,"page_height":842.04}],"runtime":33869},
  {"_key":"60c20b2f7723bebd8664540e","_id":"documents/60c20b2f7723bebd8664540e","_rev":"_cfFhBFm---","file_name":"00t28df6.pdf","md5":"B69FF33E636383FD0F70D6C92EB1CE47","id":"00t28df6","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/t2/8d/f6/00t28df6/00t28df6.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["S0264410X11007213"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1309478400000,"date-time":"2011-07-01T00:00:00Z","date-parts":[[2011,7,1]]}}],"volume":"29","pmid":"21605614","has_valid_tei":false,"DOI":"10.1016/j.vaccine.2011.05.012","original-title":[],"short-container-title":["Vaccine"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":32,"page":"5267-5275","type":"journal-article","issued":{"date-parts":[[2011,7]]},"publisher":"Elsevier BV","id":"00t28df6","short-title":[],"pmcid":"PMC7126856","has_valid_oa_url":true,"deposited":{"timestamp":1592586885000,"date-time":"2020-06-19T17:14:45Z","date-parts":[[2020,6,19]]},"indexed":{"timestamp":1607046319217,"date-time":"2020-12-04T01:45:19Z","date-parts":[[2020,12,4]]},"is-referenced-by-count":38,"title":["Bovine Neonatal Pancytopenia: Is this alloimmune syndrome caused by vaccine-induced alloreactive antibodies?"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/ff/3b/PMC7126856.tar.gz","has_valid_thumbnail":false,"ISSN":["0264-410X"],"references-count":32,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.vaccine.2011.05.012","journal-issue":{"published-print":{"date-parts":[[2011,7]]},"issue":"32"},"issn-type":[{"value":"0264-410X","type":"print"}],"container-title":["Vaccine"],"has_valid_ref_annotation":false,"issue":"32","member":"78","abstract":"Bovine Neonatal Pancytopenia (BNP) is a new emerging disease observed since 2007 in Germany and neighbouring countries. The syndrome affects newborn calves and is characterized by pancytopenia, severe bleeding and high lethality. So far, a causative role of infectious or toxic agents has been ruled out. Instead, the syndrome is induced after ingestion of colostrum, the first milk that supplies the calf with maternal antibodies. In analogy to similar diseases in humans it has therefore been postulated that BNP is caused by alloreactive, maternal antibodies. There is a striking association between BNP and a previous vaccination of the respective dams with a particular vaccine against Bovine Virus Diarrhoea (BVD). This association has led to a suspension of the marketing authorisation for the vaccine, by the European Commission. The current study investigates the role of this vaccine in the pathogenesis of BNP. By flow cytometry we were able to demonstrate that sera of BNP dams (dams that gave birth to a BNP calf) harbour alloreactive antibodies binding to surface antigens on bovine leukocytes. A significantly weaker alloreactivity was observed with sera of non-BNP dams that have been vaccinated with the same vaccine but delivered healthy calves. No binding was seen with non-BVD-vaccinated control cows and animals that were vaccinated with other inactivated BVD vaccines so far not associated with BNP. The binding is functionally relevant, because opsonization of bovine leukocytes with alloantibodies led to an elevated cytophagocytosis by bovine macrophages. To test whether the vaccine induces alloreactive antibodies two strategies were employed: Guinea pigs were vaccinated with a panel of commercially available BVD-vaccines. Only the incriminated vaccine induced antibodies binding surface antigens on bovine leukocytes. Additionally, two calves were repeatedly vaccinated with the suspected vaccine and the development of alloreactivity was monitored. In dependence of the number of booster immunizations the induction of alloreactive antibodies could be observed. Finally, by affinity purification we were able to directly demonstrate that BNP associated alloantibodies cross react with the bovine kidney cell line used for vaccine production. Together this provides strong evidence that this particular BVD vaccine has the potential to induce BNP associated alloantibodies.","published-print":{"date-parts":[[2011,7]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Bastian","given":"Max","affiliation":[]},{"sequence":"additional","family":"Holsteg","given":"Mark","affiliation":[]},{"sequence":"additional","family":"Hanke-Robinson","given":"Heidrun","affiliation":[]},{"sequence":"additional","family":"Duchow","given":"Karin","affiliation":[]},{"sequence":"additional","family":"Cussler","given":"Klaus","affiliation":[]}],"subject":["Public Health, Environmental and Occupational Health","General Immunology and Microbiology","Molecular Medicine","General Veterinary","Infectious Diseases"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0264410X11007213?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0264410X11007213?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1306433330000,"date-time":"2011-05-26T18:08:50Z","date-parts":[[2011,5,26]]},"language":"en","score":1,"source":"Crossref","cord_sha":"dd8738920d2fdd2f606f249d47665b32dc33f1ea"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7},{"page_width":595.3,"page_height":793.7}],"runtime":12344},
  {"_key":"60c20b307723bebd86645410","_id":"documents/60c20b307723bebd86645410","_rev":"_cfFhBFy---","file_name":"00szhzq1.pdf","md5":"FEEB828E1F85B49F2DC63188B570D1E1","id":"00szhzq1","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/sz/hz/q1/00szhzq1/00szhzq1.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["10.3399/BJGP.2020.0750"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1549929600000,"date-time":"2019-02-12T00:00:00Z","date-parts":[[2019,2,12]]}}],"volume":"71","pmid":"33558330","journal-issue":{"published-print":{"date-parts":[[2021,4]]},"issue":"705","published-online":{"date-parts":[[2021,3,26]]}},"has_valid_tei":false,"DOI":"10.3399/bjgp.2020.0750","license-simplified":"cc-by","original-title":[],"published-print":{"date-parts":[[2021,4]]},"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":37,"page":"e258-e265","type":"journal-article","issued":{"date-parts":[[2020,12,14]]},"publisher":"Royal College of General Practitioners","id":"00szhzq1","short-title":[],"title":["Diagnosing community-acquired pneumonia via a smartphone-based algorithm: a prospective cohort study in primary and acute-care consultations"],"has_valid_oa_url":true,"deposited":{"timestamp":1617100171000,"date-time":"2021-03-30T10:29:31Z","date-parts":[[2021,3,30]]},"indexed":{"timestamp":1617102671267,"date-time":"2021-03-30T11:11:11Z","date-parts":[[2021,3,30]]},"is-referenced-by-count":0,"short-container-title":["Br J Gen Pract"],"prefix":"10.3399","oaLink":"https://bjgp.org/content/bjgp/early/2021/02/08/BJGP.2020.0750.full.pdf","has_valid_thumbnail":false,"references-count":37,"published-online":{"date-parts":[[2020,12,14]]},"subtitle":[],"URL":"http://dx.doi.org/10.3399/bjgp.2020.0750","ISSN":["0960-1643","1478-5242"],"issn-type":[{"value":"0960-1643","type":"print"},{"value":"1478-5242","type":"electronic"}],"container-title":["British Journal of General Practice"],"has_valid_ref_annotation":false,"issue":"705","member":"1987","abstract":"BACKGROUND Community-acquired pneumonia (CAP) is an essential consideration in patients presenting to primary care with respiratory symptoms; however, accurate diagnosis is difficult when clinical and radiological examinations are not possible, such as during telehealth consultations. AIM To develop and test a smartphone-based algorithm for diagnosing CAP without need for clinical examination or radiological inputs. DESIGN AND SETTING A prospective cohort study using data from participants aged >12 years presenting with acute respiratory symptoms to a hospital in Western Australia. METHOD Five cough audio-segments were recorded and four patient-reported symptoms (fever, acute cough, productive cough, and age) were analysed by the smartphone-based algorithm to generate an immediate diagnostic output for CAP. Independent cohorts were recruited to train and test the accuracy of the algorithm. Diagnostic agreement was calculated against the confirmed discharge diagnosis of CAP by specialist physicians. Specialist radiologists reported medical imaging. RESULTS The smartphone-based algorithm had high percentage agreement (PA) with the clinical diagnosis of CAP in the total cohort (n = 322, positive PA [PPA] = 86.2%, negative PA [NPA] = 86.5%, area under the receiver operating characteristic curve [AUC] = 0.95); in participants 22-<65 years (n = 192, PPA = 85.7%, NPA = 87.0%, AUC = 0.94), and in participants aged ≥65 years (n = 86, PPA = 85.7%, NPA = 87.5%, AUC = 0.94). Agreement was preserved across CAP severity: 85.1% (n = 80/94) of participants with CRB-65 scores 1 or 2, and 87.7% (n = 57/65) with a score of 0, were correctly diagnosed by the algorithm. CONCLUSION The algorithm provides rapid and accurate diagnosis of CAP. It offers improved accuracy over current protocols when clinical evaluation is difficult. It provides increased capabilities for primary and acute care, including telehealth services, required during the COVID-19 pandemic.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Porter","given":"Paul","affiliation":[]},{"sequence":"additional","given":"Joanna","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3364-5414","family":"Brisbane","affiliation":[]},{"sequence":"additional","family":"Abeyratne","given":"Udantha","affiliation":[]},{"sequence":"additional","family":"Bear","given":"Natasha","affiliation":[]},{"sequence":"additional","family":"Wood","given":"Javan","affiliation":[]},{"sequence":"additional","family":"Peltonen","given":"Vesa","affiliation":[]},{"sequence":"additional","family":"Della","given":"Phillip","affiliation":[]},{"sequence":"additional","family":"Smith","given":"Claire","affiliation":[]},{"sequence":"additional","family":"Claxton","given":"Scott","affiliation":[]}],"subject":["Family Practice"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.3399/BJGP.2020.0750","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1608155455000,"date-time":"2020-12-16T21:50:55Z","date-parts":[[2020,12,16]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":14591},
  {"_key":"60c20b347723bebd86645412","_id":"documents/60c20b347723bebd86645412","_rev":"_cfFhBG----","file_name":"00tprg6w.pdf","md5":"812167A2DAFAAD0D308675344FB7C6DE","id":"00tprg6w","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/tp/rg/6w/00tprg6w/00tprg6w.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["S0022215120001267"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1592438400000,"date-time":"2020-06-18T00:00:00Z","date-parts":[[2020,6,18]]}}],"volume":"134","pmid":"32613916","has_valid_tei":false,"created":{"timestamp":1592465407000,"date-time":"2020-06-18T07:30:07Z","date-parts":[[2020,6,18]]},"DOI":"10.1017/s0022215120001267","original-title":[],"published-print":{"date-parts":[[2020,8]]},"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":11,"page":"680-683","type":"journal-article","issued":{"date-parts":[[2020,6,18]]},"publisher":"Cambridge University Press (CUP)","id":"00tprg6w","short-title":[],"title":["North East London coronavirus disease 2019 protocol for diagnostics in two-week wait head and neck cancer patients"],"pmcid":"PMC7399153","has_valid_oa_url":true,"deposited":{"timestamp":1615290679000,"date-time":"2021-03-09T11:51:19Z","date-parts":[[2021,3,9]]},"indexed":{"timestamp":1615292121584,"date-time":"2021-03-09T12:15:21Z","date-parts":[[2021,3,9]]},"is-referenced-by-count":3,"short-container-title":["J. Laryngol. Otol."],"prefix":"10.1017","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/dd/f6/PMC7399153.tar.gz","has_valid_thumbnail":false,"ISSN":["0022-2151","1748-5460"],"references-count":11,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"published-print":{"date-parts":[[2020,8]]},"issue":"8"},"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"container-title":["The Journal of Laryngology & Otology"],"published-online":{"date-parts":[[2020,6,18]]},"issue":"8","member":"56","abstract":"BACKGROUND: The coronavirus disease 2019 pandemic requires urgent modification to existing head and neck cancer diagnosis and management practices. A protocol was established that utilises risk stratification, early investigation prior to clinical review and a reduction in aerosol generating procedures to lessen the risk of coronavirus disease 2019 spread. METHODS: Two-week wait referrals were stratified into low, intermediate and high risk. Low risk patients were referred back to primary care with advice; intermediate and high risk patients underwent investigation. Clinical encounters and aerosol generating procedures were minimised. A combined diagnostic and therapeutic surgical approach was undertaken where possible. RESULTS: Forty-one patients were used to assess feasibility. Thirty-one per cent were low risk, 35 per cent were intermediate and 33 per cent were high risk. Thirty-three per cent were discharged with no imaging. CONCLUSION: Implementing this protocol reduces the future burden on tertiary services, by empowering primary care physicians to re-refer low risk patients. The protocol is applicable across the UK and avoids diagnostic delay.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Warner","given":"E","affiliation":[]},{"sequence":"additional","family":"Scholfield","given":"D W","affiliation":[]},{"sequence":"additional","family":"Adams","given":"A","affiliation":[]},{"sequence":"additional","family":"Richards","given":"P","affiliation":[]},{"sequence":"additional","family":"Ali","given":"S","affiliation":[]},{"sequence":"additional","family":"Ahmed","given":"J","affiliation":[]},{"sequence":"additional","family":"Ghufoor","given":"K","affiliation":[]}],"subject":["Otorhinolaryngology","General Medicine"],"link":[{"URL":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022215120001267","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1017/s0022215120001267","language":"en","score":1,"source":"Crossref","cord_sha":"f8888e195680f58ab6a413e7cafcf1b17339c549"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":13143},
  {"_key":"60c20b3d7723bebd86645414","_id":"documents/60c20b3d7723bebd86645414","_rev":"_cfFhBGK---","file_name":"00tal94i.pdf","md5":"8FE5ED345E83CEB000A2BE2105838A0A","id":"00tal94i","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/ta/l9/4i/00tal94i/00tal94i.pdf","date":"2021-06-10T12:53+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-50423-6_4","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"45-58","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"00tal94i","reference-count":18,"title":["Grammatical Inference by Answer Set Programming"],"pmcid":"PMC7303697","has_valid_oa_url":true,"deposited":{"timestamp":1592564886000,"date-time":"2020-06-19T11:08:06Z","date-parts":[[2020,6,19]]},"indexed":{"timestamp":1592566841044,"date-time":"2020-06-19T11:40:41Z","date-parts":[[2020,6,19]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,6,15]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030504229","type":"print"},{"value":"9783030504236","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/34/c8/PMC7303697.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-50423-6_4","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Lecture Notes in Computer Science","Computational Science – ICCS 2020"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"In this paper, the identification of context-free grammars based on the presentation of samples is investigated. The main idea of solving this problem proposed in the literature is reformulated in two different ways: in terms of general constrains and as an answer set program. In a series of experiments, we showed that our answer set programming approach is much faster than our alternative method and the original SAT encoding method. Similarly to a pioneer work, some well-known context-free grammars have been induced correctly, and we also followed its test procedure with randomly generated grammars, making it clear that using our answer set programs increases computational efficiency. The research can be regarded as another evidence that solutions based on the stable model (answer set) semantics of logic programming may be a right choice for complex problems.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Wojciech","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3191-9151","family":"Wieczorek","affiliation":[]},{"sequence":"additional","given":"Łukasz","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1074-2847","family":"Strąk","affiliation":[]},{"sequence":"additional","given":"Arkadiusz","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8304-5746","family":"Nowakowski","affiliation":[]},{"sequence":"additional","given":"Olgierd","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-4722-176X","family":"Unold","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030504229","9783030504236"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-50423-6_4","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1592560981000,"date-time":"2020-06-19T10:03:01Z","date-parts":[[2020,6,19]]},"references-count":18,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"15 June 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"ICCS","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"International Conference on Computational Science","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Amsterdam","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"The Netherlands","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"3 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"5 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"20","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"iccs-computsci2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"https://www.iccs-meeting.org/iccs2020/","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Single-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"230","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"98","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"3","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"43% - The value is computed by the equation \"Number of Full Papers Accepted / Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Acceptance Rate of Full Papers","name":"acceptance_rate_of_full_papers"},{"order":7,"value":"2.5","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Reviews per Paper","name":"average_number_of_reviews_per_paper"},{"order":8,"value":"4","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Papers per Reviewer","name":"average_number_of_papers_per_reviewer"},{"order":9,"value":"Yes","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"External Reviewers Involved","name":"external_reviewers_involved"},{"order":10,"value":"248 workshop papers were selected from 489 submissions to the thematic tracks. The conference was canceled due to the COVID-19 pandemic.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Additional Info on Review Process","name":"additional_info_on_review_process"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"4d5c137435acb3275d289724597382822ce67e54"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":24956},
  {"_key":"60c20b3f7723bebd8664541d","_id":"documents/60c20b3f7723bebd8664541d","_rev":"_cfFhBGW---","file_name":"00tgpr65.pdf","md5":"A7E4CFA3037C8981EC468400CE1DEB57","id":"00tgpr65","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/tg/pr/65/00tgpr65/00tgpr65.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["929"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1588032000000,"date-time":"2020-04-28T00:00:00Z","date-parts":[[2020,4,28]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1588032000000,"date-time":"2020-04-28T00:00:00Z","date-parts":[[2020,4,28]]}}],"article-number":"198","volume":"3","pmid":"32346058","journal-issue":{"published-print":{"date-parts":[[2020,12]]},"issue":"1"},"has_valid_tei":false,"created":{"timestamp":1588068261000,"date-time":"2020-04-28T10:04:21Z","date-parts":[[2020,4,28]]},"DOI":"10.1038/s42003-020-0929-x","original-title":[],"published-print":{"date-parts":[[2020,12]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":58,"type":"journal-article","issued":{"date-parts":[[2020,4,28]]},"publisher":"Springer Science and Business Media LLC","id":"00tgpr65","short-title":[],"title":["The challenge of intracellular antibiotic accumulation, a function of fluoroquinolone influx versus bacterial efflux"],"has_valid_oa_url":true,"deposited":{"timestamp":1613809812000,"date-time":"2021-02-20T08:30:12Z","date-parts":[[2021,2,20]]},"indexed":{"timestamp":1615249467079,"date-time":"2021-03-09T00:24:27Z","date-parts":[[2021,3,9]]},"is-referenced-by-count":6,"short-container-title":["Commun Biol"],"prefix":"10.1038","oaLink":"https://www.nature.com/articles/s42003-020-0929-x.pdf","has_valid_thumbnail":false,"references-count":58,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"ISSN":["2399-3642"],"issn-type":[{"value":"2399-3642","type":"electronic"}],"container-title":["Communications Biology"],"score":1,"published-online":{"date-parts":[[2020,4,28]]},"issue":"1","member":"297","abstract":"With the spreading of antibiotic resistance, the translocation of antibiotics through bacterial envelopes is crucial for their antibacterial activity. In Gram-negative bacteria, the interplay between membrane permeability and drug efflux pumps must be investigated as a whole. Here, we quantified the intracellular accumulation of a series of fluoroquinolones in population and in individual cells of Escherichia coli according to the expression of the AcrB efflux transporter. Computational results supported the accumulation levels measured experimentally and highlighted how fluoroquinolones side chains interact with specific residues of the distal pocket of the AcrB tight monomer during recognition and binding steps.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Vergalli","given":"Julia","affiliation":[]},{"sequence":"additional","family":"Atzori","given":"Alessio","affiliation":[]},{"sequence":"additional","family":"Pajovic","given":"Jelena","affiliation":[]},{"sequence":"additional","family":"Dumont","given":"Estelle","affiliation":[]},{"sequence":"additional","given":"Giuliano","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-5985-257X","family":"Malloci","affiliation":[]},{"sequence":"additional","family":"Masi","given":"Muriel","affiliation":[]},{"sequence":"additional","given":"Attilio Vittorio","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-4013-8867","family":"Vargiu","affiliation":[]},{"sequence":"additional","given":"Mathias","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1604-3318","family":"Winterhalter","affiliation":[]},{"sequence":"additional","given":"Matthieu","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3281-2308","family":"Réfrégiers","affiliation":[]},{"sequence":"additional","given":"Paolo","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-0825-0824","family":"Ruggerone","affiliation":[]},{"sequence":"additional","given":"Jean-Marie","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-7092-7977","family":"Pagès","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://www.nature.com/articles/s42003-020-0929-x.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://www.nature.com/articles/s42003-020-0929-x","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://www.nature.com/articles/s42003-020-0929-x.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1038/s42003-020-0929-x","language":"en","assertion":[{"order":1,"value":"6 December 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"31 March 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"28 April 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"The authors declare no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362}],"runtime":25609},
  {"_key":"60c20b437723bebd86645428","_id":"documents/60c20b437723bebd86645428","_rev":"_cfFhBGi---","file_name":"00uejbyg.pdf","md5":"CFDCA8F52971D13D3A81237EFDF4D724","id":"00uejbyg","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/ue/jb/yg/00uejbyg/00uejbyg.pdf","date":"2021-06-10T12:53+0000","metadata":{"published-print":{"date-parts":[[2021,1]]},"volume":"10","pmid":"33633950","author":[{"sequence":"first","family":"Zhou","given":"Qi","affiliation":[]},{"sequence":"additional","family":"Li","given":"Weiguo","affiliation":[]},{"sequence":"additional","family":"Zhao","given":"Siya","affiliation":[]},{"sequence":"additional","family":"Li","given":"Qinyuan","affiliation":[]},{"sequence":"additional","family":"Shi","given":"Qianling","affiliation":[]},{"sequence":"additional","family":"Wang","given":"Zijun","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Hui","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Xiao","affiliation":[]},{"sequence":"additional","family":"Estill","given":"Janne","affiliation":[]},{"sequence":"additional","family":"Luo","given":"Zhengxiu","affiliation":[]},{"sequence":"additional","family":"Li","given":"Qiu","affiliation":[]},{"sequence":"additional","family":"Yang","given":"Kehu","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Enmei","affiliation":[]},{"sequence":"additional","family":"Chen","given":"Yaolong","affiliation":[]}],"DOI":"10.21037/tp-20-290","license-simplified":"unk","original-title":[],"title":["Guidelines for the Management of Children and Adolescent with COVID-19: protocol for an update"],"content-domain":{"domain":["amegroups.com"],"crossmark-restriction":false},"reference-count":0,"page":"177-182","type":"journal-article","issued":{"date-parts":[[2021,1]]},"update-policy":"http://dx.doi.org/10.21037/ame_crossmark_policy","publisher":"AME Publishing Company","id":"00uejbyg","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1611643832000,"date-time":"2021-01-26T06:50:32Z","date-parts":[[2021,1,26]]},"indexed":{"timestamp":1611645390323,"date-time":"2021-01-26T07:16:30Z","date-parts":[[2021,1,26]]},"is-referenced-by-count":0,"short-container-title":["Transl Pediatr"],"prefix":"10.21037","published-online":{"date-parts":[[2021,1]]},"has_valid_thumbnail":false,"references-count":0,"oaLink":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7882303/pdf/","subtitle":[],"URL":"http://dx.doi.org/10.21037/tp-20-290","ISSN":["2224-4336","2224-4344"],"issn-type":[{"value":"2224-4336","type":"print"},{"value":"2224-4344","type":"electronic"}],"container-title":["Translational Pediatrics"],"has_valid_ref_annotation":false,"issue":"1","member":"8611","abstract":"Background Coronavirus disease 2019 (COVID-19) has become a constant threat to people's lives, bringing huge challenges to the global public health and medical service system. In order to ensure the timeliness and reliability of the recommendations in guidelines, the working group of the Rapid Advice Guidelines for Management of Children with COVID-19 decided to update the guideline to incorporate the latest evidence to guide the management of COVID-19 in children and adolescent. Methods We will update the guidelines, originally developed as a rapid advice guideline, into a standard guideline. We will follow the clinical practice guideline (CPG) update manuals of the National Institute for Health and Clinical Excellence (NICE) and the Spanish National Health System (SNHS). The updated guidelines will also follow the RIGHT (Reporting Items for Practice Guidelines in Healthcare) checklist and Checklist for the Reporting of Updated Guidelines (CheckUp). Discussion Through systematic search, evaluation and grading of the best available relevant clinical evidence, combined with the experience of frontline clinical experts in the fight against the epidemic and the wishes of patients and their caretakers, we will update our previous rapid advice guidelines into a high-quality, implementable standard guidelines for the management of COVID-19 in children and adolescent. Trial registration The standard guideline update has been registered at the International Practice Guidelines Registry Platform (http://guidelines-registry.cn/?lang=en, registration No. IPGRP-2020CN101).","has_valid_pdf":true,"has_valid_tei":false,"subject":["Pediatrics, Perinatology, and Child Health"],"link":[{"URL":"https://tp.amegroups.com/article/download/59007/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{},"created":{"timestamp":1611643811000,"date-time":"2021-01-26T06:50:11Z","date-parts":[[2021,1,26]]},"journal-issue":{"published-print":{"date-parts":[[2021,1]]},"issue":"1","published-online":{"date-parts":[[2021,1]]}},"score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528}],"runtime":3640},
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We also find that both image related and textual attributes have significant incremental predictive power over each other.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s41109-021-00358-7.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s41109-021-00358-7/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s41109-021-00358-7.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1615258981000,"date-time":"2021-03-09T03:03:01Z","date-parts":[[2021,3,9]]},"ISSN":["2364-8228"],"assertion":[{"order":1,"value":"13 October 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"2 February 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"9 March 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"cbecffca88603cdb4951669bc59d4231675cef79"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":14689},
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  {"_key":"60c20b577723bebd8664543e","_id":"documents/60c20b577723bebd8664543e","_rev":"_cfFhBHm---","file_name":"00z7x46i.pdf","md5":"1458702E11A539576F2F892A8FB4ED4F","id":"00z7x46i","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/z7/x4/6i/00z7x46i/00z7x46i.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["S0907444904027258"],"license":[{"URL":"http://journals.iucr.org/services/copyrightpolicy.html","content-version":"vor","delay-in-days":0,"start":{"timestamp":1101427200000,"date-time":"2004-11-26T00:00:00Z","date-parts":[[2004,11,26]]}},{"URL":"http://journals.iucr.org/services/copyrightpolicy.html#TDM","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1101427200000,"date-time":"2004-11-26T00:00:00Z","date-parts":[[2004,11,26]]}}],"volume":"60","pmid":"15583393","journal-issue":{"published-print":{"date-parts":[[2004,12]]},"issue":"12"},"has_valid_tei":false,"DOI":"10.1107/s0907444904027258","license-simplified":"no-cc","original-title":[],"short-container-title":["Acta Crystallogr D Biol Cryst","Acta Cryst D","Acta Crystallogr Sect D Biol Crystallogr","Acta Crystallogr Sect D","Acta Crystallogr D Biol Crystallogr","Acta Cryst Sect D","Acta Crystallogr D"],"content-domain":{"domain":["iucr.org","wiley.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1107/cm_01","page":"2377-2379","type":"journal-article","issued":{"date-parts":[[2004,11,26]]},"publisher":"International Union of Crystallography (IUCr)","id":"00z7x46i","reference-count":0,"pmcid":"PMC7161635","has_valid_oa_url":true,"deposited":{"timestamp":1481307366000,"date-time":"2016-12-09T18:16:06Z","date-parts":[[2016,12,9]]},"indexed":{"timestamp":1616379839046,"date-time":"2021-03-22T02:23:59Z","date-parts":[[2021,3,22]]},"is-referenced-by-count":4,"title":["Crystallization and preliminary crystallographic analysis of the heptad-repeat complex of SARS coronavirus spike protein"],"prefix":"10.1107","published-online":{"date-parts":[[2004,11,26]]},"has_valid_thumbnail":false,"references-count":0,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/30/ce/PMC7161635.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1107/s0907444904027258","short-title":[],"issn-type":[{"value":"0907-4449","type":"print"}],"container-title":["Acta Crystallographica Section D Biological Crystallography"],"score":1,"has_valid_ref_annotation":false,"issue":"12","member":"329","abstract":"The aetiological agent of an emergent outbreak of atypical pneumonia, severe acute respiratory syndrome (SARS), is a positive‐stranded RNA virus (SARS‐CoV) belonging to the Coronaviridae family with a genome that differs substantially from those of other known coronaviruses. Highly conserved heptad‐repeat (HR1 and HR2) regions in class I viral fusion proteins, including spike protein from SARS coronavirus, interact with each other to form a six‐helix bundle, which is called a fusion core. The crystal structure of the fusion core is expected to greatly facilitate drug design. Crystals of the fusion core of SARS‐CoV spike protein have been grown at 291 K using PEG 4000 as precipitant. The diffraction pattern of the crystal extends to 2.8 Å resolution at 100 K in‐house. The crystals have unit‐cell parameters a = 121.2, b = 66.3, c = 70.0 Å, α = γ = 90, β = 107.4° and belong to space group C2. Assuming the presence of six molecules per asymmetric unit, the solvent content is estimated to be about 28%.","published-print":{"date-parts":[[2004,12,1]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Xu","given":"Yanhui","affiliation":[]},{"sequence":"additional","family":"Su","given":"Nan","affiliation":[]},{"sequence":"additional","family":"Qin","given":"Lan","affiliation":[]},{"sequence":"additional","family":"Bai","given":"Zhihong","affiliation":[]},{"sequence":"additional","family":"Gao","given":"George F.","affiliation":[]},{"sequence":"additional","family":"Rao","given":"Zihe","affiliation":[]}],"subject":["Structural Biology","General Medicine"],"link":[{"URL":"http://journals.iucr.org/d/issues/2004/12/02/pu0140/pu0140.pdf","content-version":"vor","intended-application":"text-mining","content-type":"unspecified"},{"URL":"http://journals.iucr.org/d/issues/2004/12/02/pu0140/pu0140.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{},"created":{"timestamp":1101831866000,"date-time":"2004-11-30T16:24:26Z","date-parts":[[2004,11,30]]},"ISSN":["0907-4449"],"assertion":[{"explanation":{"URL":"http://journals.iucr.org/d"},"value":"Acta Crystallographica Section D: Biological Crystallography","label":"Journal","name":"journal"},{"explanation":{"URL":"http://journals.iucr.org/d/issues/2011/01/00/me0434/index.html"},"value":"crystallization papers","label":"Content type","name":"content_type"},{"order":0,"value":"Yes","group":{"label":"Peer review","name":"peer_review"},"label":"Peer reviewed","name":"peer_reviewed"},{"order":1,"value":"Single blind","group":{"label":"Peer review","name":"peer_review"},"label":"Review process","name":"review_process"},{"order":0,"value":"2 September 2004","group":{"label":"Publication history","name":"publication_history"},"label":"Received","name":"received"},{"order":1,"value":"25 October 2004","group":{"label":"Publication history","name":"publication_history"},"label":"Accepted","name":"accepted"},{"order":2,"value":"26 November 2004","group":{"label":"Publication history","name":"publication_history"},"label":"Published online","name":"published_online"},{"explanation":{"URL":"http://journals.iucr.org/services/copyrightpolicy.html"},"label":"Copyright","name":"copyright","order":0,"value":"© 2004 International Union of Crystallography","group":{"label":"Copyright and licencing","name":"copyright_and_licensing"}}],"source":"Crossref","cord_sha":"9e39675858f85b1ce699ed312c7ac0976f2d27d2"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":8780},
  {"_key":"60c20b587723bebd86645441","_id":"documents/60c20b587723bebd86645441","_rev":"_cfFhBHy---","file_name":"00z7ycsu.pdf","md5":"2CE92318C45FE26A053A506B655053F8","id":"00z7ycsu","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/z7/yc/su/00z7ycsu/00z7ycsu.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["1566"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1611532800000,"date-time":"2021-01-25T00:00:00Z","date-parts":[[2021,1,25]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1611532800000,"date-time":"2021-01-25T00:00:00Z","date-parts":[[2021,1,25]]}}],"language":"en","pmid":"33495884","has_valid_tei":false,"DOI":"10.1007/s15010-020-01566-6","license-simplified":"no-cc","original-title":[],"short-container-title":["Infection"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Microbiology (medical)","Infectious Diseases","General Medicine"],"type":"journal-article","issued":{"date-parts":[[2021,1,25]]},"funder":[{"doi-asserted-by":"publisher","award":["R01GM131044"],"DOI":"10.13039/100000057","name":"National Institute of General Medical Sciences"}],"publisher":"Springer Science and Business Media LLC","id":"00z7ycsu","reference-count":20,"pmcid":"PMC7831629","has_valid_oa_url":true,"deposited":{"timestamp":1611598464000,"date-time":"2021-01-25T18:14:24Z","date-parts":[[2021,1,25]]},"indexed":{"timestamp":1616049895886,"date-time":"2021-03-18T06:44:55Z","date-parts":[[2021,3,18]]},"is-referenced-by-count":1,"title":["Worldwide inverse correlation between Bacille Calmette–Guérin (BCG) immunization and COVID-19 mortality"],"prefix":"10.1007","published-online":{"date-parts":[[2021,1,25]]},"has_valid_thumbnail":false,"references-count":20,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/cb/34/PMC7831629.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s15010-020-01566-6","short-title":[],"issn-type":[{"value":"0300-8126","type":"print"},{"value":"1439-0973","type":"electronic"}],"container-title":["Infection"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"PURPOSE: The coronavirus disease 2019 (COVID-19) pandemic has spread to all countries in the world, and different countries have been impacted differently. The study aims to understand what factors contribute to different COVID-19 impacts at the country level. METHODS: Multivariate statistical analyses were used to evaluate COVID-19 deaths and cases relative to nine other demographic and socioeconomic factors in all countries and regions of the world using data as of August 1, 2020. The factors analyzed in the study include a country’s total COVID-19 deaths and cases per million population, per capita gross domestic product (GDP), population density, virus tests per million population, median age, government response stringency index, hospital beds availability per thousand population, extreme poverty rate, Bacille Calmette–Guérin (BCG) vaccination rate, and diphtheria–tetanus–pertussis (DTP3) immunization rate. RESULTS: The study reveals that COVID-19 deaths per million population in a country most significantly correlates, inversely, with the country’s BCG vaccination rate (r = − 0.50, p = 5.3e-5), and also significantly correlates a country’s per capita GDP (r = 0.39, p = 7.4e-3) and median age (r = 0.30, p = 0.042), while COVID-19 cases per million population significantly correlate with per capita GDP and tests per thousand population. To control for possible confounding effects of age, the correlation was assessed in countries propensity score matched for age. The inverse correlation between BCG vaccination rates and COVID-19 case (r = − 0.30, p = 0.02) and death (r = − 0.42, p = 0.0007) remained significant among the top 61 countries with the highest median age. CONCLUSION: This study contributes to a growing body of evidence supporting the notion that BCG vaccination may be protective against COVID-19 mortality. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s15010-020-01566-6.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Willis X.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9041-7341","family":"Li","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s15010-020-01566-6.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s15010-020-01566-6/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s15010-020-01566-6.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1611594331000,"date-time":"2021-01-25T17:05:31Z","date-parts":[[2021,1,25]]},"ISSN":["0300-8126","1439-0973"],"assertion":[{"order":1,"value":"16 September 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"10 December 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"25 January 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with ethical standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The author declares no conflicts of interest.","group":{"label":"Conflicts of interest","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"All data are in the text and supplementary file.","group":{"label":"Availability of data and material","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"2dcc8c126b75efb4a373fa4d5e3612bb5c4d7d28"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":10166},
  {"_key":"60c20b607723bebd86645446","_id":"documents/60c20b607723bebd86645446","_rev":"_cfFhBI----","file_name":"00zszbwg.pdf","md5":"EFAB6867F88871BAE2B6969C3CEF03DF","id":"00zszbwg","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/00/zs/zb/wg/00zszbwg/00zszbwg.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["9695"],"published-print":{"date-parts":[[2020,12]]},"article-number":"1589","language":"en","volume":"20","pmid":"33087109","journal-issue":{"published-print":{"date-parts":[[2020,12]]},"issue":"1"},"author":[{"sequence":"first","family":"Li","given":"Jian-Bin","affiliation":[]},{"sequence":"additional","family":"Yang","given":"An","affiliation":[]},{"sequence":"additional","given":"Kai","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-2449-7969","family":"Dou","affiliation":[]},{"sequence":"additional","family":"Wang","given":"Lin-Xin","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Ming-Chen","affiliation":[]},{"sequence":"additional","family":"Lin","given":"Xiao-Qi","affiliation":[]}],"DOI":"10.1186/s12889-020-09695-1","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1603238400000,"date-time":"2020-10-21T00:00:00Z","date-parts":[[2020,10,21]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1603238400000,"date-time":"2020-10-21T00:00:00Z","date-parts":[[2020,10,21]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Public Health, Environmental and Occupational Health"],"type":"journal-article","issued":{"date-parts":[[2020,10,21]]},"funder":[{"award":[],"name":"the FEHD’s Internationalization & Exchange Research Scheme of the Education University of Hong Kong"},{"award":["2020GZYB92"],"name":"the 13th Five-Year Plan of Philosophy and Social Science of Guangzhou"},{"award":["YK2020025"],"name":"the Key Research Items from Guangzhou University"},{"award":["299-X5216193 and 299-GK19G062"],"name":"the grant of Guangdong University of Foreign Studies"}],"publisher":"Springer Science and Business Media LLC","id":"00zszbwg","reference-count":40,"title":["Chinese public’s knowledge, perceived severity, and perceived controllability of COVID-19 and their associations with emotional and behavioural reactions, social participation, and precautionary behaviour: a national survey"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/55/f2/PMC7576982.tar.gz","pmcid":"PMC7576982","has_valid_oa_url":true,"deposited":{"timestamp":1603558980000,"date-time":"2020-10-24T17:03:00Z","date-parts":[[2020,10,24]]},"indexed":{"timestamp":1617674767151,"date-time":"2021-04-06T02:06:07Z","date-parts":[[2021,4,6]]},"is-referenced-by-count":20,"short-container-title":["BMC Public Health"],"prefix":"10.1186","published-online":{"date-parts":[[2020,10,21]]},"has_valid_thumbnail":false,"references-count":40,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12889-020-09695-1","short-title":[],"issn-type":[{"value":"1471-2458","type":"electronic"}],"container-title":["BMC Public Health"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND: The outbreak of the coronavirus disease-19 (COVID-19) has caused enormous stress among the public in China. Intellectual input from various aspects is needed to fight against COVID-19, including understanding of the public’s emotion and behaviour and their antecedents from the psychological perspectives. Drawing upon the cognitive appraisal theory, this study examined three cognitive appraisals (i.e., perceived severity, perceived controllability, and knowledge of COVID-19) and their associations with a wide range of emotional and behavioural outcomes among the Chinese public. METHODS: Participants were 4607 citizens (age range: 17–90 years, Mage = 23.71 years) from 31 provinces in China and they took part in a cross-sectional survey online. RESULTS: The results showed that the public’s emotional and behavioural reactions were slightly affected by the outbreak of COVID-19. Moreover, the public had limited participation in the events regarding COVID-19 but actively engaged in precautionary behaviour. In addition, results of structural equation model with latent variables revealed that the three appraisals were differentially related to the outcome variables (i.e., negative emotion, positive emotion, sleep problems, aggression, substance use, mobile phone use, social participation, and precautionary behaviour). CONCLUSIONS: The findings highlight the utility of cognitive appraisal, as a core process of coping stress, in explaining the public’s emotion and behaviour in the encounter of public health concern. Practically, the findings facilitate the government and practitioners to design and deliver targeted intervention programs to the public.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12889-020-09695-1.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s12889-020-09695-1/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s12889-020-09695-1.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1603285556000,"date-time":"2020-10-21T13:05:56Z","date-parts":[[2020,10,21]]},"ISSN":["1471-2458"],"assertion":[{"order":1,"value":"29 February 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"14 October 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"21 October 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"The study received ethical approval from the Ethics Review Committee of Education School, Guangzhou University [GZHU2020001] and all participants provided consent to participate online.","group":{"label":"Ethics approval and consent to participate","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Not applicable.","group":{"label":"Consent for publication","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"283ea12074168f183f99d9a163740abf80df4fd9"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":11042},
  {"_key":"60c20b637723bebd8664544b","_id":"documents/60c20b637723bebd8664544b","_rev":"_cfFhBIK---","file_name":"010lano6.pdf","md5":"E02C06E000C34C3A7C1D5332BAB8B356","id":"010lano6","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/0l/an/o6/010lano6/010lano6.pdf","date":"2021-06-10T12:53+0000","metadata":{"alternative-id":["S096808960900399X"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1243814400000,"date-time":"2009-06-01T00:00:00Z","date-parts":[[2009,6,1]]}}],"volume":"17","pmid":"19423354","has_valid_tei":false,"DOI":"10.1016/j.bmc.2009.04.038","original-title":[],"short-container-title":["Bioorganic & Medicinal Chemistry"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":14,"page":"3810-3817","type":"journal-article","issued":{"date-parts":[[2009,6]]},"publisher":"Elsevier BV","id":"010lano6","short-title":[],"pmcid":"PMC7172530","has_valid_oa_url":true,"deposited":{"timestamp":1558274427000,"date-time":"2019-05-19T14:00:27Z","date-parts":[[2019,5,19]]},"indexed":{"timestamp":1586817742637,"date-time":"2020-04-13T22:42:22Z","date-parts":[[2020,4,13]]},"is-referenced-by-count":9,"title":["Design and synthesis of novel chloramphenicol amine derivatives as potent aminopeptidase N (APN/CD13) inhibitors"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/0f/7d/PMC7172530.tar.gz","has_valid_thumbnail":false,"ISSN":["0968-0896"],"references-count":14,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.bmc.2009.04.038","journal-issue":{"published-print":{"date-parts":[[2009,6]]},"issue":"11"},"issn-type":[{"value":"0968-0896","type":"print"}],"container-title":["Bioorganic & Medicinal Chemistry"],"has_valid_ref_annotation":false,"issue":"11","member":"78","abstract":"Herein we report a series of novel chloramphenicol amine derivatives as aminopeptidase N (APN)/CD13 inhibitors. All compounds were synthesized starting from commercially available (1S,2S)-2-amino-1-(4-nitrophenyl) propane-1,3-diol. The preliminary biological screening showed that some compounds exhibited potent inhibitory activity against APN. It should be noted that one compound, 13b (IC(50) = 7.1 μM), possess similar APN inhibitory activity compared with Bestatin (IC(50) = 3.0 μM).","published-print":{"date-parts":[[2009,6]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Yang","given":"Kanghui","affiliation":[]},{"sequence":"additional","family":"Wang","given":"Qiang","affiliation":[]},{"sequence":"additional","family":"Su","given":"Li","affiliation":[]},{"sequence":"additional","family":"Fang","given":"Hao","affiliation":[]},{"sequence":"additional","family":"Wang","given":"Xuejian","affiliation":[]},{"sequence":"additional","family":"Gong","given":"Jianzhi","affiliation":[]},{"sequence":"additional","family":"Wang","given":"Binghe","affiliation":[]},{"sequence":"additional","family":"Xu","given":"Wenfang","affiliation":[]}],"subject":["Organic Chemistry","Clinical Biochemistry","Molecular Medicine","Biochemistry","Molecular Biology","Drug Discovery","Pharmaceutical Science"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S096808960900399X?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S096808960900399X?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1240639191000,"date-time":"2009-04-25T05:59:51Z","date-parts":[[2009,4,25]]},"language":"en","score":1,"source":"Crossref","cord_sha":"1490e55551708a2af75905b694c5fc1911c9b409"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":11919},
  {"_key":"60c20b6c7723bebd8664544e","_id":"documents/60c20b6c7723bebd8664544e","_rev":"_cfFhBIW---","file_name":"011k6mm0.pdf","md5":"60CDDA304C0A8DF233297926DDCC04A2","id":"011k6mm0","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/1k/6m/m0/011k6mm0/011k6mm0.pdf","date":"2021-06-10T12:54+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,2,29]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.02.26.20028084","group-title":"Public and Global Health","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/02/29/2020.02.26.20028084.full.pdf","original-title":[],"title":["Evaluation of the clinical characteristics of suspected or confirmed cases of COVID-19 during home care with isolation: A new retrospective analysis based on O2O"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":18,"short-title":[],"issued":{"date-parts":[[2020,2,29]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,2,29]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Summary Background The recent outbreak of the novel coronavirus in December 2019 (COVID-19) has activated top-level response nationwide. We developed a new treatment model based on the online-to-offline (O2O) model for the home isolated patients, because in the early stages the medical staff were insufficient to cope with so many patients. Methods In this single-centered, retrospective study, we enrolled 48 confirmed/suspected COVID-19 patients who underwent home isolation in Wuhan between January 6 and January 31, 2020. By WeChat and online document editing all patients were treated with medical observation scale. The clinical indications such as Fever, Muscle soreness, Dyspnea and Lack of strength were collected with this system led by medical staff in management, medicine, nursing, rehabilitation and psychology. Findings The mean(SD) age of 48 patients was 39.08(13.88) years, 35(72.9%) were women. Compared with non-hospitalized patients, inpatients were older(≥8805;70years, 2.4% vs 33.3%, P<0.04). All inpatients had fever, 50% inpatients had coughs and showed infiltration in both lungs at the time of diagnosis. 33.3% inpatients exhibited negative changes in their CT results at initial diagnosis. The body temperature of non-hospitalized patients with mild symptoms returned to normal by day 4-5. While dyspnea peaked on day 6 for non-hospitalized patients with mild symptoms, it persisted in hospitalized patients and exacerbated over time. The lack of strength and muscle soreness were both back to normal by day 4 for non-hospitalized patients. Interpretation Monitoring the trends of symptoms is more important for identifying severe cases. Excessive laboratory data and physical examination are not necessary for the evaluation of patients with mild symptoms. The system we developed is the first to convert the subjective symptoms of patients into objective scores. This type of O2O, subjective-to-objective strategy may be used in regions with similar highly infectious diseases to minimize the possibility of infection among medical staff.","deposited":{"timestamp":1605045383000,"date-time":"2020-11-10T21:56:23Z","date-parts":[[2020,11,10]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Xu","given":"Hui","affiliation":[]},{"sequence":"additional","family":"Huang","given":"Sufang","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Shangkun","affiliation":[]},{"sequence":"additional","family":"Deng","given":"Juan","affiliation":[]},{"sequence":"additional","family":"Jiao","given":"Bo","affiliation":[]},{"sequence":"additional","family":"Ai","given":"Ling","affiliation":[]},{"sequence":"additional","family":"Xiao","given":"Yaru","affiliation":[]},{"sequence":"additional","family":"Yan","given":"Li","affiliation":[]},{"sequence":"additional","family":"Li","given":"Shusheng","affiliation":[]}],"DOI":"10.1101/2020.02.26.20028084","reference-count":18,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.02.26.20028084","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1582994111000,"date-time":"2020-02-29T16:35:11Z","date-parts":[[2020,2,29]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"011k6mm0","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1605046364344,"date-time":"2020-11-10T22:12:44Z","date-parts":[[2020,11,10]]},"cord_sha":"c954675ee859e2f7b8f352a398a67469b50f05de"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":645,"page_height":540},{"page_width":460.8,"page_height":493.92}],"runtime":8771},
  {"_key":"60c20b6d7723bebd86645452","_id":"documents/60c20b6d7723bebd86645452","_rev":"_cfFhBIi---","file_name":"010xj69x.pdf","md5":"4FD2B336A1EDBD4CC1CCC11079132339","id":"010xj69x","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/0x/j6/9x/010xj69x/010xj69x.pdf","date":"2021-06-10T12:54+0000","metadata":{"alternative-id":["10.7554/eLife.47615"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1567468800000,"date-time":"2019-09-03T00:00:00Z","date-parts":[[2019,9,3]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"am","delay-in-days":0,"start":{"timestamp":1567468800000,"date-time":"2019-09-03T00:00:00Z","date-parts":[[2019,9,3]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1567468800000,"date-time":"2019-09-03T00:00:00Z","date-parts":[[2019,9,3]]}}],"volume":"8","pmid":"31478480","has_valid_tei":false,"URL":"http://dx.doi.org/10.7554/elife.47615","id":"010xj69x","original-title":[],"title":["Endangered wild salmon infected by newly discovered viruses"],"content-domain":{"domain":[],"crossmark-restriction":false},"type":"journal-article","issued":{"date-parts":[[2019,9,3]]},"funder":[{"doi-asserted-by":"publisher","award":["SSHI"],"DOI":"10.13039/501100000233","name":"Genome British Columbia"},{"doi-asserted-by":"publisher","award":["SSHI"],"DOI":"10.13039/501100004489","name":"Mitacs"},{"award":["SSHI"],"name":"Pacific Salmon Foundation"}],"publisher":"eLife Sciences Publications, Ltd","DOI":"10.7554/elife.47615","reference-count":43,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a3/17/PMC6721791.tar.gz","pmcid":"PMC6721791","has_valid_oa_url":true,"deposited":{"timestamp":1569972935000,"date-time":"2019-10-01T23:35:35Z","date-parts":[[2019,10,1]]},"indexed":{"timestamp":1616611502652,"date-time":"2021-03-24T18:45:02Z","date-parts":[[2021,3,24]]},"is-referenced-by-count":20,"short-container-title":[],"prefix":"10.7554","license-simplified":"cc-by","has_valid_thumbnail":false,"ISSN":["2050-084X"],"references-count":43,"published-online":{"date-parts":[[2019,9,3]]},"subtitle":[],"archive":["CLOCKSS"],"short-title":[],"issn-type":[{"value":"2050-084X","type":"electronic"}],"container-title":["eLife"],"has_valid_ref_annotation":false,"member":"4374","abstract":"The collapse of iconic, keystone populations of sockeye (Oncorhynchus nerka) and Chinook (Oncorhynchus tshawytscha) salmon in the Northeast Pacific is of great concern. It is thought that infectious disease may contribute to declines, but little is known about viruses endemic to Pacific salmon. Metatranscriptomic sequencing and surveillance of dead and moribund cultured Chinook salmon revealed a novel arenavirus, reovirus and nidovirus. Sequencing revealed two different arenavirus variants which each infect wild Chinook and sockeye salmon. In situ hybridisation localised arenavirus mostly to blood cells. Population surveys of >6000 wild juvenile Chinook and sockeye salmon showed divergent distributions of viruses, implying different epidemiological processes. The discovery in dead and dying farmed salmon of previously unrecognised viruses that are also widely distributed in wild salmon, emphasizes the potential role that viral disease may play in the population dynamics of wild fish stocks, and the threat that these viruses may pose to aquaculture.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Gideon J","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-8397-9194","family":"Mordecai","affiliation":[{"name":"Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada"}]},{"sequence":"additional","family":"Miller","given":"Kristina M","affiliation":[{"name":"Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, Canada"}]},{"sequence":"additional","family":"Di Cicco","given":"Emiliano","affiliation":[{"name":"Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, Canada"},{"name":"Pacific Salmon Foundation, Vancouver, Canada"}]},{"sequence":"additional","family":"Schulze","given":"Angela D","affiliation":[{"name":"Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, Canada"}]},{"sequence":"additional","family":"Kaukinen","given":"Karia H","affiliation":[{"name":"Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, Canada"}]},{"sequence":"additional","family":"Ming","given":"Tobi J","affiliation":[{"name":"Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, Canada"}]},{"sequence":"additional","family":"Li","given":"Shaorong","affiliation":[{"name":"Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, Canada"}]},{"sequence":"additional","family":"Tabata","given":"Amy","affiliation":[{"name":"Pacific Biological Station, Fisheries and Oceans Canada, Nanaimo, Canada"}]},{"sequence":"additional","family":"Teffer","given":"Amy","affiliation":[{"name":"Department of Forest Sciences, University of British Columbia, Vancouver, Canada"}]},{"sequence":"additional","family":"Patterson","given":"David A","affiliation":[{"name":"Fisheries and Oceans Canada, Science Branch, Cooperative Resource Management Institute, School of Resource and Environmental Management, Simon Fraser University, Burnaby, Canada"}]},{"sequence":"additional","family":"Ferguson","given":"Hugh W","affiliation":[{"name":"School of Veterinary Medicine, St. George’s University, True Blue, Grenada"}]},{"sequence":"additional","given":"Curtis A","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-0372-0033","family":"Suttle","affiliation":[{"name":"Department of Earth, Ocean and Atmospheric Sciences, University of British Columbia, Vancouver, Canada"},{"name":"Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada"},{"name":"Department of Botany, University of British Columbia, Vancouver, Canada"},{"name":"Institute for the Oceans and Fisheries, University of British Columbia, Vancouver, 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  {"_key":"60c20b8b7723bebd86645466","_id":"documents/60c20b8b7723bebd86645466","_rev":"_cfFhBIq---","file_name":"0154n4w4.pdf","md5":"5819E61674A97DCE27FAA9C354E8E126","id":"0154n4w4","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/54/n4/w4/0154n4w4/0154n4w4.pdf","date":"2021-06-10T12:54+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by-nc/3.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1401408000000,"date-time":"2014-05-30T00:00:00Z","date-parts":[[2014,5,30]]}}],"volume":"36","pmid":"25045577","author":[{"sequence":"first","family":"Cho","given":"Kyung Sook","affiliation":[]},{"sequence":"additional","family":"Yoon","given":"Jangho","affiliation":[]}],"DOI":"10.4178/epih/e2014004","license-simplified":"cc-by","original-title":[],"short-container-title":["Epidemiol Health"],"content-domain":{"domain":["e-epih.org"],"crossmark-restriction":true},"page":"e2014004","issued":{"date-parts":[[2014,5,30]]},"publisher":"Korean Society of Epidemiology","id":"0154n4w4","reference-count":17,"short-title":[],"pmcid":"PMC4101989","has_valid_oa_url":true,"deposited":{"timestamp":1564171283000,"date-time":"2019-07-26T20:01:23Z","date-parts":[[2019,7,26]]},"indexed":{"timestamp":1607058454770,"date-time":"2020-12-04T05:07:34Z","date-parts":[[2020,12,4]]},"is-referenced-by-count":15,"title":["Fever Screening and Detection of Febrile Arrivals at an International Airport in Korea: Association among Self-reported Fever, Infrared Thermal Camera Scanning, and Tympanic Temperature"],"prefix":"10.4178","published-online":{"date-parts":[[2014,5,30]]},"has_valid_thumbnail":false,"ISSN":["2092-7193"],"references-count":17,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/e7/f5/PMC4101989.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.4178/epih/e2014004","type":"journal-article","issn-type":[{"value":"2092-7193","type":"electronic"}],"container-title":["Epidemiology and Health"],"score":1,"has_valid_ref_annotation":false,"member":"2679","abstract":"OBJECTIVES: The purpose of this research was to measure fever prevalence and the effectiveness of a fever screening procedure in detecting febrile arrivals at an international airport in Korea. METHODS: Data were retrieved from arrivals’ health declaration forms and questionnaires for febrile arrivals at an international airport collected by a national quarantine station during the year 2012. Self-reported health declaration forms were returned by 355,887 arrivals (61% of the total arrivals). Of these, 608 symptomatic arrivals (0.2%) including 6 febrile arrivals were analyzed. RESULTS: Fever prevalence at an international airport in Korea was 0.002%. Self-reported fever was significantly positively associated with tympanic temperature (p<0.001). The difference between the thermal camera temperature (36.83°C) and tympanic (or ear) temperature (38.14°C) was not statistically significant. CONCLUSIONS: The findings imply that a procedure for mass detection of fever such as self-reported questionnaires and thermal camera scanning may serve as an effective tool for detecting febrile arrivals at quarantine stations. Future research can benefit from looking at the sensitivity, specificity, positive predictive value, and negative predictive value of the entry screening system.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.4178/crossmark_policy","link":[{"URL":"http://www.e-epih.org/upload/pdf/epih-36-e2014004.pdf","content-version":"tdm","intended-application":"text-mining","content-type":"unspecified"},{"URL":"http://www.e-epih.org/upload/pdf/epih-36-e2014004.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1401712845000,"date-time":"2014-06-02T12:40:45Z","date-parts":[[2014,6,2]]},"language":"en","assertion":[{"order":0,"value":"2014-02-27","group":{"label":"Publication History","name":"publication_history"},"label":"Received","name":"received"},{"order":1,"value":"2014-04-29","group":{"label":"Publication History","name":"publication_history"},"label":"Accepted","name":"accepted"},{"order":2,"value":"2014-05-30","group":{"label":"Publication History","name":"publication_history"},"label":"Published","name":"published"}],"source":"Crossref","cord_sha":"fe2c4dd2b0a96acbdcd6566d94bf227c497995ef"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":4364},
  {"_key":"60c20b8f7723bebd86645468","_id":"documents/60c20b8f7723bebd86645468","_rev":"_cfFhBI2---","file_name":"014xrnl0.pdf","md5":"62F22BCC4C263F72E5304B52E1659041","id":"014xrnl0","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/4x/rn/l0/014xrnl0/014xrnl0.pdf","date":"2021-06-10T12:54+0000","metadata":{"alternative-id":["genes11091010"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1598486400000,"date-time":"2020-08-27T00:00:00Z","date-parts":[[2020,8,27]]}}],"volume":"11","pmid":"32867305","has_valid_tei":false,"created":{"timestamp":1598536022000,"date-time":"2020-08-27T13:47:02Z","date-parts":[[2020,8,27]]},"DOI":"10.3390/genes11091010","original-title":[],"title":["COVID-19 and Genetic Variants of Protein Involved in the SARS-CoV-2 Entry into the Host Cells"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":28,"page":"1010","type":"journal-article","issued":{"date-parts":[[2020,8,27]]},"publisher":"MDPI AG","id":"014xrnl0","short-title":[],"pmcid":"PMC7565048","has_valid_oa_url":true,"deposited":{"timestamp":1598776112000,"date-time":"2020-08-30T08:28:32Z","date-parts":[[2020,8,30]]},"indexed":{"timestamp":1618898661630,"date-time":"2021-04-20T06:04:21Z","date-parts":[[2021,4,20]]},"is-referenced-by-count":17,"short-container-title":["Genes"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/bd/3e/PMC7565048.tar.gz","has_valid_thumbnail":false,"ISSN":["2073-4425"],"references-count":28,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9]]}},"issn-type":[{"value":"2073-4425","type":"electronic"}],"container-title":["Genes"],"published-online":{"date-parts":[[2020,8,27]]},"issue":"9","member":"1968","abstract":"The recent global COVID-19 public health emergency is caused by SARS-CoV-2 infections and can manifest extremely variable clinical symptoms. Host human genetic variability could influence susceptibility and response to infection. It is known that ACE2 acts as a receptor for this pathogen, but the viral entry into the target cell also depends on other proteins. The aim of this study was to investigate the variability of genes coding for these proteins involved in the SARS-CoV-2 entry into the cells. We analyzed 131 COVID-19 patients by exome sequencing and examined the genetic variants of TMPRSS2, PCSK3, DPP4, and BSG genes. In total we identified seventeen variants. In PCSK3 gene, we observed a missense variant (c.893G>A) statistically more frequent compared to the EUR GnomAD reference population and a missense mutation (c.1906A>G) not found in the GnomAD database. In TMPRSS2 gene, we observed a significant difference in the frequency of c.331G>A, c.23G>T, and c.589G>A variant alleles in COVID-19 patients, compared to the corresponding allelic frequency in GnomAD. Genetic variants in these genes could influence the entry of the SARS-CoV-2. These data also support the hypothesis that host genetic variability may contribute to the variability in infection susceptibility and severity.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Latini","given":"Andrea","affiliation":[]},{"sequence":"additional","given":"Emanuele","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6543-6225","family":"Agolini","affiliation":[]},{"sequence":"additional","given":"Antonio","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-9037-4297","family":"Novelli","affiliation":[]},{"sequence":"additional","family":"Borgiani","given":"Paola","affiliation":[]},{"sequence":"additional","family":"Giannini","given":"Rosalinda","affiliation":[]},{"sequence":"additional","family":"Gravina","given":"Paolo","affiliation":[]},{"sequence":"additional","family":"Smarrazzo","given":"Andrea","affiliation":[]},{"sequence":"additional","family":"Dauri","given":"Mario","affiliation":[]},{"sequence":"additional","family":"Andreoni","given":"Massimo","affiliation":[]},{"sequence":"additional","family":"Rogliani","given":"Paola","affiliation":[]},{"sequence":"additional","family":"Bernardini","given":"Sergio","affiliation":[]},{"sequence":"additional","family":"Helmer-Citterich","given":"Manuela","affiliation":[]},{"sequence":"additional","family":"Biancolella","given":"Michela","affiliation":[]},{"sequence":"additional","given":"Giuseppe","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7781-602X","family":"Novelli","affiliation":[]}],"subject":["Genetics(clinical)","Genetics"],"link":[{"URL":"https://www.mdpi.com/2073-4425/11/9/1010/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.3390/genes11091010","language":"en","score":1,"source":"Crossref","cord_sha":"dc96774a0b851633a893c06b0db1d4023bd171ee"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":841.89,"page_height":595.276},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":8051},
  {"_key":"60c20b8f7723bebd86645473","_id":"documents/60c20b8f7723bebd86645473","_rev":"_cfFhBJC---","file_name":"0153qxhr.pdf","md5":"2A8ED4BE3423B36307B8A521595BE642","id":"0153qxhr","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/53/qx/hr/0153qxhr/0153qxhr.pdf","date":"2021-06-10T12:54+0000","metadata":{"alternative-id":["10.1002/cm.21632"],"published-print":{"date-parts":[[2020,9]]},"volume":"77","pmid":"32885903","journal-issue":{"published-print":{"date-parts":[[2020,9]]},"issue":"9"},"author":[{"sequence":"first","family":"Taneja","given":"Nilay","affiliation":[{"name":"Department of Cell and Developmental Biology Vanderbilt University  Nashville Tennessee USA"}]},{"sequence":"additional","family":"Bersi","given":"Matthew R.","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"}]},{"sequence":"additional","family":"Rasmussen","given":"Megan L.","affiliation":[{"name":"Department of Cell and Developmental Biology Vanderbilt University  Nashville Tennessee USA"}]},{"sequence":"additional","family":"Gama","given":"Vivian","affiliation":[{"name":"Department of Cell and Developmental Biology Vanderbilt University  Nashville Tennessee USA"}]},{"sequence":"additional","family":"Merryman","given":"W. David","affiliation":[{"name":"Department of Biomedical Engineering Vanderbilt University  Nashville Tennessee USA"}]},{"sequence":"additional","family":"Burnette","given":"Dylan T.","affiliation":[{"name":"Department of Cell and Developmental Biology Vanderbilt University  Nashville Tennessee USA"}]}],"URL":"http://dx.doi.org/10.1002/cm.21632","DOI":"10.1002/cm.21632","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":8,"start":{"timestamp":1599609600000,"date-time":"2020-09-09T00:00:00Z","date-parts":[[2020,9,9]]}},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1598918400000,"date-time":"2020-09-01T00:00:00Z","date-parts":[[2020,9,1]]}}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"subject":["Cell Biology","Structural Biology"],"page":"342-350","type":"journal-article","issued":{"date-parts":[[2020,9]]},"funder":[{"doi-asserted-by":"publisher","award":["18PRE33960551","19PRE34380515"],"DOI":"10.13039/100000968","name":"American Heart Association"},{"doi-asserted-by":"publisher","award":["K99 HL146951","R35 HL135790"],"DOI":"10.13039/100000050","name":"National Heart, Lung, and Blood Institute"},{"doi-asserted-by":"publisher","award":["R35 GM125028","R35 GM128915"],"DOI":"10.13039/100000057","name":"National Institute of General Medical Sciences"}],"publisher":"Wiley","id":"0153qxhr","reference-count":37,"title":["Inhibition of focal adhesion kinase increases myofibril viscosity in cardiac myocytes"],"oaLink":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cm.21632","has_valid_oa_url":true,"deposited":{"timestamp":1602875077000,"date-time":"2020-10-16T19:04:37Z","date-parts":[[2020,10,16]]},"indexed":{"timestamp":1602877529159,"date-time":"2020-10-16T19:45:29Z","date-parts":[[2020,10,16]]},"is-referenced-by-count":0,"short-container-title":["Cytoskeleton"],"prefix":"10.1002","license-simplified":"cc-by","has_valid_thumbnail":false,"ISSN":["1949-3584","1949-3592"],"references-count":37,"published-online":{"date-parts":[[2020,9,9]]},"subtitle":[],"archive":["Portico"],"short-title":[],"issn-type":[{"value":"1949-3584","type":"print"},{"value":"1949-3592","type":"electronic"}],"container-title":["Cytoskeleton"],"score":1,"has_valid_ref_annotation":false,"issue":"9","member":"311","abstract":"The coordinated generation of mechanical forces by cardiac myocytes is required for proper heart function. Myofibrils are the functional contractile units of force production within individual cardiac myocytes. At the molecular level, myosin motors form cross-bridges with actin filaments and use ATP to convert chemical energy into mechanical forces. The energetic efficiency of the cross-bridge cycle is influenced by the viscous damping of myofibril contraction. The viscoelastic response of myofibrils is an emergent property of their individual mechanical components. Previous studies have implicated titin-actin interactions, cell-ECM adhesion, and microtubules as regulators of the viscoelastic response of myofibrils. Here we probed the viscoelastic response of myofibrils using laser-assisted dissection. As a proof-of-concept, we found actomyosin contractility was required to endow myofibrils with their viscoelastic response, with blebbistatin treatment resulting in decreased myofibril tension and viscous damping. Focal adhesion kinase (FAK) is a key regulator of cell-ECM adhesion, microtubule stability and myofibril assembly. We found inhibition of FAK signaling altered the viscoelastic properties of myofibrils. Specifically, inhibition of FAK resulted in increased viscous damping of myofibril retraction following laser ablation. This damping was not associated with acute changes in the electrophysiological properties of cardiac myocytes. These results implicate FAK as a regulator of mechanical properties of myofibrils. This article is protected by copyright. All rights reserved.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1002/crossmark_policy","link":[{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cm.21632","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/cm.21632","content-version":"vor","intended-application":"text-mining","content-type":"application/xml"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/cm.21632","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1599216201000,"date-time":"2020-09-04T10:43:21Z","date-parts":[[2020,9,4]]},"language":"en","assertion":[{"order":0,"value":"2020-05-22","group":{"label":"Publication History","name":"publication_history"},"label":"Received","name":"received"},{"order":1,"value":"2020-08-28","group":{"label":"Publication History","name":"publication_history"},"label":"Accepted","name":"accepted"},{"order":2,"value":"2020-09-09","group":{"label":"Publication History","name":"publication_history"},"label":"Published","name":"published"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362}],"runtime":8615},
  {"_key":"60c20b927723bebd86645478","_id":"documents/60c20b927723bebd86645478","_rev":"_cfFhBJO---","file_name":"014qnrcg.pdf","md5":"F7F63A731CABD43E66473AB0F71A5F9D","id":"014qnrcg","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/4q/nr/cg/014qnrcg/014qnrcg.pdf","date":"2021-06-10T12:54+0000","metadata":{"alternative-id":["2940"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1415836800000,"date-time":"2014-11-13T00:00:00Z","date-parts":[[2014,11,13]]}}],"volume":"42","pmid":"25391547","journal-issue":{"published-print":{"date-parts":[[2015,2]]},"issue":"2"},"has_valid_tei":false,"created":{"timestamp":1415965605000,"date-time":"2014-11-14T11:46:45Z","date-parts":[[2014,11,14]]},"DOI":"10.1007/s00259-014-2940-2","original-title":[],"short-container-title":["Eur J Nucl Med Mol Imaging"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":41,"page":"288-301","type":"journal-article","issued":{"date-parts":[[2014,11,13]]},"publisher":"Springer Science and Business Media LLC","id":"014qnrcg","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1551208391000,"date-time":"2019-02-26T19:13:11Z","date-parts":[[2019,2,26]]},"indexed":{"timestamp":1617281085716,"date-time":"2021-04-01T12:44:45Z","date-parts":[[2021,4,1]]},"is-referenced-by-count":44,"title":["Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging"],"prefix":"10.1007","oaLink":"https://link.springer.com/content/pdf/10.1007%2Fs00259-014-2940-2.pdf","has_valid_thumbnail":false,"references-count":41,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"ISSN":["1619-7070","1619-7089"],"issn-type":[{"value":"1619-7070","type":"print"},{"value":"1619-7089","type":"electronic"}],"container-title":["European Journal of Nuclear Medicine and Molecular Imaging"],"published-online":{"date-parts":[[2014,11,13]]},"issue":"2","member":"297","abstract":"PURPOSE Human epidermal growth factor receptor-2 (HER2) overexpression is a predictor of response to anti-HER2 therapy in breast and gastric cancer. Currently, HER2 status is assessed by tumour biopsy, but this may not be representative of the larger tumour mass or other metastatic sites, risking misclassification and selection of suboptimal therapy. The designed ankyrin repeat protein (DARPin) G3 binds HER2 with high affinity at an epitope that does not overlap with trastuzumab and is biologically inert. We hypothesized that radiolabelled DARPin G3 would be capable of selectively imaging HER2-positive tumours, and aimed to identify a suitable format for clinical application. METHODS G3 DARPins tagged with hexahistidine (His6) or with histidine glutamate (HE)3 and untagged G3 DARPins were manufactured using a GMP-compatible Pichia pastoris protocol and radiolabelled with (125)I, or with (111)In via DOTA linked to a C-terminal cysteine. BALB/c mice were injected with radiolabelled G3 and tissue biodistribution was evaluated by gamma counting. The lead construct ((HE)3-G3) was assessed in mice bearing HER2-positive human breast tumour (BT474) xenografts. RESULTS For both isotopes, (HE)3-G3 had significantly lower liver uptake than His6-G3 and untagged G3 counterparts in non-tumour-bearing mice, and there was no significantly different liver uptake between His6-G3 and untagged G3. (HE)3-G3 was taken forward for evaluation in mice bearing HER2-positive tumour xenografts. The results demonstrated that radioactivity from (111)In-(HE)3-G3 was better maintained in tumours and cleared faster from serum than radioactivity from (125)I-(HE)3-G3, achieving superior tumour-to-blood ratios (343.7 ± 161.3 vs. 22.0 ± 11.3 at 24 h, respectively). On microSPECT/CT, (111)In-labelled and (125)I-labelled (HE)3-G3 could image HER2-positive tumours at 4 h after administration, but there was less normal tissue uptake of radioactivity with (111)In-(HE)3-G3. Preadministration of trastuzumab did not affect the uptake of (HE)3-G3 by HER2-positive tumours. CONCLUSION Radiolabelled DARPin (HE)3-G3 is a versatile radioligand with potential to allow the acquisition of whole-body HER2 scans on the day of administration.","published-print":{"date-parts":[[2015,2]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Goldstein","given":"Robert","affiliation":[]},{"sequence":"additional","family":"Sosabowski","given":"Jane","affiliation":[]},{"sequence":"additional","family":"Livanos","given":"Maria","affiliation":[]},{"sequence":"additional","family":"Leyton","given":"Julius","affiliation":[]},{"sequence":"additional","family":"Vigor","given":"Kim","affiliation":[]},{"sequence":"additional","family":"Bhavsar","given":"Gaurav","affiliation":[]},{"sequence":"additional","family":"Nagy-Davidescu","given":"Gabriela","affiliation":[]},{"sequence":"additional","family":"Rashid","given":"Mohammed","affiliation":[]},{"sequence":"additional","family":"Miranda","given":"Enrique","affiliation":[]},{"sequence":"additional","family":"Yeung","given":"Jenny","affiliation":[]},{"sequence":"additional","family":"Tolner","given":"Berend","affiliation":[]},{"sequence":"additional","family":"Plückthun","given":"Andreas","affiliation":[]},{"sequence":"additional","family":"Mather","given":"Stephen","affiliation":[]},{"sequence":"additional","family":"Meyer","given":"Tim","affiliation":[]},{"sequence":"additional","family":"Chester","given":"Kerry","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/article/10.1007/s00259-014-2940-2/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00259-014-2940-2.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00259-014-2940-2","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1007/s00259-014-2940-2","language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":11654},
  {"_key":"60c20b947723bebd8664547d","_id":"documents/60c20b947723bebd8664547d","_rev":"_cfFhBJa---","file_name":"01630gpn.pdf","md5":"3318233FFEA66EA00618A37825D553B6","id":"01630gpn","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/63/0g/pn/01630gpn/01630gpn.pdf","date":"2021-06-10T12:54+0000","metadata":{"alternative-id":["1719"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1612915200000,"date-time":"2021-02-10T00:00:00Z","date-parts":[[2021,2,10]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1612915200000,"date-time":"2021-02-10T00:00:00Z","date-parts":[[2021,2,10]]}}],"article-number":"37","language":"en","volume":"45","pmid":"33566170","journal-issue":{"published-print":{"date-parts":[[2021,3]]},"issue":"3"},"has_valid_tei":false,"DOI":"10.1007/s10916-021-01719-6","license-simplified":"no-cc","original-title":[],"short-container-title":["J Med Syst"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Health Informatics","Health Information Management","Medicine (miscellaneous)","Information Systems"],"type":"journal-article","issued":{"date-parts":[[2021,2,10]]},"publisher":"Springer Science and Business Media LLC","id":"01630gpn","reference-count":20,"pmcid":"PMC7873515","has_valid_oa_url":true,"deposited":{"timestamp":1613730811000,"date-time":"2021-02-19T10:33:31Z","date-parts":[[2021,2,19]]},"indexed":{"timestamp":1613733293933,"date-time":"2021-02-19T11:14:53Z","date-parts":[[2021,2,19]]},"is-referenced-by-count":0,"title":["Perioperative Cryoprecipitate Waste Reduction"],"prefix":"10.1007","published-online":{"date-parts":[[2021,2,10]]},"has_valid_thumbnail":false,"references-count":20,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/b7/cd/PMC7873515.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s10916-021-01719-6","short-title":[],"issn-type":[{"value":"0148-5598","type":"print"},{"value":"1573-689X","type":"electronic"}],"container-title":["Journal of Medical Systems"],"score":1,"has_valid_ref_annotation":false,"issue":"3","member":"297","abstract":"Improvement of operating room efficiency regarding perioperative blood product transfusion is fundamental for surgical patients. The aim of this study was to 1) assess the use of cryoprecipitate in the operating room at our institution 2) identify and address gaps in knowledge regarding the process of ordering and returning cryoprecipitate 3) aim to reduce cryoprecipitate wastage by 50% over a 14-month period. Institutional data from Dec. 2017 to April 2020 was retrieved on cryoprecipitate that was ordered, thawed, and delivered to the operating room. Additionally, data was collected regarding cryoprecipitate that was wasted. A retrospective analysis of weekly intraoperative cryoprecipitate utilization was performed to compare wastage before and after implementation of interventions. Pre-intervention (Dec 2017 - March 2019), a total of 453 units of cryoprecipitate were issued with 14 units wasted (3% wastage). Between March 2019 and April 2020, the 14 months after our intervention, there were 402 units of cryoprecipitate issued with only 1 unit wasted (0.25% wastage). The overall cryoprecipitate waste rate was reduced by 91.66%. Month-to-month comparison of pre-intervention and post-intervention data identified significant reduction in average monthly wastage (0.875 vs 0.071 units respectively, p < 0.05). Appropriately, there was not a significant change in the mean monthly cryoprecipitate issued to the operating room (28.31 vs. 28.7 units, p = 0.94). These results demonstrate that utilizing educational initiatives for optimization of blood product management can reduce unnecessary ordering, transfusions, and wastage; an outcome that could ultimately reduce costs.","published-print":{"date-parts":[[2021,3]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Burk","given":"Camden","affiliation":[]},{"sequence":"additional","family":"Eliason","given":"Kent","affiliation":[]},{"sequence":"additional","family":"Doney","given":"Allison","affiliation":[]},{"sequence":"additional","family":"Mountjoy","given":"Jeremi","affiliation":[]},{"sequence":"additional","given":"Adam A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6054-9650","family":"Dalia","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s10916-021-01719-6.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s10916-021-01719-6/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s10916-021-01719-6.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1612948138000,"date-time":"2021-02-10T09:08:58Z","date-parts":[[2021,2,10]]},"ISSN":["0148-5598","1573-689X"],"assertion":[{"order":1,"value":"7 December 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"1 February 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"10 February 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Declarations","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"None relevant to this work.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"79b7384b0ce5812e8b1f2a6ef9eb13fc905b3d36"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":10599},
  {"_key":"60c20b957723bebd8664547f","_id":"documents/60c20b957723bebd8664547f","_rev":"_cfFhBJm---","file_name":"015onu9n.pdf","md5":"81C3B0A26DDFEB03644FE11EAE937745","id":"015onu9n","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/5o/nu/9n/015onu9n/015onu9n.pdf","date":"2021-06-10T12:54+0000","metadata":{"alternative-id":["S0002929720302871"],"published-print":{"date-parts":[[2020,10]]},"volume":"107","pmid":"32937143","journal-issue":{"published-print":{"date-parts":[[2020,10]]},"issue":"4"},"author":[{"sequence":"first","family":"Mendoza-Ferreira","given":"Natalia","affiliation":[]},{"sequence":"additional","family":"Karakaya","given":"Mert","affiliation":[]},{"sequence":"additional","family":"Cengiz","given":"Nur","affiliation":[]},{"sequence":"additional","family":"Beijer","given":"Danique","affiliation":[]},{"sequence":"additional","family":"Brigatti","given":"Karlla W.","affiliation":[]},{"sequence":"additional","family":"Gonzaga-Jauregui","given":"Claudia","affiliation":[]},{"sequence":"additional","family":"Fuhrmann","given":"Nico","affiliation":[]},{"sequence":"additional","family":"Hölker","given":"Irmgard","affiliation":[]},{"sequence":"additional","family":"Thelen","given":"Maximilian P.","affiliation":[]},{"sequence":"additional","family":"Zetzsche","given":"Sebastian","affiliation":[]},{"sequence":"additional","family":"Rombo","given":"Roman","affiliation":[]},{"sequence":"additional","family":"Puffenberger","given":"Erik G.","affiliation":[]},{"sequence":"additional","family":"De Jonghe","given":"Peter","affiliation":[]},{"sequence":"additional","family":"Deconinck","given":"Tine","affiliation":[]},{"sequence":"additional","family":"Zuchner","given":"Stephan","affiliation":[]},{"sequence":"additional","family":"Strauss","given":"Kevin A.","affiliation":[]},{"sequence":"additional","family":"Carson","given":"Vincent","affiliation":[]},{"sequence":"additional","family":"Schrank","given":"Bertold","affiliation":[]},{"sequence":"additional","family":"Wunderlich","given":"Gilbert","affiliation":[]},{"sequence":"additional","family":"Baets","given":"Jonathan","affiliation":[]},{"sequence":"additional","family":"Wirth","given":"Brunhilde","affiliation":[]}],"created":{"timestamp":1600180845000,"date-time":"2020-09-15T14:40:45Z","date-parts":[[2020,9,15]]},"DOI":"10.1016/j.ajhg.2020.08.018","original-title":[],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1601510400000,"date-time":"2020-10-01T00:00:00Z","date-parts":[[2020,10,1]]}},{"URL":"http://www.elsevier.com/open-access/userlicense/1.0/","content-version":"vor","delay-in-days":183,"start":{"timestamp":1617321600000,"date-time":"2021-04-02T00:00:00Z","date-parts":[[2021,4,2]]}}],"content-domain":{"domain":["ajhg.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Genetics(clinical)","Genetics"],"page":"763-777","type":"journal-article","issued":{"date-parts":[[2020,10]]},"funder":[{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100004963","name":"Seventh Framework Programme"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100009983","name":"Center for Molecular Medicine Cologne, University of Cologne"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100001659","name":"Deutsche Forschungsgemeinschaft"}],"publisher":"Elsevier BV","id":"015onu9n","short-title":[],"title":["De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation"],"pmcid":"PMC7491385","has_valid_oa_url":true,"deposited":{"timestamp":1617366051000,"date-time":"2021-04-02T12:20:51Z","date-parts":[[2021,4,2]]},"indexed":{"timestamp":1618830237127,"date-time":"2021-04-19T11:03:57Z","date-parts":[[2021,4,19]]},"is-referenced-by-count":1,"short-container-title":["The American Journal of Human Genetics"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/15/01/PMC7491385.tar.gz","has_valid_thumbnail":false,"references-count":79,"license-simplified":"no-cc","subtitle":[],"reference-count":79,"ISSN":["0002-9297"],"issn-type":[{"value":"0002-9297","type":"print"}],"container-title":["The American Journal of Human Genetics"],"score":1,"has_valid_ref_annotation":false,"issue":"4","member":"78","abstract":"Distal hereditary motor neuropathies (HMNs) and axonal Charcot-Marie-Tooth neuropathy (CMT2) are clinically and genetically heterogeneous diseases characterized primarily by motor neuron degeneration and distal weakness. The genetic cause for about half of the individuals affected by HMN/CMT2 remains unknown. Here, we report the identification of pathogenic variants in GBF1 (Golgi brefeldin A-resistant guanine nucleotide exchange factor 1) in four unrelated families with individuals affected by sporadic or dominant HMN/CMT2. Genomic sequencing analyses in seven affected individuals uncovered four distinct heterozygous GBF1 variants, two of which occurred de novo. Other known HMN/CMT2-implicated genes were excluded. Affected individuals show HMN/CMT2 with slowly progressive distal muscle weakness and musculoskeletal deformities. Electrophysiological studies confirmed axonal damage with chronic neurogenic changes. Three individuals had additional distal sensory loss. GBF1 encodes a guanine-nucleotide exchange factor that facilitates the activation of members of the ARF (ADP-ribosylation factor) family of small GTPases. GBF1 is mainly involved in the formation of coatomer protein complex (COPI) vesicles, maintenance and function of the Golgi apparatus, and mitochondria migration and positioning. We demonstrate that GBF1 is present in mouse spinal cord and muscle tissues and is particularly abundant in neuropathologically relevant sites, such as the motor neuron and the growth cone. Consistent with the described role of GBF1 in Golgi function and maintenance, we observed marked increase in Golgi fragmentation in primary fibroblasts derived from all affected individuals in this study. Our results not only reinforce the existing link between Golgi fragmentation and neurodegeneration but also demonstrate that pathogenic variants in GBF1 are associated with HMN/CMT2.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S0002929720302871?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0002929720302871?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1016/j.ajhg.2020.08.018","language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"De Novo and Inherited Variants in GBF1 are Associated with Axonal Neuropathy Caused by Golgi Fragmentation","label":"Article Title","name":"articletitle"},{"value":"The American Journal of Human Genetics","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.ajhg.2020.08.018","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 American Society of Human Genetics.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"ce43732a3a8fc1247b69d7ea16ec1e4f8116189d; fc0444a0aa1cec36122383adc772b5b559d79cba; b52f4f21db1ca4f8152b59e7ea2deba2dd2cf0f3"},"application":"software-mentions","pages":[{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":782.986,"page_height":602.986},{"page_width":782.986,"page_height":602.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986},{"page_width":602.986,"page_height":782.986}],"runtime":13614},
  {"_key":"60c20b9d7723bebd86645488","_id":"documents/60c20b9d7723bebd86645488","_rev":"_cfFhBJy---","file_name":"016odyhf.pdf","md5":"DAA2F30A56FF6D14A3D5F87F952AAB22","id":"016odyhf","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/6o/dy/hf/016odyhf/016odyhf.pdf","date":"2021-06-10T12:54+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,11,3]]},"license-simplified":"biorxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.11.02.365049","group-title":"Bioinformatics","oaLink":"https://www.biorxiv.org/content/biorxiv/early/2020/11/03/2020.11.02.365049.full.pdf","original-title":[],"title":["Computational prediction of SARS-CoV-2 encoded miRNAs and their putative host targets"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":61,"short-title":[],"issued":{"date-parts":[[2020,11,3]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,11,3]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Over the past two decades, there has been a continued research on the role of small non-coding RNAs including microRNAs (miRNAs) in various diseases. Studies have shown that viruses modulate the host cellular machinery and hijack its metabolic and immune signalling pathways by miRNA mediated gene silencing. Given the immensity of coronavirus disease 19 (COVID-19) pandemic and the strong association of viral encoded miRNAs with their pathogenesis, it is important to study Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) miRNAs. To address this unexplored area, we identified 8 putative novel miRNAs from SARS-CoV-2 genome and explored their possible human gene targets. A significant proportion of these targets populated key immune and metabolic pathways such as MAPK signalling pathway, maturity-onset diabetes, Insulin signalling pathway, endocytosis, RNA transport, TGF-β signalling pathway, to name a few. The data from this work is backed up by recently reported high-throughput transcriptomics datasets obtains from SARS-CoV-2 infected samples. Analysis of these datasets reveal that a significant proportion of the target human genes were down-regulated upon SARS-CoV-2 infection. The current study brings to light probable host metabolic and immune pathways susceptible to viral miRNA mediated silencing in a SARS-CoV-2 infection, and discusses its effects on the host pathophysiology.","deposited":{"timestamp":1604680534000,"date-time":"2020-11-06T16:35:34Z","date-parts":[[2020,11,6]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Sonia","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5920-7792","family":"Verma","affiliation":[]},{"sequence":"additional","family":"Dwivedy","given":"Abhisek","affiliation":[]},{"sequence":"additional","family":"Kumar","given":"Neeraj","affiliation":[]},{"sequence":"additional","family":"Biswal","given":"Bichitra K.","affiliation":[]}],"DOI":"10.1101/2020.11.02.365049","reference-count":61,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.11.02.365049","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1604459723000,"date-time":"2020-11-04T03:15:23Z","date-parts":[[2020,11,4]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"bioRxiv"},"id":"016odyhf","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1604683179265,"date-time":"2020-11-06T17:19:39Z","date-parts":[[2020,11,6]]},"cord_sha":"448dc8c5c814f313b155e050c9e5a05b17fefb7a"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":14159},
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The detection process on video images has been divided into 3 stages: determining the regions of interest (ROI) for a given frame, scanning the frame in ROI areas using the DNN-CNN classifier, in order to obtain a confidence of bee occurrence in each window in any position and any scale, and form one detection window from a cloud of windows provided by a positive classification. The process has been performed by a method of weighted cluster analysis, which is the main contribution of this work. The paper also describes a process of building the detector, during which the main challenge was the selection of clustering parameters that gives the smallest generalization error. The results of the experiments show the advantage of the cluster analysis method over the greedy method and the advantage of the optimization of cluster analysis parameters over standard-heuristic parameter values, provided that a sufficiently long learning fragment of the movie is used to optimize the parameters.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Jerzy","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6011-1955","family":"Dembski","affiliation":[]},{"sequence":"additional","given":"Julian","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5029-6768","family":"Szymański","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030504250","9783030504267"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-50426-7_34","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1592510992000,"date-time":"2020-06-18T20:09:52Z","date-parts":[[2020,6,18]]},"references-count":14,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"15 June 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"ICCS","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"International Conference on Computational Science","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Amsterdam","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"The Netherlands","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"3 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"5 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"20","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"iccs-computsci2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"https://www.iccs-meeting.org/iccs2020/","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Single-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"230","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"98","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"3","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"43% - 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  {"_key":"60c20ba37723bebd866454a4","_id":"documents/60c20ba37723bebd866454a4","_rev":"_cfFhBKG---","file_name":"018te609.pdf","md5":"AB8460FB39E47D42C9A4347486AB2139","id":"018te609","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/8t/e6/09/018te609/018te609.pdf","date":"2021-06-10T12:54+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","WHO_Covidence":"#20176636","subtitle":[],"accepted":{"date-parts":[[2020,8,18]]},"license-simplified":"cc-by-nd","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.08.17.20176636","group-title":"Infectious Diseases (except HIV/AIDS)","oaLink":"https://www.tandfonline.com/doi/pdf/10.1080/20477724.2020.1847778?needAccess=true","original-title":[],"title":["Evolving Virulence? Decreasing COVID-19 Complications among Massachusetts Healthcare Workers: A Cohort Study"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":9,"short-title":[],"issued":{"date-parts":[[2020,8,18]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,8,18]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"The hypothesis of attenuating SARS-CoV-2 virulence has been raised. We examined the temporal distribution of COVID-19 complications (ER visits, hospitalization, intubation/code, and/or death) among healthcare workers in one system that applied uniform screening criteria throughout the research period, and found the complication rate significantly decreased after April 15, 2020.","source":"Crossref","has_valid_pdf":true,"author":[{"sequence":"first","family":"Lan","given":"Fan-Yun","affiliation":[]},{"sequence":"additional","family":"Filler","given":"Robert","affiliation":[]},{"sequence":"additional","family":"Mathew","given":"Soni","affiliation":[]},{"sequence":"additional","family":"Iliaki","given":"Eirini","affiliation":[]},{"sequence":"additional","family":"Osgood","given":"Rebecca","affiliation":[]},{"sequence":"additional","family":"Bruno-Murtha","given":"Lou Ann","affiliation":[]},{"sequence":"additional","family":"Kales","given":"Stefanos N.","affiliation":[]}],"DOI":"10.1101/2020.08.17.20176636","reference-count":9,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.08.17.20176636","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[],"is-preprint-of":[{"id":"10.1080/20477724.2020.1847778","id-type":"doi","asserted-by":"subject"}]},"created":{"timestamp":1597762962000,"date-time":"2020-08-18T15:02:42Z","date-parts":[[2020,8,18]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"018te609","type":"posted-content","score":1,"deposited":{"timestamp":1612330552000,"date-time":"2021-02-03T05:35:52Z","date-parts":[[2021,2,3]]},"indexed":{"timestamp":1612332897913,"date-time":"2021-02-03T06:14:57Z","date-parts":[[2021,2,3]]},"cord_sha":""},"application":"software-mentions","pages":[{"page_width":634.32,"page_height":833.04},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":5954},
  {"_key":"60c20ba67723bebd866454a5","_id":"documents/60c20ba67723bebd866454a5","_rev":"_cfFhBKS---","file_name":"018lcuxh.pdf","md5":"75F62314A1D423373308E8F6760F9212","id":"018lcuxh","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/8l/cu/xh/018lcuxh/018lcuxh.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["545"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1592006400000,"date-time":"2020-06-13T00:00:00Z","date-parts":[[2020,6,13]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1592006400000,"date-time":"2020-06-13T00:00:00Z","date-parts":[[2020,6,13]]}}],"language":"en","author":[{"sequence":"first","given":"Stefan","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3411-2345","family":"Kreyer","affiliation":[]},{"sequence":"additional","family":"Baker","given":"William L.","affiliation":[]},{"sequence":"additional","family":"Scaravilli","given":"Vittorio","affiliation":[]},{"sequence":"additional","family":"Linden","given":"Katharina","affiliation":[]},{"sequence":"additional","family":"Belenkiy","given":"Slava M.","affiliation":[]},{"sequence":"additional","family":"Necsoiu","given":"Corina","affiliation":[]},{"sequence":"additional","family":"Muders","given":"Thomas","affiliation":[]},{"sequence":"additional","family":"Putensen","given":"Christian","affiliation":[]},{"sequence":"additional","family":"Chung","given":"Kevin K.","affiliation":[]},{"sequence":"additional","family":"Cancio","given":"Leopoldo C.","affiliation":[]},{"sequence":"additional","family":"Batchinsky","given":"Andriy I.","affiliation":[]}],"DOI":"10.1007/s10877-020-00545-4","license-simplified":"cc-by","original-title":[],"short-container-title":["J Clin Monit Comput"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Anesthesiology and Pain Medicine","Health Informatics","Critical Care and Intensive Care Medicine"],"issued":{"date-parts":[[2020,6,13]]},"funder":[{"doi-asserted-by":"crossref","award":["12340055"],"DOI":"10.13039/100000182","name":"Medical Research and Materiel Command"}],"publisher":"Springer Science and Business Media LLC","id":"018lcuxh","reference-count":31,"pmcid":"PMC7293172","has_valid_oa_url":true,"deposited":{"timestamp":1592053421000,"date-time":"2020-06-13T13:03:41Z","date-parts":[[2020,6,13]]},"indexed":{"timestamp":1592055636409,"date-time":"2020-06-13T13:40:36Z","date-parts":[[2020,6,13]]},"is-referenced-by-count":0,"title":["Assessment of spontaneous breathing during pressure controlled ventilation with superimposed spontaneous breathing using respiratory flow signal analysis"],"prefix":"10.1007","published-online":{"date-parts":[[2020,6,13]]},"has_valid_thumbnail":false,"references-count":31,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/41/56/PMC7293172.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s10877-020-00545-4","ISSN":["1387-1307","1573-2614"],"issn-type":[{"value":"1387-1307","type":"print"},{"value":"1573-2614","type":"electronic"}],"container-title":["Journal of Clinical Monitoring and Computing"],"score":1,"has_valid_ref_annotation":false,"member":"297","short-title":[],"has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","abstract":"Integrating spontaneous breathing into mechanical ventilation (MV) can speed up liberation from it and reduce its invasiveness. On the other hand, inadequate and asynchronous spontaneous breathing has the potential to aggravate lung injury. During use of airway-pressure-release-ventilation (APRV), the assisted breaths are difficult to measure. We developed an algorithm to differentiate the breaths in a setting of lung injury in spontaneously breathing ewes. We hypothesized that differentiation of breaths into spontaneous, mechanical and assisted is feasible using a specially developed for this purpose algorithm. Ventilation parameters were recorded by software that integrated ventilator output variables. The flow signal, measured by the EVITA® XL (Lübeck, Germany), was measured every 2 ms by a custom Java-based computerized algorithm (Breath-Sep). By integrating the flow signal, tidal volume (V(T)) of each breath was calculated. By using the flow curve the algorithm separated the different breaths and numbered them for each time point. Breaths were separated into mechanical, assisted and spontaneous. Bland Altman analysis was used to compare parameters. Comparing the values calculated by Breath-Sep with the data from the EVITA® using Bland–Altman analyses showed a mean bias of − 2.85% and 95% limits of agreement from − 25.76 to 20.06% for MV(total). For respiratory rate (RR) RR(set) a bias of 0.84% with a SD of 1.21% and 95% limits of agreement from − 1.53 to 3.21% were found. In the cluster analysis of the 25th highest breaths of each group RR(total) was higher using the EVITA®. In the mechanical subgroup the values for RR(spont) and MV(spont) the EVITA® showed higher values compared to Breath-Sep. We developed a computerized method for respiratory flow-curve based differentiation of breathing cycle components during mechanical ventilation with superimposed spontaneous breathing. Further studies in humans and optimizing of this technique is necessary to allow for real-time use at the bedside. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s10877-020-00545-4) contains supplementary material, which is available to authorized users.","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s10877-020-00545-4.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s10877-020-00545-4/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s10877-020-00545-4.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1592053372000,"date-time":"2020-06-13T13:02:52Z","date-parts":[[2020,6,13]]},"type":"journal-article","assertion":[{"order":1,"value":"4 December 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"6 June 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"13 June 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with ethical standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Dr. Batchinsky has past (2013) relationships as a Medical Advisory Board member for Hemolung and invited speaker by Maquet Cardiovascular, Germany (2016). Alung Technologies, Inc.: loaned to us the equipment used in this study without financial contribution (2014-5). All other authors report no conflicts of interest relevant to this manuscript. This paper is a second analyses of data of an already published paper [CitationRef removed].","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"This study was approved by the U.S. Army Institute of Surgical Research Institutional Animal Care and Use Committee (Protocol A-13-012). It was conducted in compliance with the Animal Welfare Act and the implementing Animal Welfare Regulations and in accordance with the principles of the <i>Guide for the Care and Use of Laboratory Animals</i>.","group":{"label":"Ethical approval","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"d0212b73d578c0840e5b020f96932cd8b0c1e42a"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":8630},
  {"_key":"60c20ba77723bebd866454a9","_id":"documents/60c20ba77723bebd866454a9","_rev":"_cfFhBKe---","file_name":"018vktwu.pdf","md5":"32996994A7AA4DA34B450E5F0E012B4C","id":"018vktwu","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/8v/kt/wu/018vktwu/018vktwu.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["S1090023314000422"],"published-print":{"date-parts":[[2014,4]]},"volume":"200","pmid":"24613416","has_valid_tei":false,"created":{"timestamp":1391544103000,"date-time":"2014-02-04T20:01:43Z","date-parts":[[2014,2,4]]},"DOI":"10.1016/j.tvjl.2014.01.017","original-title":[],"title":["The central role of chloride in the metabolic acid–base changes in canine parvoviral enteritis"],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","page":"152-156","type":"journal-article","issued":{"date-parts":[[2014,4]]},"publisher":"Elsevier BV","id":"018vktwu","short-title":[],"pmcid":"PMC7128572","has_valid_oa_url":true,"deposited":{"timestamp":1538863195000,"date-time":"2018-10-06T21:59:55Z","date-parts":[[2018,10,6]]},"indexed":{"timestamp":1596039712598,"date-time":"2020-07-29T16:21:52Z","date-parts":[[2020,7,29]]},"is-referenced-by-count":5,"short-container-title":["The Veterinary Journal"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/b6/a6/PMC7128572.tar.gz","has_valid_thumbnail":false,"ISSN":["1090-0233"],"references-count":30,"license-simplified":"no-cc","subtitle":[],"reference-count":30,"journal-issue":{"published-print":{"date-parts":[[2014,4]]},"issue":"1"},"issn-type":[{"value":"1090-0233","type":"print"}],"container-title":["The Veterinary Journal"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"78","abstract":"The acid–base disturbances in canine parvoviral (CPV) enteritis are not well described. In addition, the mechanisms causing these perturbations have not been fully elucidated. The purpose of the present study was to assess acid–base changes in puppies suffering from CPV enteritis, using a modified strong ion model (SIM). The hypothesis of the study was that severe acid–base disturbances would be present and that the SIM would provide insights into pathological mechanisms, which have not been fully appreciated by the Henderson–Hasselbalch model. The study analysed retrospective data, obtained from 42 puppies with confirmed CPV enteritis and 10 healthy control dogs. The CPV-enteritis group had been allocated a clinical score, to allow classification of the data according to clinical severity. The effects of changes in free water, chloride, l-lactate, albumin and phosphate were calculated, using a modification of the base excess algorithm. When the data were summated for each patient, and correlated to each individual component, the most important contributor to the metabolic acid–base changes, according to the SIM, was chloride (P < 0.001). Severely-affected animals tended to demonstrate hypochloraemic alkalosis, whereas mildly-affected puppies had a hyperchloraemic acidosis (P = 0.007). In conclusion, the acid–base disturbances in CPV enteritis are multifactorial and complex, with the SIM providing information in terms of the origin of these changes.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Burchell","given":"Richard K.","affiliation":[]},{"sequence":"additional","family":"Schoeman","given":"Johan P.","affiliation":[]},{"sequence":"additional","family":"Leisewitz","given":"Andrew L.","affiliation":[]}],"subject":["Animal Science and Zoology","General Veterinary"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S1090023314000422?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1090023314000422?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1016/j.tvjl.2014.01.017","language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"The central role of chloride in the metabolic acid–base changes in canine parvoviral enteritis","label":"Article Title","name":"articletitle"},{"value":"The Veterinary Journal","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.tvjl.2014.01.017","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"Copyright © 2014 Elsevier Ltd. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"444139f42a123635d16c1a93223a40a1dbd1b188"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":8555},
  {"_key":"60c20bab7723bebd866454ab","_id":"documents/60c20bab7723bebd866454ab","_rev":"_cfFhBKu---","file_name":"019oy69k.pdf","md5":"65F036C26F34AEAC2A4EFCA8BCF5800F","id":"019oy69k","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/9o/y6/9k/019oy69k/019oy69k.pdf","date":"2021-06-10T12:55+0000","metadata":{"published-print":{"date-parts":[[2014,4,1]]},"volume":"35","pmid":"24184523","author":[{"sequence":"first","family":"Hetts","given":"S. W.","affiliation":[]},{"sequence":"additional","family":"Turk","given":"A.","affiliation":[]},{"sequence":"additional","family":"English","given":"J. D.","affiliation":[]},{"sequence":"additional","family":"Dowd","given":"C. F.","affiliation":[]},{"sequence":"additional","family":"Mocco","given":"J.","affiliation":[]},{"sequence":"additional","family":"Prestigiacomo","given":"C.","affiliation":[]},{"sequence":"additional","family":"Nesbit","given":"G.","affiliation":[]},{"sequence":"additional","family":"Ge","given":"S. G.","affiliation":[]},{"sequence":"additional","family":"Jin","given":"J. N.","affiliation":[]},{"sequence":"additional","family":"Carroll","given":"K.","affiliation":[]},{"sequence":"additional","family":"Murayama","given":"Y.","affiliation":[]},{"sequence":"additional","family":"Gholkar","given":"A.","affiliation":[]},{"sequence":"additional","family":"Barnwell","given":"S.","affiliation":[]},{"sequence":"additional","family":"Lopes","given":"D.","affiliation":[]},{"sequence":"additional","family":"Johnston","given":"S. C.","affiliation":[]},{"sequence":"additional","family":"McDougall","given":"C.","affiliation":[]},{"sequence":"additional","affiliation":[],"name":"on behalf of the Matrix and Platinum Science Trial Investigators"}],"DOI":"10.3174/ajnr.a3755","license-simplified":"cc-by","original-title":[],"title":["Stent-Assisted Coiling versus Coiling Alone in Unruptured Intracranial Aneurysms in the Matrix and Platinum Science Trial: Safety, Efficacy, and Mid-Term Outcomes"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":23,"page":"698-705","type":"journal-article","issued":{"date-parts":[[2013,11,1]]},"publisher":"American Society of Neuroradiology (ASNR)","id":"019oy69k","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1498094397000,"date-time":"2017-06-22T01:19:57Z","date-parts":[[2017,6,22]]},"indexed":{"timestamp":1615830315450,"date-time":"2021-03-15T17:45:15Z","date-parts":[[2021,3,15]]},"is-referenced-by-count":83,"short-container-title":["American Journal of Neuroradiology"],"prefix":"10.3174","published-online":{"date-parts":[[2013,11,1]]},"has_valid_thumbnail":false,"ISSN":["0195-6108","1936-959X"],"references-count":23,"oaLink":"http://www.ajnr.org/content/ajnr/35/4/698.full.pdf","subtitle":[],"URL":"http://dx.doi.org/10.3174/ajnr.a3755","journal-issue":{"published-print":{"date-parts":[[2014,4,1]]},"issue":"4","published-online":{"date-parts":[[2014,4,10]]}},"issn-type":[{"value":"0195-6108","type":"print"},{"value":"1936-959X","type":"electronic"}],"container-title":["American Journal of Neuroradiology"],"has_valid_ref_annotation":false,"issue":"4","member":"1756","abstract":"BACKGROUND AND PURPOSE Stent-assisted coiling may result in less aneurysm recanalization but more complications than coiling alone. We evaluated outcomes of coiling with and without stents in the multicenter Matrix and Platinum Science Trial. MATERIALS AND METHODS All patients in the Matrix and Platinum Science Trial with unruptured intracranial aneurysms treated per protocol were included. Baseline patient and aneurysm characteristics, procedural details, neurologic outcomes, angiographic outcomes, and safety data were analyzed. RESULTS Overall, 137 of 361 (38%) patients were treated with a stent. Stent-coiled aneurysms had wider necks (≥4 mm in 62% with stents versus 33% without, P < .0001) and lower dome-to-neck ratios (1.3 versus 1.8, P < .0001). Periprocedural serious adverse events occurred infrequently in those treated with and without stents (6.6% versus 4.5%, P = .39). At 1 year, total significant adverse events, mortality, and worsening of mRS were similar in treatment groups, but ischemic strokes were more common in stent-coiled patients than in coiled patients (8.8% versus 2.2%, P = .005). However, multivariate analysis confirmed that at 2 years after treatment, prior cerebrovascular accident (OR, 4.7; P = .0089) and aneurysm neck width ≥4 mm (OR, 4.5; P = .02) were the only independent predictors of ischemic stroke. Stent use was not an independent predictor of ischemic stroke at 2 years (OR, 1.1; P = .94). Stent use did not predict target aneurysm recurrence at 2 years, but aneurysm dome size ≥10 mm (OR, 9.94; P < .0001) did predict target aneurysm recurrence. CONCLUSIONS Stent-coiling had similar outcomes as coiling despite stented aneurysms having more difficult morphology than coiled aneurysms. Increased ischemic events in stent-coiled aneurysms were attributable to baseline risk factors and aneurysm morphology.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Radiology Nuclear Medicine and imaging","Clinical Neurology"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.3174/ajnr.A3755","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1383360464000,"date-time":"2013-11-02T02:47:44Z","date-parts":[[2013,11,2]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":9236},
  {"_key":"60c20bb17723bebd866454ad","_id":"documents/60c20bb17723bebd866454ad","_rev":"_cfFhBL----","file_name":"01a8er2v.pdf","md5":"C795E0E61BBD8FE74BA853578A3120B5","id":"01a8er2v","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/a8/er/2v/01a8er2v/01a8er2v.pdf","date":"2021-06-10T12:55+0000","metadata":{"is-referenced-by-count":1,"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1199145600000,"date-time":"2008-01-01T00:00:00Z","date-parts":[[2008,1,1]]}}],"prefix":"10.1016","pmcid":"PMC7149781","subtitle":[],"license-simplified":"els-covid","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1016/b978-012374410-4.00706-8","references-count":10,"id":"01a8er2v","original-title":[],"short-container-title":[],"content-domain":{"domain":[],"crossmark-restriction":false},"page":"174-184","short-title":[],"issued":{"date-parts":[[2008]]},"container-title":["Encyclopedia of Virology"],"has_valid_oa_url":true,"has_valid_ref_annotation":false,"publisher":"Elsevier","member":"78","abstract":"The study of virus evolution has historically been concerned with disease and its emergence and has not been integrated into the general study of evolution. Yet viruses dominate our planet and their evolution is a broad and applied field that can be studied in the real time (such HIV in human disease) and can also be applied to biotechnological problems. Virus evolution is very similar, but not identical, to host evolution. Darwinian principles apply, such as with Fisher population genetics, but other features, such as reticulated and quasispecies-based evolution, distinguish virus evolution. In RNA viruses, high error rates have led to the quasispecies concept in which collective populations are the basis of evolution. These populations provide viruses with high capacities for adaptation. Yet some RNA viruses show remarkable evolutionary stability. With DNA viruses, especially of bacteria, extensive recombination defines vast dynamic and ancient genetic pools. Temperate viruses can directly affect host gene pools by stable colonization. DNA viruses can be genetically complex and have evolved many unique viral genes. The retroviruses show both quasispecies-based rapid evolution and host-linked slow coevolution (e.g., endogenous retroviruses). Thus, virus evolution impacts all life and viral emergence continues to threaten human health.","deposited":{"timestamp":1589587351000,"date-time":"2020-05-16T00:02:31Z","date-parts":[[2020,5,16]]},"published-print":{"date-parts":[[2008]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Villarreal","given":"L.P.","affiliation":[]}],"DOI":"10.1016/b978-012374410-4.00706-8","reference-count":10,"title":["Evolution of Viruses"],"ISBN":["9780123744104"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:B9780123744104007068?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:B9780123744104007068?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1235062485000,"date-time":"2009-02-19T16:54:45Z","date-parts":[[2009,2,19]]},"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/89/d7/PMC7149781.tar.gz","isbn-type":[{"value":"9780123744104","type":"print"}],"type":"book-chapter","score":1,"source":"Crossref","indexed":{"timestamp":1617917592393,"date-time":"2021-04-08T21:33:12Z","date-parts":[[2021,4,8]]},"cord_sha":"8b6f8c93695fbc49950229c48b4ced5abbb7d8dc"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":11309},
  {"_key":"60c20bb87723bebd866454b2","_id":"documents/60c20bb87723bebd866454b2","_rev":"_cfFhBLO---","file_name":"01b94ids.pdf","md5":"A3A5E79AA9EE451DDD2D890FB1C0AD8A","id":"01b94ids","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/b9/4i/ds/01b94ids/01b94ids.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["S2590229620300101"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1606780800000,"date-time":"2020-12-01T00:00:00Z","date-parts":[[2020,12,1]]}},{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1598313600000,"date-time":"2020-08-25T00:00:00Z","date-parts":[[2020,8,25]]}}],"article-number":"100012","language":"en","volume":"1","pmid":"32905018","has_valid_tei":false,"DOI":"10.1016/j.hpopen.2020.100012","original-title":[],"published-print":{"date-parts":[[2020,12]]},"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"page":"100012","issued":{"date-parts":[[2020,12]]},"funder":[{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100007391","name":"Association pour la Recherche sur le Cancer"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100002910","name":"Fédération Wallonie-Bruxelles"}],"publisher":"Elsevier BV","id":"01b94ids","reference-count":70,"title":["An assessment of the core capacities of the Senegalese health system to deliver Universal Health Coverage"],"pmcid":"PMC7462834","has_valid_oa_url":true,"deposited":{"timestamp":1608826934000,"date-time":"2020-12-24T16:22:14Z","date-parts":[[2020,12,24]]},"indexed":{"timestamp":1608828225135,"date-time":"2020-12-24T16:43:45Z","date-parts":[[2020,12,24]]},"is-referenced-by-count":1,"short-container-title":["Health Policy OPEN"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/d2/69/PMC7462834.tar.gz","has_valid_thumbnail":false,"ISSN":["2590-2296"],"references-count":70,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.hpopen.2020.100012","short-title":[],"issn-type":[{"value":"2590-2296","type":"print"}],"container-title":["Health Policy OPEN"],"score":1,"has_valid_ref_annotation":false,"member":"78","has_valid_pdf":true,"author":[{"sequence":"first","given":"Elisabeth","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3928-4093","family":"Paul","affiliation":[]},{"sequence":"additional","family":"Ndiaye","given":"Youssoupha","affiliation":[]},{"sequence":"additional","family":"Sall","given":"Farba L.","affiliation":[]},{"sequence":"additional","family":"Fecher","given":"Fabienne","affiliation":[]},{"sequence":"additional","family":"Porignon","given":"Denis","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S2590229620300101?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S2590229620300101?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1599018676000,"date-time":"2020-09-02T03:51:16Z","date-parts":[[2020,9,2]]},"type":"journal-article","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"An assessment of the core capacities of the Senegalese health system to deliver Universal Health Coverage","label":"Article Title","name":"articletitle"},{"value":"Health Policy OPEN","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.hpopen.2020.100012","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 The Author(s). Published by Elsevier B.V.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"f8bfb0b881e4f48d2526c6a2ee86a0056775ef26"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":9956},
  {"_key":"60c20bba7723bebd866454b4","_id":"documents/60c20bba7723bebd866454b4","_rev":"_cfFhBLa---","file_name":"01bjz2qq.pdf","md5":"C3FD93164B92D5124252821CDD9A28C5","id":"01bjz2qq","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/bj/z2/qq/01bjz2qq/01bjz2qq.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["S2590098620300518"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1606780800000,"date-time":"2020-12-01T00:00:00Z","date-parts":[[2020,12,1]]}},{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1600128000000,"date-time":"2020-09-15T00:00:00Z","date-parts":[[2020,9,15]]}}],"article-number":"100064","volume":"8","pmid":"32964205","has_valid_tei":false,"DOI":"10.1016/j.medidd.2020.100064","original-title":[],"published-print":{"date-parts":[[2020,12]]},"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"page":"100064","type":"journal-article","issued":{"date-parts":[[2020,12]]},"publisher":"Elsevier BV","id":"01bjz2qq","reference-count":18,"title":["Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study"],"pmcid":"PMC7499070","has_valid_oa_url":true,"deposited":{"timestamp":1611035741000,"date-time":"2021-01-19T05:55:41Z","date-parts":[[2021,1,19]]},"indexed":{"timestamp":1619194773539,"date-time":"2021-04-23T16:19:33Z","date-parts":[[2021,4,23]]},"is-referenced-by-count":22,"short-container-title":["Medicine in Drug Discovery"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/2f/46/PMC7499070.tar.gz","has_valid_thumbnail":false,"ISSN":["2590-0986"],"references-count":18,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.medidd.2020.100064","short-title":[],"issn-type":[{"value":"2590-0986","type":"print"}],"container-title":["Medicine in Drug Discovery"],"score":1,"has_valid_ref_annotation":false,"member":"78","abstract":"BACKGROUND: The COVID-19 pandemic has placed an enormous and growing burden on the population and health infrastructure, warranting innovative ways to mitigate risk of contracting and developing severe forms of this disease. A growing body of literature raises the issue of Vitamin C and Vitamin D as a risk-assessment tool, and therapeutic option, in COVID-19. OBJECTIVE: The objective of this pilot study was to measure serum Vitamin C and Vitamin D levels in a cohort of patients with critical COVID-19 illness in our community hospital ICU, correlate with other illness risk factors (age, BMI, HgbA1c, smoking status), generate hypotheses, and suggest further therapeutic intervention studies. METHOD: This pilot study included all 21 critically ill COVID-19 patients hospitalized in May 2020 in the ICU of North Suburban Medical Center, Thornton, Colorado, in whose care the principal investigator (C.A.) was involved. We measured patients' serum Vitamin C and Vitamin D levels, and standard risk factors like age, BMI, HbA1c, and smoking status. Variables in this study were gauged using descriptive statistics. RESULTS: Of 21 critically ill COVID-19 patients (15 males and 6 females, 17 Hispanic and 4 Caucasian, of median age 61 years, range 20–94), there were 11 survivors. Serum levels of Vitamin C and Vitamin D were low in most of our critically ill COVID-19 ICU patients. Older age and low Vitamin C level appeared co-dependent risk factors for mortality from COVID-19 in our sample. Insulin resistance and obesity were prevalent in our small cohort, but smoking was not. CONCLUSION: Our pilot study found low serum levels of Vitamin C and Vitamin D in most of our critically ill COVID-19 ICU patients. Older age and low Vitamin C level appeared co-dependent risk factors for mortality. Many were also insulin-resistant or diabetic, overweight or obese, known as independent risk factors for low Vitamin C and Vitamin D levels, and for COVID-19. These findings suggest the need to further explore whether caring for COVID-19 patients ought to routinely include measuring and correcting serum Vitamin C and Vitamin D levels, and whether treating critically ill COVID-19 warrants acute parenteral Vitamin C and Vitamin D replacement.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Arvinte","given":"Cristian","affiliation":[]},{"sequence":"additional","family":"Singh","given":"Maharaj","affiliation":[]},{"sequence":"additional","family":"Marik","given":"Paul E.","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S2590098620300518?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S2590098620300518?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1600417320000,"date-time":"2020-09-18T08:22:00Z","date-parts":[[2020,9,18]]},"language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Serum Levels of Vitamin C and Vitamin D in a Cohort of Critically Ill COVID-19 Patients of a North American Community Hospital Intensive Care Unit in May 2020: A Pilot Study","label":"Article Title","name":"articletitle"},{"value":"Medicine in Drug Discovery","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.medidd.2020.100064","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 The Author(s). Published by Elsevier B.V.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"f99f17818c6c1e051d880c6a58473ac838b0da4d"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":8778},
  {"_key":"60c20bc57723bebd866454b6","_id":"documents/60c20bc57723bebd866454b6","_rev":"_cfFhBLm---","file_name":"01c1hxav.pdf","md5":"7154D4B772DC13A14F132B1DE8EE0CFB","id":"01c1hxav","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/c1/hx/av/01c1hxav/01c1hxav.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["10.1136/bmjopen-2020-045048"],"license":[{"URL":"http://creativecommons.org/licenses/by-nc/4.0/","content-version":"unspecified","delay-in-days":4,"start":{"timestamp":1614902400000,"date-time":"2021-03-05T00:00:00Z","date-parts":[[2021,3,5]]}}],"language":"en","volume":"11","pmid":"33674377","has_valid_tei":false,"created":{"timestamp":1614974021000,"date-time":"2021-03-05T19:53:41Z","date-parts":[[2021,3,5]]},"DOI":"10.1136/bmjopen-2020-045048","license-simplified":"cc-by-nc","original-title":[],"published-print":{"date-parts":[[2021,3]]},"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1136/crossmarkpolicy","page":"e045048","type":"journal-article","issued":{"date-parts":[[2021,3]]},"publisher":"BMJ","id":"01c1hxav","short-title":[],"title":["Drivers and mediators of healthcare workers’ anxiety in one of the most affected hospitals by COVID-19: a qualitative analysis"],"pmcid":"PMC7938469","has_valid_oa_url":true,"deposited":{"timestamp":1614974036000,"date-time":"2021-03-05T19:53:56Z","date-parts":[[2021,3,5]]},"indexed":{"timestamp":1615078798088,"date-time":"2021-03-07T00:59:58Z","date-parts":[[2021,3,7]]},"is-referenced-by-count":0,"short-container-title":["BMJ Open"],"prefix":"10.1136","published-online":{"date-parts":[[2021,3,5]]},"has_valid_thumbnail":false,"references-count":31,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/46/ed/PMC7938469.tar.gz","subtitle":[],"reference-count":31,"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"container-title":["BMJ Open"],"has_valid_ref_annotation":false,"issue":"3","member":"239","abstract":"OBJECTIVE: To report the driving and mediating factors of healthcare workers’ anxiety during the COVID-19 pandemic. DESIGN: Qualitative indepth interview study. SETTING: The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. PARTICIPANTS: 53 healthcare workers who were or were not diagnosed with COVID-19. RESULTS: During the COVID-19 pandemic, healthcare workers were initially not sufficiently psychologically prepared. Then they suffered from severe anxiety and apprehension during the peak stage, regardless of whether they were infected with SARS-CoV-2 or not. These negative emotions were exacerbated by four drivers, namely infection risk, supplies, isolation and media. As the epidemic gradually came under control, healthcare workers experienced less anxiety from these factors, but became concerned about their low financial status. To reduce anxiety, healthcare workers diverted their attention from the risk of infection through personal entertainment and religious beliefs and focused on treating their patients. Furthermore, assistance from other people, including colleagues, families, friends, patients and society, helped protect healthcare workers from anxiety. CONCLUSIONS: Personal and social support can relieve healthcare workers’ anxiety to some extent during the different stages of an epidemic. Both protective equipment and financial allowance motivate healthcare workers to focus on patient care, although the latter matters more as the epidemic comes under control.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Fang","given":"Mengling","affiliation":[]},{"sequence":"additional","family":"Xia","given":"Bo","affiliation":[]},{"sequence":"additional","family":"Tian","given":"Tian","affiliation":[]},{"sequence":"additional","family":"Hao","given":"Yan","affiliation":[]},{"sequence":"additional","given":"Zhenghao","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8468-1234","family":"Wu","affiliation":[]}],"subject":["General Medicine"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1136/bmjopen-2020-045048","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1136/bmjopen-2020-045048","journal-issue":{"published-print":{"date-parts":[[2021,3]]},"issue":"3","published-online":{"date-parts":[[2021,3,5]]}},"score":1,"source":"Crossref","cord_sha":"03aac63144e6d1d38681f66dc972e5c0e9b15821; 9730c162c112a6c34f09f0c2d25b741fc3e33c7d"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":17860},
  {"_key":"60c20bcd7723bebd866454b8","_id":"documents/60c20bcd7723bebd866454b8","_rev":"_cfFhBLy---","file_name":"01d80kyl.pdf","md5":"D6EAC8168A770BC54C95FF81D2E74A02","id":"01d80kyl","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/d8/0k/yl/01d80kyl/01d80kyl.pdf","date":"2021-06-10T12:55+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1596758400000,"date-time":"2020-08-07T00:00:00Z","date-parts":[[2020,8,7]]}}],"language":"en","volume":"15","pmid":"32764780","has_valid_tei":false,"created":{"timestamp":1596822057000,"date-time":"2020-08-07T17:40:57Z","date-parts":[[2020,8,7]]},"DOI":"10.1371/journal.pone.0237167","license-simplified":"cc-by","original-title":[],"short-container-title":["PLoS ONE"],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1371/journal.pone.corrections_policy","page":"e0237167","type":"journal-article","issued":{"date-parts":[[2020,8,7]]},"funder":[{"doi-asserted-by":"publisher","award":["241961032"],"DOI":"10.13039/501100001659","name":"Deutsche Forschungsgemeinschaft"}],"publisher":"Public Library of Science (PLoS)","id":"01d80kyl","short-title":[],"editor":[{"sequence":"first","family":"Winkler","given":"Christoph","affiliation":[]}],"has_valid_oa_url":true,"deposited":{"timestamp":1596822076000,"date-time":"2020-08-07T17:41:16Z","date-parts":[[2020,8,7]]},"indexed":{"timestamp":1596823879586,"date-time":"2020-08-07T18:11:19Z","date-parts":[[2020,8,7]]},"is-referenced-by-count":0,"title":["All-age whole mount in situ hybridization to reveal larval and juvenile expression patterns in zebrafish"],"prefix":"10.1371","published-online":{"date-parts":[[2020,8,7]]},"has_valid_thumbnail":false,"references-count":29,"oaLink":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0237167&type=printable","subtitle":[],"reference-count":29,"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"container-title":["PLOS ONE"],"has_valid_ref_annotation":false,"issue":"8","member":"340","abstract":"The zebrafish Danio rerio is a valuable and common model for scientists in the fields of genetics and developmental biology. Since zebrafish are also amenable to genetic manipulation, modelling of human diseases or behavioral experiments have moved into the focus of zebrafish research. Consequently, gene expression data beyond embryonic and larval stages become more important, yet there is a dramatic knowledge gap of gene expression beyond day four of development. Like in other model organisms, the visualization of spatial and temporal gene expression by whole mount in situ hybridization (ISH) becomes increasingly difficult when zebrafish embryos develop further and hence the growing tissues become dense and less permeable. Here we introduce a modified method for whole mount ISH, which overcomes these penetration and detection problem. The method is an all in one solution that enables the detection and visualization of gene expression patterns up to the late larval stage in a 3D manner without the need for tissue sectioning and offers a valuable extension for whole mount ISH by immunohistochemistry in the zebrafish field.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Franz","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-0275-1433","family":"Vauti","affiliation":[]},{"sequence":"additional","family":"Stegemann","given":"Luisa A.","affiliation":[]},{"sequence":"additional","family":"Vögele","given":"Viktoria","affiliation":[]},{"sequence":"additional","family":"Köster","given":"Reinhard W.","affiliation":[]}],"subject":["General Biochemistry, Genetics and Molecular Biology","General Agricultural and Biological Sciences","General Medicine"],"link":[{"URL":"https://dx.plos.org/10.1371/journal.pone.0237167","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1371/journal.pone.0237167","journal-issue":{"issue":"8","published-online":{"date-parts":[[2020,8,7]]}},"score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":19671},
  {"_key":"60c20bcf7723bebd866454bb","_id":"documents/60c20bcf7723bebd866454bb","_rev":"_cfFhBM----","file_name":"01dhp7nn.pdf","md5":"0477CE5BA3E83A2333D2272997B2E2C2","id":"01dhp7nn","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/dh/p7/nn/01dhp7nn/01dhp7nn.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["S0009739X20303171"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1601510400000,"date-time":"2020-10-01T00:00:00Z","date-parts":[[2020,10,1]]}}],"pmid":"33218670","author":[{"sequence":"first","family":"Maqueda Gonzalez","given":"Rocío","affiliation":[]},{"sequence":"additional","family":"Cerdán Santacruz","given":"Carlos","affiliation":[]},{"sequence":"additional","family":"García Septiem","given":"Javier","affiliation":[]},{"sequence":"additional","family":"Blanco Terés","given":"Lara","affiliation":[]},{"sequence":"additional","family":"Lopesino González","given":"Jose María","affiliation":[]},{"sequence":"additional","family":"Fernández Jiménez","given":"Guillermo","affiliation":[]},{"sequence":"additional","family":"Martín-Pérez","given":"Elena","affiliation":[]}],"DOI":"10.1016/j.ciresp.2020.10.002","short-title":[],"original-title":[],"short-container-title":["Cirugía Española"],"content-domain":{"domain":[],"crossmark-restriction":false},"issued":{"date-parts":[[2020,10]]},"publisher":"Elsevier BV","id":"01dhp7nn","reference-count":27,"pmcid":"PMC7584434","has_valid_oa_url":true,"deposited":{"timestamp":1605686019000,"date-time":"2020-11-18T07:53:39Z","date-parts":[[2020,11,18]]},"indexed":{"timestamp":1605692093753,"date-time":"2020-11-18T09:34:53Z","date-parts":[[2020,11,18]]},"is-referenced-by-count":0,"title":["Proctologic emergency consultation during COVID-19: Comparative cross-sectional cohort study"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/80/25/PMC7584434.tar.gz","has_valid_thumbnail":false,"ISSN":["0009-739X"],"references-count":27,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.ciresp.2020.10.002","type":"journal-article","issn-type":[{"value":"0009-739X","type":"print"}],"container-title":["Cirugía Española"],"has_valid_ref_annotation":false,"member":"78","abstract":"Introduction: Proctologic issues entail a frequent reason for consultation in the emergency department (ED). We aim to analyze how the SARS-COV-2 pandemic has impacted in the demand for proctological consultations. Material and method: Descriptive comparative retrospective study of cross-sectional cohorts of patients attending the ED for proctological complaints from March to April in 2020 and 2019. Demographic variables, comorbidities, reasons for consultation and diagnosis, treatment and readmission were included. Four periods were analyzed according to the different stages of the pandemic derived limitations. Results: A total of 191 patients were reviewed, 58 in 2020 and 133 in 2019 with an average age of 48 years (SD 20.1) and 112 (58.6%) males. The average number of daily consultations was 2.18 patients in 2019 versus 0.95 in 2020 (p=0.025) meaning a 56% reduction in consultations for proctological reasons. This difference in average consultations was significant in both periods of lockout (p=0.001) and previous de-escalation (p=0.014). The diagnosis distribution was similar between both periods; however, perianal abscesses doubled their rate in 2020, 22.4% versus 11.3% (p=0.045). There was an increasing need for surgery, 31% vs 15% (p=0.011) with no difference in outpatients regimen after emergency surgery (12.5% vs 7.5%, p=0.201). Three patients in 2020 required readmission to the ED (5.2% vs 12.9%, p=0.086). Conclusion: There was a decrease of a 56% in proctologic emergency consultation, however, the need for surgery was twice more frequent during the study period. Reflection on the use of emergencies for proctological reasons is warranted.","published-print":{"date-parts":[[2020,10]]},"has_valid_pdf":true,"has_valid_tei":false,"subject":["Surgery"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0009739X20303171?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0009739X20303171?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1603477585000,"date-time":"2020-10-23T18:26:25Z","date-parts":[[2020,10,23]]},"language":"en","score":1,"source":"Crossref","cord_sha":"d6b1941462bdaee9cdafad45257425db48440a45"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":19962},
  {"_key":"60c20bd07723bebd866454bd","_id":"documents/60c20bd07723bebd866454bd","_rev":"_cfFhBMK---","file_name":"01eop0dt.pdf","md5":"3B4A673FDFE9DEB917470DD910DF52A5","id":"01eop0dt","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/eo/p0/dt/01eop0dt/01eop0dt.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["7320813","7320813"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1596758400000,"date-time":"2020-08-07T00:00:00Z","date-parts":[[2020,8,7]]}}],"volume":"2020","pmid":"32802219","has_valid_tei":false,"DOI":"10.1155/2020/7320813","original-title":[],"published-print":{"date-parts":[[2020,8,7]]},"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":14,"page":"1-6","issued":{"date-parts":[[2020,8,7]]},"funder":[{"award":[],"name":"The First Hospital of Changsha"}],"publisher":"Hindawi Limited","id":"01eop0dt","short-title":[],"title":["The Predictive Effectiveness of Blood Biochemical Indexes for the Severity of COVID-19"],"pmcid":"PMC7414353","has_valid_oa_url":true,"deposited":{"timestamp":1596845290000,"date-time":"2020-08-08T00:08:10Z","date-parts":[[2020,8,8]]},"indexed":{"timestamp":1602055421324,"date-time":"2020-10-07T07:23:41Z","date-parts":[[2020,10,7]]},"is-referenced-by-count":1,"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"prefix":"10.1155","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/5e/71/PMC7414353.tar.gz","has_valid_thumbnail":false,"ISSN":["1712-9532","1918-1493"],"references-count":14,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1155/2020/7320813","type":"journal-article","issn-type":[{"value":"1712-9532","type":"print"},{"value":"1918-1493","type":"electronic"}],"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"has_valid_ref_annotation":false,"member":"98","abstract":"Objective We aimed to explore the predictive effectiveness of blood biochemical indexes for COVID-19 severity. Method We retrospectively analyzed the clinical data of COVID-19 patients who were cured and discharged from the Public Health Treatment Center of Changsha from January 30, 2020, to February 19, 2020. According to the clinical classification of the disease, the patients were divided into severe and nonsevere groups. General clinical data and underlying medical conditions were recorded through the electronic medical record (EMR) system. Laboratory examination results of the patients during their hospitalization were collected, including the first results for erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), peripheral blood lymphocyte ratio and count, and peripheral blood white blood cell (WBC) count. Univariate and multivariate logistic regression models were used to analyze the predictive effectiveness of blood biochemical indexes and other related factors for COVID-19 severity. Result In all, 108 COVID-19 patients (median age: 43.9 years (range: 1-75); male patients: 56 (51.85%)) were enrolled, of whom 24 (22.22%) showed severe disease and 84 (77.78%) showed nonsevere disease, and two in 24 patients with severe disease developed into a critically severe type and died. Fever was the most common onset symptom (67.59%), followed by cough (48.15%) and fatigue (37.04%). Comorbidities were important factors affecting the severity of COVID-19, and among the patients with severe disease, the proportion with comorbidities was 70.83%, and the proportion without comorbidities was 29.17%. The intergroup difference was significant (P < 0.05). In patients with CRP levels (mg/L) of ≤8, >8-≤20, >20-≤40, and >40, the proportions of those with severe and nonsevere disease were 0 to 32, 7 to 19, 6 to 23, and 11 to 10, respectively; the intergroup difference was significant (P < 0.05). Conclusion The presence or absence of comorbidities and CRP elevation were independent significant predictors of COVID-19 severity, and hypertension was found as the most common comorbidity in patients with severe disease.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Zhou","given":"Yingchu","affiliation":[{"name":"The First Hospital of Changsha, The Hospital of Infectious Diseases of Changsha, The Public Health Treatment Center of Changsha, Changsha 410005, China"}]},{"sequence":"additional","given":"Bo","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-9282-5517","family":"Li","affiliation":[{"name":"The First Hospital of Changsha, The Hospital of Infectious Diseases of Changsha, The Public Health Treatment Center of Changsha, Changsha 410005, China"}]},{"sequence":"additional","family":"Liu","given":"Jiyang","affiliation":[{"name":"The First Hospital of Changsha, The Hospital of Infectious Diseases of Changsha, The Public Health Treatment Center of Changsha, Changsha 410005, China"}]},{"sequence":"additional","family":"Chen","given":"Dong","affiliation":[{"name":"The First Hospital of Changsha, The Hospital of Infectious Diseases of Changsha, The Public Health Treatment Center of Changsha, Changsha 410005, China"}]}],"subject":["Microbiology (medical)","Infectious Diseases"],"link":[{"URL":"http://downloads.hindawi.com/journals/cjidmm/2020/7320813.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://downloads.hindawi.com/journals/cjidmm/2020/7320813.xml","content-version":"vor","intended-application":"text-mining","content-type":"application/xml"},{"URL":"http://downloads.hindawi.com/journals/cjidmm/2020/7320813.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1596845280000,"date-time":"2020-08-08T00:08:00Z","date-parts":[[2020,8,8]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":600.038,"page_height":800.05},{"page_width":600.038,"page_height":800.05},{"page_width":600.038,"page_height":800.05},{"page_width":600.038,"page_height":800.05},{"page_width":600.038,"page_height":800.05},{"page_width":600.038,"page_height":800.05}],"runtime":13740},
  {"_key":"60c20bd37723bebd866454c0","_id":"documents/60c20bd37723bebd866454c0","_rev":"_cfFhBMW---","file_name":"01evo8h1.pdf","md5":"E4ABB1949DDB8D1F8457D19EE824B449","id":"01evo8h1","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/ev/o8/h1/01evo8h1/01evo8h1.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["S1062030320300583"],"published-print":{"date-parts":[[2020,12]]},"volume":"38","pmid":"33279106","journal-issue":{"published-print":{"date-parts":[[2020,12]]},"issue":"4"},"author":[{"sequence":"first","family":"Moran","given":"Alexandra","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Esther S.H.","affiliation":[]},{"sequence":"additional","family":"Beckman","given":"Joshua A.","affiliation":[]},{"sequence":"additional","family":"Aday","given":"Aaron W.","affiliation":[]}],"created":{"timestamp":1596128902000,"date-time":"2020-07-30T17:08:22Z","date-parts":[[2020,7,30]]},"DOI":"10.1016/j.jvn.2020.07.008","original-title":[],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1606780800000,"date-time":"2020-12-01T00:00:00Z","date-parts":[[2020,12,1]]}}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Medical–Surgical"],"page":"176-179","type":"journal-article","issued":{"date-parts":[[2020,12]]},"funder":[{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100000002","name":"National Institutes of Health"}],"publisher":"Elsevier BV","id":"01evo8h1","short-title":[],"title":["Vascular medicine in the COVID-19 era: The Vanderbilt experience"],"pmcid":"PMC7392174","has_valid_oa_url":true,"deposited":{"timestamp":1606946772000,"date-time":"2020-12-02T22:06:12Z","date-parts":[[2020,12,2]]},"indexed":{"timestamp":1606948914594,"date-time":"2020-12-02T22:41:54Z","date-parts":[[2020,12,2]]},"is-referenced-by-count":0,"short-container-title":["Journal of Vascular Nursing"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/fb/50/PMC7392174.tar.gz","has_valid_thumbnail":false,"references-count":12,"license-simplified":"els-covid","subtitle":[],"reference-count":12,"ISSN":["1062-0303"],"issn-type":[{"value":"1062-0303","type":"print"}],"container-title":["Journal of Vascular Nursing"],"score":1,"has_valid_ref_annotation":false,"issue":"4","member":"78","abstract":"• COVID-19 poses significant risks for patients with vascular disease; • Telemedicine can help clinicians care for patients with vascular disease while socially distancing due to COVID-19; • Diagnosis-based algorithms helped clinicians identify candidate patients for telemedicine versus in-person evaluation; • These algorithms guided clinicians in both the inpatient and outpatient setting.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S1062030320300583?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1062030320300583?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1016/j.jvn.2020.07.008","language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Vascular medicine in the COVID-19 era: The Vanderbilt experience","label":"Article Title","name":"articletitle"},{"value":"Journal of Vascular Nursing","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.jvn.2020.07.008","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 Society for Vascular Nursing. Published by Elsevier Inc. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"204312b4e86df8507f61f6a3b377c8c38ce99c8c"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":5799},
  {"_key":"60c20bd77723bebd866454c2","_id":"documents/60c20bd77723bebd866454c2","_rev":"_cfFhBMi---","file_name":"01f2eq0v.pdf","md5":"E89E553365E9012E246C808EDB32AB70","id":"01f2eq0v","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/f2/eq/0v/01f2eq0v/01f2eq0v.pdf","date":"2021-06-10T12:55+0000","metadata":{"published-print":{"date-parts":[[2012,2,1]]},"volume":"55","pmid":"22269299","author":[{"sequence":"first","family":"Choi","given":"Yoon","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Zisun","affiliation":[]},{"sequence":"additional","family":"Hur","given":"Kyung","affiliation":[]}],"DOI":"10.1503/cjs.019610","original-title":["EN"],"short-container-title":["Can J Surg"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":0,"page":"33-36","type":"journal-article","issued":{"date-parts":[[2012,2,1]]},"publisher":"Joule Inc.","id":"01f2eq0v","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1557766786000,"date-time":"2019-05-13T16:59:46Z","date-parts":[[2019,5,13]]},"indexed":{"timestamp":1596064629818,"date-time":"2020-07-29T23:17:09Z","date-parts":[[2020,7,29]]},"is-referenced-by-count":38,"title":["Learning curve for laparoscopic totally extraperitoneal repair of inguinal hernia"],"prefix":"10.1503","oaLink":"http://canjsurg.ca/wp-content/uploads/55-1-33.pdf","has_valid_thumbnail":false,"references-count":0,"license-simplified":"unk","subtitle":[],"URL":"http://dx.doi.org/10.1503/cjs.019610","ISSN":["0008-428X"],"issn-type":[{"value":"0008-428X","type":"print"}],"container-title":["Canadian Journal of Surgery"],"has_valid_ref_annotation":false,"issue":"1","member":"382","abstract":"BACKGROUND Laparoscopic totally extraperitoneal (TEP) repair has been accepted as a popular procedure for inguinal hernia repair, but surgeons still encounter technical difficulties owing to unfamiliar pelvic anatomy and limited working space. We sought to estimate the learning curve for laparoscopic TEP repair without supervision. METHODS We retrospectively analyzed the medical records of patients scheduled for laparoscopic TEP repair of an inguinal hernia from December 2000 to October 2007. RESULTS We reviewed medical records for 700 patients. The cases were divided into 8 groups: 20 patients each in groups I-V and 200 patients each in groups VI-VIII. No significant difference in demographic characteristics was identified among the groups. The mean duration of surgery significantly decreased (p < 0.001) in relation to experience; it reached a plateau of less than 30 minutes (mean 28 min) after 60 cases. The mean length of stay in hospital was 0.97 days, reaching a plateau after 20 cases. Six patients were converted to other techniques: 1 patient each in groups III and VIII and 4 patients in group VII. Three recurrences were detected; however, 2 were excluded because the patient had bilateral inguinal hernias. CONCLUSION We estimate the learning curve for laparoscopic TEP repair is 60 cases for a beginner surgeon. The presence of an experienced supervisor during the first 60 cases can help prevent unnecessary complications and shorten the duration of surgery.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Surgery"],"link":[{"URL":"https://canjsurg.ca/wp-content/uploads/55-1-33.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{},"created":{"timestamp":1403182606000,"date-time":"2014-06-19T12:56:46Z","date-parts":[[2014,6,19]]},"journal-issue":{"published-print":{"date-parts":[[2012,2,1]]},"issue":"1"},"score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":2081},
  {"_key":"60c20bda7723bebd866454c4","_id":"documents/60c20bda7723bebd866454c4","_rev":"_cfFhBMu---","file_name":"01f5mvsc.pdf","md5":"734E3811DD97D8BAEBFA0FD65E33A86F","id":"01f5mvsc","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/f5/mv/sc/01f5mvsc/01f5mvsc.pdf","date":"2021-06-10T12:55+0000","metadata":{"is-referenced-by-count":1,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,4,7]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.04.05.20054775","group-title":"Public and Global Health","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/04/07/2020.04.05.20054775.full.pdf","original-title":[],"title":["Increased Detection coupled with Social Distancing and Health Capacity Planning Reduce the Burden of COVID-19 Cases and Fatalities: A Proof of Concept Study using a Stochastic Computational Simulation Model"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":20,"short-title":[],"issued":{"date-parts":[[2020,4,7]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,4,7]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Objective: In absence of any vaccine, the Corona Virus Disease 2019 (COVID-19) pandemic is being contained through a non-pharmaceutical measure termed Social Distancing (SD). However, whether SD alone is enough to flatten the epidemic curve is debatable. Using a Stochastic Computational Simulation Model, we investigated the impact of increasing SD, hospital beds and COVID-19 detection rates in preventing COVID-19 cases and fatalities. Research Design and Methods: The Stochastic Simulation Model was built using the EpiModel package in R. As a proof of concept study, we ran the simulation on Kasaragod, the most affected district in Kerala. We added 3 compartments to the SEIR model to obtain a SEIQHRF (Susceptible-Exposed-Infectious-Quarantined-Hospitalised-Recovered-Fatal) model. Results: Implementing SD only delayed the appearance of peak prevalence of COVID-19 cases. Doubling of hospital beds could not reduce the fatal cases probably due to its overwhelming number compared to the hospital beds. Increasing detection rates could significantly flatten the curve and reduce the peak prevalence of cases (increasing detection rate by 5 times could reduce case number to half). Conclusions: An effective strategy to contain the epidemic spread of COVID-19 in India is to increase detection rates in combination with SD measures and increase in hospital beds.","deposited":{"timestamp":1606337175000,"date-time":"2020-11-25T20:46:15Z","date-parts":[[2020,11,25]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Ghosh","given":"Pramit","affiliation":[]},{"sequence":"additional","family":"Basheer","given":"Salah","affiliation":[]},{"sequence":"additional","given":"Sandip","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-7406-3598","family":"Paul","affiliation":[]},{"sequence":"additional","given":"Partha","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9502-8695","family":"Chakrabarti","affiliation":[]},{"sequence":"additional","given":"Jit","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-9964-6287","family":"Sarkar","affiliation":[]}],"DOI":"10.1101/2020.04.05.20054775","reference-count":20,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.04.05.20054775","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1586296853000,"date-time":"2020-04-07T22:00:53Z","date-parts":[[2020,4,7]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"01f5mvsc","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1606338682468,"date-time":"2020-11-25T21:11:22Z","date-parts":[[2020,11,25]]},"cord_sha":"a5cdc10ddf08b16f4e3363504118803f37a5b683"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":793.7,"page_height":446.456},{"page_width":793.7,"page_height":446.456},{"page_width":793.7,"page_height":446.456},{"page_width":793.7,"page_height":446.456}],"runtime":4892},
  {"_key":"60c20bde7723bebd866454c8","_id":"documents/60c20bde7723bebd866454c8","_rev":"_cfFhBM6---","file_name":"01gi1w3m.pdf","md5":"FF98D2F3B22CA1F395EA6DC2712E751B","id":"01gi1w3m","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/gi/1w/3m/01gi1w3m/01gi1w3m.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["S0168365918302116"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1527811200000,"date-time":"2018-06-01T00:00:00Z","date-parts":[[2018,6,1]]}}],"volume":"279","pmid":"29673641","has_valid_tei":false,"DOI":"10.1016/j.jconrel.2018.04.028","short-title":[],"original-title":[],"published-print":{"date-parts":[[2018,6]]},"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Pharmaceutical Science"],"page":"243-250","issued":{"date-parts":[[2018,6]]},"funder":[{"award":["NIDCD R01 DC014464"],"name":"National Institute for Deafness and Communication Disorders"}],"publisher":"Elsevier BV","id":"01gi1w3m","reference-count":20,"title":["A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss"],"has_valid_oa_url":true,"deposited":{"timestamp":1563625177000,"date-time":"2019-07-20T12:19:37Z","date-parts":[[2019,7,20]]},"indexed":{"timestamp":1617812904696,"date-time":"2021-04-07T16:28:24Z","date-parts":[[2021,4,7]]},"is-referenced-by-count":16,"short-container-title":["Journal of Controlled Release"],"prefix":"10.1016","oaLink":"http://europepmc.org/articles/pmc6344933?pdf=render","has_valid_thumbnail":false,"ISSN":["0168-3659"],"references-count":20,"license-simplified":"unk","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.jconrel.2018.04.028","type":"journal-article","issn-type":[{"value":"0168-3659","type":"print"}],"container-title":["Journal of Controlled Release"],"score":1,"has_valid_ref_annotation":false,"member":"78","abstract":"Hearing loss is the most prevalent sensory disability worldwide and may be caused by age, drugs or exposure to excessive noise. We have previously developed a minimally-invasive nanohydrogel drug delivery system that successfully delivers nanoparticles into the inner ear. We have substantially extended this technique by functionalizing the nanoparticles and introducing a targeting peptide which recognizes prestin, a transmembrane electromotile protein uniquely expressed in outer hair cells (OHCs) of the inner ear. We demonstrate the successful delivery of molecules and plasmids specifically to OHCs. When compared to untargeted nanoparticles, the delivery of a c-Jun N-terminal kinase (JNK) inhibitor, D-JNKi-1, to OHCs by targeted nanoparticles improved protection from noise induced hearing loss (NIHL). This is the first demonstration of a protection from NIHL using a novel safe and controllable delivery system which is minimally-invasive to the inner ear and, as such, is an extremely appealing technique for use in many clinical applications.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Kayyali","given":"Mohammad N.","affiliation":[]},{"sequence":"additional","family":"Wooltorton","given":"Julian R.A.","affiliation":[]},{"sequence":"additional","family":"Ramsey","given":"Andrew J.","affiliation":[]},{"sequence":"additional","family":"Lin","given":"Mei","affiliation":[]},{"sequence":"additional","family":"Chao","given":"Tiffany N.","affiliation":[]},{"sequence":"additional","family":"Tsourkas","given":"Andrew","affiliation":[]},{"suffix":"Jr","sequence":"additional","family":"O'Malley","given":"Bert W.","affiliation":[]},{"sequence":"additional","family":"Li","given":"Daqing","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S0168365918302116?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0168365918302116?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1523896687000,"date-time":"2018-04-16T16:38:07Z","date-parts":[[2018,4,16]]},"language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss","label":"Article Title","name":"articletitle"},{"value":"Journal of Controlled Release","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.jconrel.2018.04.028","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2018 Published by Elsevier B.V.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":9249},
  {"_key":"60c20bdf7723bebd866454cf","_id":"documents/60c20bdf7723bebd866454cf","_rev":"_cfFhBNG---","file_name":"01f36rld.pdf","md5":"3CEEB4A48D123CF6C8D02FD6E2AFD8D1","id":"01f36rld","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/f3/6r/ld/01f36rld/01f36rld.pdf","date":"2021-06-10T12:55+0000","metadata":{"alternative-id":["22899"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1521158400000,"date-time":"2018-03-16T00:00:00Z","date-parts":[[2018,3,16]]}}],"article-number":"4726","language":"en","volume":"8","pmid":"29549333","journal-issue":{"published-print":{"date-parts":[[2018,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1038/s41598-018-22899-1","license-simplified":"cc-by","original-title":[],"short-container-title":["Sci Rep"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Multidisciplinary"],"type":"journal-article","issued":{"date-parts":[[2018,3,16]]},"publisher":"Springer Science and Business Media LLC","id":"01f36rld","reference-count":61,"pmcid":"PMC5856848","has_valid_oa_url":true,"deposited":{"timestamp":1603952129000,"date-time":"2020-10-29T06:15:29Z","date-parts":[[2020,10,29]]},"indexed":{"timestamp":1604032971389,"date-time":"2020-10-30T04:42:51Z","date-parts":[[2020,10,30]]},"is-referenced-by-count":3,"title":["Bat-mouse bone marrow chimera: a novel animal model for dissecting the uniqueness of the bat immune system"],"prefix":"10.1038","published-online":{"date-parts":[[2018,3,16]]},"has_valid_thumbnail":false,"references-count":61,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/6d/cf/PMC5856848.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1038/s41598-018-22899-1","short-title":[],"issn-type":[{"value":"2045-2322","type":"electronic"}],"container-title":["Scientific Reports"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"Bats are an important animal model with long lifespans, low incidences of tumorigenesis and an ability to asymptomatically harbour pathogens. Currently, in vivo studies of bats are hampered due to their low reproduction rates. To overcome this, we transplanted bat cells from bone marrow (BM) and spleen into an immunodeficient mouse strain NOD-scid IL-2R(−/−) (NSG), and have successfully established stable, long-term reconstitution of bat immune cells in mice (bat-mice). Immune functionality of our bat-mouse model was demonstrated through generation of antigen-specific antibody response by bat cells following immunization. Post-engraftment of total bat BM cells and splenocytes, bat immune cells survived, expanded and repopulated the mouse without any observable clinical abnormalities. Utilizing bat’s remarkable immunological functions, this novel model has a potential to be transformed into a powerful platform for basic and translational research.","published-print":{"date-parts":[[2018,12]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Yong","given":"Kylie Su Mei","affiliation":[]},{"sequence":"additional","given":"Justin Han Jia","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1076-6013","family":"Ng","affiliation":[]},{"sequence":"additional","family":"Her","given":"Zhisheng","affiliation":[]},{"sequence":"additional","family":"Hey","given":"Ying Ying","affiliation":[]},{"sequence":"additional","family":"Tan","given":"Sue Yee","affiliation":[]},{"sequence":"additional","family":"Tan","given":"Wilson Wei Sheng","affiliation":[]},{"sequence":"additional","family":"Irac","given":"Sergio Erdal","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Min","affiliation":[]},{"sequence":"additional","given":"Xue Ying","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1685-0531","family":"Chan","affiliation":[]},{"sequence":"additional","family":"Gunawan","given":"Merry","affiliation":[]},{"sequence":"additional","family":"Foo","given":"Randy Jee Hiang","affiliation":[]},{"sequence":"additional","given":"Dolyce Hong Wen","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-4399-7325","family":"Low","affiliation":[]},{"sequence":"additional","family":"Mendenhall","given":"Ian Hewitt","affiliation":[]},{"sequence":"additional","family":"Chionh","given":"Yok Teng","affiliation":[]},{"sequence":"additional","family":"Dutertre","given":"Charles-Antoine","affiliation":[]},{"sequence":"additional","family":"Chen","given":"Qingfeng","affiliation":[]},{"sequence":"additional","given":"Lin-Fa","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2752-0535","family":"Wang","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://www.nature.com/articles/s41598-018-22899-1.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://www.nature.com/articles/s41598-018-22899-1","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://www.nature.com/articles/s41598-018-22899-1.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1520870022000,"date-time":"2018-03-12T15:53:42Z","date-parts":[[2018,3,12]]},"ISSN":["2045-2322"],"assertion":[{"order":1,"value":"13 July 2017","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"27 February 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"16 March 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"The authors declare no competing interests.","group":{"label":"Competing Interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"dc3df0a30a76ca925a5cc4466528ea0c4dab9638"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362}],"runtime":9952},
  {"_key":"60c20be47723bebd866454d2","_id":"documents/60c20be47723bebd866454d2","_rev":"_cfFhBNS---","file_name":"01he0rl1.pdf","md5":"D33D9F8A733F21DCBD7BE4654637CF24","id":"01he0rl1","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/he/0r/l1/01he0rl1/01he0rl1.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["3237"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1611532800000,"date-time":"2021-01-25T00:00:00Z","date-parts":[[2021,1,25]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1611532800000,"date-time":"2021-01-25T00:00:00Z","date-parts":[[2021,1,25]]}}],"language":"en","volume":"591","pmid":"33494095","has_valid_tei":false,"DOI":"10.1038/s41586-021-03237-4","license-simplified":"unk","original-title":[],"published-print":{"date-parts":[[2021,3,11]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","page":"293-299","type":"journal-article","issued":{"date-parts":[[2021,1,25]]},"publisher":"Springer Science and Business Media LLC","id":"01he0rl1","reference-count":42,"title":["Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis"],"has_valid_oa_url":true,"deposited":{"timestamp":1615324829000,"date-time":"2021-03-09T21:20:29Z","date-parts":[[2021,3,9]]},"indexed":{"timestamp":1617874137236,"date-time":"2021-04-08T09:28:57Z","date-parts":[[2021,4,8]]},"is-referenced-by-count":24,"short-container-title":["Nature"],"prefix":"10.1038","published-online":{"date-parts":[[2021,1,25]]},"has_valid_thumbnail":false,"references-count":42,"oaLink":"https://www.nature.com/articles/s41586-021-03237-4.pdf","subtitle":[],"URL":"http://dx.doi.org/10.1038/s41586-021-03237-4","ISSN":["0028-0836","1476-4687"],"issn-type":[{"value":"0028-0836","type":"print"},{"value":"1476-4687","type":"electronic"}],"container-title":["Nature"],"score":1,"has_valid_ref_annotation":false,"issue":"7849","member":"297","short-title":[],"has_valid_pdf":true,"author":[{"sequence":"first","family":"Johnson","given":"Bryan A.","affiliation":[]},{"sequence":"additional","given":"Xuping","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-0918-016X","family":"Xie","affiliation":[]},{"sequence":"additional","given":"Adam L.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6560-9680","family":"Bailey","affiliation":[]},{"sequence":"additional","family":"Kalveram","given":"Birte","affiliation":[]},{"sequence":"additional","family":"Lokugamage","given":"Kumari G.","affiliation":[]},{"sequence":"additional","family":"Muruato","given":"Antonio","affiliation":[]},{"sequence":"additional","family":"Zou","given":"Jing","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Xianwen","affiliation":[]},{"sequence":"additional","family":"Juelich","given":"Terry","affiliation":[]},{"sequence":"additional","family":"Smith","given":"Jennifer K.","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Lihong","affiliation":[]},{"sequence":"additional","family":"Bopp","given":"Nathen","affiliation":[]},{"sequence":"additional","given":"Craig","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-9804-2246","family":"Schindewolf","affiliation":[]},{"sequence":"additional","family":"Vu","given":"Michelle","affiliation":[]},{"sequence":"additional","family":"Vanderheiden","given":"Abigail","affiliation":[]},{"sequence":"additional","family":"Winkler","given":"Emma S.","affiliation":[]},{"sequence":"additional","given":"Daniele","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6694-5571","family":"Swetnam","affiliation":[]},{"sequence":"additional","given":"Jessica A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-4768-7458","family":"Plante","affiliation":[]},{"sequence":"additional","family":"Aguilar","given":"Patricia","affiliation":[]},{"sequence":"additional","given":"Kenneth S.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7485-3167","family":"Plante","affiliation":[]},{"sequence":"additional","family":"Popov","given":"Vsevolod","affiliation":[]},{"sequence":"additional","given":"Benhur","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-0760-1709","family":"Lee","affiliation":[]},{"sequence":"additional","given":"Scott C.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8016-8556","family":"Weaver","affiliation":[]},{"sequence":"additional","family":"Suthar","given":"Mehul S.","affiliation":[]},{"sequence":"additional","given":"Andrew L.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-2874-5990","family":"Routh","affiliation":[]},{"sequence":"additional","given":"Ping","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-4022-6667","family":"Ren","affiliation":[]},{"sequence":"additional","family":"Ku","given":"Zhiqiang","affiliation":[]},{"sequence":"additional","given":"Zhiqiang","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9309-2335","family":"An","affiliation":[]},{"sequence":"additional","family":"Debbink","given":"Kari","affiliation":[]},{"sequence":"additional","family":"Diamond","given":"Michael S.","affiliation":[]},{"sequence":"additional","given":"Pei-Yong","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5553-1616","family":"Shi","affiliation":[]},{"sequence":"additional","family":"Freiberg","given":"Alexander N.","affiliation":[]},{"sequence":"additional","given":"Vineet D.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8803-7606","family":"Menachery","affiliation":[]}],"subject":["Multidisciplinary"],"abstract":"SARS-CoV-2, a novel coronavirus (CoV)-producing worldwide pandemic1, has a furin cleavage site (PRRAR) in its spike protein that is absent in other group 2B CoVs2. To explore whether the furin cleavage site contributes to infection and pathogenesis, we generated a mutant SARS-CoV-2 deleting the furin cleavage site (ΔPRRA). SARS-CoV-2 ΔPRRA replicates had faster kinetics, improved fitness in Vero E6 cells, and reduced spike protein processing as compared to parental SARS-CoV-2. However, the ΔPRRA mutant had reduced replication in a human respiratory cell line and was attenuated in both hamster and K18-hACE2 transgenic mouse models of SARS-CoV-2 pathogenesis. Despite reduced disease, the ΔPRRA mutant conferred protection against rechallenge with the parental SARS-CoV-2. Importantly, COVID-19 patient sera and receptor-binding domain (RBD) monoclonal antibodies had lower neutralization values against the ΔPRRA mutant versus parental SARS-CoV-2, likely due to increased particle/PFU ratio. Together, these results demonstrate a critical role for the furin cleavage site in SARS-CoV-2 infection and highlight the importance of this site in evaluating antibody neutralization activity.","link":[{"URL":"http://www.nature.com/articles/s41586-021-03237-4.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://www.nature.com/articles/s41586-021-03237-4","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://www.nature.com/articles/s41586-021-03237-4.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1611572801000,"date-time":"2021-01-25T11:06:41Z","date-parts":[[2021,1,25]]},"journal-issue":{"published-print":{"date-parts":[[2021,3,11]]},"issue":"7849"},"assertion":[{"order":1,"value":"26 August 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"13 January 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"25 January 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"X.X., P.-Y.S. and V.D.M. have filed a US patent on the reverse genetic system and SARS-CoV-2 reporter. M.S.D. is a consultant for Inbios, Vir Biotechnology and NGM Biopharmaceuticals, and is on the Scientific Advisory Board of Moderna and Immunome. The laboratory of M.S.D. has received unrelated funding support in sponsored research agreements from Moderna, Vir Biotechnology and Emergent BioSolutions. The other authors declare no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.22,"page_height":842},{"page_width":595.22,"page_height":842},{"page_width":595.22,"page_height":842}],"runtime":9473},
  {"_key":"60c20be87723bebd866454d9","_id":"documents/60c20be87723bebd866454d9","_rev":"_cfFhBNe---","file_name":"01h8yyqj.pdf","md5":"90FE23CBBF61F8C0CB1E1ADFE06303CC","id":"01h8yyqj","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/h8/yy/qj/01h8yyqj/01h8yyqj.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["3700"],"published-print":{"date-parts":[[2018,4]]},"volume":"163","pmid":"29327237","journal-issue":{"published-print":{"date-parts":[[2018,4]]},"issue":"4"},"author":[{"sequence":"first","family":"Zheng","given":"Xue-yan","affiliation":[]},{"sequence":"additional","family":"Xu","given":"Yan-jun","affiliation":[]},{"sequence":"additional","family":"Guan","given":"Wei-jie","affiliation":[]},{"sequence":"additional","family":"Lin","given":"Li-feng","affiliation":[]}],"DOI":"10.1007/s00705-017-3700-y","original-title":[],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1515628800000,"date-time":"2018-01-11T00:00:00Z","date-parts":[[2018,1,11]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":34,"page":"845-853","type":"journal-article","issued":{"date-parts":[[2018,1,11]]},"funder":[{"award":[],"name":"Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme 2017"}],"publisher":"Springer Science and Business Media LLC","id":"01h8yyqj","short-title":[],"title":["Regional, age and respiratory-secretion-specific prevalence of respiratory viruses associated with asthma exacerbation: a literature review"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/1d/c5/PMC7087223.tar.gz","pmcid":"PMC7087223","has_valid_oa_url":true,"deposited":{"timestamp":1584471483000,"date-time":"2020-03-17T18:58:03Z","date-parts":[[2020,3,17]]},"indexed":{"timestamp":1617901555251,"date-time":"2021-04-08T17:05:55Z","date-parts":[[2021,4,8]]},"is-referenced-by-count":68,"short-container-title":["Arch Virol"],"prefix":"10.1007","published-online":{"date-parts":[[2018,1,11]]},"has_valid_thumbnail":false,"references-count":34,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1007/s00705-017-3700-y","ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"subject":["Virology","General Medicine"],"container-title":["Archives of Virology"],"score":1,"has_valid_ref_annotation":false,"issue":"4","member":"297","abstract":"Despite increased understanding of how viral infection is involved in asthma exacerbations, it is less clear which viruses are involved and to what extent they contribute to asthma exacerbations. Here, we sought to determine the prevalence of different respiratory viruses during asthma exacerbations. Systematic computerized searches of the literature up to June 2017 without language limitation were performed. The primary focus was on the prevalence of respiratory viruses, including AdV (adenovirus), BoV (bocavirus), CoV (coronavirus), CMV (cytomegalovirus), EnV (enterovirus), HSV (herpes simplex virus), IfV (influenza virus), MpV (metapneumovirus), PiV (parainfluenzavirus), RV (rhinovirus) and RSV (respiratory syncytial virus) during asthma exacerbations. We also examined the prevalence of viral infection stratified by age, geographic region, type of respiratory secretion, and detection method. Sixty articles were included in the final analysis. During asthma exacerbations, the mean prevalence of AdV, BoV, CoV, CMV, EnV, HSV, IfV, MpV, PiV, RV and RSV was 3.8%, 6.9%, 8.4%, 7.2%, 10.1%, 12.3%, 10.0%, 5.3%, 5.6%, 42.1% and 13.6%, respectively. EnV, MPV, RV and RSV were more prevalent in children, whereas AdV, BoV, CoV, IfV and PiV were more frequently present in adults. RV was the major virus detected globally, except in Africa. RV could be detected in both the upper and lower airway. Polymerase chain reaction was the most sensitive method for detecting viral infection. Our findings indicate the need to develop prophylactic polyvalent or polyvirus (including RV, EnV, IfV and RSV) vaccines that produce herd immunity and reduce the healthcare burden associated with virus-induced asthma exacerbations. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-017-3700-y) contains supplementary material, which is available to authorized users.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/article/10.1007/s00705-017-3700-y/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00705-017-3700-y.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00705-017-3700-y.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1515669846000,"date-time":"2018-01-11T11:24:06Z","date-parts":[[2018,1,11]]},"language":"en","assertion":[{"order":1,"value":"14 October 2017","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"18 December 2017","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"11 January 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with ethical standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme 2017 (to Dr. Guan).","group":{"label":"Funding source","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"Xue-yan Zheng declares that she had no conflict of interest. Yan-jun Xu declares that she had no conflict of interest. Li-feng Lin declares that he had no conflict of interest. Wei-jie Guan declares that he had no conflict of interest.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"},{"order":4,"value":"This article does not contain any studies with human participants performed by any of the authors.","group":{"label":"Ethical approval","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"fe4bf322be214e87e13134ec352d82c40318d598"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":14267},
  {"_key":"60c20bef7723bebd866454da","_id":"documents/60c20bef7723bebd866454da","_rev":"_cfFhBNq---","file_name":"01ipi7j6.pdf","md5":"88EDE979321AEF574E3EA17521561C0E","id":"01ipi7j6","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/ip/i7/j6/01ipi7j6/01ipi7j6.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["10.3389/fncel.2020.610714"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1610409600000,"date-time":"2021-01-12T00:00:00Z","date-parts":[[2021,1,12]]}}],"volume":"14","pmid":"33510620","author":[{"sequence":"first","family":"Mamtilahun","given":"Muyassar","affiliation":[]},{"sequence":"additional","family":"Wei","given":"Zhenyu","affiliation":[]},{"sequence":"additional","family":"Qin","given":"Chuan","affiliation":[]},{"sequence":"additional","family":"Wang","given":"Yongting","affiliation":[]},{"sequence":"additional","family":"Tang","given":"Yaohui","affiliation":[]},{"sequence":"additional","family":"Shen","given":"Fan-xia","affiliation":[]},{"sequence":"additional","family":"Tian","given":"Heng-Li","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Zhijun","affiliation":[]},{"sequence":"additional","family":"Yang","given":"Guo-Yuan","affiliation":[]}],"DOI":"10.3389/fncel.2020.610714","license-simplified":"unk","original-title":[],"short-container-title":["Front. Cell. Neurosci."],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"subject":["Cellular and Molecular Neuroscience"],"issued":{"date-parts":[[2021,1,12]]},"funder":[{"doi-asserted-by":"publisher","award":["2016YFC1300600"],"DOI":"10.13039/501100012166","name":"National Key Research and Development Program of China"},{"doi-asserted-by":"publisher","award":["81801170","81771251","81771244","81771281","81974179","81870921"],"DOI":"10.13039/501100001809","name":"National Natural Science Foundation of China"},{"doi-asserted-by":"publisher","award":["GYY"],"DOI":"10.13039/501100012692","name":"K. C. Wong Education Foundation"},{"doi-asserted-by":"publisher","award":["2019-01-07-00-02-E00064"],"DOI":"10.13039/501100003395","name":"Shanghai Municipal Education Commission"}],"publisher":"Frontiers Media SA","id":"01ipi7j6","reference-count":49,"short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1610559792000,"date-time":"2021-01-13T17:43:12Z","date-parts":[[2021,1,13]]},"indexed":{"timestamp":1617123830134,"date-time":"2021-03-30T17:03:50Z","date-parts":[[2021,3,30]]},"is-referenced-by-count":1,"title":["DL-3n-Butylphthalide Improves Blood–Brain Barrier Integrity in Rat After Middle Cerebral Artery Occlusion"],"prefix":"10.3389","published-online":{"date-parts":[[2021,1,12]]},"has_valid_thumbnail":false,"references-count":49,"oaLink":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835508/pdf/","subtitle":[],"URL":"http://dx.doi.org/10.3389/fncel.2020.610714","type":"journal-article","issn-type":[{"value":"1662-5102","type":"electronic"}],"container-title":["Frontiers in Cellular Neuroscience"],"has_valid_ref_annotation":false,"member":"1965","abstract":"Objective: DL-3n-butylphthalide (NBP) has beneficial effects in different stages of ischemic stroke. Our previous studies have demonstrated that NBP promoted angiogenesis in the perifocal region of the ischemic brain. However, the molecular mechanism of NBP for blood-brain barrier protection in acute ischemic stroke was unclear. Here, we explored the neuroprotective effects of NBP on blood-brain barrier integrity in the acute phase of ischemic stroke in a rat model. Methods: Adult male Sprague-Dawley rats (n = 82) underwent 2 h of transient middle cerebral artery occlusion and received 90 mg/kg of NBP for 3 days. Brain edema, infarct volume, surface blood flow, and neurological severity score were evaluated. Blood-brain barrier integrity was evaluated by Evans blue leakage and changes in tight junction proteins. We further examined AQP4 and eNOS expression, MMP-9 enzyme activity, and possible signaling pathways for the role of NBP after ischemic stroke. Results: NBP treatment significantly increased eNOS expression and surface blood flow in the brain, reduced brain edema and infarct volume, and improved neurological severity score compared to the control group (p < 0.05). Furthermore, NBP attenuated Evans blue and IgG leakage and increased tight junction protein expression compared to the control after 1 and 3 days of ischemic stroke (p < 0.05). Finally, NBP decreased AQP4 expression, MMP-9 enzyme activity, and increased MAPK expression during acute ischemic stroke. Conclusion: NBP protected blood-brain barrier integrity and attenuated brain injury in the acute phase of ischemic stroke by decreasing AQP4 expression and MMP-9 enzyme activity. The MAPK signaling pathway may be associated in this process.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.3389/crossmark-policy","link":[{"URL":"https://www.frontiersin.org/articles/10.3389/fncel.2020.610714/full","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1610517130000,"date-time":"2021-01-13T05:52:10Z","date-parts":[[2021,1,13]]},"ISSN":["1662-5102"],"score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52}],"runtime":11039},
  {"_key":"60c20bf47723bebd866454e2","_id":"documents/60c20bf47723bebd866454e2","_rev":"_cfFhBN2---","file_name":"01j2tyvu.pdf","md5":"A4B99FE46C29F2890191451B30FE83B5","id":"01j2tyvu","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/j2/ty/vu/01j2tyvu/01j2tyvu.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["10.1128/AEM.01646-20"],"published-print":{"date-parts":[[2020,9,11]]},"language":"en","volume":"86","pmid":"32917749","has_valid_tei":false,"created":{"timestamp":1600093924000,"date-time":"2020-09-14T14:32:04Z","date-parts":[[2020,9,14]]},"DOI":"10.1128/aem.01646-20","license-simplified":"unk","original-title":[],"title":["Mining and Statistical Modeling of Natural and Variant Class IIa Bacteriocins Elucidate Activity and Selectivity Profiles across Species"],"content-domain":{"domain":["asm.org"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1128/asmj-crossmark-policy-page","type":"journal-article","issued":{"date-parts":[[2020,9,11]]},"prefix":"10.1128","publisher":"American Society for Microbiology","id":"01j2tyvu","short-title":[],"editor":[{"sequence":"additional","family":"Cann","given":"Isaac","affiliation":[]}],"has_valid_oa_url":true,"deposited":{"timestamp":1603808030000,"date-time":"2020-10-27T14:13:50Z","date-parts":[[2020,10,27]]},"indexed":{"timestamp":1603809760608,"date-time":"2020-10-27T14:42:40Z","date-parts":[[2020,10,27]]},"is-referenced-by-count":0,"short-container-title":["Appl Environ Microbiol"],"funder":[{"award":["R01GM121777"],"name":"NIH"}],"published-online":{"date-parts":[[2020,10,28]]},"has_valid_thumbnail":false,"references-count":75,"oaLink":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7642072/pdf/","subtitle":[],"reference-count":75,"ISSN":["0099-2240","1098-5336"],"issn-type":[{"value":"0099-2240","type":"print"},{"value":"1098-5336","type":"electronic"}],"container-title":["Applied and Environmental Microbiology"],"has_valid_ref_annotation":false,"issue":"22","member":"235","abstract":"Class IIa bacteriocin antimicrobial peptides (AMPs) are a compelling alternative to current antimicrobials because of potential specific activity towards antibiotic-resistant bacteria, including vancomycin-resistant enterococci. Engineering of these molecules would be enhanced by a better understanding of AMP sequence-activity relationships to improve efficacy in vivo and limit effects of off-target activity. Towards this goal, we experimentally evaluated 210 natural and variant class IIa bacteriocins for antimicrobial activity against six strains of enterococci. Inhibitory activity was ridge regressed to AMP sequence to predict performance, achieving an area under the curve of 0.70 and demonstrating the potential of statistical models for identifying and designing AMPs. Active AMPs were individually produced and evaluated against eight enterococci strains and four Listeria strains to elucidate trends in susceptibility. It was determined that the mannose phosphotransferase system sequence is informative of susceptibility to class IIa bacteriocins, yet other factors, such as membrane composition, also contribute strongly to susceptibility. A broadly potent bacteriocin variant (lactocin DT1) from a Lactobacillus ruminis genome was identified as the only variant with inhibitory activity towards all tested strains, while a novel enterocin variant (DT2) from an E. faecium genome demonstrated specificity towards Listeria strains. Eight AMPs were evaluated for proteolytic stability to trypsin, chymotrypsin, and pepsin, and three C-terminal disulfide-containing variants, including divercin V41, were identified as compelling for future in vivo studies given high potency and proteolytic stability.Importance Class IIa bacteriocin antimicrobial peptides (AMPs), an alternative to traditional small-molecule antibiotics, are capable of selective activity towards various Gram-positive bacteria, limiting negative side effects associated with broad-spectrum activity. This selective activity is achieved through targeting of the mannose phosphotransferase system (manPTS) of a subset of Gram-positive bacteria, although factors affecting this mechanism are not entirely understood. Peptides identified from genomic data, as well as variants of previously characterized AMPs, can offer insight into how peptide sequence affects activity and selectivity. The experimental methods presented here identify promising potent and selective bacteriocins for further evaluation, highlight the potential of simple computational modeling for prediction of AMP performance, and demonstrate that factors beyond manPTS sequence affect bacterial susceptibility to class IIa bacteriocins.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Tresnak","given":"Daniel T.","affiliation":[]},{"sequence":"additional","given":"Benjamin J.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3561-9463","family":"Hackel","affiliation":[]}],"subject":["Biotechnology","Food Science","Ecology","Applied Microbiology and Biotechnology"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1128/AEM.01646-20","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1128/aem.01646-20","journal-issue":{"issue":"22","published-online":{"date-parts":[[2020,10,28]]}},"score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":12182},
  {"_key":"60c20bf67723bebd866454ec","_id":"documents/60c20bf67723bebd866454ec","_rev":"_cfFhBOC---","file_name":"01j7pj2f.pdf","md5":"FE50C77D162F325969EE4166FF56D6A5","id":"01j7pj2f","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/j7/pj/2f/01j7pj2f/01j7pj2f.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["2426"],"published-print":{"date-parts":[[2020,4]]},"volume":"45","pmid":"32006072","journal-issue":{"published-print":{"date-parts":[[2020,4]]},"issue":"4"},"author":[{"sequence":"first","family":"Huang","given":"Zhi-mei","affiliation":[]},{"sequence":"additional","family":"Zuo","given":"Meng-xuan","affiliation":[]},{"sequence":"additional","family":"Gu","given":"Yang-kui","affiliation":[]},{"sequence":"additional","family":"Gu","given":"Hai-feng","affiliation":[]},{"sequence":"additional","family":"Lai","given":"Chun-xiao","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Tian-qi","affiliation":[]},{"sequence":"additional","family":"Wang","given":"Xiu-chen","affiliation":[]},{"sequence":"additional","given":"Chao","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1096-4183","family":"An","affiliation":[]},{"sequence":"additional","family":"Huang","given":"Jin-hua","affiliation":[]}],"created":{"timestamp":1580486639000,"date-time":"2020-01-31T16:03:59Z","date-parts":[[2020,1,31]]},"DOI":"10.1007/s00261-020-02426-5","original-title":[],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1580428800000,"date-time":"2020-01-31T00:00:00Z","date-parts":[[2020,1,31]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1580428800000,"date-time":"2020-01-31T00:00:00Z","date-parts":[[2020,1,31]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Urology","Radiological and Ultrasound Technology","Gastroenterology","Radiology Nuclear Medicine and imaging"],"page":"1181-1192","type":"journal-article","issued":{"date-parts":[[2020,1,31]]},"funder":[{"doi-asserted-by":"publisher","award":["201704020134","81371652","2016002"],"DOI":"10.13039/501100012325","name":"National Office for Philosophy and Social Sciences"}],"publisher":"Springer Science and Business Media LLC","id":"01j7pj2f","short-title":[],"title":["Computed tomography-guided radiofrequency ablation combined with transarterial embolization assisted by a three-dimensional visualization ablation planning system for hepatocellular carcinoma in challenging locations: a preliminary study"],"oaLink":"https://link.springer.com/content/pdf/10.1007/s00261-020-02426-5.pdf","has_valid_oa_url":true,"deposited":{"timestamp":1611967161000,"date-time":"2021-01-30T00:39:21Z","date-parts":[[2021,1,30]]},"indexed":{"timestamp":1611969079127,"date-time":"2021-01-30T01:11:19Z","date-parts":[[2021,1,30]]},"is-referenced-by-count":1,"short-container-title":["Abdom Radiol"],"prefix":"10.1007","published-online":{"date-parts":[[2020,1,31]]},"has_valid_thumbnail":false,"references-count":30,"license-simplified":"cc-by","subtitle":[],"reference-count":30,"ISSN":["2366-004X","2366-0058"],"issn-type":[{"value":"2366-004X","type":"print"},{"value":"2366-0058","type":"electronic"}],"container-title":["Abdominal Radiology"],"score":1,"has_valid_ref_annotation":false,"issue":"4","member":"297","abstract":"OBJECTIVE To assess the clinical efficacy and safety of computed tomography-guided radiofrequency ablation(CT-RFA) combined with transarterial embolization(TAE) assisted by a three-dimensional visualization ablation planning system(3DVAPS) for hepatocellular carcinoma(HCC) in challenging locations. METHODS Data from 62 treatment-naive patients with hepatocellular carcinoma(HCC), with 83 lesions in challenging locations, and who met the Milan criteria and underwent CT-RFA between June 2013 and June 2016 were reviewed. Patients were divided into one of two groups according to different treatment modalities: study group (TAE combined with RFA assisted by 3DVAPS [n = 32]); and control (RFA only [n = 30]). Oncological outcomes included ablation-related complications, local tumor progression (LTP), and overall survival (OS). Univariate and multivariate Cox proportional hazards regression analyses were performed to assess risk factors associated with LTP and OS. RESULTS HCC lesions (mean size, 1.9 ± 1.0 mm in diameter) abutting the gastrointestinal tract (n = 25), heart and diaphragm (n = 21), major vessels (n = 13), and gallbladder (n = 3) were treated. A significant difference was detected in LTP between the two groups (P = 0.034), with no significant difference in OS between the two groups (P = 0.193). There were no severe complications related to ablation. Univariate analysis revealed that sex (P = 0.046) and child-turcotte-pugh (CTP) grade (P<0.001) were risk factors for OS, whereas CTP grade and treatment method (P<0.001) were risk factors for LTP. Multivariate analysis revealed that CTP grade B (P = 0.005) was independently associated with poor OS, and RFA alone (P<0.001) was independently associated with poor LTP. CONCLUSION CT-RFA combined with TAE assisted by a 3DVAPS provided ideal clinical efficiency for HCC in challenging locations and was a highly safe treatment modality.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s00261-020-02426-5.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s00261-020-02426-5/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00261-020-02426-5.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1007/s00261-020-02426-5","language":"en","assertion":[{"order":1,"value":"31 January 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with ethical standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The authors declare no conflict of interest.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":8520},
  {"_key":"60c20bf77723bebd866454f0","_id":"documents/60c20bf77723bebd866454f0","_rev":"_cfFhBOO---","file_name":"01jluimk.pdf","md5":"0FE51C42CDBCCFAE3F13F96EE112103B","id":"01jluimk","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/jl/ui/mk/01jluimk/01jluimk.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["S1090780709002687"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1259625600000,"date-time":"2009-12-01T00:00:00Z","date-parts":[[2009,12,1]]}}],"volume":"201","pmid":"19819173","has_valid_tei":false,"DOI":"10.1016/j.jmr.2009.09.012","original-title":[],"short-container-title":["Journal of Magnetic Resonance"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":30,"page":"218-221","type":"journal-article","issued":{"date-parts":[[2009,12]]},"publisher":"Elsevier BV","id":"01jluimk","short-title":[],"pmcid":"PMC2794128","has_valid_oa_url":true,"deposited":{"timestamp":1544997099000,"date-time":"2018-12-16T21:51:39Z","date-parts":[[2018,12,16]]},"indexed":{"timestamp":1586851620895,"date-time":"2020-04-14T08:07:00Z","date-parts":[[2020,4,14]]},"is-referenced-by-count":4,"title":["Dynamics of SARS-coronavirus HR2 domain in the prefusion and transition states"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a2/14/PMC2794128.tar.gz","has_valid_thumbnail":false,"ISSN":["1090-7807"],"references-count":30,"license-simplified":"bronze-oa","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.jmr.2009.09.012","journal-issue":{"published-print":{"date-parts":[[2009,12]]},"issue":"2"},"issn-type":[{"value":"1090-7807","type":"print"}],"container-title":["Journal of Magnetic Resonance"],"has_valid_ref_annotation":false,"issue":"2","member":"78","abstract":"Abstract The envelope glycoproteins S1 and S2 of severe acute respiratory syndrome coronavirus (SARS-CoV) mediate viral entry by conformational change from a prefusion state to a postfusion state that enables fusion of the viral and target membranes. In this work we present the characterization of the dynamic properties of the SARS-CoV S2-HR2 domain (residues 1141–1193 of S) in the prefusion and newly discovered transition states by NMR 15N relaxation studies. The dynamic properties of the different states, which are stabilized under different experimental conditions, extend the current model of viral membrane fusion and give insight into the design of structure-based antagonists of SARS-CoV in particular, as well as other enveloped viruses such as HIV.","published-print":{"date-parts":[[2009,12]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"McReynolds","given":"Susanna","affiliation":[]},{"sequence":"additional","family":"Jiang","given":"Shaokai","affiliation":[]},{"sequence":"additional","family":"Rong","given":"Lijun","affiliation":[]},{"sequence":"additional","family":"Caffrey","given":"Michael","affiliation":[]}],"subject":["Nuclear and High Energy Physics","Biophysics","Biochemistry","Condensed Matter Physics"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S1090780709002687?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1090780709002687?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1253436198000,"date-time":"2009-09-20T08:43:18Z","date-parts":[[2009,9,20]]},"language":"en","score":1,"source":"Crossref","cord_sha":"045731ca03ca81ea40fe838fd9ab5e98bf01e2fe"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":8518},
  {"_key":"60c20bf87723bebd866454f5","_id":"documents/60c20bf87723bebd866454f5","_rev":"_cfFhBOa---","file_name":"01juvcaw.pdf","md5":"1E8998D89C349C38B7FA41B79E649E48","id":"01juvcaw","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/ju/vc/aw/01juvcaw/01juvcaw.pdf","date":"2021-06-10T12:56+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-53956-6_46","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"506-514","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"01juvcaw","reference-count":29,"title":["Use of the Industrial Property System in Colombia (2018): A Supervised Learning Application"],"pmcid":"PMC7354787","has_valid_oa_url":true,"deposited":{"timestamp":1609144839000,"date-time":"2020-12-28T08:40:39Z","date-parts":[[2020,12,28]]},"indexed":{"timestamp":1609146636244,"date-time":"2020-12-28T09:10:36Z","date-parts":[[2020,12,28]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,7,13]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030539559","type":"print"},{"value":"9783030539566","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/3e/b2/PMC7354787.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-53956-6_46","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Lecture Notes in Computer Science","Advances in Swarm Intelligence"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"The purpose of this paper is to establish ways to predict the spatial distribution of the use of the intellectual property system from information on industrial property applications and grants (distinctive signs and new creations) and copyright registrations in 2018. This will be done using supervised learning algorithms applied to information on industrial property applications and grants (trademarks and new creations) and copyright registrations in 2018. Within the findings, 4 algorithms were identified with a level of explanation higher than 80%: (i) Linear Regression, with an elastic network regularization; (ii) Stochastic Gradient Descent, with Hinge loss function, Ringe regularization (L2) and a constant learning rate; (iii) Neural Networks, with 1,000 layers, with Adam’s solution algorithm and 2,000 iterations; (iv) Random Forest, with 10 trees.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Lis-Gutiérrez","given":"Jenny-Paola","affiliation":[]},{"sequence":"additional","family":"Lis-Gutiérrez","given":"Melissa","affiliation":[]},{"sequence":"additional","family":"Gallego-Torres","given":"Adriana Patricia","affiliation":[]},{"sequence":"additional","family":"Ballesteros Ballesteros","given":"Vladimir Alfonso","affiliation":[]},{"sequence":"additional","family":"Romero Ospina","given":"Manuel Francisco","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030539559","9783030539566"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-53956-6_46","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1594551762000,"date-time":"2020-07-12T11:02:42Z","date-parts":[[2020,7,12]]},"references-count":29,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"13 July 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"ICSI","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"International Conference on Swarm Intelligence","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Belgrade","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"Serbia","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"14 July 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"20 July 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"11","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"swarm2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"http://www.ic-si.org/committees/","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Double-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"Confy","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"127","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"63","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"0","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"50% - 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  {"_key":"60c20bf97723bebd866454f8","_id":"documents/60c20bf97723bebd866454f8","_rev":"_cfFhBOm---","file_name":"01ky02je.pdf","md5":"11213C401C65972727420DE3801CC793","id":"01ky02je","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/ky/02/je/01ky02je/01ky02je.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["822"],"published-print":{"date-parts":[[2021,12]]},"article-number":"4","language":"en","volume":"13","pmid":"33413610","journal-issue":{"published-print":{"date-parts":[[2021,12]]},"issue":"1"},"author":[{"sequence":"first","given":"Daniel","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2571-3114","family":"Ward","affiliation":[]},{"sequence":"additional","family":"Higgins","given":"Matthew","affiliation":[]},{"sequence":"additional","family":"Phelan","given":"Jody E.","affiliation":[]},{"sequence":"additional","family":"Hibberd","given":"Martin L.","affiliation":[]},{"sequence":"additional","family":"Campino","given":"Susana","affiliation":[]},{"sequence":"additional","family":"Clark","given":"Taane G.","affiliation":[]}],"DOI":"10.1186/s13073-020-00822-6","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1609977600000,"date-time":"2021-01-07T00:00:00Z","date-parts":[[2021,1,7]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1609977600000,"date-time":"2021-01-07T00:00:00Z","date-parts":[[2021,1,7]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Genetics(clinical)","Molecular Medicine","Genetics","Molecular Biology"],"type":"journal-article","issued":{"date-parts":[[2021,1,7]]},"funder":[{"doi-asserted-by":"publisher","award":["MR/R025576/1","MR/R020973/1","MR/M01360X/1","MR/N010469/1"],"DOI":"10.13039/501100000265","name":"Medical Research Council"},{"doi-asserted-by":"publisher","award":["BB/R013063/1"],"DOI":"10.13039/501100000268","name":"Biotechnology and Biological Sciences Research Council"}],"publisher":"Springer Science and Business Media LLC","id":"01ky02je","reference-count":47,"title":["An integrated in silico immuno-genetic analytical platform provides insights into COVID-19 serological and vaccine targets"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/da/46/PMC7790334.tar.gz","pmcid":"PMC7790334","has_valid_oa_url":true,"deposited":{"timestamp":1610054732000,"date-time":"2021-01-07T21:25:32Z","date-parts":[[2021,1,7]]},"indexed":{"timestamp":1611846224551,"date-time":"2021-01-28T15:03:44Z","date-parts":[[2021,1,28]]},"is-referenced-by-count":1,"short-container-title":["Genome Med"],"prefix":"10.1186","published-online":{"date-parts":[[2021,1,7]]},"has_valid_thumbnail":false,"references-count":47,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s13073-020-00822-6","short-title":[],"issn-type":[{"value":"1756-994X","type":"electronic"}],"container-title":["Genome Medicine"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"During COVID-19, diagnostic serological tools and vaccines have been developed. To inform control activities in a post-vaccine surveillance setting, we have developed an online “immuno-analytics” resource that combines epitope, sequence, protein and SARS-CoV-2 mutation analysis. SARS-CoV-2 spike and nucleocapsid proteins are both vaccine and serological diagnostic targets. Using the tool, the nucleocapsid protein appears to be a sub-optimal target for use in serological platforms. Spike D614G (and nsp12 L314P) mutations were most frequent (> 86%), whilst spike A222V/L18F have recently increased. Also, Orf3a proteins may be a suitable target for serology. The tool can accessed from: http://genomics.lshtm.ac.uk/immuno (online); https://github.com/dan-ward-bio/COVID-immunoanalytics (source code).","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s13073-020-00822-6.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s13073-020-00822-6/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s13073-020-00822-6.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1610053533000,"date-time":"2021-01-07T21:05:33Z","date-parts":[[2021,1,7]]},"ISSN":["1756-994X"],"assertion":[{"order":1,"value":"12 May 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"14 December 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"7 January 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"Not applicable","group":{"label":"Ethics approval and consent to participate","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Not applicable","group":{"label":"Consent for publication","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"1ab87ddfa68c13810aee8df31c9784026d16386a"},"application":"software-mentions","pages":[{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842}],"runtime":4578},
  {"_key":"60c20bfd7723bebd866454fa","_id":"documents/60c20bfd7723bebd866454fa","_rev":"_cfFhBOy---","file_name":"01l0skgt.pdf","md5":"D894FF7E6B850248123D7680F4634D58","id":"01l0skgt","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/l0/sk/gt/01l0skgt/01l0skgt.pdf","date":"2021-06-10T12:56+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-51831-8_5","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"89-108","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"01l0skgt","reference-count":18,"title":["A New Property of Choice-Free Petri Net Systems"],"pmcid":"PMC7324222","has_valid_oa_url":true,"deposited":{"timestamp":1616394963000,"date-time":"2021-03-22T06:36:03Z","date-parts":[[2021,3,22]]},"indexed":{"timestamp":1616397833891,"date-time":"2021-03-22T07:23:53Z","date-parts":[[2021,3,22]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,6,30]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030518301","type":"print"},{"value":"9783030518318","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/1a/22/PMC7324222.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-51831-8_5","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Application and Theory of Petri Nets and Concurrency","Lecture Notes in Computer Science"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"When a Petri net system of some class is synthesised from a labelled transition system, it may be interesting to derive structural properties of the corresponding reachability graphs and to use them in a pre-synthesis phase in order to quickly reject inadequate transition systems, and provide fruitful error messages. The same is true for simultaneous syntheses problems. This was exploited for the synthesis of choice-free nets for instance, for which several interesting properties have been derived. We exhibit here a new property for this class, and analyse if this gets us closer to a full characterisation of choice-free synthesizable transition systems.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Best","given":"Eike","affiliation":[]},{"sequence":"additional","family":"Devillers","given":"Raymond","affiliation":[]},{"sequence":"additional","family":"Erofeev","given":"Evgeny","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030518301","9783030518318"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-51831-8_5","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1593471905000,"date-time":"2020-06-29T23:05:05Z","date-parts":[[2020,6,29]]},"references-count":18,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"30 June 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"PETRI NETS","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"International Conference on Applications and Theory of Petri Nets and Concurrency","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Paris","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"France","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"24 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"25 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"41","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"apn2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"http://conf-2020.petrinet.net/","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Single-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"56","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"23","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"0","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"41% - 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  {"_key":"60c20c027723bebd866454fc","_id":"documents/60c20c027723bebd866454fc","_rev":"_cfFhBP----","file_name":"01l27d99.pdf","md5":"986CD90263BF95A61F9F41CA801FDF11","id":"01l27d99","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/l2/7d/99/01l27d99/01l27d99.pdf","date":"2021-06-10T12:56+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,10,14]]},"license-simplified":"biorxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.10.13.338038","group-title":"Genomics","oaLink":"https://www.biorxiv.org/content/biorxiv/early/2020/10/14/2020.10.13.338038.full.pdf","original-title":[],"title":["The emergence of inter-clade hybrid SARS-CoV-2 lineages revealed by 2D nucleotide variation mapping"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":34,"short-title":[],"issued":{"date-parts":[[2020,10,14]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,10,14]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"I performed whole-genome sequencing on SARS-CoV-2 collected from COVID-19 samples at Mayo Clinic Rochester in mid-April, 2020, generated 85 consensus genome sequences and compared them to other genome sequences collected worldwide. I proposed a novel illustrating method using a 2D map to display populations of co-occurring nucleotide variants for intra- and inter-viral clades. This method is highly advantageous for the new era of “big-data” when high-throughput sequencing is becoming readily available. Using this method, I revealed the emergence of inter-clade hybrid SARS-CoV-2 lineages that are potentially caused by homologous genetic recombination.","deposited":{"timestamp":1602900620000,"date-time":"2020-10-17T02:10:20Z","date-parts":[[2020,10,17]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Wang","given":"Hai-Long","affiliation":[]}],"DOI":"10.1101/2020.10.13.338038","reference-count":34,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.10.13.338038","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1602732021000,"date-time":"2020-10-15T03:20:21Z","date-parts":[[2020,10,15]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"bioRxiv"},"id":"01l27d99","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1602902708259,"date-time":"2020-10-17T02:45:08Z","date-parts":[[2020,10,17]]},"cord_sha":"f4f4f766001b025838ab8d304228d717cb4bde91"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":12028},
  {"_key":"60c20c027723bebd8664550e","_id":"documents/60c20c027723bebd8664550e","_rev":"_cfFhBPK---","file_name":"01laioaz.pdf","md5":"A6F50A92280FC45A7ED1016FE255686C","id":"01laioaz","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/la/io/az/01laioaz/01laioaz.pdf","date":"2021-06-10T12:56+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-51938-4_8","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"152-171","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"01laioaz","reference-count":21,"title":["Cryptanalysis of FlexAEAD"],"pmcid":"PMC7334989","has_valid_oa_url":true,"deposited":{"timestamp":1616464267000,"date-time":"2021-03-23T01:51:07Z","date-parts":[[2021,3,23]]},"indexed":{"timestamp":1616465741806,"date-time":"2021-03-23T02:15:41Z","date-parts":[[2021,3,23]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,7,5]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030519377","type":"print"},{"value":"9783030519384","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/2b/7e/PMC7334989.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-51938-4_8","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["Progress in Cryptology - AFRICACRYPT 2020","Lecture Notes in Computer Science"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"This paper analyzes the internal keyed permutation of FlexAEAD which is a round-1 candidate of the NIST LightWeight Cryptography Competition. In our analysis, we report an iterated truncated differential leveraging on a particular property of the AES S-box that becomes useful due to the particular nature of the diffusion layer of the round function. The differential holds with a low probability of [Formula: see text] for one round which allows it to penetrate the same number of rounds as claimed by the designers, but with a much lower complexity. Moreover, it can be easily extended to a key-recovery attack at a little extra cost. We further report a Super-Sbox construction in the internal permutation, which is exploited using the Yoyo game to devise a 6-round deterministic distinguisher and a 7-round key recovery attack for the 128-bit internal permutation. Similar attacks can be mounted for the 64-bit and 256-bit variants. All these attacks outperform the existing results of the designers as well as other third-party results. The iterated truncated differentials can be tweaked to mount forgery attacks similar to the ones given by Eichlseder [Formula: see text] [Formula: see text] Success probabilities of all the reported distinguishing attacks are shown to be high. All practical attacks have been experimentally verified. To the best of our knowledge, this work reports the first key-recovery attack on the internal keyed permutation of FlexAEAD.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Rahman","given":"Mostafizar","affiliation":[]},{"sequence":"additional","family":"Saha","given":"Dhiman","affiliation":[]},{"sequence":"additional","family":"Paul","given":"Goutam","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030519377","9783030519384"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-51938-4_8","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1593860574000,"date-time":"2020-07-04T11:02:54Z","date-parts":[[2020,7,4]]},"references-count":21,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"5 July 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"AFRICACRYPT","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"International Conference on Cryptology in Africa","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Cairo","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"Egypt","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"20 July 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"22 July 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"12","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"africacrypt2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"http://africacrypt2020.org/index.html","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Double-blind","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"easychair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"49","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"21","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"0","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"43% - The value is computed by the equation \"Number of Full Papers Accepted / Number of Submissions Sent for Review * 100\" and then rounded to a whole number.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Acceptance Rate of Full Papers","name":"acceptance_rate_of_full_papers"},{"order":7,"value":"3","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Reviews per Paper","name":"average_number_of_reviews_per_paper"},{"order":8,"value":"4.2","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Average Number of Papers per Reviewer","name":"average_number_of_papers_per_reviewer"},{"order":9,"value":"No","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"External Reviewers Involved","name":"external_reviewers_involved"},{"order":10,"value":"The conference was held virtually due to the COVID-19 pandemic.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Additional Info on Review Process","name":"additional_info_on_review_process"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"35ce2f1f49d82499c657091b5b0053f1e2759c17"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":9807},
  {"_key":"60c20c047723bebd86645511","_id":"documents/60c20c047723bebd86645511","_rev":"_cfFhBPW---","file_name":"01lanmjl.pdf","md5":"2952A093B8EA529AE2D7627DBBD9A27A","id":"01lanmjl","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/la/nm/jl/01lanmjl/01lanmjl.pdf","date":"2021-06-10T12:56+0000","metadata":{"is-referenced-by-count":1,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2021,4,1]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.12.17.20248382","group-title":"Public and Global Health","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/12/18/2020.12.17.20248382.full.pdf","original-title":[],"title":["Forecasting sub-national trends in COVID-19 vaccine uptake in the UK"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":35,"short-title":[],"issued":{"date-parts":[[2020,12,18]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,12,18]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Introduction: There has been evidence of increases in vaccinating delays and refusals in the UK in recent years. As the United Kingdom begins a mass vaccination campaign with a novel COVID-19 vaccine, it is unclear whether refusal of the vaccine in some regions and among some socio-economic groups will pose challenges for achieving herd/community immunity against SARS-CoV-2. Methods: This study estimates uptake of a COVID-19 at unprecedented spatial resolution across the UK using a large-scale survey and state-of-the-art Bayesian statistical methods for estimating public opinion. Between 24 September and 14 October 2020, 17,684 individuals are surveyed in a cross-sectional online survey design. Regions and socio-economic groups who may be more resistant towards a new vaccine are identified using multilevel regression and poststratification. Gibbs sampling is used for Bayesian model inference, with 95% Bayesian highest posterior density intervals to capture uncertainty in parameter estimates. Findings: This study predicts that clusters of non-vaccinators will likely emerge in many regions across the UK, most notably in London (which has 13 of the 20 lowest ranking regions) and the North West (which has four, including Greater Manchester and Liverpool). Males are much more likely to state intent to accept the vaccine than females (OR 1.59, 1.47 to 1.73), while Muslims are less likely than atheists / agnostics (0.75, 0.57 to 0.96), Black / Black British are less likely than Whites (0.47, 0.38 to 0.60), and Polish speakers (0.45, 0.31 to 0.63) are less likely than those who primarily speak English or Welsh. Across the UK, less than half the UK say they would \"definitely\" accept a COVID-19 vaccine (47.5%, 46.5 to 48.5%) and 8.7% (8.2 to 9.2%) state that they would \"definitely not\" accept a vaccine, with the rest being unsure. Interpretation: The study findings are extremely important in the context of achieving herd/community immunity. Low predicted acceptance rates in parts of London and the North West are of particular concern as many of these regions have among the highest rates of COVID-19 infection across the UK: low vaccine uptake in these regions may result in disease \"hotspots\" that amplify the spread of the disease and require increases in vaccination levels in adjacent regions to provide nationwide herd/community immunity. It is therefore extremely important to identify such regions, and to engage with communities within them in advance of vaccination rollout to the population at large. Encouragingly, intent to accept a COVID-19 vaccine is higher among older age-groups, who are among the first to receive a COVID-19 vaccine.","deposited":{"timestamp":1617463519000,"date-time":"2021-04-03T15:25:19Z","date-parts":[[2021,4,3]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7751-0645","family":"de Figueiredo","affiliation":[]}],"DOI":"10.1101/2020.12.17.20248382","reference-count":35,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.12.17.20248382","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1608665046000,"date-time":"2020-12-22T19:24:06Z","date-parts":[[2020,12,22]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"01lanmjl","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1617465137768,"date-time":"2021-04-03T15:52:17Z","date-parts":[[2021,4,3]]},"cord_sha":"1a3cc6e24497d100e6ff63dbf2b96add34b1f630"},"application":"software-mentions","pages":[{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842}],"runtime":11234},
  {"_key":"60c20c0b7723bebd86645513","_id":"documents/60c20c0b7723bebd86645513","_rev":"_cfFhBPi---","file_name":"01lu7sce.pdf","md5":"CE2DF2B09A87207B6CDCA31A3DBE35B8","id":"01lu7sce","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/lu/7s/ce/01lu7sce/01lu7sce.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["S2213260015005007"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1451606400000,"date-time":"2016-01-01T00:00:00Z","date-parts":[[2016,1,1]]}}],"volume":"4","pmid":"26704020","has_valid_tei":false,"DOI":"10.1016/s2213-2600(15)00500-7","original-title":[],"short-container-title":["The Lancet Respiratory Medicine"],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"reference-count":40,"page":"19-26","type":"journal-article","issued":{"date-parts":[[2016,1]]},"publisher":"Elsevier BV","id":"01lu7sce","short-title":[],"pmcid":"PMC7164820","has_valid_oa_url":true,"deposited":{"timestamp":1537131388000,"date-time":"2018-09-16T20:56:28Z","date-parts":[[2018,9,16]]},"indexed":{"timestamp":1616569437076,"date-time":"2021-03-24T07:03:57Z","date-parts":[[2021,3,24]]},"is-referenced-by-count":92,"title":["Azithromycin for episodes with asthma-like symptoms in young children aged 1–3 years: a randomised, double-blind, placebo-controlled trial"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/d9/96/PMC7164820.tar.gz","has_valid_thumbnail":false,"ISSN":["2213-2600"],"references-count":40,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/s2213-2600(15)00500-7","journal-issue":{"published-print":{"date-parts":[[2016,1]]},"issue":"1"},"issn-type":[{"value":"2213-2600","type":"print"}],"container-title":["The Lancet Respiratory Medicine"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"78","abstract":"Summary Background Bacteria and viruses are equally associated with the risk of acute episodes of asthma-like symptoms in young children, suggesting antibiotics as a potential treatment for such episodes. We aimed to assess the effect of azithromycin on the duration of respiratory episodes in young children with recurrent asthma-like symptoms, hypothesising that it reduces the duration of the symptomatic period. Methods In this randomised, double-blind, placebo-controlled trial, we recruited children aged 1–3 years, who were diagnosed with recurrent asthma-like symptoms from the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort; a birth cohort consisting of the general Danish population of Zealand, including Copenhagen. Exclusion criteria were macrolide allergy, heart, liver, neurological, and kidney disease, and, before each treatment, one or more clinical signs of pneumonia (respiratory frequency of ≥50 breaths per min; fever of ≥39°C; C-reactive protein concentration of ≥476·20 nmol/L [≥50 mg/L]). Each episode of asthma-like symptoms lasting at least 3 days was randomly allocated to a 3-day course of azithromycin oral solution of 10 mg/kg per day or placebo after thorough examination by a study physician at the Copenhagen Prospective Studies on Asthma research unit. Each episode was randomly allocated independently of previous treatment from a computer-generated list of random numbers in blocks of ten (generated at the Pharmacy of Glostrup). Investigators and children were masked until the youngest child turned 3 years of age and throughout the data validation and analysis phases. The primary outcome was duration of the respiratory episode after treatment, verified by prospective daily diaries and analysed with Poisson regression. Analyses were per protocol (excluding those without a primary outcome measure or who did not receive treatment). This trial is registered with ClinicalTrials.gov, number NCT01233297. Findings Between Nov 17, 2010, and Jan 28, 2014, we randomly allocated 158 asthma-like episodes in 72 children (79 [50%] to azithromycin and 79 [50%] to placebo). The mean duration of the episode after treatment was 3·4 days for children receiving azithromycin compared with 7·7 days for children receiving placebo. Azithromycin caused a significant shortening of the episode of 63·3% (95% CI 56·0–69·3; p<0·0001). The effect size increased with early initiation of treatment, showing a reduction in episode duration of 83% if treatment was initiated before day 6 of the episode compared with 36% if initiated on or after day 6 (p<0·0001). We noted no differences in clinical adverse events between the azithromycin (18 [23%] of 78 episodes included in final analysis) and placebo (24 [30%] of 79) groups (p=0·30), but we did not investigate bacterial resistance patterns after treatment. Interpretation Azithromycin reduced the duration of episodes of asthma-like symptoms in young children, suggesting that this drug could have a role in acute management of exacerbations. Further research is needed to disentangle the inflammatory versus antimicrobial aspects of this relation. Funding Lundbeck Foundation, Danish Ministry of Health, Danish Council for Strategic Research, Capital Region Research Foundation.","published-print":{"date-parts":[[2016,1]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Stokholm","given":"Jakob","affiliation":[]},{"sequence":"additional","family":"Chawes","given":"Bo L","affiliation":[]},{"sequence":"additional","family":"Vissing","given":"Nadja H","affiliation":[]},{"sequence":"additional","family":"Bjarnadóttir","given":"Elín","affiliation":[]},{"sequence":"additional","family":"Pedersen","given":"Tine M","affiliation":[]},{"sequence":"additional","family":"Vinding","given":"Rebecca K","affiliation":[]},{"sequence":"additional","family":"Schoos","given":"Ann-Marie M","affiliation":[]},{"sequence":"additional","family":"Wolsk","given":"Helene M","affiliation":[]},{"sequence":"additional","family":"Thorsteinsdóttir","given":"Sunna","affiliation":[]},{"sequence":"additional","family":"Hallas","given":"Henrik W","affiliation":[]},{"sequence":"additional","family":"Arianto","given":"Lambang","affiliation":[]},{"sequence":"additional","family":"Schjørring","given":"Susanne","affiliation":[]},{"sequence":"additional","family":"Krogfelt","given":"Karen A","affiliation":[]},{"sequence":"additional","family":"Fischer","given":"Thea K","affiliation":[]},{"sequence":"additional","family":"Pipper","given":"Christian B","affiliation":[]},{"sequence":"additional","family":"Bønnelykke","given":"Klaus","affiliation":[]},{"sequence":"additional","family":"Bisgaard","given":"Hans","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S2213260015005007?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S2213260015005007?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1450439725000,"date-time":"2015-12-18T11:55:25Z","date-parts":[[2015,12,18]]},"language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Azithromycin for episodes with asthma-like symptoms in young children aged 1–3 years: a randomised, double-blind, placebo-controlled trial","label":"Article Title","name":"articletitle"},{"value":"The Lancet Respiratory Medicine","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/S2213-2600(15)00500-7","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"https://doi.org/10.1016/S2213-2600(15)00520-2","label":"CrossRef DOI link to the associated document","name":"associatedlink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"Copyright © 2016 Elsevier Ltd. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"5c47b032f439e60d8c7945ce9ac4a2fb86a87617"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":799.37},{"page_width":595.276,"page_height":799.37},{"page_width":595.276,"page_height":799.37},{"page_width":595.276,"page_height":799.37},{"page_width":595.276,"page_height":799.37},{"page_width":595.276,"page_height":799.37},{"page_width":595.276,"page_height":799.37},{"page_width":595.276,"page_height":799.37}],"runtime":11988},
  {"_key":"60c20c1b7723bebd86645514","_id":"documents/60c20c1b7723bebd86645514","_rev":"_cfFhBPu---","file_name":"01nkxwst.pdf","md5":"7FC6C75B06B855A2631654AF98078B29","id":"01nkxwst","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/nk/xw/st/01nkxwst/01nkxwst.pdf","date":"2021-06-10T12:56+0000","metadata":{"alternative-id":["S2052252520012944"],"published-print":{"date-parts":[[2020,11,1]]},"volume":"7","pmid":"33063792","journal-issue":{"issue":"6","published-online":{"date-parts":[[2020,11]]}},"has_valid_tei":false,"DOI":"10.1107/s2052252520012944","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/legalcode","content-version":"vor","delay-in-days":0,"start":{"timestamp":1601337600000,"date-time":"2020-09-29T00:00:00Z","date-parts":[[2020,9,29]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/legalcode","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1601337600000,"date-time":"2020-09-29T00:00:00Z","date-parts":[[2020,9,29]]}}],"content-domain":{"domain":["iucr.org","wiley.com","iucrj.org"],"crossmark-restriction":true},"reference-count":88,"page":"1048-1058","issued":{"date-parts":[[2020,9,29]]},"funder":[{"doi-asserted-by":"publisher","award":["R01-GM132595","U54-GM094662"],"DOI":"10.13039/100000057","name":"National Institute of General Medical Sciences"},{"doi-asserted-by":"publisher","award":["PPN/BEK/2018/1/00058/U/00001"],"DOI":"10.13039/501100014434","name":"Narodowa Agencja Wymiany Akademickiej"},{"doi-asserted-by":"publisher","award":["2020/01/0/NZ1/00134"],"DOI":"10.13039/501100004281","name":"Narodowe Centrum Nauki"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100008457","name":"University of Virginia"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100010557","name":"Office of the Vice President for Research, University of South Carolina"}],"publisher":"International Union of Crystallography (IUCr)","id":"01nkxwst","short-title":[],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/f6/8f/PMC7553145.tar.gz","pmcid":"PMC7553145","has_valid_oa_url":true,"deposited":{"timestamp":1617539334000,"date-time":"2021-04-04T12:28:54Z","date-parts":[[2021,4,4]]},"indexed":{"timestamp":1617542429421,"date-time":"2021-04-04T13:20:29Z","date-parts":[[2021,4,4]]},"is-referenced-by-count":2,"title":["Molecular determinants of vascular transport of dexamethasone in COVID-19 therapy"],"prefix":"10.1107","accepted":{"date-parts":[[2020,9,22]]},"published-online":{"date-parts":[[2020,9,29]]},"has_valid_thumbnail":false,"references-count":88,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1107/s2052252520012944","type":"journal-article","issn-type":[{"value":"2052-2525","type":"electronic"}],"container-title":["IUCrJ"],"score":1,"has_valid_ref_annotation":false,"issue":"6","member":"329","short-container-title":["Int Union Crystallogr J","IUCr J","Int Union Cryst J","IUCrJ"],"has_valid_pdf":true,"author":[{"sequence":"first","given":"Ivan G.","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-3955-9242","family":"Shabalin","affiliation":[]},{"sequence":"additional","given":"Mateusz P.","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-8973-4569","family":"Czub","affiliation":[]},{"sequence":"additional","given":"Karolina A.","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-0973-9085","family":"Majorek","affiliation":[]},{"sequence":"additional","given":"Dariusz","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-9723-525X","family":"Brzezinski","affiliation":[]},{"sequence":"additional","given":"Marek","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-8072-4919","family":"Grabowski","affiliation":[]},{"sequence":"additional","given":"David R.","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-5240-9789","family":"Cooper","affiliation":[]},{"sequence":"additional","given":"Mateusz","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-1978-846X","family":"Panasiuk","affiliation":[]},{"sequence":"additional","given":"Maksymilian","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-7521-5485","family":"Chruszcz","affiliation":[]},{"sequence":"additional","given":"Wladek","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-7075-7090","family":"Minor","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1107/cm_01","abstract":"Dexamethasone, a widely used corticosteroid, has recently been reported as the first drug to increase the survival chances of patients with severe COVID-19. Therapeutic agents, including dexamethasone, are mostly transported through the body by binding to serum albumin. Here, the first structure of serum albumin in complex with dexamethasone is reported. Dexamethasone binds to drug site 7, which is also the binding site for commonly used nonsteroidal anti-inflammatory drugs and testosterone, suggesting potentially problematic binding competition. This study bridges structural findings with an analysis of publicly available clinical data from Wuhan and suggests that an adjustment of the dexamethasone regimen should be further investigated as a strategy for patients affected by two major COVID-19 risk factors: low albumin levels and diabetes.","link":[{"URL":"http://journals.iucr.org/m/issues/2020/06/00/be5285/be5285.pdf","content-version":"vor","intended-application":"text-mining","content-type":"unspecified"},{"URL":"http://journals.iucr.org/m/issues/2020/06/00/be5285/be5285.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[],"is-supplemented-by":[{"id":"10.1107/S2052252520012944/be5285sup1.pdf","id-type":"doi","asserted-by":"subject"},{"id":"10.2210/pdb6xk0/pdb","id-type":"doi","asserted-by":"subject"},{"id":"10.18430/m3.irrmc.5571","id-type":"doi","asserted-by":"subject"}]},"created":{"timestamp":1601294722000,"date-time":"2020-09-28T12:05:22Z","date-parts":[[2020,9,28]]},"ISSN":["2052-2525"],"assertion":[{"explanation":{"URL":"http://www.iucrj.org/"},"label":"Publication","name":"journal","order":0,"value":"IUCrJ","group":{"label":"General","name":"general"}},{"explanation":{"URL":"https://journals.iucr.org/m/services/notesforauthors.html"},"label":"Content type","name":"content_type","order":1,"value":"research papers","group":{"label":"General","name":"general"}},{"label":"Article metrics","name":"article_metrics","order":2,"URL":"https://scripts.iucr.org/cgi-bin/citedin?be5285","value":"Available","group":{"label":"General","name":"general"}},{"order":0,"value":"Yes","group":{"label":"Peer review","name":"peer_review"},"label":"Peer reviewed","name":"peer_reviewed"},{"order":1,"value":"Single blind","group":{"label":"Peer review","name":"peer_review"},"label":"Review process","name":"review_process"},{"order":0,"value":"30 July 2020","group":{"label":"Publication history","name":"publication_history"},"label":"Received","name":"received"},{"order":1,"value":"22 September 2020","group":{"label":"Publication history","name":"publication_history"},"label":"Accepted","name":"accepted"},{"order":2,"value":"29 September 2020","group":{"label":"Publication history","name":"publication_history"},"label":"Published online","name":"published_online"},{"explanation":{"URL":"https://scripts.iucr.org/cgi-bin/sendsup?be5285"},"value":"This article has supporting information","label":"Supplementary materials","name":"supplementary_materials"},{"explanation":{"URL":"http://journals.iucr.org/services/copyrightpolicy.html"},"label":"Copyright","name":"copyright","order":0,"value":"© 2020 Ivan G. Shabalinet al.","group":{"label":"Copyright and licencing","name":"copyright_and_licencing"}},{"explanation":{"URL":"https://creativecommons.org/licenses/by/4.0/legalcode"},"label":"Licence","name":"license","order":1,"value":"Creative Commons Attribution (CC-BY)","group":{"label":"Copyright and licencing","name":"copyright_and_licencing"}}],"source":"Crossref","cord_sha":"02f3e52b0425a6f326106874579931e9416cedc2"},"application":"software-mentions","pages":[{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701},{"page_width":609.675,"page_height":793.701}],"runtime":7569},
  {"_key":"60c20c207723bebd8664551c","_id":"documents/60c20c207723bebd8664551c","_rev":"_cfFhBP2---","file_name":"01o15wd4.pdf","md5":"0B2D849E536E13BE36657851655C2FC0","id":"01o15wd4","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/o1/5w/d4/01o15wd4/01o15wd4.pdf","date":"2021-06-10T12:57+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1210723200000,"date-time":"2008-05-14T00:00:00Z","date-parts":[[2008,5,14]]}}],"language":"en","volume":"3","pmid":"18478121","has_valid_tei":false,"created":{"timestamp":1210705592000,"date-time":"2008-05-13T19:06:32Z","date-parts":[[2008,5,13]]},"DOI":"10.1371/journal.pone.0002183","license-simplified":"cc-by","original-title":[],"short-container-title":["PLoS ONE"],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1371/journal.pone.corrections_policy","page":"e2183","type":"journal-article","issued":{"date-parts":[[2008,5,14]]},"publisher":"Public Library of Science (PLoS)","id":"01o15wd4","short-title":[],"editor":[{"sequence":"first","family":"Nixon","given":"Douglas F.","affiliation":[]}],"pmcid":"PMC2367437","has_valid_oa_url":true,"deposited":{"timestamp":1540199855000,"date-time":"2018-10-22T09:17:35Z","date-parts":[[2018,10,22]]},"indexed":{"timestamp":1611135851053,"date-time":"2021-01-20T09:44:11Z","date-parts":[[2021,1,20]]},"is-referenced-by-count":23,"title":["IL-12 RB1 Genetic Variants Contribute to Human Susceptibility to Severe Acute Respiratory Syndrome Infection among Chinese"],"prefix":"10.1371","published-online":{"date-parts":[[2008,5,14]]},"has_valid_thumbnail":false,"references-count":30,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/f6/a4/PMC2367437.tar.gz","subtitle":[],"reference-count":30,"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"container-title":["PLoS ONE"],"has_valid_ref_annotation":false,"issue":"5","member":"340","abstract":"BACKGROUND: Cytokines play important roles in antiviral action. We examined whether polymorphisms of interleukin (IL)-12 receptor B1 (IL-12RB1) affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS). METHODS: A case-control study was carried out in Chinese SARS patients and healthy controls. The genotypes of 4SNPs on IL-12 RB1 gene, +705A/G,+1158T/C, +1196G/C and +1664 C/T, were determined by PCR-RFLP. Haplotypes were estimated from the genotype data using the expectation-maximisation algorithm. RESULTS: Comparison between patients and close contacts showed that individuals with the +1664 C/T (CT and TT) genotype had a 2.09-fold (95% confidence interval [CI], 1.90–7.16) and 2.34-fold (95% CI, 1.79–13.37) increased risk of developing SARS, respectively. For any of the other three polymorphisms, however, no significant difference can be detected in allele or genotype frequencies between patients and controls. Additionally, estimation of the frequencies of multiple-locus haplotypes revealed potential risk haplotypes (GCCT) for SARS infection. CONCLUSIONS: Our data indicate that genetic variants of IL12RB1confer genetic susceptibility to SARS infection, but not necessary associated with the progression of the disease in Chinese population.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Tang","given":"Fang","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Wei","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Fang","affiliation":[]},{"sequence":"additional","family":"Xin","given":"Zhong-Tao","affiliation":[]},{"sequence":"additional","family":"Wei","given":"Mao-Ti","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Pan-He","affiliation":[]},{"sequence":"additional","family":"Yang","given":"Hong","affiliation":[]},{"sequence":"additional","family":"Ly","given":"Hinh","affiliation":[]},{"sequence":"additional","family":"Cao","given":"Wu-Chun","affiliation":[]}],"subject":["General Biochemistry, Genetics and Molecular Biology","General Agricultural and Biological Sciences","General Medicine"],"link":[{"URL":"http://dx.plos.org/10.1371/journal.pone.0002183","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1371/journal.pone.0002183","journal-issue":{"issue":"5","published-online":{"date-parts":[[2008,5,14]]}},"score":1,"source":"Crossref","cord_sha":"7a5478dfe79fbf67551ac9261f190d899ba719b3"},"application":"software-mentions","pages":[{"page_width":612.283,"page_height":790.866},{"page_width":612.283,"page_height":790.866},{"page_width":612.283,"page_height":790.866},{"page_width":612.283,"page_height":790.866},{"page_width":612.283,"page_height":790.866},{"page_width":612.283,"page_height":790.866}],"runtime":10709},
  {"_key":"60c20c287723bebd8664551f","_id":"documents/60c20c287723bebd8664551f","_rev":"_cfFhBQC---","file_name":"01o1w8bt.pdf","md5":"38E9681758B9DE6C2650EAAE8BB2A7DF","id":"01o1w8bt","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/o1/w8/bt/01o1w8bt/01o1w8bt.pdf","date":"2021-06-10T12:57+0000","metadata":{"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1577836800000,"date-time":"2020-01-01T00:00:00Z","date-parts":[[2020,1,1]]}}],"has_valid_tei":false,"DOI":"10.1007/978-3-030-49461-2_1","license-simplified":"no-cc","original-title":[],"published-print":{"date-parts":[[2020]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"publisher-location":"Cham","page":"3-19","type":"book-chapter","issued":{"date-parts":[[2020]]},"publisher":"Springer International Publishing","id":"01o1w8bt","reference-count":38,"title":["Handling Impossible Derivations During Stream Reasoning"],"pmcid":"PMC7250624","has_valid_oa_url":true,"deposited":{"timestamp":1590537776000,"date-time":"2020-05-27T00:02:56Z","date-parts":[[2020,5,27]]},"indexed":{"timestamp":1590540023638,"date-time":"2020-05-27T00:40:23Z","date-parts":[[2020,5,27]]},"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1007","published-online":{"date-parts":[[2020,5,27]]},"has_valid_thumbnail":false,"isbn-type":[{"value":"9783030494605","type":"print"},{"value":"9783030494612","type":"electronic"}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a5/1c/PMC7250624.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/978-3-030-49461-2_1","short-title":[],"issn-type":[{"value":"0302-9743","type":"print"},{"value":"1611-3349","type":"electronic"}],"container-title":["The Semantic Web","Lecture Notes in Computer Science"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"With the rapid expansion of the Web and the advent of the Internet of Things, there is a growing need to design tools for intelligent analytics and decision making on streams of data. Logic-based frameworks like LARS allow the execution of complex reasoning on such streams, but it is paramount that the computation is completed in a timely manner before the stream expires. To reduce the runtime, we can extend the validity of inferred conclusions to the future to avoid repeated derivations, but this is not enough to avoid all sources of redundant computation. To further alleviate this problem, this paper introduces a new technique that infers the impossibility of certain derivations in the future and blocks the reasoner from performing computation that is doomed to fail anyway. An experimental analysis on microbenchmarks shows that our technique leads to a significant reduction of the reasoning runtime.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Bazoobandi","given":"Hamid R.","affiliation":[]},{"sequence":"additional","family":"Bal","given":"Henri","affiliation":[]},{"sequence":"additional","family":"van Harmelen","given":"Frank","affiliation":[]},{"sequence":"additional","family":"Urbani","given":"Jacopo","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","ISBN":["9783030494605","9783030494612"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/978-3-030-49461-2_1","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1590535583000,"date-time":"2020-05-26T23:26:23Z","date-parts":[[2020,5,26]]},"references-count":38,"ISSN":["0302-9743","1611-3349"],"assertion":[{"order":1,"value":"27 May 2020","group":{"label":"Chapter History","name":"ChapterHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"ESWC","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Acronym","name":"conference_acronym"},{"order":2,"value":"European Semantic Web Conference","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Name","name":"conference_name"},{"order":3,"value":"Heraklion, Crete","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference City","name":"conference_city"},{"order":4,"value":"Greece","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Country","name":"conference_country"},{"order":5,"value":"2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Year","name":"conference_year"},{"order":7,"value":"31 May 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Start Date","name":"conference_start_date"},{"order":8,"value":"4 June 2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference End Date","name":"conference_end_date"},{"order":9,"value":"17","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference Number","name":"conference_number"},{"order":10,"value":"esws2020","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference ID","name":"conference_id"},{"order":11,"value":"https://2020.eswc-conferences.org/","group":{"label":"Conference Information","name":"ConferenceInfo"},"label":"Conference URL","name":"conference_url"},{"order":1,"value":"Open","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Type","name":"type"},{"order":2,"value":"EasyChair","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Conference Management System","name":"conference_management_system"},{"order":3,"value":"166","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Submissions Sent for Review","name":"number_of_submissions_sent_for_review"},{"order":4,"value":"39","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Full Papers Accepted","name":"number_of_full_papers_accepted"},{"order":5,"value":"0","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Number of Short Papers Accepted","name":"number_of_short_papers_accepted"},{"order":6,"value":"23% - 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The conference was held virtually due to the COVID-19 pandemic.","group":{"label":"Peer Review Information (provided by the conference organizers)","name":"ConfEventPeerReviewInformation"},"label":"Additional Info on Review Process","name":"additional_info_on_review_process"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"00dd17fcbf34e0cb84272565ac52768cf14d42da"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":16788},
  {"_key":"60c20c2a7723bebd86645525","_id":"documents/60c20c2a7723bebd86645525","_rev":"_cfFhBQO---","file_name":"01oadgkh.pdf","md5":"D72B3678035E02F5C75E66216246AB98","id":"01oadgkh","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/oa/dg/kh/01oadgkh/01oadgkh.pdf","date":"2021-06-10T12:57+0000","metadata":{"alternative-id":["10.4049/jimmunol.1401459"],"published-print":{"date-parts":[[2015,4,1]]},"volume":"194","pmid":"25725102","author":[{"sequence":"first","family":"Clarner","given":"Tim","affiliation":[]},{"sequence":"additional","family":"Janssen","given":"Katharina","affiliation":[]},{"sequence":"additional","family":"Nellessen","given":"Lara","affiliation":[]},{"sequence":"additional","family":"Stangel","given":"Martin","affiliation":[]},{"sequence":"additional","family":"Skripuletz","given":"Thomas","affiliation":[]},{"sequence":"additional","family":"Krauspe","given":"Barbara","affiliation":[]},{"sequence":"additional","family":"Hess","given":"Franz-Martin","affiliation":[]},{"sequence":"additional","family":"Denecke","given":"Bernd","affiliation":[]},{"sequence":"additional","family":"Beutner","given":"Clara","affiliation":[]},{"sequence":"additional","family":"Linnartz-Gerlach","given":"Bettina","affiliation":[]},{"sequence":"additional","family":"Neumann","given":"Harald","affiliation":[]},{"sequence":"additional","family":"Vallières","given":"Luc","affiliation":[]},{"sequence":"additional","family":"Amor","given":"Sandra","affiliation":[]},{"sequence":"additional","family":"Ohl","given":"Kim","affiliation":[]},{"sequence":"additional","family":"Tenbrock","given":"Klaus","affiliation":[]},{"sequence":"additional","family":"Beyer","given":"Cordian","affiliation":[]},{"sequence":"additional","family":"Kipp","given":"Markus","affiliation":[]}],"DOI":"10.4049/jimmunol.1401459","license-simplified":"unk","original-title":[],"title":["CXCL10 Triggers Early Microglial Activation in the Cuprizone Model"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":114,"page":"3400-3413","type":"journal-article","issued":{"date-parts":[[2015,2,27]]},"publisher":"The American Association of Immunologists","id":"01oadgkh","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1560982034000,"date-time":"2019-06-19T22:07:14Z","date-parts":[[2019,6,19]]},"indexed":{"timestamp":1605720258312,"date-time":"2020-11-18T17:24:18Z","date-parts":[[2020,11,18]]},"is-referenced-by-count":64,"short-container-title":["J.I."],"prefix":"10.4049","oaLink":"https://www.jimmunol.org/content/jimmunol/194/7/3400.full.pdf","has_valid_thumbnail":false,"ISSN":["0022-1767","1550-6606"],"references-count":114,"published-online":{"date-parts":[[2015,2,27]]},"subtitle":[],"URL":"http://dx.doi.org/10.4049/jimmunol.1401459","journal-issue":{"published-print":{"date-parts":[[2015,4,1]]},"issue":"7","published-online":{"date-parts":[[2015,3,20]]}},"issn-type":[{"value":"0022-1767","type":"print"},{"value":"1550-6606","type":"electronic"}],"container-title":["The Journal of Immunology"],"has_valid_ref_annotation":false,"issue":"7","member":"2487","abstract":"A broad spectrum of diseases is characterized by myelin abnormalities and/or oligodendrocyte pathology. In most, if not all, of these diseases, early activation of microglia occurs. Our knowledge regarding the factors triggering early microglia activation is, however, incomplete. In this study, we used the cuprizone model to investigate the temporal and causal relationship of oligodendrocyte apoptosis and early microglia activation. Genome-wide gene expression studies revealed the induction of distinct chemokines, among them Cxcl10, Ccl2, and Ccl3 in cuprizone-mediated oligodendrocyte apoptosis. Early microglia activation was unchanged in CCL2- and CCL3-deficient knockouts, but was significantly reduced in CXCL10-deficient mice, resulting in an amelioration of cuprizone toxicity at later time points. Subsequent in vitro experiments revealed that recombinant CXCL10 induced migration and a proinflammatory phenotype in cultured microglia, without affecting their phagocytic activity or proliferation. In situ hybridization analyses suggest that Cxcl10 mRNA is mainly expressed by astrocytes, but also oligodendrocytes, in short-term cuprizone-exposed mice. Our results show that CXCL10 actively participates in the initiation of microglial activation. These findings have implications for the role of CXCL10 as an important mediator during the initiation of neuroinflammatory processes associated with oligodendrocyte pathology.","has_valid_pdf":true,"has_valid_tei":false,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.4049/jimmunol.1401459","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1425095561000,"date-time":"2015-02-28T03:52:41Z","date-parts":[[2015,2,28]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":584,"page_height":782},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986}],"runtime":15085},
  {"_key":"60c20c357723bebd86645529","_id":"documents/60c20c357723bebd86645529","_rev":"_cfFhBQa---","file_name":"01oveik4.pdf","md5":"0FAD164FF93C47CA35639883F1B16B7C","id":"01oveik4","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/ov/ei/k4/01oveik4/01oveik4.pdf","date":"2021-06-10T12:57+0000","metadata":{"is-referenced-by-count":1,"license":[{"URL":"https://creativecommons.org/licenses/by-nc-nd/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1614038400000,"date-time":"2021-02-23T00:00:00Z","date-parts":[[2021,2,23]]}}],"prefix":"10.1055","subtitle":[],"pmid":"33622007","published-online":{"date-parts":[[2021,2,23]]},"has_valid_tei":false,"has_valid_thumbnail":false,"ISSN":["1305-7456","1305-7464"],"URL":"http://dx.doi.org/10.1055/s-0040-1721910","references-count":17,"license-simplified":"unk","original-title":[],"title":["COVID-19: The Dentists’ Perceived Impact on the Dental Practice"],"content-domain":{"domain":[],"crossmark-restriction":false},"subject":["General Dentistry"],"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"issn-type":[{"value":"1305-7456","type":"print"},{"value":"1305-7464","type":"electronic"}],"container-title":["European Journal of Dentistry"],"has_valid_oa_url":true,"has_valid_ref_annotation":false,"publisher":"Georg Thieme Verlag KG","member":"194","short-container-title":["Eur J Dent"],"deposited":{"timestamp":1614125985000,"date-time":"2021-02-24T00:19:45Z","date-parts":[[2021,2,24]]},"has_valid_pdf":true,"author":[{"sequence":"additional","family":"Amato","given":"Alessandra","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Baronissi, Salerno, Italy"}]},{"sequence":"additional","family":"Ciacci","given":"Carolina","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Baronissi, Salerno, Italy"}]},{"sequence":"additional","family":"Martina","given":"Stefano","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Baronissi, Salerno, Italy"}]},{"sequence":"additional","family":"Caggiano","given":"Mario","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Baronissi, Salerno, Italy"}]},{"sequence":"additional","family":"Amato","given":"Massimo","affiliation":[{"name":"Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, Baronissi, Salerno, Italy"}]}],"DOI":"10.1055/s-0040-1721910","reference-count":17,"abstract":"OBJECTIVES The present study aimed to investigate the dentists' knowledge of the risks from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, and how it will impact their practice. MATERIALS AND METHODS An ad hoc self-administered anonymous questionnaire was submitted to Italian dentists. STATISTICAL ANALYSIS Differences in rates were calculated using the chi-square test. The level of significance was set at p < 0.05. RESULTS A total of 849 dentists fully completed the survey. Eighty-eight per cent of Italian dentists are worried about the health of their families, with no difference in high-risk (red zone) and low-risk (orange zone) regions. About 86% of professionals report some income loss and 94% fear a drop in patients after the quarantine phase, with the dentists working the red zone claiming a greater economic loss and fearing a reduced practice after the end of the lockdown. DISCUSSION A large majority of the Italian dentists appears to be aware of the need for changes in their dental practices by planning specific sterilization processes between appointments, testing patients for SARS-CoV-2 serology, asking patients not to be accompanied, and reducing the number of visits per day. CONCLUSION The survey expresses the serious concern of the dentists for the pandemic's effects on their profession.","link":[{"URL":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1721910.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1614125929000,"date-time":"2021-02-24T00:18:49Z","date-parts":[[2021,2,24]]},"oaLink":"http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0040-1721910.pdf","id":"01oveik4","language":"en","score":1,"source":"Crossref","indexed":{"timestamp":1615404232855,"date-time":"2021-03-10T19:23:52Z","date-parts":[[2021,3,10]]},"type":"journal-article","cord_sha":""},"application":"software-mentions","pages":[{"page_width":602.079,"page_height":799.937},{"page_width":602.079,"page_height":799.937},{"page_width":602.079,"page_height":799.937},{"page_width":602.079,"page_height":799.937},{"page_width":602.079,"page_height":799.937},{"page_width":602.079,"page_height":799.937}],"runtime":12749},
  {"_key":"60c20c397723bebd8664552b","_id":"documents/60c20c397723bebd8664552b","_rev":"_cfFhBQm---","file_name":"01pku7sl.pdf","md5":"2CED2AD7E000C47168B647C24251C210","id":"01pku7sl","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/pk/u7/sl/01pku7sl/01pku7sl.pdf","date":"2021-06-10T12:57+0000","metadata":{"alternative-id":["2764"],"published-print":{"date-parts":[[2020,6]]},"volume":"24","pmid":"31845078","journal-issue":{"published-print":{"date-parts":[[2020,6]]},"issue":"6"},"author":[{"sequence":"first","given":"Justin D.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3264-8082","family":"Smith","affiliation":[]},{"sequence":"additional","family":"Li","given":"Dennis H.","affiliation":[]},{"sequence":"additional","family":"Hirschhorn","given":"Lisa R.","affiliation":[]},{"sequence":"additional","family":"Gallo","given":"Carlos","affiliation":[]},{"sequence":"additional","family":"McNulty","given":"Moira","affiliation":[]},{"suffix":"II","sequence":"additional","family":"Phillips","given":"Gregory","affiliation":[]},{"sequence":"additional","family":"Birkett","given":"Michelle","affiliation":[]},{"sequence":"additional","family":"Rafferty","given":"Miriam","affiliation":[]},{"sequence":"additional","family":"Rao","given":"Amrita","affiliation":[]},{"sequence":"additional","family":"Villamar","given":"Juan A.","affiliation":[]},{"sequence":"additional","family":"Baral","given":"Stefan","affiliation":[]},{"sequence":"additional","family":"Mustanski","given":"Brian","affiliation":[]},{"sequence":"additional","family":"Brown","given":"C. Hendricks","affiliation":[]},{"sequence":"additional","family":"Benbow","given":"Nanette D.","affiliation":[]}],"created":{"timestamp":1576487047000,"date-time":"2019-12-16T09:04:07Z","date-parts":[[2019,12,16]]},"DOI":"10.1007/s10461-019-02764-6","original-title":[],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1576454400000,"date-time":"2019-12-16T00:00:00Z","date-parts":[[2019,12,16]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1576454400000,"date-time":"2019-12-16T00:00:00Z","date-parts":[[2019,12,16]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Public Health, Environmental and Occupational Health","Infectious Diseases","Social Psychology"],"page":"1903-1911","type":"journal-article","issued":{"date-parts":[[2019,12,16]]},"funder":[{"doi-asserted-by":"publisher","award":["P30DA027828"],"DOI":"10.13039/100000026","name":"National Institute on Drug Abuse"},{"doi-asserted-by":"publisher","award":["P30AI117943","P30AI094189"],"DOI":"10.13039/100000060","name":""}],"publisher":"Springer Science and Business Media LLC","id":"01pku7sl","short-title":[],"title":["Landscape of HIV Implementation Research Funded by the National Institutes of Health: A Mapping Review of Project Abstracts"],"oaLink":"https://link.springer.com/content/pdf/10.1007/s10461-019-02764-6.pdf","has_valid_oa_url":true,"deposited":{"timestamp":1607992427000,"date-time":"2020-12-15T00:33:47Z","date-parts":[[2020,12,15]]},"indexed":{"timestamp":1607994742317,"date-time":"2020-12-15T01:12:22Z","date-parts":[[2020,12,15]]},"is-referenced-by-count":3,"short-container-title":["AIDS Behav"],"prefix":"10.1007","published-online":{"date-parts":[[2019,12,16]]},"has_valid_thumbnail":false,"references-count":32,"license-simplified":"cc-by","subtitle":[],"reference-count":32,"ISSN":["1090-7165","1573-3254"],"issn-type":[{"value":"1090-7165","type":"print"},{"value":"1573-3254","type":"electronic"}],"container-title":["AIDS and Behavior"],"score":1,"has_valid_ref_annotation":false,"issue":"6","member":"297","abstract":"In 2019, the requisite biomedical and behavioral interventions to eliminate new HIV infections exist. \"Ending the HIV Epidemic\" now becomes primarily a challenge of will and implementation. This review maps the extent to which implementation research (IR) has been integrated into HIV research by reviewing the recent funding portfolio of the NIH. We searched NIH RePORTER for HIV and IR-related research projects funded from January 2013 to March 2018. The 4629 unique studies identified were screened using machine learning and manual methods. 216 abstracts met the eligibility criteria of HIV and IR. Key study characteristics were then abstracted. NIH currently funds HIV studies that are either formally IR (n = 109) or preparatory for IR (n = 107). Few (13%) projects mentioned a guiding implementation model, theory, or framework, and only 56% of all studies explicitly mentioned measuring an implementation outcome. Considering the study aims along an IR continuum, 18 (8%) studies examined barriers and facilitators, 43 (20%) developed implementation strategies, 46 (21%) piloted strategies, 73 (34%) tested a single strategy, and 35 (16%) compared strategies. A higher proportion of formal IR projects involved established interventions (e.g., integrated services) compared to newer interventions (e.g., pre-exposure prophylaxis). Prioritizing HIV-related IR in NIH and other federal funding opportunity announcements and expanded training in implementation science could have a substantial impact on ending the HIV pandemic. This review serves as a baseline by which to compare funding patterns and the sophistication of IR in HIV research over time.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s10461-019-02764-6.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s10461-019-02764-6/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s10461-019-02764-6.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1007/s10461-019-02764-6","language":"en","assertion":[{"order":1,"value":"16 December 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with Ethical Standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The authors declare no conflicts of interest.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":13965},
  {"_key":"60c20c457723bebd8664552e","_id":"documents/60c20c457723bebd8664552e","_rev":"_cfFhBQy---","file_name":"01q775up.pdf","md5":"A45534F4229345DB2E3B25005069B20C","id":"01q775up","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/q7/75/up/01q775up/01q775up.pdf","date":"2021-06-10T12:57+0000","metadata":{"alternative-id":["S1201971204000530"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1088640000000,"date-time":"2004-07-01T00:00:00Z","date-parts":[[2004,7,1]]}},{"URL":"https://www.elsevier.com/open-access/userlicense/1.0/","content-version":"vor","delay-in-days":3302,"start":{"timestamp":1373932800000,"date-time":"2013-07-16T00:00:00Z","date-parts":[[2013,7,16]]}}],"volume":"8","pmid":"15234325","has_valid_tei":false,"DOI":"10.1016/j.ijid.2004.03.004","original-title":[],"short-container-title":["International Journal of Infectious Diseases"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":27,"page":"217-222","type":"journal-article","issued":{"date-parts":[[2004,7]]},"publisher":"Elsevier BV","id":"01q775up","short-title":[],"pmcid":"PMC7129141","has_valid_oa_url":true,"deposited":{"timestamp":1585845842000,"date-time":"2020-04-02T16:44:02Z","date-parts":[[2020,4,2]]},"indexed":{"timestamp":1587050407268,"date-time":"2020-04-16T15:20:07Z","date-parts":[[2020,4,16]]},"is-referenced-by-count":10,"title":["Identification of six new polymorphisms in the human coronavirus 229E receptor gene (aminopeptidase N/CD13)"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/d1/95/PMC7129141.tar.gz","has_valid_thumbnail":false,"ISSN":["1201-9712"],"references-count":27,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.ijid.2004.03.004","journal-issue":{"published-print":{"date-parts":[[2004,7]]},"issue":"4"},"issn-type":[{"value":"1201-9712","type":"print"}],"container-title":["International Journal of Infectious Diseases"],"has_valid_ref_annotation":false,"issue":"4","member":"78","abstract":"Objective: Human aminopeptidase N (APN/CD13/ANPEP) has been identified as the receptor for human coronavirus (HCoV) 229E. In this study, we analyzed the region of the APN gene that encodes a stretch of amino acid residues, essential for its HCoV-229E receptor function (amino acids 260–353). Methods: Full-length APN exon 3, intron 3 and exon 4, was PCR-amplified and sequenced in DNA samples from 100 unrelated Caucasian Belgian healthy volunteers. Results: We identified seven polymorphisms, including four intron 3 and three exon 4 variations. Apart from the already known C956T exon 4 mutation, the six other polymorphisms have not yet been described. The most prevalent APN variations in this population (C956T leading to an alanine to valine substitution, G978T, G987A and intron3-C389T) always occurred together at an allele frequency of 8.5%. Haploid DNA sequencing demonstrated the presence of these four variations on the same allele. Three polymorphisms in intron 3, intron3-G395C, intron3-C86T, and intron3-C429T, were identified with an allele frequency of 3.5%, 1% and 0.5% respectively. Five haplotypes were identified in the population of 100 individuals. Conclusion: These results demonstrate that there is a relatively broad spectrum of variations in the APN domain critical for coronavirus binding. The nucleotide sequence reported here has been submitted to the GenBank database with the following accession number: AF527789.","published-print":{"date-parts":[[2004,7]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Vijgen","given":"Leen","affiliation":[]},{"sequence":"additional","family":"Keyaerts","given":"Els","affiliation":[]},{"sequence":"additional","family":"Zlateva","given":"Kalina","affiliation":[]},{"sequence":"additional","family":"Van Ranst","given":"Marc","affiliation":[]}],"subject":["Microbiology (medical)","Infectious Diseases","General Medicine"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S1201971204000530?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1201971204000530?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1088794332000,"date-time":"2004-07-02T18:52:12Z","date-parts":[[2004,7,2]]},"language":"en","score":1,"source":"Crossref","cord_sha":"8e8887d0412ee282b492096a86396c45ee54843d"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595,"page_height":793},{"page_width":595,"page_height":793},{"page_width":595,"page_height":793},{"page_width":595,"page_height":793},{"page_width":595,"page_height":793},{"page_width":595,"page_height":793}],"runtime":11732},
  {"_key":"60c20c477723bebd86645532","_id":"documents/60c20c477723bebd86645532","_rev":"_cfFhBQ6---","file_name":"01qy7hc4.pdf","md5":"1802C18A8490642A92F601A34670FA07","id":"01qy7hc4","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/qy/7h/c4/01qy7hc4/01qy7hc4.pdf","date":"2021-06-10T12:57+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1599523200000,"date-time":"2020-09-08T00:00:00Z","date-parts":[[2020,9,8]]}}],"language":"en","volume":"17","pmid":"32898149","has_valid_tei":false,"created":{"timestamp":1599585760000,"date-time":"2020-09-08T17:22:40Z","date-parts":[[2020,9,8]]},"DOI":"10.1371/journal.pmed.1003308","license-simplified":"cc-by","original-title":[],"short-container-title":["PLoS Med"],"content-domain":{"domain":["www.plosmedicine.org"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1371/journal.pmed.corrections_policy","page":"e1003308","type":"journal-article","issued":{"date-parts":[[2020,9,8]]},"publisher":"Public Library of Science (PLoS)","id":"01qy7hc4","short-title":[],"editor":[{"sequence":"first","family":"Cunningham","given":"Anne C.","affiliation":[]}],"pmcid":"PMC7478808","has_valid_oa_url":true,"deposited":{"timestamp":1599585796000,"date-time":"2020-09-08T17:23:16Z","date-parts":[[2020,9,8]]},"indexed":{"timestamp":1619015070509,"date-time":"2021-04-21T14:24:30Z","date-parts":[[2021,4,21]]},"is-referenced-by-count":17,"title":["Adverse outcomes and mortality in users of non-steroidal anti-inflammatory drugs who tested positive for SARS-CoV-2: A Danish nationwide cohort study"],"prefix":"10.1371","published-online":{"date-parts":[[2020,9,8]]},"has_valid_thumbnail":false,"references-count":34,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/f7/29/PMC7478808.tar.gz","subtitle":[],"reference-count":34,"ISSN":["1549-1676"],"issn-type":[{"value":"1549-1676","type":"electronic"}],"container-title":["PLOS Medicine"],"has_valid_ref_annotation":false,"issue":"9","member":"340","abstract":"BACKGROUND: Concerns over the safety of non-steroidal anti-inflammatory drug (NSAID) use during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection have been raised. We studied whether use of NSAIDs was associated with adverse outcomes and mortality during SARS-CoV-2 infection. METHODS AND FINDINGS: We conducted a population-based cohort study using Danish administrative and health registries. We included individuals who tested positive for SARS-CoV-2 during the period 27 February 2020 to 29 April 2020. NSAID users (defined as individuals having filled a prescription for NSAIDs up to 30 days before the SARS-CoV-2 test) were matched to up to 4 non-users on calendar week of the test date and propensity scores based on age, sex, relevant comorbidities, and use of selected prescription drugs. The main outcome was 30-day mortality, and NSAID users were compared to non-users using risk ratios (RRs) and risk differences (RDs). Secondary outcomes included hospitalization, intensive care unit (ICU) admission, mechanical ventilation, and acute renal replacement therapy. A total of 9,236 SARS-CoV-2 PCR-positive individuals were eligible for inclusion. The median age in the study cohort was 50 years, and 58% were female. Of these, 248 (2.7%) had filled a prescription for NSAIDs, and 535 (5.8%) died within 30 days. In the matched analyses, treatment with NSAIDs was not associated with 30-day mortality (RR 1.02, 95% CI 0.57 to 1.82, p = 0.95; RD 0.1%, 95% CI −3.5% to 3.7%, p = 0.95), risk of hospitalization (RR 1.16, 95% CI 0.87 to 1.53, p = 0.31; RD 3.3%, 95% CI −3.4% to 10%, p = 0.33), ICU admission (RR 1.04, 95% CI 0.54 to 2.02, p = 0.90; RD 0.2%, 95% CI −3.0% to 3.4%, p = 0.90), mechanical ventilation (RR 1.14, 95% CI 0.56 to 2.30, p = 0.72; RD 0.5%, 95% CI −2.5% to 3.6%, p = 0.73), or renal replacement therapy (RR 0.86, 95% CI 0.24 to 3.09, p = 0.81; RD −0.2%, 95% CI −2.0% to 1.6%, p = 0.81). The main limitations of the study are possible exposure misclassification, as not all individuals who fill an NSAID prescription use the drug continuously, and possible residual confounding by indication, as NSAIDs may generally be prescribed to healthier individuals due to their side effects, but on the other hand may also be prescribed for early symptoms of severe COVID-19. CONCLUSIONS: Use of NSAIDs was not associated with 30-day mortality, hospitalization, ICU admission, mechanical ventilation, or renal replacement therapy in Danish individuals who tested positive for SARS-CoV-2. TRIAL REGISTRATION: The European Union electronic Register of Post-Authorisation Studies EUPAS34734","has_valid_pdf":true,"author":[{"sequence":"first","given":"Lars Christian","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-8651-6072","family":"Lund","affiliation":[]},{"sequence":"additional","given":"Kasper Bruun","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-6373-1386","family":"Kristensen","affiliation":[]},{"sequence":"additional","given":"Mette","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-1241-4385","family":"Reilev","affiliation":[]},{"sequence":"additional","family":"Christensen","given":"Steffen","affiliation":[]},{"sequence":"additional","given":"Reimar Wernich","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-9135-3474","family":"Thomsen","affiliation":[]},{"sequence":"additional","given":"Christian Fynbo","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-0727-953X","family":"Christiansen","affiliation":[]},{"sequence":"additional","given":"Henrik","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-5821-2351","family":"Støvring","affiliation":[]},{"sequence":"additional","given":"Nanna Borup","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-3764-8532","family":"Johansen","affiliation":[]},{"sequence":"additional","family":"Brun","given":"Nikolai Constantin","affiliation":[]},{"sequence":"additional","given":"Jesper","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-8097-8708","family":"Hallas","affiliation":[]},{"sequence":"additional","given":"Anton","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0001-9314-5679","family":"Pottegård","affiliation":[]}],"subject":["General Medicine"],"link":[{"URL":"https://dx.plos.org/10.1371/journal.pmed.1003308","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1371/journal.pmed.1003308","journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,8]]}},"score":1,"source":"Crossref","cord_sha":"e81d87ea35be397b6cafe6853d9dff21b5b7a1d1"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":12199},
  {"_key":"60c20c527723bebd86645534","_id":"documents/60c20c527723bebd86645534","_rev":"_cfFhBRG---","file_name":"01rpxu69.pdf","md5":"6D2CEAC7E68CB4A6F928819F3787D357","id":"01rpxu69","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/rp/xu/69/01rpxu69/01rpxu69.pdf","date":"2021-06-10T12:57+0000","metadata":{"published-print":{"date-parts":[[2015,6,1]]},"volume":"468","pmid":"25764917","author":[{"sequence":"first","family":"Békés","given":"Miklós","affiliation":[{"name":"Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, U.S.A."}]},{"sequence":"additional","family":"Rut","given":"Wioletta","affiliation":[{"name":"Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, Wroclaw 50-370, Poland"}]},{"sequence":"additional","family":"Kasperkiewicz","given":"Paulina","affiliation":[{"name":"Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, Wroclaw 50-370, Poland"}]},{"sequence":"additional","family":"Mulder","given":"Monique P.C.","affiliation":[{"name":"Division of Cell Biology, Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"}]},{"sequence":"additional","family":"Ovaa","given":"Huib","affiliation":[{"name":"Division of Cell Biology, Netherlands Cancer Institute (NKI), Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands"}]},{"sequence":"additional","family":"Drag","given":"Marcin","affiliation":[{"name":"Division of Bioorganic Chemistry, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, Wroclaw 50-370, Poland"}]},{"sequence":"additional","family":"Lima","given":"Christopher D.","affiliation":[{"name":"Structural Biology Program, Sloan-Kettering Institute, 1275 York Ave, New York, NY 10065, U.S.A."},{"name":"Howard Hughes Medical Institute, 1275 York Ave, New York, NY 10065, U.S.A."}]},{"sequence":"additional","family":"Huang","given":"Tony T.","affiliation":[{"name":"Department of Biochemistry & Molecular Pharmacology, New York University School of Medicine, New York, NY 10016, U.S.A."}]}],"DOI":"10.1042/bj20141170","license-simplified":"unk","original-title":[],"title":["SARS hCoV papain-like protease is a unique Lys48 linkage-specific di-distributive deubiquitinating enzyme"],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"reference-count":47,"page":"215-226","type":"journal-article","issued":{"date-parts":[[2015,5,22]]},"publisher":"Portland Press Ltd.","id":"01rpxu69","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1572125799000,"date-time":"2019-10-26T21:36:39Z","date-parts":[[2019,10,26]]},"indexed":{"timestamp":1614589436052,"date-time":"2021-03-01T09:03:56Z","date-parts":[[2021,3,1]]},"is-referenced-by-count":38,"short-container-title":[],"prefix":"10.1042","published-online":{"date-parts":[[2015,5,22]]},"has_valid_thumbnail":false,"ISSN":["0264-6021","1470-8728"],"references-count":47,"oaLink":"http://europepmc.org/articles/pmc4447217?pdf=render","subtitle":[],"URL":"http://dx.doi.org/10.1042/bj20141170","journal-issue":{"published-print":{"date-parts":[[2015,6,1]]},"issue":"2"},"issn-type":[{"value":"0264-6021","type":"print"},{"value":"1470-8728","type":"electronic"}],"container-title":["Biochemical Journal"],"has_valid_ref_annotation":false,"issue":"2","member":"288","abstract":"Ubiquitin (Ub) and the Ub-like (Ubl) modifier interferon-stimulated gene 15 (ISG15) participate in the host defence of viral infections. Viruses, including the severe acute respiratory syndrome human coronavirus (SARS hCoV), have co-opted Ub-ISG15 conjugation pathways for their own advantage or have evolved effector proteins to counter pro-inflammatory properties of Ub-ISG15-conjugated host proteins. In the present study, we compare substrate specificities of the papain-like protease (PLpro) from the recently emerged Middle East respiratory syndrome (MERS) hCoV to the related protease from SARS, SARS PLpro. Through biochemical assays, we show that, similar to SARS PLpro, MERS PLpro is both a deubiquitinating (DUB) and a deISGylating enzyme. Further analysis of the intrinsic DUB activity of these viral proteases revealed unique differences between the recognition and cleavage specificities of polyUb chains. First, MERS PLpro shows broad linkage specificity for the cleavage of polyUb chains, whereas SARS PLpro prefers to cleave Lys48-linked polyUb chains. Secondly, MERS PLpro cleaves polyUb chains in a 'mono-distributive' manner (one Ub at a time) and SARS PLpro prefers to cleave Lys48-linked polyUb chains by sensing a di-Ub moiety as a minimal recognition element using a 'di-distributive' cleavage mechanism. The di-distributive cleavage mechanism for SARS PLpro appears to be uncommon among USP (Ub-specific protease)-family DUBs, as related USP family members from humans do not display such a mechanism. We propose that these intrinsic enzymatic differences between SARS and MERS PLpro will help to identify pro-inflammatory substrates of these viral DUBs and can guide in the design of therapeutics to combat infection by coronaviruses.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1042/crossmark_policy","link":[{"URL":"http://portlandpress.com/biochemj/article-pdf/468/2/215/683925/bj4680215.pdf","content-version":"vor","intended-application":"syndication","content-type":"application/pdf"},{"URL":"http://portlandpress.com/biochemj/article-pdf/468/2/215/683925/bj4680215.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1426248277000,"date-time":"2015-03-13T12:04:37Z","date-parts":[[2015,3,13]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":13458},
  {"_key":"60c20c537723bebd86645539","_id":"documents/60c20c537723bebd86645539","_rev":"_cfFhBRS---","file_name":"01rv15er.pdf","md5":"1CEE8108D1D89EA3037CE153206A9E79","id":"01rv15er","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/rv/15/er/01rv15er/01rv15er.pdf","date":"2021-06-10T12:57+0000","metadata":{"alternative-id":["10.3389/fphar.2020.594321"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1604966400000,"date-time":"2020-11-10T00:00:00Z","date-parts":[[2020,11,10]]}}],"volume":"11","pmid":"33244300","author":[{"sequence":"first","family":"Uckun","given":"Fatih M.","affiliation":[]},{"sequence":"additional","family":"Carlson","given":"James","affiliation":[]},{"sequence":"additional","family":"Orhan","given":"Cemal","affiliation":[]},{"sequence":"additional","family":"Powell","given":"Joy","affiliation":[]},{"sequence":"additional","family":"Pizzimenti","given":"Natalie M.","affiliation":[]},{"sequence":"additional","family":"van Wyk","given":"Hendrik","affiliation":[]},{"sequence":"additional","family":"Ozercan","given":"Ibrahim H.","affiliation":[]},{"sequence":"additional","family":"Volk","given":"Michael","affiliation":[]},{"sequence":"additional","family":"Sahin","given":"Kazim","affiliation":[]}],"DOI":"10.3389/fphar.2020.594321","license-simplified":"cc-by","original-title":[],"short-container-title":["Front. Pharmacol."],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.3389/crossmark-policy","type":"journal-article","issued":{"date-parts":[[2020,11,10]]},"publisher":"Frontiers Media SA","id":"01rv15er","reference-count":58,"pmcid":"PMC7683794","has_valid_oa_url":true,"deposited":{"timestamp":1604992040000,"date-time":"2020-11-10T07:07:20Z","date-parts":[[2020,11,10]]},"indexed":{"timestamp":1619196559708,"date-time":"2021-04-23T16:49:19Z","date-parts":[[2021,4,23]]},"is-referenced-by-count":6,"title":["Rejuveinix Shows a Favorable Clinical Safety Profile in Human Subjects and Exhibits Potent Preclinical Protective Activity in the Lipopolysaccharide-Galactosamine Mouse Model of Acute Respiratory Distress Syndrome and Multi‐Organ Failure"],"prefix":"10.3389","published-online":{"date-parts":[[2020,11,10]]},"has_valid_thumbnail":false,"references-count":58,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/5f/3d/PMC7683794.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.3389/fphar.2020.594321","short-title":[],"issn-type":[{"value":"1663-9812","type":"electronic"}],"container-title":["Frontiers in Pharmacology"],"has_valid_ref_annotation":false,"member":"1965","abstract":"Background: New treatment platforms that can prevent acute respiratory distress syndrome (ARDS) or reduce its mortality rate in high-risk coronavirus disease 2019 (COVID-19) patients, such as those with an underlying cancer, are urgently needed. Rejuveinix (RJX) is an intravenous formulation of anti-oxidants and anti-inflammatory agents. Its active ingredients include ascorbic acid, cyanocobalamin, thiamine hydrochloride, riboflavin 5′ phosphate, niacinamide, pyridoxine hydrochloride, and calcium D-pantothenate. RJX is being developed as an anti-inflammatory and anti-oxidant treatment platform for patients with sepsis, including COVID-19 patients with viral sepsis and ARDS. Here, we report its clinical safety profile in a phase 1 clinical study (ClinicalTrials.gov Identifier: NCT03680105) and its potent protective activity in the lipopolysaccharide galactosamine (LPS-GalN) mouse model of ARDS. Methods: A phase 1, double-blind, placebo-controlled, randomized, two-part, ascending dose-escalation study was performed in participating 76 healthy volunteer human subjects in compliance with the ICH (E6) good clinical practice guidelines to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of RJX (Protocol No. RPI003; ClinicalTrials.gov Identifier: NCT03680105). The ability of RJX to prevent fatal shock, ARDS, and multi-organ failure was examined in the well-established LPS-GalN mouse model of sepsis and ARDS. Standard methods were employed for the statistical analysis of data in both studies. Findings: In the phase 1 clinical study, no participant developed serious adverse events (SAEs) or Grade 3-Grade 4 adverse events (AEs) or prematurely discontinued participation in the study. In the non-clinical study, RJX exhibited potent and dose-dependent protective activity, decreased the inflammatory cytokine responses (interleukin-6, tumor necrosis factor alpha, transforming growth factor beta), and improved survival in the LPS-GalN mouse model of sepsis and ARDS. Histopathological examinations showed that RJX attenuated the LPS-GalN induced acute lung injury (ALI) and pulmonary edema as well as liver damage. Conclusion: RJX showed a very favorable safety profile and tolerability in human subjects. It shows potential to favorably affect the clinical course of high-risk COVID-19 by preventing ARDS and its complications.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Pharmacology (medical)","Pharmacology"],"link":[{"URL":"https://www.frontiersin.org/articles/10.3389/fphar.2020.594321/full","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1604992035000,"date-time":"2020-11-10T07:07:15Z","date-parts":[[2020,11,10]]},"ISSN":["1663-9812"],"score":1,"source":"Crossref","cord_sha":"93493e04d38ba828b2b47cdf40b629fcda0255aa"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":792,"page_height":612},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":14255},
  {"_key":"60c20c567723bebd8664553c","_id":"documents/60c20c567723bebd8664553c","_rev":"_cfFhBRe---","file_name":"01s21vh0.pdf","md5":"FC832B2A2A515A3D68D27165752AD0B1","id":"01s21vh0","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/s2/1v/h0/01s21vh0/01s21vh0.pdf","date":"2021-06-10T12:57+0000","metadata":{"alternative-id":["v8120322"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1480377600000,"date-time":"2016-11-29T00:00:00Z","date-parts":[[2016,11,29]]}}],"volume":"8","pmid":"27916837","has_valid_tei":false,"created":{"timestamp":1480432188000,"date-time":"2016-11-29T15:09:48Z","date-parts":[[2016,11,29]]},"DOI":"10.3390/v8120322","original-title":[],"short-container-title":["Viruses"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":56,"page":"322","type":"journal-article","issued":{"date-parts":[[2016,11,29]]},"publisher":"MDPI AG","id":"01s21vh0","short-title":[],"pmcid":"PMC5192383","has_valid_oa_url":true,"deposited":{"timestamp":1601221760000,"date-time":"2020-09-27T15:49:20Z","date-parts":[[2020,9,27]]},"indexed":{"timestamp":1617942068332,"date-time":"2021-04-09T04:21:08Z","date-parts":[[2021,4,9]]},"is-referenced-by-count":149,"title":["Chloroquine, an Endocytosis Blocking Agent, Inhibits Zika Virus Infection in Different Cell Models"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/be/0d/PMC5192383.tar.gz","has_valid_thumbnail":false,"ISSN":["1999-4915"],"references-count":56,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2016,12]]}},"issn-type":[{"value":"1999-4915","type":"electronic"}],"container-title":["Viruses"],"published-online":{"date-parts":[[2016,11,29]]},"issue":"12","member":"1968","abstract":"Zika virus (ZIKV) infection in utero might lead to microcephaly and other congenital defects. Since no specific therapy is available thus far, there is an urgent need for the discovery of agents capable of inhibiting its viral replication and deleterious effects. Chloroquine is widely used as an antimalarial drug, anti-inflammatory agent, and it also shows antiviral activity against several viruses. Here we show that chloroquine exhibits antiviral activity against ZIKV in Vero cells, human brain microvascular endothelial cells, human neural stem cells, and mouse neurospheres. We demonstrate that chloroquine reduces the number of ZIKV-infected cells in vitro, and inhibits virus production and cell death promoted by ZIKV infection without cytotoxic effects. In addition, chloroquine treatment partially reveres morphological changes induced by ZIKV infection in mouse neurospheres.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Delvecchio","given":"Rodrigo","affiliation":[]},{"sequence":"additional","family":"Higa","given":"Luiza","affiliation":[]},{"sequence":"additional","family":"Pezzuto","given":"Paula","affiliation":[]},{"sequence":"additional","family":"Valadão","given":"Ana","affiliation":[]},{"sequence":"additional","family":"Garcez","given":"Patrícia","affiliation":[]},{"sequence":"additional","family":"Monteiro","given":"Fábio","affiliation":[]},{"sequence":"additional","family":"Loiola","given":"Erick","affiliation":[]},{"sequence":"additional","family":"Dias","given":"André","affiliation":[]},{"sequence":"additional","family":"Silva","given":"Fábio","affiliation":[]},{"sequence":"additional","family":"Aliota","given":"Matthew","affiliation":[]},{"sequence":"additional","family":"Caine","given":"Elizabeth","affiliation":[]},{"sequence":"additional","family":"Osorio","given":"Jorge","affiliation":[]},{"sequence":"additional","family":"Bellio","given":"Maria","affiliation":[]},{"sequence":"additional","family":"O’Connor","given":"David","affiliation":[]},{"sequence":"additional","family":"Rehen","given":"Stevens","affiliation":[]},{"sequence":"additional","family":"de Aguiar","given":"Renato","affiliation":[]},{"sequence":"additional","family":"Savarino","given":"Andrea","affiliation":[]},{"sequence":"additional","given":"Loraine","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9172-1951","family":"Campanati","affiliation":[]},{"sequence":"additional","family":"Tanuri","given":"Amilcar","affiliation":[]}],"subject":["Virology","Infectious Diseases"],"link":[{"URL":"http://www.mdpi.com/1999-4915/8/12/322/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.3390/v8120322","language":"en","score":1,"source":"Crossref","cord_sha":"fc524fbd93be3db421c75c589e2299524a75fa26"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":14445},
  {"_key":"60c20c5a7723bebd86645540","_id":"documents/60c20c5a7723bebd86645540","_rev":"_cfFhBRq---","file_name":"01sxd6py.pdf","md5":"E5F0CCD06D05892BC175AEA66B2D3A9D","id":"01sxd6py","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/sx/d6/py/01sxd6py/01sxd6py.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["S0006349520314417"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1612137600000,"date-time":"2021-02-01T00:00:00Z","date-parts":[[2021,2,1]]}}],"volume":"120","journal-issue":{"published-print":{"date-parts":[[2021,2]]},"issue":"3"},"author":[{"sequence":"first","family":"Reza Arastoo","given":"Mohammad","affiliation":[]},{"sequence":"additional","family":"Moreno Pescador","given":"Guillermo Sergio","affiliation":[]},{"sequence":"additional","family":"Lysdal Veje","given":"Emilie","affiliation":[]},{"sequence":"additional","family":"Østbye","given":"Henrik","affiliation":[]},{"sequence":"additional","family":"Daniels","given":"Robert","affiliation":[]},{"sequence":"additional","family":"Martin Bendix","given":"Poul","affiliation":[]}],"DOI":"10.1016/j.bpj.2020.11.534","original-title":[],"short-container-title":["Biophysical Journal"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":0,"page":"48a","issued":{"date-parts":[[2021,2]]},"publisher":"Elsevier BV","id":"01sxd6py","short-title":[],"pmcid":"PMC7879799","has_valid_oa_url":true,"deposited":{"timestamp":1613170383000,"date-time":"2021-02-12T22:53:03Z","date-parts":[[2021,2,12]]},"indexed":{"timestamp":1613173669669,"date-time":"2021-02-12T23:47:49Z","date-parts":[[2021,2,12]]},"is-referenced-by-count":0,"title":["Phase Partitioning of influenza Virus Neuraminidase in a Model Membrane"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/07/26/PMC7879799.tar.gz","has_valid_thumbnail":false,"ISSN":["0006-3495"],"references-count":0,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.bpj.2020.11.534","type":"journal-article","issn-type":[{"value":"0006-3495","type":"print"}],"container-title":["Biophysical Journal"],"has_valid_ref_annotation":false,"issue":"3","member":"78","published-print":{"date-parts":[[2021,2]]},"has_valid_pdf":true,"has_valid_tei":false,"subject":["Biophysics"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0006349520314417?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0006349520314417?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{},"created":{"timestamp":1613170383000,"date-time":"2021-02-12T22:53:03Z","date-parts":[[2021,2,12]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":602.986,"page_height":782.986}],"runtime":11936},
  {"_key":"60c20c607723bebd86645542","_id":"documents/60c20c607723bebd86645542","_rev":"_cfFhBR2---","file_name":"01sy3u7h.pdf","md5":"5B6747C62EB5E96B7A8AC5E6AEEE8772","id":"01sy3u7h","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/sy/3u/7h/01sy3u7h/01sy3u7h.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["S0021925820682862"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1230768000000,"date-time":"2009-01-01T00:00:00Z","date-parts":[[2009,1,1]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":4286,"start":{"timestamp":1601078400000,"date-time":"2020-09-26T00:00:00Z","date-parts":[[2020,9,26]]}}],"volume":"284","pmid":"18986988","journal-issue":{"published-print":{"date-parts":[[2009,1]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1074/jbc.m807518200","original-title":[],"short-container-title":["Journal of Biological Chemistry"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":88,"page":"6-16","type":"journal-article","issued":{"date-parts":[[2009,1]]},"publisher":"Elsevier BV","id":"01sy3u7h","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1615500853000,"date-time":"2021-03-11T22:14:13Z","date-parts":[[2021,3,11]]},"indexed":{"timestamp":1618209894826,"date-time":"2021-04-12T06:44:54Z","date-parts":[[2021,4,12]]},"is-referenced-by-count":23,"title":["The Polysialic Acid-specific O-Acetyltransferase OatC from Neisseria meningitidis Serogroup C Evolved Apart from Other Bacterial Sialate O-Acetyltransferases*"],"prefix":"10.1016","oaLink":"http://www.jbc.org/content/284/1/6.full.pdf","has_valid_thumbnail":false,"references-count":88,"license-simplified":"unk","subtitle":[],"URL":"http://dx.doi.org/10.1074/jbc.m807518200","ISSN":["0021-9258"],"issn-type":[{"value":"0021-9258","type":"print"}],"container-title":["Journal of Biological Chemistry"],"has_valid_ref_annotation":false,"issue":"1","member":"78","abstract":"Neisseria meningitidis serogroup C is a major cause of bacterial meningitis and septicaemia. This human pathogen is protected by a capsule composed of alpha2,9-linked polysialic acid that represents an important virulence factor. In the majority of strains, the capsular polysaccharide is modified by O-acetylation at C-7 or C-8 of the sialic acid residues. The gene encoding the capsule modifying O-acetyltransferase is part of the capsule gene complex and shares no sequence similarities with other proteins. Here, we describe the purification and biochemical characterization of recombinant OatC. The enzyme was found as a homodimer, with the first 34 amino acids forming an efficient oligomerization domain that worked even in a different protein context. Using acetyl-CoA as donor substrate, OatC transferred acetyl groups exclusively onto polysialic acid joined by alpha2,9-linkages and did not act on free or CMP-activated sialic acid. Motif scanning revealed a nucleophile elbow motif (GXS286XGG), which is a hallmark of alpha/beta-hydrolase fold enzymes. In a comprehensive site-directed mutagenesis study, we identified a catalytic triad composed of Ser-286, Asp-376, and His-399. Consistent with a double-displacement mechanism common to alpha/beta-hydrolase fold enzymes, a covalent acetylenzyme intermediate was found. Together with secondary structure prediction highlighting an alpha/beta-hydrolase fold topology, our data provide strong evidence that OatC belongs to the alpha/beta-hydrolase fold family. This clearly distinguishes OatC from all other bacterial sialate O-acetyltransferases known so far because these are members of the hexapeptide repeat family, a class of acyltransferases that adopt a left-handed beta-helix fold and assemble into catalytic trimers.","published-print":{"date-parts":[[2009,1]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Bergfeld","given":"Anne K.","affiliation":[]},{"sequence":"additional","family":"Claus","given":"Heike","affiliation":[]},{"sequence":"additional","family":"Lorenzen","given":"Nina K.","affiliation":[]},{"sequence":"additional","family":"Spielmann","given":"Fabian","affiliation":[]},{"sequence":"additional","family":"Vogel","given":"Ulrich","affiliation":[]},{"sequence":"additional","family":"Mu¨hlenhoff","given":"Martina","affiliation":[]}],"subject":["Cell Biology","Biochemistry","Molecular Biology"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0021925820682862?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0021925820682862?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"},{"URL":"https://syndication.highwire.org/content/doi/10.1074/jbc.M807518200","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1225933990000,"date-time":"2008-11-06T01:13:10Z","date-parts":[[2008,11,6]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783},{"page_width":594,"page_height":783}],"runtime":14696},
  {"_key":"60c20c647723bebd86645546","_id":"documents/60c20c647723bebd86645546","_rev":"_cfFhBSC---","file_name":"01tncjq0.pdf","md5":"792474AD89E0A49ADCBF1146B809FE8B","id":"01tncjq0","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/tn/cj/q0/01tncjq0/01tncjq0.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["S0950268814000946"],"license":[{"URL":"http://creativecommons.org/licenses/by/3.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1398902400000,"date-time":"2014-05-01T00:00:00Z","date-parts":[[2014,5,1]]}}],"language":"en","volume":"142","pmid":"24787145","has_valid_tei":false,"DOI":"10.1017/s0950268814000946","license-simplified":"cc-by","original-title":[],"published-print":{"date-parts":[[2014,9]]},"content-domain":{"domain":["journals.cambridge.org"],"crossmark-restriction":true},"reference-count":40,"page":"1978-1989","type":"journal-article","issued":{"date-parts":[[2014,5,1]]},"publisher":"Cambridge University Press (CUP)","id":"01tncjq0","short-title":[],"title":["Validation of three geolocation strategies for health-facility attendees for research and public health surveillance in a rural setting in western Kenya"],"pmcid":"PMC4102101","has_valid_oa_url":true,"deposited":{"timestamp":1597774585000,"date-time":"2020-08-18T18:16:25Z","date-parts":[[2020,8,18]]},"indexed":{"timestamp":1597810225892,"date-time":"2020-08-19T04:10:25Z","date-parts":[[2020,8,19]]},"is-referenced-by-count":7,"short-container-title":["Epidemiol. Infect."],"prefix":"10.1017","published-online":{"date-parts":[[2014,5,1]]},"has_valid_thumbnail":false,"references-count":40,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/49/3b/PMC4102101.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1017/s0950268814000946","ISSN":["0950-2688","1469-4409"],"issn-type":[{"value":"0950-2688","type":"print"},{"value":"1469-4409","type":"electronic"}],"subject":["Epidemiology","Infectious Diseases"],"container-title":["Epidemiology and Infection"],"score":1,"has_valid_ref_annotation":false,"issue":"9","member":"56","abstract":"Understanding the spatial distribution of disease is critical for effective disease control. Where formal address networks do not exist, tracking spatial patterns of clinical disease is difficult. Geolocation strategies were tested at rural health facilities in western Kenya. Methods included geocoding residence by head of compound, participatory mapping and recording the self-reported nearest landmark. Geocoding was able to locate 72·9% [95% confidence interval (CI) 67·7–77·6] of individuals to within 250 m of the true compound location. The participatory mapping exercise was able to correctly locate 82·0% of compounds (95% CI 78·9–84·8) to a 2 × 2·5 km area with a 500 m buffer. The self-reported nearest landmark was able to locate 78·1% (95% CI 73·8–82·1) of compounds to the correct catchment area. These strategies tested provide options for quickly obtaining spatial information on individuals presenting at health facilities.","has_valid_pdf":true,"author":[{"sequence":"first","family":"STRESMAN","given":"G. H.","affiliation":[]},{"sequence":"additional","family":"STEVENSON","given":"J. 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  {"_key":"60c20c647723bebd8664554f","_id":"documents/60c20c647723bebd8664554f","_rev":"_cfFhBSK---","file_name":"01u5admm.pdf","md5":"3FAA2A3312D581017FEE31C72D1D9036","id":"01u5admm","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/u5/ad/mm/01u5admm/01u5admm.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["10.3389/fimmu.2020.517544"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1613347200000,"date-time":"2021-02-15T00:00:00Z","date-parts":[[2021,2,15]]}}],"volume":"11","pmid":"33658989","author":[{"sequence":"first","family":"Qin","given":"Tao","affiliation":[]},{"sequence":"additional","family":"Jia","given":"Yanjun","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Yuhang","affiliation":[]},{"sequence":"additional","family":"Dai","given":"Rongxin","affiliation":[]},{"sequence":"additional","family":"Zhou","given":"Lina","affiliation":[]},{"sequence":"additional","family":"Okada","given":"Satoshi","affiliation":[]},{"sequence":"additional","family":"Tsumura","given":"Miyuki","affiliation":[]},{"sequence":"additional","family":"Ohnishi","given":"Hidenori","affiliation":[]},{"sequence":"additional","family":"Kato","given":"Zenichiro","affiliation":[]},{"sequence":"additional","family":"Kanegane","given":"Hirokazu","affiliation":[]},{"sequence":"additional","family":"Sun","given":"Xiulian","affiliation":[]},{"sequence":"additional","family":"Zhao","given":"Xiaodong","affiliation":[]}],"DOI":"10.3389/fimmu.2020.517544","license-simplified":"cc-by","original-title":[],"short-container-title":["Front. Immunol."],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"type":"journal-article","issued":{"date-parts":[[2021,2,15]]},"publisher":"Frontiers Media SA","id":"01u5admm","reference-count":30,"pmcid":"PMC7917045","has_valid_oa_url":true,"deposited":{"timestamp":1613365869000,"date-time":"2021-02-15T05:11:09Z","date-parts":[[2021,2,15]]},"indexed":{"timestamp":1613368550057,"date-time":"2021-02-15T05:55:50Z","date-parts":[[2021,2,15]]},"is-referenced-by-count":0,"title":["A Novel Homozygous Mutation Destabilizes IKKβ and Leads to Human Combined Immunodeficiency"],"prefix":"10.3389","published-online":{"date-parts":[[2021,2,15]]},"has_valid_thumbnail":false,"references-count":30,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/46/9c/PMC7917045.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.3389/fimmu.2020.517544","short-title":[],"issn-type":[{"value":"1664-3224","type":"electronic"}],"container-title":["Frontiers in Immunology"],"has_valid_ref_annotation":false,"member":"1965","abstract":"Mutations in the IKBKB gene cause severe immunodeficiency, characterized clinically by persistent respiratory or gastrointestinal infections. Targeted gene panel sequencing revealed a novel homozygous missense mutation in the IKBKB gene of a patient with immune dysregulation and combined T and B cell functional defects. PBMCs from the patient, Ikbkb Y397H mice, and transfected cells were used to elucidate how the Y395H mutation triggers IKKβ deficiency and impairs immune function. Here, we found that cells from both the patient and Ikbkb Y397H mice lacked or showed decreased levels of IKKβ protein, along with impaired lymphocyte function. IKKα and IKKγ protein expression by human PBMCs harboring the Y395H mutation was normal, but degradation of IKKβ protein was accelerated. Binding of human NF-κB to DNA in patient PBMCs fell upon stimulation with TNF-α or LPS. Additionally, a structural model of Y395H revealed loss of the hydrogen bond with D389. These data suggest that IKBKB deficiency induces abnormal IKKβ protein degradation, leading to impaired NF-κB signaling and immune function. We postulate that the Y395H variant in the IKKβ protein lost the hydrogen bond with D389, thereby affecting interaction between Y395 and D389 and increasing protein instability.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.3389/crossmark-policy","link":[{"URL":"https://www.frontiersin.org/articles/10.3389/fimmu.2020.517544/full","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1613365866000,"date-time":"2021-02-15T05:11:06Z","date-parts":[[2021,2,15]]},"ISSN":["1664-3224"],"score":1,"source":"Crossref","cord_sha":"8341211f8351fd31ed42e14a40b2bf09101e27ac"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528},{"page_width":595.276,"page_height":779.528}],"runtime":10744},
  {"_key":"60c20c697723bebd86645556","_id":"documents/60c20c697723bebd86645556","_rev":"_cfFhBSW---","file_name":"01veywnr.pdf","md5":"04ACAC2E34F6D97E8BB6628144C0BA26","id":"01veywnr","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/ve/yw/nr/01veywnr/01veywnr.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["10.1177/1535370220976386"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1608076800000,"date-time":"2020-12-16T00:00:00Z","date-parts":[[2020,12,16]]}}],"volume":"246","pmid":"33325749","has_valid_tei":false,"DOI":"10.1177/1535370220976386","short-title":[],"original-title":[],"published-print":{"date-parts":[[2021,3]]},"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1177/sage-journals-update-policy","page":"740-748","type":"journal-article","issued":{"date-parts":[[2020,12,16]]},"publisher":"SAGE Publications","id":"01veywnr","reference-count":29,"title":["COVID-19 global pandemic planning: Performance and electret charge of N95 respirators after recommended decontamination methods"],"has_valid_oa_url":true,"deposited":{"timestamp":1615536479000,"date-time":"2021-03-12T08:07:59Z","date-parts":[[2021,3,12]]},"indexed":{"timestamp":1615538609557,"date-time":"2021-03-12T08:43:29Z","date-parts":[[2021,3,12]]},"is-referenced-by-count":1,"published-online":{"date-parts":[[2020,12,16]]},"short-container-title":["Exp Biol Med (Maywood)"],"prefix":"10.1177","oaLink":"https://journals.sagepub.com/doi/pdf/10.1177/1535370220976386","has_valid_thumbnail":false,"ISSN":["1535-3702","1535-3699"],"references-count":29,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1177/1535370220976386","journal-issue":{"published-print":{"date-parts":[[2021,3]]},"issue":"6"},"issn-type":[{"value":"1535-3702","type":"print"},{"value":"1535-3699","type":"electronic"}],"container-title":["Experimental Biology and Medicine"],"has_valid_ref_annotation":false,"issue":"6","member":"179","abstract":"Shortages of N95 respirators for use by medical personnel have driven consideration of novel conservation strategies, including decontamination for reuse and extended use. Decontamination methods listed as promising by the Centers for Disease Control and Prevention (CDC) (vaporous hydrogen peroxide (VHP), wet heat, ultraviolet irradiation (UVI)) and several methods considered for low resource environments (bleach, isopropyl alcohol and detergent/soap) were studied for two commonly used surgical N95 respirators (3M™ 1860 and 1870+ Aura™). Although N95 filtration performance depends on the electrostatically charged electret filtration layer, the impact of decontamination on this layer is largely unexplored. As such, respirator performance following decontamination was assessed based on the fit, filtration efficiency, and pressure drop, along with the relationship between (1) surface charge of the electret layer, and (2) elastic properties of the straps. Decontamination with VHP, wet heat, UVI, and bleach did not degrade fit and filtration performance or electret charge. Isopropyl alcohol and soap significantly degraded fit, filtration performance, and electret charge. Pressure drop across the respirators was unchanged. Modest degradation of N95 strap elasticity was observed in mechanical fatigue testing, a model for repeated donnings and doffings. CDC recommended decontamination methods including VHP, wet heat, and UV light did not degrade N95 respirator fit or filtration performance in these tests. Extended use of N95 respirators may degrade strap elasticity, but a loss of face seal integrity should be apparent during user seal checks. NIOSH recommends performing user seal checks after every donning to detect loss of appropriate fit. Decontamination methods which degrade electret charge such as alcohols or detergents should not be used on N95 respirators. The loss of N95 performance due to electret degradation would not be apparent to a respirator user or evident during a negative pressure user seal check.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Anne M","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5267-630X","family":"Grillet","affiliation":[{"name":"Thermal/Fluid Component Sciences, Sandia National Laboratories, Albuquerque, NM 87185, USA"}]},{"sequence":"additional","family":"Nemer","given":"Martin B","affiliation":[{"name":"Diagnostic Science and Engineering, Sandia National Laboratories, Albuquerque, NM 87185, USA"}]},{"sequence":"additional","family":"Storch","given":"Steven","affiliation":[{"name":"WMD Threats and Aerosol Science, Sandia National Laboratories, Albuquerque, NM 87185, USA"}]},{"sequence":"additional","family":"Sanchez","given":"Andres L","affiliation":[{"name":"WMD Threats and Aerosol Science, Sandia National Laboratories, Albuquerque, NM 87185, USA"}]},{"sequence":"additional","family":"Piekos","given":"Edward S","affiliation":[{"name":"Thermal/Fluid Component Sciences, Sandia National Laboratories, Albuquerque, NM 87185, USA"}]},{"sequence":"additional","family":"Leonard","given":"Jonathan","affiliation":[{"name":"Diagnostic Science and Engineering, Sandia National Laboratories, Albuquerque, NM 87185, USA"}]},{"sequence":"additional","family":"Hurwitz","given":"Ivy","affiliation":[{"name":"Department of Internal Medicine, Center for Global Health, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"}]},{"sequence":"additional","given":"Douglas J","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9390-6255","family":"Perkins","affiliation":[{"name":"Department of Internal Medicine, Center for Global Health, University of New Mexico Health Science Center, Albuquerque, NM 87131, USA"},{"name":"University of New Mexico-Kenya Programs, Kisumu and Siaya 40100, Kenya"}]}],"subject":["General Biochemistry, Genetics and Molecular Biology"],"link":[{"URL":"http://journals.sagepub.com/doi/pdf/10.1177/1535370220976386","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://journals.sagepub.com/doi/full-xml/10.1177/1535370220976386","content-version":"vor","intended-application":"text-mining","content-type":"application/xml"},{"URL":"http://journals.sagepub.com/doi/pdf/10.1177/1535370220976386","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1608153207000,"date-time":"2020-12-16T21:13:27Z","date-parts":[[2020,12,16]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":8441},
  {"_key":"60c20c737723bebd86645559","_id":"documents/60c20c737723bebd86645559","_rev":"_cfFhBSi---","file_name":"01w038rb.pdf","md5":"22C18DEE2900FDC8C68C78EC39AE896C","id":"01w038rb","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/w0/38/rb/01w038rb/01w038rb.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["S1658387620301801"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1606780800000,"date-time":"2020-12-01T00:00:00Z","date-parts":[[2020,12,1]]}},{"URL":"http://creativecommons.org/licenses/by-nc-nd/4.0/","content-version":"vor","delay-in-days":21,"start":{"timestamp":1608595200000,"date-time":"2020-12-22T00:00:00Z","date-parts":[[2020,12,22]]}}],"pmid":"33387453","author":[{"sequence":"first","given":"Jamshed","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-7579-0102","family":"Ali","affiliation":[]},{"sequence":"additional","family":"Sajjad","given":"Kashif","affiliation":[]},{"sequence":"additional","family":"Farooqi","given":"Amer Rehman","affiliation":[]},{"sequence":"additional","family":"Aziz","given":"Muhammad Tahir","affiliation":[]},{"sequence":"additional","family":"Rahat","given":"Ayesha","affiliation":[]},{"sequence":"additional","family":"Khan","given":"Sarah","affiliation":[]}],"DOI":"10.1016/j.hemonc.2020.12.001","short-title":[],"original-title":[],"short-container-title":["Hematology/Oncology and Stem Cell Therapy"],"content-domain":{"domain":[],"crossmark-restriction":false},"issued":{"date-parts":[[2020,12]]},"publisher":"Elsevier BV","id":"01w038rb","reference-count":14,"pmcid":"PMC7759333","has_valid_oa_url":true,"deposited":{"timestamp":1610299424000,"date-time":"2021-01-10T17:23:44Z","date-parts":[[2021,1,10]]},"indexed":{"timestamp":1610300564850,"date-time":"2021-01-10T17:42:44Z","date-parts":[[2021,1,10]]},"is-referenced-by-count":0,"title":["COVID-19-positive cancer patients undergoing active anticancer treatment: An analysis of clinical features and outcomes"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/e9/06/PMC7759333.tar.gz","has_valid_thumbnail":false,"ISSN":["1658-3876"],"references-count":14,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.hemonc.2020.12.001","type":"journal-article","issn-type":[{"value":"1658-3876","type":"print"}],"container-title":["Hematology/Oncology and Stem Cell Therapy"],"has_valid_ref_annotation":false,"member":"78","abstract":"Background Cancer patients particularly those on active anti-cancer treatment have been reported to be at a high risk of severe COVID-19 infection and deaths. This study aimed to describe the clinical characteristics and outcomes of patients diagnosed with COVID-19 whilst on anti-cancer treatment in a developing country. Methods This is a retrospective observational study of all adult cancer patients at SKMCH & RC Pakistan, from 15th March - 10th July,2020 diagnosed with COVID-19 within 4 weeks of receiving anti-cancer treatment, where a purposive sampling was carried out. Cancer Patients who did not receive anti-cancer treatment and clinical or radiological diagnosis of COVID-19 without a positive RT-PCR test were excluded. The primary endpoint was all-cause mortality after 30 days of COVID‐19 test. Data was analyzed through SPSS version 23. Categorical parameters were computed using Chi-Square test, keeping p-value <0.05 as significant. Results A total of 201 cancer patients with COVID‐19 were analyzed. The median age of patients was 45 (18-78) years. Mild symptoms were present in 162(80.6%) patients and 39(19.4%) had severe symptoms. The risk of death was statistically significant (p-value <0.05) amongst patients above 50 years of age, with metastatic disease and on palliative anti-cancer treatment. Anti-cancer treatment (chemotherapy, radiotherapy, hormonal therapy, targeted therapy and surgery) recieved within preceding 4 weeks, had no statistically significant (p-value >0.05) impact on mortality. Conclusion In cancer patients with COVID-19, mortality appears to be principally driven by age, advanced stage of the disease and palliative intent of cancer treatment. We did not identify evidence that cancer patients on chemotherapy are at significant risk of mortality from COVID-19 correlating to those not on chemotherapy.","published-print":{"date-parts":[[2020,12]]},"has_valid_pdf":true,"has_valid_tei":false,"subject":["Oncology","Hematology","General Medicine"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S1658387620301801?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1658387620301801?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1608848637000,"date-time":"2020-12-24T22:23:57Z","date-parts":[[2020,12,24]]},"language":"en","score":1,"source":"Crossref","cord_sha":"0452685fd9582b4b2fb62d3f76dafdf9c99f18b4"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":4293},
  {"_key":"60c20c747723bebd8664555c","_id":"documents/60c20c747723bebd8664555c","_rev":"_cfFhBSu---","file_name":"01w8vp3b.pdf","md5":"C2131E65324B94062598B45B0A499F0B","id":"01w8vp3b","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/w8/vp/3b/01w8vp3b/01w8vp3b.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["ijerph17238838"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1606435200000,"date-time":"2020-11-27T00:00:00Z","date-parts":[[2020,11,27]]}}],"volume":"17","pmid":"33261157","has_valid_tei":false,"URL":"http://dx.doi.org/10.3390/ijerph17238838","DOI":"10.3390/ijerph17238838","original-title":[],"title":["Association of Individual Health Literacy with Preventive Behaviours and Family Well-Being during COVID-19 Pandemic: Mediating Role of Family Information Sharing"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":21,"page":"8838","type":"journal-article","issued":{"date-parts":[[2020,11,27]]},"publisher":"MDPI AG","id":"01w8vp3b","short-title":[],"pmcid":"PMC7730256","has_valid_oa_url":true,"deposited":{"timestamp":1606702818000,"date-time":"2020-11-30T02:20:18Z","date-parts":[[2020,11,30]]},"indexed":{"timestamp":1606704135483,"date-time":"2020-11-30T02:42:15Z","date-parts":[[2020,11,30]]},"is-referenced-by-count":0,"short-container-title":["IJERPH"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/7c/d6/PMC7730256.tar.gz","has_valid_thumbnail":false,"ISSN":["1660-4601"],"references-count":21,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2020,12]]}},"issn-type":[{"value":"1660-4601","type":"electronic"}],"container-title":["International Journal of Environmental Research and Public Health"],"published-online":{"date-parts":[[2020,11,27]]},"issue":"23","member":"1968","abstract":"Objective: We tested a model of individual health literacy information sharing with family members, personal preventive behaviours and family well-being during the Coronavirus Disease 2019 (COVID-19) pandemic in Hong Kong. Methods: We analysed data of 1501 randomly selected Chinese adults from a cross-sectional survey in Hong Kong from 9 to 23 April, 2020. Individual health literacy about COVID-19 with the items extracted from the questionnaire in World Health Organization Risk Communication and Community Engagement (RCCE) Action Plan Guidance for COVID-19 preparedness and response, COVID-19 information sharing with family members, preventive behaviours against COVID-19 and family well-being were measured. Structural equation modelling analysis tested the proposed model. Findings: COVID-19 information sharing with family members partially mediated the association between individual health literacy and personal preventive behaviours. The direct effect of 0.24 was shown, and the indirect effect through COVID-19 information sharing with family members was small at 0.03 (Z = 3.66, p < 0.001). Family well-being was associated with personal preventive behaviours against COVID-19. The model was adjusted for sex, age, and socioeconomic status factors and had good fit with RMSEA = 0.04, CFI = 0.98, TLI = 0.96, and SRMR = 0.02. Conclusion: COVID-19 information sharing with family members was a partial mediator between individual health literacy and personal preventive behaviours against COVID-19. Strategies for enhancing health literacy and preventive measures against COVID-19 are needed to promote family well-being in the pandemic.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Janet Yuen Ha","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3000-4577","family":"Wong","affiliation":[]},{"sequence":"additional","given":"Abraham Ka Chung","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9984-8156","family":"Wai","affiliation":[]},{"sequence":"additional","family":"Zhao","given":"Shengzhi","affiliation":[]},{"sequence":"additional","family":"Yip","given":"Faustina","affiliation":[]},{"sequence":"additional","given":"Jung Jae","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9704-2116","family":"Lee","affiliation":[]},{"sequence":"additional","given":"Carlos King Ho","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6895-6071","family":"Wong","affiliation":[]},{"sequence":"additional","given":"Man Ping","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-4000-2388","family":"Wang","affiliation":[]},{"sequence":"additional","family":"Lam","given":"Tai Hing","affiliation":[]}],"link":[{"URL":"https://www.mdpi.com/1660-4601/17/23/8838/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1606553476000,"date-time":"2020-11-28T08:51:16Z","date-parts":[[2020,11,28]]},"language":"en","score":1,"source":"Crossref","cord_sha":"b734dbadab538ad592198554e67a6b10b65cf870"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":5465},
  {"_key":"60c20c777723bebd8664555e","_id":"documents/60c20c777723bebd8664555e","_rev":"_cfFhBS6---","file_name":"01w9kap5.pdf","md5":"A9A3E3E99E01536F415C79A1289ED57A","id":"01w9kap5","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/w9/ka/p5/01w9kap5/01w9kap5.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["10244"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1593388800000,"date-time":"2020-06-29T00:00:00Z","date-parts":[[2020,6,29]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1593388800000,"date-time":"2020-06-29T00:00:00Z","date-parts":[[2020,6,29]]}}],"language":"en","volume":"26","pmid":"32837233","has_valid_tei":false,"DOI":"10.1007/s10639-020-10244-x","license-simplified":"no-cc","original-title":[],"short-container-title":["Educ Inf Technol"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":50,"page":"17-33","type":"journal-article","issued":{"date-parts":[[2020,6,29]]},"publisher":"Springer Science and Business Media LLC","id":"01w9kap5","short-title":[],"pmcid":"PMC7322218","has_valid_oa_url":true,"deposited":{"timestamp":1610648186000,"date-time":"2021-01-14T18:16:26Z","date-parts":[[2021,1,14]]},"indexed":{"timestamp":1610650144579,"date-time":"2021-01-14T18:49:04Z","date-parts":[[2021,1,14]]},"is-referenced-by-count":0,"title":["Deconstructing self-regulated learning in MOOCs: In search of help-seeking mechanisms"],"prefix":"10.1007","published-online":{"date-parts":[[2020,6,29]]},"has_valid_thumbnail":false,"references-count":50,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/68/7b/PMC7322218.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s10639-020-10244-x","ISSN":["1360-2357","1573-7608"],"issn-type":[{"value":"1360-2357","type":"print"},{"value":"1573-7608","type":"electronic"}],"subject":["Education","Library and Information Sciences"],"container-title":["Education and Information Technologies"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"Researchers see self-regulated learning (SRL) as a fundamental skill for succeeding in massive open online courses (MOOCs). However, there is no sufficient evidence of adequate functioning of SRL dimensions such as environment structuring, goal setting, time management, help-seeking, task strategies, and self-evaluation in the MOOC environment. This study fills the gap in understanding the structure of SRL skills utilising the Online Self-Regulated Learning Questionnaire (OSLQ). The construct-related validity of the OSLQ is evaluated based on self-reported survey responses of 913 Russian MOOC learners with confirmatory factor analysis and criterion-related validity is checked with independent samples t-tests comparison. The results show that the original six-factor hierarchical model does not fit the data adequately. The evidence implies that the dimension ‘help-seeking’ is not effective in the MOOC environment. Therefore, a redefined five-factor hierarchical model of the OSLQ is suggested.","published-print":{"date-parts":[[2021,1]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Kseniia","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2161-0409","family":"Vilkova","affiliation":[]},{"sequence":"additional","family":"Shcheglova","given":"Irina","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s10639-020-10244-x.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s10639-020-10244-x/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s10639-020-10244-x.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1593417756000,"date-time":"2020-06-29T08:02:36Z","date-parts":[[2020,6,29]]},"journal-issue":{"published-print":{"date-parts":[[2021,1]]},"issue":"1"},"assertion":[{"order":1,"value":"27 April 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"9 June 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"29 June 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"78bb07657460a8b625d0b5b5f6b83b38e1e90495"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":8503},
  {"_key":"60c20c817723bebd86645561","_id":"documents/60c20c817723bebd86645561","_rev":"_cfFhBTG---","file_name":"01vr3uxs.pdf","md5":"8C7472A6065BF14958D59B13E8230BF1","id":"01vr3uxs","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/vr/3u/xs/01vr3uxs/01vr3uxs.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["S016344532030654X"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1614556800000,"date-time":"2021-03-01T00:00:00Z","date-parts":[[2021,3,1]]}}],"language":"en","volume":"82","pmid":"33131700","has_valid_tei":false,"created":{"timestamp":1603349228000,"date-time":"2020-10-22T06:47:08Z","date-parts":[[2020,10,22]]},"DOI":"10.1016/j.jinf.2020.10.012","original-title":[],"short-container-title":["Journal of Infection"],"content-domain":{"domain":["clinicalkey.jp","journalofinfection.com","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","page":"414-451","type":"journal-article","issued":{"date-parts":[[2021,3]]},"publisher":"Elsevier BV","id":"01vr3uxs","short-title":[],"pmcid":"PMC7578700","has_valid_oa_url":true,"deposited":{"timestamp":1616121814000,"date-time":"2021-03-19T02:43:34Z","date-parts":[[2021,3,19]]},"indexed":{"timestamp":1616123764271,"date-time":"2021-03-19T03:16:04Z","date-parts":[[2021,3,19]]},"is-referenced-by-count":1,"title":["Sex-disaggregated data confirm serum ferritin as an independent predictor of disease severity both in male and female COVID-19 patients"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/d3/3a/PMC7578700.tar.gz","has_valid_thumbnail":false,"references-count":8,"license-simplified":"no-cc","subtitle":[],"reference-count":8,"ISSN":["0163-4453"],"issn-type":[{"value":"0163-4453","type":"print"}],"container-title":["Journal of Infection"],"score":1,"has_valid_ref_annotation":false,"issue":"3","member":"78","published-print":{"date-parts":[[2021,3]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Gandini","given":"O.","affiliation":[]},{"sequence":"additional","family":"Criniti","given":"A.","affiliation":[]},{"sequence":"additional","family":"Gagliardi","given":"M.C.","affiliation":[]},{"sequence":"additional","family":"Ballesio","given":"L.","affiliation":[]},{"sequence":"additional","family":"Giglio","given":"S.","affiliation":[]},{"sequence":"additional","family":"Balena","given":"A.","affiliation":[]},{"sequence":"additional","family":"Caputi","given":"A.","affiliation":[]},{"sequence":"additional","family":"Angeloni","given":"A.","affiliation":[]},{"sequence":"additional","family":"Lubrano","given":"C.","affiliation":[]}],"subject":["Microbiology (medical)","Infectious Diseases"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S016344532030654X?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S016344532030654X?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1016/j.jinf.2020.10.012","journal-issue":{"published-print":{"date-parts":[[2021,3]]},"issue":"3"},"assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Sex-disaggregated data confirm serum ferritin as an independent predictor of disease severity both in male and female COVID-19 patients","label":"Article Title","name":"articletitle"},{"value":"Journal of Infection","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.jinf.2020.10.012","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"simple-article","label":"Content Type","name":"content_type"},{"value":"© 2020 The British Infection Association. Published by Elsevier Ltd. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"d5ff17b125db0634f80c673c15ad96a0212b23d2"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92},{"page_width":595.245,"page_height":793.92}],"runtime":18654},
  {"_key":"60c20c867723bebd86645566","_id":"documents/60c20c867723bebd86645566","_rev":"_cfFhBTS---","file_name":"01wqidou.pdf","md5":"4B69406E12A2FC4D9F2F8E539D502A04","id":"01wqidou","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/wq/id/ou/01wqidou/01wqidou.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["10.1242/dev.190249"],"published-print":{"date-parts":[[2020,10,1]]},"volume":"147","pmid":"32764029","journal-issue":{"published-print":{"date-parts":[[2020,10,1]]},"issue":"19","published-online":{"date-parts":[[2020,10,7]]}},"has_valid_tei":false,"DOI":"10.1242/dev.190249","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":62,"start":{"timestamp":1602028800000,"date-time":"2020-10-07T00:00:00Z","date-parts":[[2020,10,7]]}}],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":56,"page":"dev190249","type":"journal-article","issued":{"date-parts":[[2020,8,6]]},"funder":[{"doi-asserted-by":"publisher","award":["31003A_159795/1"],"DOI":"10.13039/501100001711","name":"Schweizerischer Nationalfonds zur F&#x00F6;rderung der Wissenschaftlichen Forschung"},{"award":["33CM30-124101"],"name":"Special Programme University Medicine"}],"publisher":"The Company of Biologists","id":"01wqidou","short-title":[],"title":["Endogenous erythropoietin signaling regulates migration and laminar positioning of upper-layer neurons in the developing neocortex"],"oaLink":"https://dev.biologists.org/content/develop/147/19/dev190249.full.pdf","has_valid_oa_url":true,"deposited":{"timestamp":1602084930000,"date-time":"2020-10-07T15:35:30Z","date-parts":[[2020,10,7]]},"indexed":{"timestamp":1607490411213,"date-time":"2020-12-09T05:06:51Z","date-parts":[[2020,12,9]]},"is-referenced-by-count":1,"short-container-title":["Development"],"prefix":"10.1242","published-online":{"date-parts":[[2020,8,6]]},"has_valid_thumbnail":false,"references-count":56,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1242/dev.190249","ISSN":["0950-1991","1477-9129"],"issn-type":[{"value":"0950-1991","type":"print"},{"value":"1477-9129","type":"electronic"}],"container-title":["Development"],"has_valid_ref_annotation":false,"issue":"19","member":"237","abstract":"Erythropoietin (EPO), the hypoxia-inducible hematopoietic hormone, has well-established neuroprotective/neurotrophic roles in the developing central nervous system and the therapeutic potential of EPO has been widely explored in clinical studies for treatment of perinatal hypoxic brain lesion as well as prematurity. Here we reveal, that both EPO and EPOR are expressed in the developing rat somatosensory cortex during radial migration and laminar positioning of granular and supragranular neurons. Experimental deregulation of EPO signaling using genetic approaches results in aberrant migration as well as permanent neuronal misplacement leading to abnormal network activity and protracted sensory behavioral deficits. We identify ERK as the downstream effector of the EPO signaling pathway for neuronal migration. These findings reveal a critical role for endogenous EPO signaling in neuronal migration and offer important insights for understanding how temporary deregulation of EPO could results in migration defects leading to abnormal behavior in the adult.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Constanthin","given":"Paul E.","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}]},{"sequence":"additional","given":"Alessandro","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6528-1403","family":"Contestabile","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}]},{"sequence":"additional","family":"Petrenko","given":"Volodymyr","affiliation":[{"name":"Division of Endocrinology, Diabetes, Hypertension and Nutrition, Department of Internal Medicine Specialties, University Hospital of Geneva, 1201 Geneva, Switzerland"},{"name":"Department of Cell Physiology and Metabolism; Diabetes Center, Faculty of Medicine, University of Geneva; Institute of Genetics and Genomics in Geneva (iGE3), 1201 Geneva, Switzerland"}]},{"sequence":"additional","family":"Quairiaux","given":"Charles","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}]},{"sequence":"additional","family":"Salmon","given":"Patrick","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}]},{"sequence":"additional","family":"Hüppi","given":"Petra S.","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, University Hospital of Geneva, 1201 Geneva, Switzerland"}]},{"sequence":"additional","given":"Jozsef Z.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-2809-4788","family":"Kiss","affiliation":[{"name":"Department of Fundamental Neurosciences, University Medical Center, University of Geneva, 1201 Geneva, Switzerland"}]}],"subject":["Developmental Biology","Molecular Biology"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1242/dev.190249","content-version":"vor","intended-application":"syndication","content-type":"unspecified"},{"URL":"https://syndication.highwire.org/content/doi/10.1242/dev.190249","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1596742182000,"date-time":"2020-08-06T19:29:42Z","date-parts":[[2020,8,6]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":19780},
  {"_key":"60c20c887723bebd86645572","_id":"documents/60c20c887723bebd86645572","_rev":"_cfFhBTa---","file_name":"01x170cl.pdf","md5":"650D69F7533E0C0B39BB7EE347CAE6E8","id":"01x170cl","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/x1/70/cl/01x170cl/01x170cl.pdf","date":"2021-06-10T12:58+0000","metadata":{"alternative-id":["10.1161/STROKEAHA.113.004260"],"published-print":{"date-parts":[[2014,3]]},"volume":"45","pmid":"24503670","author":[{"sequence":"first","family":"Yoo","given":"Albert J.","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Zaidat","given":"Osama O.","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Chaudhry","given":"Zeshan A.","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Berkhemer","given":"Olvert A.","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"González","given":"R. Gilberto","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Goyal","given":"Mayank","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Demchuk","given":"Andrew M.","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Menon","given":"Bijoy K.","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Mualem","given":"Elan","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Ueda","given":"Dawn","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Buell","given":"Hope","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Sit","given":"Siu Po","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]},{"sequence":"additional","family":"Bose","given":"Arani","affiliation":[{"name":"From Massachusetts General Hospital, Boston, MA (A.J.Y., Z.A.C., O.A.B., R.G.G.); Medical College of Wisconsin, Milwaukee, WI (O.O.Z.); University of Calgary, Calgary, AB, Canada (M.G., A.M.D., B.K.M.); Penumbra Inc, Alameda, CA (E.M., D.U., H.B., S.P.S., A.B.)."}]}],"DOI":"10.1161/strokeaha.113.004260","short-title":[],"original-title":[],"title":["Impact of Pretreatment Noncontrast CT Alberta Stroke Program Early CT Score on Clinical Outcome After Intra-Arterial Stroke Therapy"],"content-domain":{"domain":["ahajournals.org"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1161/crossmarkpolicy","page":"746-751","type":"journal-article","issued":{"date-parts":[[2014,3]]},"publisher":"Ovid Technologies (Wolters Kluwer Health)","id":"01x170cl","reference-count":26,"has_valid_oa_url":true,"deposited":{"timestamp":1538024704000,"date-time":"2018-09-27T05:05:04Z","date-parts":[[2018,9,27]]},"indexed":{"timestamp":1616586396374,"date-time":"2021-03-24T11:46:36Z","date-parts":[[2021,3,24]]},"is-referenced-by-count":60,"short-container-title":["Stroke"],"prefix":"10.1161","oaLink":"https://www.ahajournals.org/doi/pdf/10.1161/STROKEAHA.113.004260","has_valid_thumbnail":false,"ISSN":["0039-2499","1524-4628"],"references-count":26,"license-simplified":"unk","subtitle":[],"URL":"http://dx.doi.org/10.1161/strokeaha.113.004260","journal-issue":{"published-print":{"date-parts":[[2014,3]]},"issue":"3"},"issn-type":[{"value":"0039-2499","type":"print"},{"value":"1524-4628","type":"electronic"}],"container-title":["Stroke"],"has_valid_ref_annotation":false,"issue":"3","member":"276","abstract":"BACKGROUND AND PURPOSE The efficacy of intra-arterial treatment remains uncertain. Because most centers performing IAT use noncontrast CT (NCCT) imaging, it is critical to understand the impact of NCCT findings on treatment outcomes. This study aimed to compare functional independence and safety among patients undergoing intra-arterial treatment stratified by the extent of ischemic change on pretreatment NCCT. METHODS The study cohort was derived from multicenter trials of the Penumbra System. Inclusion criteria were anterior circulation proximal occlusion, evaluable pretreatment NCCT, and known time to reperfusion. Ischemic change was quantified using the Alberta Stroke Program Early CT Score (ASPECTS) and stratified into 3 prespecified groups for comparison: 0 to 4 (most ischemic change) versus 5 to 7 versus 8 to 10 (least ischemic change). RESULTS A total of 249 patients were analyzed: 40 with ASPECTS 0 to 4, 83 with ASPECTS 5 to 7, and 126 with ASPECTS 8 to 10. For ASPECTS 0 to 4, 5 to 7, and 8 to 10, respectively, good outcome (modified Rankin Scale score, 0-2) rates were 5%, 38.6%, and 46% (P<0.0001), and mortality rates were 55%, 28.9%, and 19% (P=0.0001). The only significant pairwise differences were between ASPECTS 0 to 4 and other groups. Symptomatic hemorrhage was more common with lower ASPECTS (P=0.02). Shorter time to reperfusion was significantly associated with better outcomes among patients with ASPECTS 8 to 10 (P=0.01). A similar relationship was seen for ASPECTS 5 to 7 but was not statistically significant. No such relationship was seen for ASPECTS 0 to 4. CONCLUSIONS NCCT seems useful for excluding patients with the greatest burden of ischemic damage from futile intra-arterial treatment, which is unlikely to result in patient functional independence and increases the risk of hemorrhage.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Advanced and Specialised Nursing","Clinical Neurology","Cardiology and Cardiovascular Medicine"],"relation":{"cites":[]},"created":{"timestamp":1391740190000,"date-time":"2014-02-07T02:29:50Z","date-parts":[[2014,2,7]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":17492},
  {"_key":"60c20c8c7723bebd86645574","_id":"documents/60c20c8c7723bebd86645574","_rev":"_cfFhBTm---","file_name":"01xdd8zf.pdf","md5":"35BB2CB4DFC4D851580AF2B84ECCF697","id":"01xdd8zf","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/xd/d8/zf/01xdd8zf/01xdd8zf.pdf","date":"2021-06-10T12:58+0000","metadata":{"is-referenced-by-count":2,"short-container-title":[],"prefix":"10.1101","pmcid":"PMC7359535","subtitle":[],"pmid":"32676610","accepted":{"date-parts":[[2020,7,7]]},"license-simplified":"cc-by-nc-nd","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.07.06.20120386","group-title":"Infectious Diseases (except HIV/AIDS)","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a0/7a/PMC7359535.tar.gz","original-title":[],"id":"01xdd8zf","title":["Renin-angiotensin-aldosterone system inhibitors and COVID-19 infection or hospitalization: a cohort study"],"content-domain":{"domain":[],"crossmark-restriction":false},"short-title":[],"issued":{"date-parts":[[2020,7,7]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,7,7]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"There are plausible mechanisms by which angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may increase the risk of COVID-19 infection or affect disease severity. To examine the association between these medications and COVID-19 infection or hospitalization, we conducted a retrospective cohort study within a US integrated healthcare system. Among people aged ≥18 years enrolled in the health plan for at least 4 months as of 2/29/2020, current ACEI and ARB use was identified from pharmacy data, and the estimated daily dose was calculated and standardized across medications. COVID-19 infections were identified through 6/14/2020 from laboratory and hospitalization data. We used logistic regression to estimate adjusted odds ratios (ORs) and 95% confidence intervals. Among 322,044 individuals, 720 developed COVID-19 infection. Among people using ACEI/ARBs, 183/56,105 developed COVID-19 (3.3 per 1000 individuals) compared with 537/265,939 without ACEI/ARB use (2.0 per 1000), yielding an adjusted OR of 0.94 (95% CI 0.75-1.16). For use of < 1 defined daily dose vs. nonuse, the adjusted OR for infection was 0.89 (95% CI 0.62-1.26); for 1 to < 2 defined daily doses, 0.97 (95% CI 0.71-1.31); and for ≥2 defined daily doses, 0.94 (95% CI 0.72-1.23). The OR was similar for ACEIs and ARBs and in subgroups by age and sex. 29% of people with COVID-19 infection were hospitalized; the adjusted OR for hospitalization in relation to ACEI/ARB use was 0.92 (95% CI 0.54-1.57), and there was no association with dose. These findings support current recommendations that individuals on these medications continue their use.","deposited":{"timestamp":1610500105000,"date-time":"2021-01-13T01:08:25Z","date-parts":[[2021,1,13]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Sascha","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6649-3659","family":"Dublin","affiliation":[]},{"sequence":"additional","family":"Walker","given":"Rod","affiliation":[]},{"sequence":"additional","family":"Floyd","given":"James S.","affiliation":[]},{"sequence":"additional","family":"Shortreed","given":"Susan M.","affiliation":[]},{"sequence":"additional","family":"Fuller","given":"Sharon","affiliation":[]},{"sequence":"additional","family":"Albertson-Junkans","given":"Ladia","affiliation":[]},{"sequence":"additional","family":"Harrington","given":"Laura B.","affiliation":[]},{"sequence":"additional","family":"Greenwood-Hickman","given":"Mikael Anne","affiliation":[]},{"sequence":"additional","family":"Green","given":"Beverly B.","affiliation":[]},{"sequence":"additional","family":"Psaty","given":"Bruce M.","affiliation":[]}],"DOI":"10.1101/2020.07.06.20120386","reference-count":22,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.07.06.20120386","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1594162511000,"date-time":"2020-07-07T22:55:11Z","date-parts":[[2020,7,7]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"references-count":22,"indexed":{"timestamp":1611763427756,"date-time":"2021-01-27T16:03:47Z","date-parts":[[2021,1,27]]},"score":1,"source":"Crossref","type":"posted-content","cord_sha":"3e076d86865a8bf6a46ed6e5be5d0bea2a54e802; 8ab3a297f1c135e531e93d2289299f99093cf4a8"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":362,"page_height":503},{"page_width":576,"page_height":432},{"page_width":576,"page_height":414}],"runtime":10848},
  {"_key":"60c20c987723bebd86645575","_id":"documents/60c20c987723bebd86645575","_rev":"_cfFhBTy---","file_name":"01xwbdse.pdf","md5":"C18F2981B988BC1AA4C1AB64F6FDBA88","id":"01xwbdse","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/xw/bd/se/01xwbdse/01xwbdse.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["10.1080/03007995.2021.1876005"],"published-print":{"date-parts":[[2021,3,4]]},"volume":"37","pmid":"33459077","journal-issue":{"published-print":{"date-parts":[[2021,3,4]]},"issue":"3"},"has_valid_tei":false,"DOI":"10.1080/03007995.2021.1876005","original-title":[],"title":["Predictors of clinical deterioration in non-severe patients with COVID-19: a retrospective cohort study"],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"reference-count":25,"page":"385-391","type":"journal-article","issued":{"date-parts":[[2021,2,4]]},"prefix":"10.1080","publisher":"Informa UK Limited","id":"01xwbdse","short-title":[],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/f6/5d/PMC7876670.tar.gz","pmcid":"PMC7876670","has_valid_oa_url":true,"deposited":{"timestamp":1616138608000,"date-time":"2021-03-19T07:23:28Z","date-parts":[[2021,3,19]]},"indexed":{"timestamp":1616139739570,"date-time":"2021-03-19T07:42:19Z","date-parts":[[2021,3,19]]},"is-referenced-by-count":0,"short-container-title":["Current Medical Research and Opinion"],"funder":[{"award":["19ykpy10"],"name":"The Fundamental Research Funds for the Central Universities"}],"published-online":{"date-parts":[[2021,2,4]]},"has_valid_thumbnail":false,"references-count":25,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1080/03007995.2021.1876005","ISSN":["0300-7995","1473-4877"],"issn-type":[{"value":"0300-7995","type":"print"},{"value":"1473-4877","type":"electronic"}],"subject":["General Medicine"],"container-title":["Current Medical Research and Opinion"],"score":1,"has_valid_ref_annotation":false,"issue":"3","member":"301","abstract":"OBJECTIVE: Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains pandemic with considerable morbidity and mortality around the world. The aim of this study was to identify the predictors for clinical deterioration in patients with COVID-19 who did not show clinical deterioration upon hospital admission. METHODS: Two hundred fifty-seven patients with confirmed COVID-19 pneumonia admitted to Guangzhou Eighth People’s Hospital between 23 January and 21 March 2020 were retrospectively enrolled. Demographic data, symptoms, laboratory values, comorbidities and treatments were all collected. The study endpoint was clinical deterioration within 20 days from hospital admission. Univariate and multivariable logistic regression methods were used to explore the risk factors associated with clinical deterioration. RESULTS: A total of 49 (19%) patients showed clinical deterioration after admission. Compared with patients that did not experience clinical deterioration, clinically deteriorated patients had more dyspnea, cough and myalgia (65.3% versus 29.3%) symptoms and more had comorbidities (89.8% versus 36.1%). Clinical and laboratory characteristics at admission that were associated with clinical deterioration included senior age, diabetes, hypertension, myalgia, higher temperature, systolic blood pressure, C-reactive protein (CRP), procalcitonin, activated partial thromboplastin time, aspartate aminotransferase, alanine transaminase, direct bilirubin, plasma creatinine, lymphocytopenia, thrombocytopenia, decreased albumin and bicarbonate concentration. Medical history of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers, calcium channel blockers and metformin were also risk factors. CONCLUSION: The four best predictors for clinical deterioration were CRP, procalcitonin, age and albumin. A “best” multivariable prediction model, resulting from using a variable selection procedure, included senior age, presentation with myalgia, and higher level of CRP and serum creatinine (bias-corrected c-statistic = 0.909). Sensitivity and specificity corresponding to a cut point of CRP ≥18.45 mg/L for predicting clinical deterioration were 85% and 74%, respectively.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Yitao","given":"Zhang","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Mu","given":"Chen","affiliation":[{"name":"Department of Pulmonology, Guangzhou Eighth People’s Hospital, Guangzhou, China"}]},{"sequence":"additional","family":"Ling","given":"Zhou","affiliation":[{"name":"The First Clinical Medical College, Jinan University, Guangzhou, China"},{"name":"Ultrasonic Department, Hospital of South China University of Technology, Guangzhou, China"}]},{"sequence":"additional","family":"Shiyao","given":"Cheng","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Jiaojie","given":"Xue","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Zhichong","given":"Chen","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Huajing","given":"Peng","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Maode","given":"Ou","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Kanglin","given":"Cheng","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Mao","given":"Ou Yang","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]},{"sequence":"additional","family":"Xiaoneng","given":"Mo","affiliation":[{"name":"Department of Pulmonology, Guangzhou Eighth People’s Hospital, Guangzhou, China"}]},{"sequence":"additional","family":"Weijie","given":"Zeng","affiliation":[{"name":"The Cardiovascular Department, the Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}]}],"update-policy":"http://dx.doi.org/10.1080/tandf_crossmark_01","link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/03007995.2021.1876005","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1610796788000,"date-time":"2021-01-16T11:33:08Z","date-parts":[[2021,1,16]]},"language":"en","assertion":[{"order":1,"value":"The publishing and review policy for this title is described in its Aims & Scope.","label":"Peer Review Statement","name":"peerreview_statement"},{"order":2,"URL":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=icmo20","value":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=icmo20","label":"Aim & Scope","name":"aims_and_scope_url"},{"order":0,"value":"2020-06-22","group":{"label":"Publication History","name":"publication_history"},"label":"Received","name":"received"},{"order":1,"value":"2020-12-16","group":{"label":"Publication History","name":"publication_history"},"label":"Revised","name":"revised"},{"order":2,"value":"2021-01-10","group":{"label":"Publication History","name":"publication_history"},"label":"Accepted","name":"accepted"},{"order":3,"value":"2021-02-04","group":{"label":"Publication History","name":"publication_history"},"label":"Published","name":"published"}],"source":"Crossref","cord_sha":"c957efa51fbe82eac28cbaf607ede12bbe215b4d"},"application":"software-mentions","pages":[{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701},{"page_width":609.449,"page_height":793.701}],"runtime":13982},
  {"_key":"60c20c9a7723bebd86645578","_id":"documents/60c20c9a7723bebd86645578","_rev":"_cfFhBU----","file_name":"01yc7lzk.pdf","md5":"3A3CBFC00FBC9E3029D3E44189C53156","id":"01yc7lzk","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/yc/7l/zk/01yc7lzk/01yc7lzk.pdf","date":"2021-06-10T12:59+0000","metadata":{"license":[{"URL":"https://creativecommons.org/publicdomain/zero/1.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1398297600000,"date-time":"2014-04-24T00:00:00Z","date-parts":[[2014,4,24]]}}],"language":"en","volume":"10","pmid":"24762851","has_valid_tei":false,"created":{"timestamp":1398371668000,"date-time":"2014-04-24T20:34:28Z","date-parts":[[2014,4,24]]},"DOI":"10.1371/journal.pcbi.1003587","license-simplified":"cc0","original-title":[],"short-container-title":["PLoS Comput Biol"],"content-domain":{"domain":["www.ploscompbiol.org"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1371/journal.pcbi.corrections_policy","page":"e1003587","type":"journal-article","issued":{"date-parts":[[2014,4,24]]},"publisher":"Public Library of Science (PLoS)","id":"01yc7lzk","short-title":[],"editor":[{"sequence":"first","family":"Ferrari","given":"Matthew","affiliation":[]}],"pmcid":"PMC3998883","has_valid_oa_url":true,"deposited":{"timestamp":1597745047000,"date-time":"2020-08-18T10:04:07Z","date-parts":[[2020,8,18]]},"indexed":{"timestamp":1616257443917,"date-time":"2021-03-20T16:24:03Z","date-parts":[[2021,3,20]]},"is-referenced-by-count":22,"title":["Bayesian Analysis for Inference of an Emerging Epidemic: Citrus Canker in Urban Landscapes"],"prefix":"10.1371","published-online":{"date-parts":[[2014,4,24]]},"has_valid_thumbnail":false,"references-count":70,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/9a/af/PMC3998883.tar.gz","subtitle":[],"reference-count":70,"ISSN":["1553-7358"],"issn-type":[{"value":"1553-7358","type":"electronic"}],"container-title":["PLoS Computational Biology"],"has_valid_ref_annotation":false,"issue":"4","member":"340","abstract":"Outbreaks of infectious diseases require a rapid response from policy makers. The choice of an adequate level of response relies upon available knowledge of the spatial and temporal parameters governing pathogen spread, affecting, amongst others, the predicted severity of the epidemic. Yet, when a new pathogen is introduced into an alien environment, such information is often lacking or of no use, and epidemiological parameters must be estimated from the first observations of the epidemic. This poses a challenge to epidemiologists: how quickly can the parameters of an emerging disease be estimated? How soon can the future progress of the epidemic be reliably predicted? We investigate these issues using a unique, spatially and temporally resolved dataset for the invasion of a plant disease, Asiatic citrus canker in urban Miami. We use epidemiological models, Bayesian Markov-chain Monte Carlo, and advanced spatial statistical methods to analyse rates and extent of spread of the disease. A rich and complex epidemic behaviour is revealed. The spatial scale of spread is approximately constant over time and can be estimated rapidly with great precision (although the evidence for long-range transmission is inconclusive). In contrast, the rate of infection is characterised by strong monthly fluctuations that we associate with extreme weather events. Uninformed predictions from the early stages of the epidemic, assuming complete ignorance of the future environmental drivers, fail because of the unpredictable variability of the infection rate. Conversely, predictions improve dramatically if we assume prior knowledge of either the main environmental trend, or the main environmental events. A contrast emerges between the high detail attained by modelling in the spatiotemporal description of the epidemic and the bottleneck imposed on epidemic prediction by the limits of meteorological predictability. We argue that identifying such bottlenecks will be a fundamental step in future modelling of weather-driven epidemics.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Neri","given":"Franco M.","affiliation":[]},{"sequence":"additional","family":"Cook","given":"Alex R.","affiliation":[]},{"sequence":"additional","family":"Gibson","given":"Gavin J.","affiliation":[]},{"sequence":"additional","family":"Gottwald","given":"Tim R.","affiliation":[]},{"sequence":"additional","family":"Gilligan","given":"Christopher A.","affiliation":[]}],"subject":["Ecology","Modelling and Simulation","Computational Theory and Mathematics","Genetics","Ecology, Evolution, Behavior and Systematics","Molecular Biology","Cellular and Molecular Neuroscience"],"link":[{"URL":"http://dx.plos.org/10.1371/journal.pcbi.1003587","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1371/journal.pcbi.1003587","journal-issue":{"issue":"4","published-online":{"date-parts":[[2014,4,24]]}},"score":1,"source":"Crossref","cord_sha":"90394841ad2cbaec78bf51646d5ca1ae26fadba6; 03e779f9defa0b9cb6a9943947e41b9c1532e3d3"},"application":"software-mentions","pages":[{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842},{"page_width":595,"page_height":842}],"runtime":14040},
  {"_key":"60c20c9b7723bebd8664557a","_id":"documents/60c20c9b7723bebd8664557a","_rev":"_cfFhBUK---","file_name":"01xyjaih.pdf","md5":"CE4E5FF43F589D8ED554FFAF188EA40B","id":"01xyjaih","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/xy/ja/ih/01xyjaih/01xyjaih.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["S1871402120303180"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1604188800000,"date-time":"2020-11-01T00:00:00Z","date-parts":[[2020,11,1]]}}],"language":"en","volume":"14","pmid":"32853901","has_valid_tei":false,"created":{"timestamp":1597733122000,"date-time":"2020-08-18T06:45:22Z","date-parts":[[2020,8,18]]},"DOI":"10.1016/j.dsx.2020.08.015","original-title":[],"short-container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Internal Medicine","Endocrinology, Diabetes and Metabolism","General Medicine"],"page":"1563-1569","type":"journal-article","issued":{"date-parts":[[2020,11]]},"publisher":"Elsevier BV","id":"01xyjaih","short-title":[],"pmcid":"PMC7434433","has_valid_oa_url":true,"deposited":{"timestamp":1616946900000,"date-time":"2021-03-28T15:55:00Z","date-parts":[[2021,3,28]]},"indexed":{"timestamp":1616947859597,"date-time":"2021-03-28T16:10:59Z","date-parts":[[2021,3,28]]},"is-referenced-by-count":14,"title":["Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/9b/f0/PMC7434433.tar.gz","has_valid_thumbnail":false,"references-count":59,"license-simplified":"no-cc","subtitle":[],"reference-count":59,"ISSN":["1871-4021"],"issn-type":[{"value":"1871-4021","type":"print"}],"container-title":["Diabetes & Metabolic Syndrome: Clinical Research & Reviews"],"score":1,"has_valid_ref_annotation":false,"issue":"6","member":"78","abstract":"BACKGROUND AND AIM: To perform a systematic literature review and analyze the demographic/biochemical parameters and clinical outcomes of COVID-19 patients with diabetic ketoacidosis (DKA) and combined DKA/HHS (hyperglycemic hyperosmolar syndrome). METHODS: PubMed, Scopus, Embase, and Google Scholar databases were systematically searched till August 3, 2020 to identify studies reporting COVID-19 patients with DKA and combined DKA/HHS. A total of 19 articles reporting 110 patients met the eligibility criteria. RESULTS: Of the 110 patients, 91 (83%) patients had isolated DKA while 19 (17%) had DKA/HHS. The majority of the patients were male (63%) and belonged to black ethnicity (36%). The median age at presentation ranged from 45.5 to 59.0 years. Most of the patients (77%) had pre-existing type 2 diabetes mellitus. Only 10% of the patients had newly diagnosed diabetes mellitus. The median blood glucose at presentation ranged from 486.0 to 568.5 mg/dl, being higher in patients with DKA/HHS compared to isolated DKA. The volume of fluid replaced in the first 24 h was higher in patients with DKA/HHS in contrast to patients with DKA alone. The in-hospital mortality rate was 45%, with higher mortality in the DKA/HHS group than in the isolated DKA group (67% vs. 29%). pH was lower in patients who had died compared to those who were discharged. CONCLUSION: DKA in COVID-19 patients portends a poor prognosis with a mortality rate approaching 50%. Differentiating isolated DKA from combined DKA/HHS is essential as the latter represents around one-fifth of the DKA cases and tends to have higher mortality than DKA alone.","published-print":{"date-parts":[[2020,11]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Pal","given":"Rimesh","affiliation":[]},{"sequence":"additional","given":"Mainak","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6656-8569","family":"Banerjee","affiliation":[]},{"sequence":"additional","family":"Yadav","given":"Urmila","affiliation":[]},{"sequence":"additional","family":"Bhattacharjee","given":"Sukrita","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S1871402120303180?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S1871402120303180?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1016/j.dsx.2020.08.015","journal-issue":{"published-print":{"date-parts":[[2020,11]]},"issue":"6"},"assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Clinical profile and outcomes in COVID-19 patients with diabetic ketoacidosis: A systematic review of literature","label":"Article Title","name":"articletitle"},{"value":"Diabetes & Metabolic Syndrome: Clinical Research & Reviews","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.dsx.2020.08.015","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"4f2aedc07b5fe9dff5d846d21219eee6e8ac207c"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":15482},
  {"_key":"60c20ca67723bebd8664557c","_id":"documents/60c20ca67723bebd8664557c","_rev":"_cfFhBUW---","file_name":"01yq2p7h.pdf","md5":"35B901045A79A621D1AA79AD06BFA9E8","id":"01yq2p7h","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/yq/2p/7h/01yq2p7h/01yq2p7h.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["10.1128/JVI.01505-08"],"published-print":{"date-parts":[[2009,4,1]]},"volume":"83","pmid":"19153232","journal-issue":{"published-print":{"date-parts":[[2009,4,1]]},"issue":"7"},"has_valid_tei":false,"URL":"http://dx.doi.org/10.1128/jvi.01505-08","DOI":"10.1128/jvi.01505-08","short-title":[],"original-title":[],"title":["Severe Acute Respiratory Syndrome Coronavirus nsp9 Dimerization Is Essential for Efficient Viral Growth"],"content-domain":{"domain":["asm.org"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1128/asmj-crossmark-policy-page","page":"3007-3018","type":"journal-article","issued":{"date-parts":[[2009,1,19]]},"publisher":"American Society for Microbiology","id":"01yq2p7h","reference-count":69,"has_valid_oa_url":true,"deposited":{"timestamp":1586432917000,"date-time":"2020-04-09T11:48:37Z","date-parts":[[2020,4,9]]},"indexed":{"timestamp":1617625436944,"date-time":"2021-04-05T12:23:56Z","date-parts":[[2021,4,5]]},"is-referenced-by-count":56,"short-container-title":["JVI"],"prefix":"10.1128","oaLink":"https://jvi.asm.org/content/jvi/83/7/3007.full.pdf","has_valid_thumbnail":false,"references-count":69,"license-simplified":"unk","subtitle":[],"archive":["LOCKSS"],"ISSN":["0022-538X","1098-5514"],"issn-type":[{"value":"0022-538X","type":"print"},{"value":"1098-5514","type":"electronic"}],"container-title":["Journal of Virology"],"has_valid_ref_annotation":false,"issue":"7","member":"235","abstract":"The severe acute respiratory syndrome coronavirus (SARS-CoV) devotes a significant portion of its genome to producing nonstructural proteins required for viral replication. SARS-CoV nonstructural protein 9 (nsp9) was identified as an essential protein with RNA/DNA-binding activity, and yet its biological function within the replication complex remains unknown. Nsp9 forms a dimer through the interaction of parallel alpha-helices containing the protein-protein interaction motif GXXXG. In order to study the role of the nsp9 dimer in viral reproduction, residues G100 and G104 at the helix interface were targeted for mutation. Multi-angle light scattering measurements indicated that G100E, G104E, and G104V mutants are monomeric in solution, thereby disrupting the dimer. However, electrophoretic mobility assays revealed that the mutants bound RNA with similar affinity. Further experiments using fluorescence anisotropy showed a 10-fold reduction in RNA binding in the G100E and G104E mutants, whereas the G104V mutant had only a 4-fold reduction. The structure of G104E nsp9 was determined to 2.6-A resolution, revealing significant changes at the dimer interface. The nsp9 mutations were introduced into SARS-CoV using a reverse genetics approach, and the G100E and G104E mutations were found to be lethal to the virus. The G104V mutant produced highly debilitated virus and eventually reverted back to the wild-type protein sequence through a codon transversion. Together, these data indicate that dimerization of SARS-CoV nsp9 at the GXXXG motif is not critical for RNA binding but is necessary for viral replication.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Miknis","given":"Zachary J.","affiliation":[{"name":"Department of Structural Biology, State University of New York at Buffalo, Buffalo, New York 14203"}]},{"sequence":"additional","family":"Donaldson","given":"Eric F.","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel-Hill, Chapel-Hill, North Carolina 27599"}]},{"sequence":"additional","family":"Umland","given":"Timothy C.","affiliation":[{"name":"Department of Structural Biology, State University of New York at Buffalo, Buffalo, New York 14203"},{"name":"Hauptman-Woodward Medical Research Institute, Buffalo, New York 14203"}]},{"sequence":"additional","family":"Rimmer","given":"Ryan A.","affiliation":[{"name":"Hauptman-Woodward Medical Research Institute, Buffalo, New York 14203"}]},{"sequence":"additional","family":"Baric","given":"Ralph S.","affiliation":[{"name":"Department of Microbiology and Immunology, University of North Carolina at Chapel-Hill, Chapel-Hill, North Carolina 27599"}]},{"sequence":"additional","family":"Schultz","given":"L. Wayne","affiliation":[{"name":"Department of Structural Biology, State University of New York at Buffalo, Buffalo, New York 14203"},{"name":"Hauptman-Woodward Medical Research Institute, Buffalo, New York 14203"}]}],"subject":["Immunology","Insect Science","Microbiology","Virology"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1128/JVI.01505-08","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1232418245000,"date-time":"2009-01-20T02:24:05Z","date-parts":[[2009,1,20]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":15803},
  {"_key":"60c20ca77723bebd86645595","_id":"documents/60c20ca77723bebd86645595","_rev":"_cfFhBUi---","file_name":"01ysvhvq.pdf","md5":"1D6B83867F5D2DFF8C3CE9458A5AA4D0","id":"01ysvhvq","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/ys/vh/vq/01ysvhvq/01ysvhvq.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["4758"],"published-print":{"date-parts":[[2020,11]]},"volume":"165","journal-issue":{"published-print":{"date-parts":[[2020,11]]},"issue":"11"},"has_valid_tei":false,"DOI":"10.1007/s00705-020-04758-5","short-title":[],"original-title":[],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1597104000000,"date-time":"2020-08-11T00:00:00Z","date-parts":[[2020,8,11]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1597104000000,"date-time":"2020-08-11T00:00:00Z","date-parts":[[2020,8,11]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","page":"2503-2512","type":"journal-article","issued":{"date-parts":[[2020,8,11]]},"funder":[{"doi-asserted-by":"publisher","award":["IRN60W0002"],"DOI":"10.13039/501100004396","name":"Thailand Research Fund"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100013238","name":"Faculty of Medicine Siriraj Hospital, Mahidol University"}],"publisher":"Springer Science and Business Media LLC","id":"01ysvhvq","reference-count":12,"title":["Responses to the Sb epitope contributed to antigenic drift of the influenza A 2009 H1N1 virus"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/35/f7/PMC7418886.tar.gz","pmcid":"PMC7418886","has_valid_oa_url":true,"deposited":{"timestamp":1608192400000,"date-time":"2020-12-17T08:06:40Z","date-parts":[[2020,12,17]]},"indexed":{"timestamp":1608194965959,"date-time":"2020-12-17T08:49:25Z","date-parts":[[2020,12,17]]},"is-referenced-by-count":0,"short-container-title":["Arch Virol"],"prefix":"10.1007","published-online":{"date-parts":[[2020,8,11]]},"has_valid_thumbnail":false,"references-count":12,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1007/s00705-020-04758-5","ISSN":["0304-8608","1432-8798"],"issn-type":[{"value":"0304-8608","type":"print"},{"value":"1432-8798","type":"electronic"}],"container-title":["Archives of Virology"],"score":1,"has_valid_ref_annotation":false,"issue":"11","member":"297","abstract":"Immunodominance is recognized as a key factor in the antigenic drift of seasonal influenza viruses. In the immunodominance model, each individual in a population predominantly responds to a single epitope among the five antigenic epitopes of the viral hemagglutinin (HA), driving escape mutations one at a time, and sequential mutations in multiple individuals who respond to different epitopes eventually generate a drifted strain with mutations in epitopes that are targeted by a majority of the population. A focused antibody response to the Sa epitope in people born between 1965 and 1979 was believed to contribute to a mutation at HA residue 163 and the first antigenic drift of the 2009 pandemic influenza A H1N1 virus. A serine-to-threonine mutation at HA residue 185 in the Sb epitope emerged in 2010 even before the 163 mutation. We show here that a large fraction of the population in 2010-2011 had responses to the Sb epitope, as shown by 47% of tested sera having altered titers to the S185T mutant. Responses to the Sb epitope showed an age-specific trend similar to that found for the response to Sa epitope in these subjects. Together, the focused responses to Sa and Sb epitopes may have driven the first antigenic drift of the 2009 pandemic H1N1 virus.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Ketklao","given":"S.","affiliation":[]},{"sequence":"additional","family":"Boonarkart","given":"C.","affiliation":[]},{"sequence":"additional","family":"Phakaratsakul","given":"S.","affiliation":[]},{"sequence":"additional","family":"Auewarakul","given":"P.","affiliation":[]},{"sequence":"additional","given":"Ornpreya","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-0832-0079","family":"Suptawiwat","affiliation":[]}],"subject":["Virology","General Medicine"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s00705-020-04758-5.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s00705-020-04758-5/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00705-020-04758-5.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1597165517000,"date-time":"2020-08-11T17:05:17Z","date-parts":[[2020,8,11]]},"language":"en","assertion":[{"order":1,"value":"21 March 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"27 June 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"11 August 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Compliance with ethical standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The authors declare no conflicts of interest.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"cb109341e29d70ef6ada4f4ed3e5bb5ccb8e8ec9"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":13104},
  {"_key":"60c20ca87723bebd86645599","_id":"documents/60c20ca87723bebd86645599","_rev":"_cfFhBUu---","file_name":"01yq8d0k.pdf","md5":"88B6A2764369ED988379FCE0A2987836","id":"01yq8d0k","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/yq/8d/0k/01yq8d0k/01yq8d0k.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["268"],"published-print":{"date-parts":[[2021,4]]},"volume":"7","journal-issue":{"published-print":{"date-parts":[[2021,4]]},"issue":"2"},"has_valid_tei":false,"DOI":"10.1007/s40747-020-00268-8","original-title":[],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1611446400000,"date-time":"2021-01-24T00:00:00Z","date-parts":[[2021,1,24]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1611446400000,"date-time":"2021-01-24T00:00:00Z","date-parts":[[2021,1,24]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":47,"page":"1079-1098","type":"journal-article","issued":{"date-parts":[[2021,1,24]]},"funder":[{"award":[],"name":"CouncilofScientific and Industrial Research, India"}],"publisher":"Springer Science and Business Media LLC","id":"01yq8d0k","short-title":[],"title":["Second-order neutrosophic boundary-value problem"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/7d/77/PMC7829035.tar.gz","pmcid":"PMC7829035","has_valid_oa_url":true,"deposited":{"timestamp":1617356118000,"date-time":"2021-04-02T09:35:18Z","date-parts":[[2021,4,2]]},"indexed":{"timestamp":1617358413130,"date-time":"2021-04-02T10:13:33Z","date-parts":[[2021,4,2]]},"is-referenced-by-count":0,"short-container-title":["Complex Intell. Syst."],"prefix":"10.1007","published-online":{"date-parts":[[2021,1,24]]},"has_valid_thumbnail":false,"references-count":47,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1007/s40747-020-00268-8","ISSN":["2199-4536","2198-6053"],"issn-type":[{"value":"2199-4536","type":"print"},{"value":"2198-6053","type":"electronic"}],"container-title":["Complex & Intelligent Systems"],"score":1,"has_valid_ref_annotation":false,"issue":"2","member":"297","abstract":"In this article, some properties of neutrosophic derivative and neutrosophic numbers have been presented. This properties have been used to develop the neutrosophic differential calculus. By considering different types of first- and second-order derivatives, different kind of systems of derivatives have been developed. This is the first time where a second-order neutrosophic boundary-value problem has been introduced with different types of first- and second-order derivatives. Some numerical examples have been examined to explain different systems of neutrosophic differential equation.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Moi","given":"Sandip","affiliation":[]},{"sequence":"additional","given":"Suvankar","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3305-0130","family":"Biswas","affiliation":[]},{"sequence":"additional","family":"Pal(Sarkar)","given":"Smita","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s40747-020-00268-8.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s40747-020-00268-8/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s40747-020-00268-8.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1611515000000,"date-time":"2021-01-24T19:03:20Z","date-parts":[[2021,1,24]]},"language":"en","assertion":[{"order":1,"value":"15 August 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"29 December 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"24 January 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"}],"source":"Crossref","cord_sha":"00610ff55eea66f3d441693fd9b0241e804192ba"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":15714},
  {"_key":"60c20cae7723bebd8664559f","_id":"documents/60c20cae7723bebd8664559f","_rev":"_cfFhBU6---","file_name":"01zhue4a.pdf","md5":"222ECE13F034234688A64670234809D8","id":"01zhue4a","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/01/zh/ue/4a/01zhue4a/01zhue4a.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["464"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1611532800000,"date-time":"2021-01-25T00:00:00Z","date-parts":[[2021,1,25]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1611532800000,"date-time":"2021-01-25T00:00:00Z","date-parts":[[2021,1,25]]}}],"article-number":"9","volume":"13","has_valid_tei":false,"DOI":"10.1186/s12544-020-00464-0","short-title":[],"original-title":[],"published-print":{"date-parts":[[2021,12]]},"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","type":"journal-article","issued":{"date-parts":[[2021,1,25]]},"publisher":"Springer Science and Business Media LLC","id":"01zhue4a","reference-count":41,"title":["Lifespans of passenger cars in Europe: empirical modelling of fleet turnover dynamics"],"pmcid":"PMC7829067","has_valid_oa_url":true,"deposited":{"timestamp":1614161173000,"date-time":"2021-02-24T10:06:13Z","date-parts":[[2021,2,24]]},"indexed":{"timestamp":1614163784833,"date-time":"2021-02-24T10:49:44Z","date-parts":[[2021,2,24]]},"is-referenced-by-count":1,"published-online":{"date-parts":[[2021,1,25]]},"short-container-title":["Eur. Transp. Res. Rev."],"prefix":"10.1186","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/67/a4/PMC7829067.tar.gz","has_valid_thumbnail":false,"ISSN":["1867-0717","1866-8887"],"references-count":41,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12544-020-00464-0","journal-issue":{"published-print":{"date-parts":[[2021,12]]},"issue":"1"},"issn-type":[{"value":"1867-0717","type":"print"},{"value":"1866-8887","type":"electronic"}],"container-title":["European Transport Research Review"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"Cars have a high share of global transport-related CO(2) emissions. To model the market diffusion of new energy carriers and powertrains like electric vehicles, fleet turnover models are commonly used. A decisive influence factor for the substitution dynamics of such transformations is the survival rate of the national car fleet of a country. It represents the likelihood of a car reaching a certain lifespan. Due to a lack of data, current methods to estimate such survival probabilities neglect the imports and exports of used cars. Existing studies are limited to countries with a predominant market of new cars, compared to low numbers of imported and exported used cars. In this study, we resolve this marked simplification and propose a new method to estimate survival probabilities for countries with a high number of imported and exported used cars. Empirical data on the car stock, on inflows of new and used cars, and on outflows of exported and scrapped cars are gathered from 71 national statistics offices. Survival rates of the car fleets of 31 European countries are derived, for which we find a pronounced regional variability. Average lifespans of cars vary from 8.0 to 35.1 years, with a mean of 18.1 years in Western and 28.4 years in Eastern European countries, revealing the high impact of cross-border flows of cars. The study also shows that survival rate estimates can be improved significantly even in the absence of reliable data if a combination of a Weibull and a Gaussian distribution is used. It is likely that the predictive power of existing models (regarding the future environmental impact of car fleets) could be improved significantly if these findings were considered accordingly. The findings of this study can directly be included in fleet turnover and policy assessment models. They also enable the analysis of economic and environmental spillover effects from the imports and exports of used cars between countries. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at (10.1186/s12544-020-00464-0).","has_valid_pdf":true,"author":[{"sequence":"first","given":"Maximilian","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3751-3902","family":"Held","affiliation":[]},{"sequence":"additional","family":"Rosat","given":"Nicolas","affiliation":[]},{"sequence":"additional","family":"Georges","given":"Gil","affiliation":[]},{"sequence":"additional","family":"Pengg","given":"Hermann","affiliation":[]},{"sequence":"additional","family":"Boulouchos","given":"Konstantinos","affiliation":[]}],"subject":["Mechanical Engineering","Automotive Engineering","Transportation"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12544-020-00464-0.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s12544-020-00464-0/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s12544-020-00464-0.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1611540221000,"date-time":"2021-01-25T02:03:41Z","date-parts":[[2021,1,25]]},"language":"en","assertion":[{"order":1,"value":"7 October 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"21 December 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"25 January 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":4,"value":"24 February 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"Change Date","name":"change_date"},{"order":5,"value":"Correction","group":{"label":"Article History","name":"ArticleHistory"},"label":"Change Type","name":"change_type"},{"order":6,"value":"A Correction to this paper has been published:","group":{"label":"Article History","name":"ArticleHistory"},"label":"Change Details","name":"change_details"},{"label":"Change Details","name":"change_details","order":7,"URL":"https://doi.org/10.1186/s12544-021-00479-1","value":"https://doi.org/10.1186/s12544-021-00479-1","group":{"label":"Article History","name":"ArticleHistory"}},{"order":1,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"4c57f732c5883d0b3aff55c1928c32157fc42b6e; 929133f549747156c5cf04ec472f761c4ebf2e75; bb71d9fae01647ce7b1911a6403132e512894680"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":17296},
  {"_key":"60c20cb57723bebd866455a5","_id":"documents/60c20cb57723bebd866455a5","_rev":"_cfFhBVG---","file_name":"02025787.pdf","md5":"465866D2498BD2832408720DE13F4842","id":"02025787","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/02/57/87/02025787/02025787.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["s20205837"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1602720000000,"date-time":"2020-10-15T00:00:00Z","date-parts":[[2020,10,15]]}}],"volume":"20","pmid":"33076402","has_valid_tei":false,"created":{"timestamp":1602766923000,"date-time":"2020-10-15T13:02:03Z","date-parts":[[2020,10,15]]},"DOI":"10.3390/s20205837","original-title":[],"title":["Sensor-Enabled Context-Aware and Pro-Active Queue Management Systems in Intelligent Environments"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":57,"page":"5837","type":"journal-article","issued":{"date-parts":[[2020,10,15]]},"publisher":"MDPI AG","id":"02025787","short-title":[],"pmcid":"PMC7602596","has_valid_oa_url":true,"deposited":{"timestamp":1607046015000,"date-time":"2020-12-04T01:40:15Z","date-parts":[[2020,12,4]]},"indexed":{"timestamp":1607047947820,"date-time":"2020-12-04T02:12:27Z","date-parts":[[2020,12,4]]},"is-referenced-by-count":0,"short-container-title":["Sensors"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/c4/70/PMC7602596.tar.gz","has_valid_thumbnail":false,"ISSN":["1424-8220"],"references-count":57,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"20","published-online":{"date-parts":[[2020,10]]}},"issn-type":[{"value":"1424-8220","type":"electronic"}],"container-title":["Sensors"],"published-online":{"date-parts":[[2020,10,15]]},"issue":"20","member":"1968","abstract":"Queue systems are practically used in various institutions and commercial enterprises constituting a challenge for the intelligent environments in smart cities. The management of the flow of customers guarantees the elimination or reduction of the queues as well as the economic benefits which follow the clients’ satisfaction of a better quality of service. An intelligent queue management system has been proposed which is designed as the pro-active and context-aware ecosystem based on multiple low-level sensors and devices constituting the IoT (Internet of Things) network. The designed context-driven system is characterised by user friendliness, as well as the client behaviour recognition and understanding which generate actions that support clients, establishing wealthy environments. A prototype version of the system has been proposed which has been validated by formal analysis and simulation. This prototype can be used as a necessary experience and as a reference point when building a target system and meeting requirements typical for context-aware and pro-active systems based on IoT networks which process massive data streams.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Radosław","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-9061-561X","family":"Klimek","affiliation":[]}],"subject":["Electrical and Electronic Engineering","Analytical Chemistry","Atomic and Molecular Physics, and Optics","Biochemistry"],"link":[{"URL":"https://www.mdpi.com/1424-8220/20/20/5837/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.3390/s20205837","language":"en","score":1,"source":"Crossref","cord_sha":"4e4209d2bc87cf06c015f200c8043b6bd4e7ead7"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":13504},
  {"_key":"60c20cb87723bebd866455aa","_id":"documents/60c20cb87723bebd866455aa","_rev":"_cfFhBVS---","file_name":"0204iiah.pdf","md5":"5660F35B0CCAB53DB8CD77D08822BEB2","id":"0204iiah","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/04/ii/ah/0204iiah/0204iiah.pdf","date":"2021-06-10T12:59+0000","metadata":{"alternative-id":["2377"],"published-print":{"date-parts":[[2018,12]]},"article-number":"313","language":"en","volume":"18","pmid":"30497462","journal-issue":{"published-print":{"date-parts":[[2018,12]]},"issue":"1"},"author":[{"sequence":"first","family":"Yang","given":"Su-Tso","affiliation":[]},{"sequence":"additional","family":"Lin","given":"Yi-Rong","affiliation":[]},{"sequence":"additional","family":"Wu","given":"Mei-Yao","affiliation":[]},{"sequence":"additional","family":"Chiang","given":"Jen-Huai","affiliation":[]},{"sequence":"additional","family":"Yang","given":"Pei-Shan","affiliation":[]},{"sequence":"additional","family":"Hsia","given":"Te-Chun","affiliation":[]},{"sequence":"additional","given":"Hung-Rong","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-0131-1658","family":"Yen","affiliation":[]}],"DOI":"10.1186/s12906-018-2377-4","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1543449600000,"date-time":"2018-11-29T00:00:00Z","date-parts":[[2018,11,29]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Complementary and alternative medicine","General Medicine"],"type":"journal-article","issued":{"date-parts":[[2018,11,29]]},"funder":[{"doi-asserted-by":"publisher","award":["Chinese Medicine Research Center, China Medical University, under the Featured Areas Research Center Program within the framework of the Higher Education Sprout Project"],"DOI":"10.13039/100010002","name":"Ministry of Education"},{"doi-asserted-by":"publisher","award":["MOHW107-TDU-B-212-123004","MOHW107-TDU-B-212-114024"],"DOI":"10.13039/100008903","name":"Ministry of Health and Welfare"},{"doi-asserted-by":"publisher","award":["DMR-106-183"],"DOI":"10.13039/501100004391","name":"China Medical University Hospital"}],"publisher":"Springer Science and Business Media LLC","id":"0204iiah","reference-count":91,"title":["Utilization of Chinese medicine for respiratory discomforts by patients with a medical history of tuberculosis in Taiwan"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/d0/9f/PMC6267063.tar.gz","pmcid":"PMC6267063","has_valid_oa_url":true,"deposited":{"timestamp":1574985972000,"date-time":"2019-11-29T00:06:12Z","date-parts":[[2019,11,29]]},"indexed":{"timestamp":1585061570117,"date-time":"2020-03-24T14:52:50Z","date-parts":[[2020,3,24]]},"is-referenced-by-count":0,"short-container-title":["BMC Complement Altern Med"],"prefix":"10.1186","published-online":{"date-parts":[[2018,11,29]]},"has_valid_thumbnail":false,"references-count":91,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12906-018-2377-4","short-title":[],"issn-type":[{"value":"1472-6882","type":"electronic"}],"container-title":["BMC Complementary and Alternative Medicine"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND: Tuberculosis (TB) is one of the world’s major communicable infectious diseases, and it still imposes a great health burden in developing countries. The development of drug-resistant TB during the treatment increases the treatment complexity, and the long-term pulmonary complications after completing treatment raise the epidemic health burden. This study intended to investigate the utilization of Chinese medicine (CM) for respiratory symptoms by patients with a medical history of TB in Taiwan. METHODS: We analyzed a cohort of one million individuals who were randomly selected from the National Health Insurance Research Database in Taiwan. The inclusion criteria of patients (n = 7905) with history of TB (ICD-9-CM codes 010–018 and A02) were: (1) TB diagnosed between January 1, 1997 and December 31, 2010 (2) 18 years old or over (3) Clinical records for at least 2 months with complete demographic information (4) Record of treatment with first-line TB medication prescriptions. CM users for conditions other than respiratory discomforts (n = 3980) were excluded. Finally, a total of 3925 TB patients were categorized as: CM users for respiratory discomforts (n = 2051) and non-CM users (n = 1874). RESULTS: Among the 3925 subjects, 2051 (52.25%) were CM users, and 1874 (44.753%) were non-CM users. Female patients and those who were younger (18–39 y/o) and who lived in urbanized areas relatively tended to be CM users (p < .0001). Most of the CM users (1944, 94.78%) received Chinese medicines. The most commonly prescribed herbal formulas and single herbs were Xiao-Qing-Long-Tang and Radix Platycodonis (Jie-Geng), respectively. The core pattern of Chinese medicines for TB patients consisted of Ma-Xing-Gan-Shi-Tang, Bulbus Fritillariae Thunbergii (Bei-Mu), Radix Platycodonis (Jie-Geng) and Semen Armeniacae (Xing-Ren). CONCLUSIONS: The use of CM is popular among patients with a medical history of TB complicated with long-term respiratory discomforts in Taiwan. Further pharmacological investigations and clinical trials are required.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12906-018-2377-4.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s12906-018-2377-4/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s12906-018-2377-4.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1543498472000,"date-time":"2018-11-29T13:34:32Z","date-parts":[[2018,11,29]]},"ISSN":["1472-6882"],"assertion":[{"order":1,"value":"31 March 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"15 November 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"29 November 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"This study followed the ethical standards of the responsible committee and with the Helsinki Declaration of 1964 and later versions. All the datasets were de-identified and encrypted before released by the National Health Research Institutes, Taiwan. All of the individuals or care providers could not be identified in the database. Patient consent was exempted for the total anonymity of all research data in this study. Therefore, the Research Ethics Committee of China Medical University and Hospital approved this study and waived the requirement for informed consent (CMUH104-REC2–115).","group":{"label":"Ethics approval and consent to participate","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"Not applicable.","group":{"label":"Consent for publication","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"The authors declare that they have no conflicts of interest to disclose.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"},{"order":4,"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","group":{"label":"Publisher’s Note","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":"30c57af407724c03de7e5b24b175c3de44ea79a6"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":11157},
  {"_key":"60c20cd87723bebd866455ad","_id":"documents/60c20cd87723bebd866455ad","_rev":"_cfFhBVa---","file_name":"021xc03g.pdf","md5":"CBDDCABC245732F1ED09666846409A90","id":"021xc03g","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/1x/c0/3g/021xc03g/021xc03g.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["930"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1602028800000,"date-time":"2020-10-07T00:00:00Z","date-parts":[[2020,10,7]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1602028800000,"date-time":"2020-10-07T00:00:00Z","date-parts":[[2020,10,7]]}}],"language":"en","pmid":"33029678","author":[{"sequence":"first","given":"Miriam","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-0534-7383","family":"Schiff","affiliation":[]},{"sequence":"additional","family":"Zasiekina","given":"Larysa","affiliation":[]},{"sequence":"additional","family":"Pat-Horenczyk","given":"Ruth","affiliation":[]},{"sequence":"additional","family":"Benbenishty","given":"Rami","affiliation":[]}],"DOI":"10.1007/s10900-020-00930-9","license-simplified":"no-cc","original-title":[],"short-container-title":["J Community Health"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["Public Health, Environmental and Occupational Health","Health(social science)"],"type":"journal-article","issued":{"date-parts":[[2020,10,7]]},"publisher":"Springer Science and Business Media LLC","id":"021xc03g","reference-count":28,"pmcid":"PMC7540431","has_valid_oa_url":true,"deposited":{"timestamp":1602097665000,"date-time":"2020-10-07T19:07:45Z","date-parts":[[2020,10,7]]},"indexed":{"timestamp":1616051037344,"date-time":"2021-03-18T07:03:57Z","date-parts":[[2021,3,18]]},"is-referenced-by-count":2,"title":["COVID-Related Functional Difficulties and Concerns Among University Students During COVID-19 Pandemic: A Binational Perspective"],"prefix":"10.1007","published-online":{"date-parts":[[2020,10,7]]},"has_valid_thumbnail":false,"references-count":28,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/c1/20/PMC7540431.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s10900-020-00930-9","short-title":[],"issn-type":[{"value":"0094-5145","type":"print"},{"value":"1573-3610","type":"electronic"}],"container-title":["Journal of Community Health"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"The COVID-19 pandemic has created a sense of threat, and stress that has surged globally at an alarming pace. University students were confronted with new challenges. This study examined university students’ functional difficulties and concerns during COVID-19 pandemic in two countries: Israel and Ukraine. Additionally, it examined the similarities and differences in prediction of COVID-related concerns in both countries. Two large samples of university students were drawn from both countries. Results showed that students’ main functional difficulties in both countries were: worries about their family health status and their learning assignments. In both countries, COVID-related functional difficulties and stress associated with exposure to the media added a significant amount of the explained variance of COVID-related concerns after controlling for background variables. In conclusion—while the level of exposure and difficulties may differ by country and context, their associations with students’ concerns seem robust. Additionally, repeated exposure to media coverage about a community threat can lead to increased anxiety.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s10900-020-00930-9.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s10900-020-00930-9/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s10900-020-00930-9.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1602093771000,"date-time":"2020-10-07T18:02:51Z","date-parts":[[2020,10,7]]},"ISSN":["0094-5145","1573-3610"],"assertion":[{"order":1,"value":"28 September 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":2,"value":"7 October 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"b16ceeaa6b7652c354dc53013e747af1c0177a22"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":34286},
  {"_key":"60c20cd97723bebd866455b1","_id":"documents/60c20cd97723bebd866455b1","_rev":"_cfFhBVm---","file_name":"0238bsxb.pdf","md5":"63059DDC0094FE27E6BE8EB116A56314","id":"0238bsxb","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/38/bs/xb/0238bsxb/0238bsxb.pdf","date":"2021-06-10T13:00+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1484179200000,"date-time":"2017-01-12T00:00:00Z","date-parts":[[2017,1,12]]}}],"volume":"12","pmid":"28081264","journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,1,12]]}},"has_valid_tei":false,"DOI":"10.1371/journal.pone.0170123","original-title":[],"short-container-title":["PLoS ONE"],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"reference-count":42,"page":"e0170123","type":"journal-article","issued":{"date-parts":[[2017,1,12]]},"funder":[{"doi-asserted-by":"publisher","award":["31602038","31672592","31602083"],"DOI":"10.13039/501100001809","name":"National Natural Science Foundation of China"}],"publisher":"Public Library of Science (PLoS)","id":"0238bsxb","short-title":[],"editor":[{"sequence":"first","family":"Cao","given":"Yongchang","affiliation":[]}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/0b/df/PMC5231368.tar.gz","pmcid":"PMC5231368","has_valid_oa_url":true,"deposited":{"timestamp":1540313678000,"date-time":"2018-10-23T16:54:38Z","date-parts":[[2018,10,23]]},"indexed":{"timestamp":1617901554811,"date-time":"2021-04-08T17:05:54Z","date-parts":[[2021,4,8]]},"is-referenced-by-count":27,"title":["The Important Role of Lipid Raft-Mediated Attachment in the Infection of Cultured Cells by Coronavirus Infectious Bronchitis Virus Beaudette Strain"],"prefix":"10.1371","published-online":{"date-parts":[[2017,1,12]]},"has_valid_thumbnail":false,"references-count":42,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1371/journal.pone.0170123","ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"container-title":["PLOS ONE"],"has_valid_ref_annotation":false,"issue":"1","member":"340","abstract":"Lipid raft is an important element for the cellular entry of some viruses, including coronavirus infectious bronchitis virus (IBV). However, the exact role of lipid rafts in the cellular membrane during the entry of IBV into host cells is still unknown. In this study, we biochemically fractionated IBV-infected cells via sucrose density gradient centrifugation after depleting plasma membrane cholesterol with methyl-β-cyclodextrin or Mevastatin. Our results demonstrated that unlike IBV non-structural proteins, IBV structural proteins co-localized with lipid raft marker caveolin-1. Infectivity assay results of Vero cells illustrated that the drug-induced disruption of lipid rafts significantly suppressed IBV infection. Further studies revealed that lipid rafts were not required for IBV genome replication or virion release at later stages. However, the drug-mediated depletion of lipid rafts in Vero cells before IBV attachment significantly reduced the expression of viral structural proteins, suggesting that drug treatment impaired the attachment of IBV to the cell surface. Our results indicated that lipid rafts serve as attachment factors during the early stages of IBV infection, especially during the attachment stage.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Guo","given":"Huichen","affiliation":[]},{"sequence":"additional","family":"Huang","given":"Mei","affiliation":[]},{"sequence":"additional","family":"Yuan","given":"Quan","affiliation":[]},{"sequence":"additional","family":"Wei","given":"Yanquan","affiliation":[]},{"sequence":"additional","family":"Gao","given":"Yuan","affiliation":[]},{"sequence":"additional","family":"Mao","given":"Lejiao","affiliation":[]},{"sequence":"additional","family":"Gu","given":"Lingjun","affiliation":[]},{"sequence":"additional","family":"Tan","given":"Yong Wah","affiliation":[]},{"sequence":"additional","family":"Zhong","given":"Yanxin","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Dingxiang","affiliation":[]},{"sequence":"additional","family":"Sun","given":"Shiqi","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1371/journal.pone.corrections_policy","link":[{"URL":"http://dx.plos.org/10.1371/journal.pone.0170123","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1484247715000,"date-time":"2017-01-12T19:01:55Z","date-parts":[[2017,1,12]]},"language":"en","score":1,"source":"Crossref","cord_sha":"ebbaea6d90c8fe4ccbb6e65a842689b104acba90"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":32324},
  {"_key":"60c20cdc7723bebd866455b3","_id":"documents/60c20cdc7723bebd866455b3","_rev":"_cfFhBVy---","file_name":"023bubn8.pdf","md5":"3F92D062DF73CA6BB328114A0D4C3F19","id":"023bubn8","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/3b/ub/n8/023bubn8/023bubn8.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["9470"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1599004800000,"date-time":"2020-09-02T00:00:00Z","date-parts":[[2020,9,2]]}},{"URL":"https://creativecommons.org/licenses/by/4.0","content-version":"vor","delay-in-days":0,"start":{"timestamp":1599004800000,"date-time":"2020-09-02T00:00:00Z","date-parts":[[2020,9,2]]}}],"author":[{"sequence":"first","given":"Nina","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6591-205X","family":"Bergdahl","affiliation":[]},{"sequence":"additional","given":"Jalal","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-9942-8730","family":"Nouri","affiliation":[]}],"DOI":"10.1007/s10758-020-09470-6","short-title":[],"original-title":[],"title":["Covid-19 and Crisis-Prompted Distance Education in Sweden"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","issued":{"date-parts":[[2020,9,2]]},"funder":[{"doi-asserted-by":"crossref","award":[],"DOI":"10.13039/501100009244","name":"Stockholms Universitet"}],"publisher":"Springer Science and Business Media LLC","id":"023bubn8","reference-count":47,"pmcid":"PMC7463097","has_valid_oa_url":true,"deposited":{"timestamp":1605943010000,"date-time":"2020-11-21T07:16:50Z","date-parts":[[2020,11,21]]},"indexed":{"timestamp":1615460686702,"date-time":"2021-03-11T11:04:46Z","date-parts":[[2021,3,11]]},"is-referenced-by-count":2,"published-online":{"date-parts":[[2020,9,2]]},"short-container-title":["Tech Know Learn"],"prefix":"10.1007","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a6/06/PMC7463097.tar.gz","has_valid_thumbnail":false,"ISSN":["2211-1662","2211-1670"],"references-count":47,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1007/s10758-020-09470-6","type":"journal-article","issn-type":[{"value":"2211-1662","type":"print"},{"value":"2211-1670","type":"electronic"}],"container-title":["Technology, Knowledge and Learning"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"This study represents the first research effort to explore the transition from traditional teaching into distance teaching in Swedish schools enforced by covid-19. Governments made gradual and injudicious decisions to impede the spread of the pandemic (covid-19) in 2020. The enactment of new measures affected critical societal functions and included travel restrictions, closing of borders, school closures and lockdowns of entire countries worldwide. Social distancing became the new reality for many, and for many teachers and students, the school closure prompted a rapid transition from traditional to distance education. This study aims to capture the early stages of that transition. We distributed a questionnaire to teachers’ (n = 153) to gain insights into teacher and school preparedness, plans to deliver distance education, and teachers’ experience when making this transition. Results show that the school preparedness was mainly related to technical aspects, and that teachers lack pedagogical strategies needed in the emerging learning landscape of distance education. Findings reveal four distinct pedagogical activities central for distance education in a crisis, and many challenges faced during the transition. While preparedness to ensure continuity of education was halting, schools and teachers worked with tremendous effort to overcome the challenges. Results expand on previous findings on school closure during virus outbreaks and may in the short-term support teachers and school leaders in making informed decisions during the shift into distance education. The study may also inform the development of preparedness plans for schools, and offers a historical documentation.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Human-Computer Interaction","Education","Mathematics (miscellaneous)","Computer Science Applications"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s10758-020-09470-6.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s10758-020-09470-6/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s10758-020-09470-6.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1599033883000,"date-time":"2020-09-02T08:04:43Z","date-parts":[[2020,9,2]]},"language":"en","assertion":[{"order":1,"value":"2 September 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"}],"source":"Crossref","cord_sha":"8d3771e593258c29af379781c954e66b0ef18991"},"application":"software-mentions","pages":[{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142},{"page_width":439.37,"page_height":666.142}],"runtime":9074},
  {"_key":"60c20ce37723bebd866455b8","_id":"documents/60c20ce37723bebd866455b8","_rev":"_cfFhBW----","file_name":"023h20vk.pdf","md5":"54A0C5D862D4E703B9D43DFDBC8C5704","id":"023h20vk","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/3h/20/vk/023h20vk/023h20vk.pdf","date":"2021-06-10T13:00+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,6,14]]},"license-simplified":"biorxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.06.10.143545","group-title":"Bioinformatics","oaLink":"https://www.biorxiv.org/content/biorxiv/early/2020/06/14/2020.06.10.143545.full.pdf","original-title":[],"title":["In silico multi-epitope vaccine against covid19 showing effective interaction with HLA-B*15:03"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":46,"short-title":[],"issued":{"date-parts":[[2020,6,14]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,6,14]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"The recent outbreak of severe acute respiratory syndrome (SARS) coronavirus (CoV)-2 (SARS-CoV-2) causing coronavirus disease (covid19) has posed a great threat to human health. Previous outbreaks of SARS-CoV and Middle East respiratory Syndrome CoV (MERS-CoV) from the same CoV family had posed similar threat to human health and economic growth. To date, not even a single drug specific to any of these CoVs has been developed nor any anti-viral vaccine is available for the treatment of diseases caused by CoVs. Subunits present in spike glycoproteins of SARS-CoV and SARS-CoV-2 are involved in binding to human ACE2 Receptor which is the primary method of viral invasion. As it has been observed in the previous studies that there are very minor differences in the spike glycoproteins of SARS-CoV and SARS-CoV-2. SARS-CoV-2 has an additional furin cleavage site that makes it different from SARS-CoV (Walls et al., 2020). In this study, we have analyzed spike glycoproteins of SARS-CoV-2 and SARS-CoV phylogenetically and subjected them to selection pressure analysis. Selection pressure analysis has revealed some important sites in SARS-CoV-2 and SARS-CoV spike glycoproteins that might be involved in their pathogenicity. Further, we have developed a potential multi-epitope vaccine candidate against SARS-CoV-2 by analyzing its interactions with HLA-B*15:03 subtype. This vaccine consists of multiple T-helper (TH) cells, B-cells, and Cytotoxic T-cells (CTL) epitopes joined by linkers and an adjuvant to increase its immunogenicity. Conservation of selected epitopes in SARS, MERS, and human hosts, suggests that the designed vaccine could provide cross-protection. The vaccine is designed in silico by following a reverse vaccinology method acknowledging its antigenicity, immunogenicity, toxicity, and allergenicity. The vaccine candidate that we have designed as a result of this work shows promising result indicating its potential capability of simulating an immune response.","deposited":{"timestamp":1592466319000,"date-time":"2020-06-18T07:45:19Z","date-parts":[[2020,6,18]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Muniba","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-4711-4075","family":"Faiza","affiliation":[]},{"sequence":"additional","given":"Tariq","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3860-4745","family":"Abdullah","affiliation":[]},{"sequence":"additional","family":"Calderon-Tantalean","given":"Jose Franklin","affiliation":[]},{"sequence":"additional","family":"Upadhyay","given":"Manish Ravindranath","affiliation":[]},{"sequence":"additional","family":"Abdelmoneim","given":"Abdelrahman H.","affiliation":[]},{"sequence":"additional","family":"Akram","given":"Fareeha","affiliation":[]},{"sequence":"additional","family":"Thakur","given":"Bhupender Singh","affiliation":[]},{"sequence":"additional","family":"Abdulaziz","given":"Ibrahim","affiliation":[]},{"sequence":"additional","family":"Ononamadu","given":"Chimaobi James","affiliation":[]},{"sequence":"additional","family":"Ghoraba","given":"Dina Abdelazim","affiliation":[]},{"sequence":"additional","family":"Munawar","given":"Saba","affiliation":[]},{"sequence":"additional","family":"Faruque","given":"MD Fakhrul Islam","affiliation":[]},{"sequence":"additional","family":"Kigen","given":"Collins","affiliation":[]},{"sequence":"additional","family":"Sharma","given":"Abhishek","affiliation":[]},{"sequence":"additional","family":"Kumar","given":"Ashwani","affiliation":[]},{"sequence":"additional","family":"Khalid","given":"Aqsa","affiliation":[]},{"sequence":"additional","family":"Gharip","given":"Ali","affiliation":[]},{"sequence":"additional","family":"Gupta","given":"Ankit","affiliation":[]},{"sequence":"additional","family":"Manikumar","given":"Manne","affiliation":[]},{"sequence":"additional","family":"Chaudhary","given":"Uma","affiliation":[]}],"DOI":"10.1101/2020.06.10.143545","reference-count":46,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.06.10.143545","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1592217321000,"date-time":"2020-06-15T10:35:21Z","date-parts":[[2020,6,15]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"bioRxiv"},"id":"023h20vk","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1592467842326,"date-time":"2020-06-18T08:10:42Z","date-parts":[[2020,6,18]]},"cord_sha":"bdad47079700e7b9aae9bf35b79f6f170c1c93eb"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":14606},
  {"_key":"60c20ce77723bebd866455d5","_id":"documents/60c20ce77723bebd866455d5","_rev":"_cfFhBWK---","file_name":"0243hw58.pdf","md5":"935DB40AF49633236B5178CB1E7489D5","id":"0243hw58","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/43/hw/58/0243hw58/0243hw58.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["S0022215120002480"],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":16,"start":{"timestamp":1605571200000,"date-time":"2020-11-17T00:00:00Z","date-parts":[[2020,11,17]]}}],"volume":"134","pmid":"33198822","has_valid_tei":false,"created":{"timestamp":1605587670000,"date-time":"2020-11-17T04:34:30Z","date-parts":[[2020,11,17]]},"DOI":"10.1017/s0022215120002480","original-title":[],"published-print":{"date-parts":[[2020,11]]},"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":22,"page":"992-997","type":"journal-article","issued":{"date-parts":[[2020,11]]},"publisher":"Cambridge University Press (CUP)","id":"0243hw58","short-title":[],"title":["Patient satisfaction from ENT telephone consultations during the coronavirus disease 2019 pandemic"],"pmcid":"PMC7729151","has_valid_oa_url":true,"deposited":{"timestamp":1615367515000,"date-time":"2021-03-10T09:11:55Z","date-parts":[[2021,3,10]]},"indexed":{"timestamp":1615369777421,"date-time":"2021-03-10T09:49:37Z","date-parts":[[2021,3,10]]},"is-referenced-by-count":1,"short-container-title":["J. Laryngol. Otol."],"prefix":"10.1017","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/3f/dd/PMC7729151.tar.gz","has_valid_thumbnail":false,"ISSN":["0022-2151","1748-5460"],"references-count":22,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"published-print":{"date-parts":[[2020,11]]},"issue":"11"},"issn-type":[{"value":"0022-2151","type":"print"},{"value":"1748-5460","type":"electronic"}],"container-title":["The Journal of Laryngology & Otology"],"published-online":{"date-parts":[[2020,11,17]]},"issue":"11","member":"56","abstract":"BACKGROUND: Telephone consultations have rapidly increased in the out-patient setting because of the coronavirus pandemic. A quality improvement project was implemented to improve patient satisfaction of telephone consultations in our unit. METHODS: This was a prospective complete-cycle project. Patient satisfaction questionnaires were sent to patients following telephone consultations in ENT clinics. Based on a literature review and initial results, clinicians were encouraged to follow a structured consultation format. A second questionnaire survey was conducted following its implementation. RESULTS: One hundred patient questionnaires were collected during the survey (April and June 2020). There was significant improvement over the two surveys in terms of satisfaction scores (p = 0.026), along with a significantly increased preference for telephone consultations over face-to-face consultations (p = 0.021). CONCLUSION: This study showed significant improvement in patient satisfaction and an increased telephone consultation preference through the use of a structured consultation model. The potential benefits in terms of infection control and impact on out-patient workload may see telephone consultations persist in the post-coronavirus era.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Zammit","given":"M","affiliation":[]},{"sequence":"additional","family":"Siau","given":"R","affiliation":[]},{"sequence":"additional","family":"Williams","given":"C","affiliation":[]},{"sequence":"additional","family":"Hussein","given":"A","affiliation":[]}],"subject":["Otorhinolaryngology","General Medicine"],"link":[{"URL":"https://www.cambridge.org/core/services/aop-cambridge-core/content/view/S0022215120002480","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1017/s0022215120002480","language":"en","score":1,"source":"Crossref","cord_sha":"fa957ff3ea769cae214a306ed6ebdab3edce6ac5"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":3201},
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Rubel","affiliation":[{"name":"Division of Infectious Diseases and Division of Computer-Aided Drug Design, The Red-Green Research Centre, BICCB, Tejgaon, Dhaka, Bangladesh"}]},{"sequence":"additional","family":"Islam","given":"Rajib","affiliation":[{"name":"Division of Infectious Diseases and Division of Computer-Aided Drug Design, The Red-Green Research Centre, BICCB, Tejgaon, Dhaka, Bangladesh"}]},{"sequence":"additional","family":"Hossain","given":"Md Nayeem","affiliation":[{"name":"Division of Infectious Diseases and Division of Computer-Aided Drug Design, The Red-Green Research Centre, BICCB, Tejgaon, Dhaka, Bangladesh"}]},{"sequence":"additional","family":"Mamun","given":"Abdulla Al","affiliation":[{"name":"Key Laboratory of Soft Chemistry and Functional Materials of MOE, Department of Chemical Engineering, Nanjing University of Science and Technology, Nanjing, China"}]},{"sequence":"additional","family":"Khan","given":"Maksud","affiliation":[{"name":"Division of Infectious Diseases and Division of Computer-Aided Drug Design, The Red-Green Research Centre, BICCB, Tejgaon, Dhaka, Bangladesh"}]},{"sequence":"additional","family":"Ali","given":"Md Ackas","affiliation":[{"name":"Division of Infectious Diseases and Division of Computer-Aided Drug Design, The Red-Green Research Centre, BICCB, Tejgaon, Dhaka, Bangladesh"}]},{"sequence":"additional","given":"Mohammad A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1698-7044","family":"Halim","affiliation":[{"name":"Division of Infectious Diseases and Division of Computer-Aided Drug Design, The Red-Green Research Centre, BICCB, Tejgaon, Dhaka, Bangladesh"},{"name":"Department of Physical Sciences, University of Arkansas-Fort Smith, Fort Smith, AR, USA"}]}],"DOI":"10.1080/07391102.2020.1794974","license-simplified":"no-cc","original-title":[],"title":["Virtual screening, molecular dynamics and structure–activity relationship studies to identify potent approved drugs for Covid-19 treatment"],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"subject":["Molecular Biology","Structural Biology","General Medicine"],"page":"1-11","type":"journal-article","issued":{"date-parts":[[2020,7,21]]},"publisher":"Informa UK Limited","id":"024y5k72","reference-count":40,"pmcid":"PMC7441776","has_valid_oa_url":true,"deposited":{"timestamp":1616744997000,"date-time":"2021-03-26T07:49:57Z","date-parts":[[2021,3,26]]},"indexed":{"timestamp":1616746427450,"date-time":"2021-03-26T08:13:47Z","date-parts":[[2021,3,26]]},"is-referenced-by-count":8,"short-container-title":["Journal of Biomolecular Structure and Dynamics"],"prefix":"10.1080","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/d1/0f/PMC7441776.tar.gz","has_valid_thumbnail":false,"ISSN":["0739-1102","1538-0254"],"references-count":40,"published-online":{"date-parts":[[2020,7,21]]},"subtitle":[],"URL":"http://dx.doi.org/10.1080/07391102.2020.1794974","short-title":[],"issn-type":[{"value":"0739-1102","type":"print"},{"value":"1538-0254","type":"electronic"}],"container-title":["Journal of Biomolecular Structure and Dynamics"],"score":1,"has_valid_ref_annotation":false,"member":"301","abstract":"Computer-aided drug screening by molecular docking, molecular dynamics (MD) and structural–activity relationship (SAR) can offer an efficient approach to identify promising drug repurposing candidates for COVID-19 treatment. In this study, computational screening is performed by molecular docking of 1615 Food and Drug Administration (FDA) approved drugs against the main protease (Mpro) of SARS-CoV-2. Several promising approved drugs, including Simeprevir, Ergotamine, Bromocriptine and Tadalafil, stand out as the best candidates based on their binding energy, fitting score and noncovalent interactions at the binding sites of the receptor. All selected drugs interact with the key active site residues, including His41 and Cys145. Various noncovalent interactions including hydrogen bonding, hydrophobic interactions, pi–sulfur and pi–pi interactions appear to be dominant in drug–Mpro complexes. MD simulations are applied for the most promising drugs. Structural stability and compactness are observed for the drug–Mpro complexes. The protein shows low flexibility in both apo and holo form during MD simulations. The MM/PBSA binding free energies are also measured for the selected drugs. For pattern recognition, structural similarity and binding energy prediction, multiple linear regression (MLR) models are used for the quantitative structural–activity relationship. The binding energy predicted by MLR model shows an 82% accuracy with the binding energy determined by molecular docking. Our details results can facilitate rational drug design targeting the SARS-CoV-2 main protease. Communicated by Ramaswamy H. 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  {"_key":"60c20cfb7723bebd866455ea","_id":"documents/60c20cfb7723bebd866455ea","_rev":"_cfFhBWi---","file_name":"024tqkcf.pdf","md5":"396398204FE57023A0135839C3796A8B","id":"024tqkcf","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/4t/qk/cf/024tqkcf/024tqkcf.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["601"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1615420800000,"date-time":"2021-03-11T00:00:00Z","date-parts":[[2021,3,11]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1615420800000,"date-time":"2021-03-11T00:00:00Z","date-parts":[[2021,3,11]]}}],"language":"en","pmid":"33727982","has_valid_tei":false,"DOI":"10.1007/s12145-021-00601-w","license-simplified":"no-cc","original-title":[],"short-container-title":["Earth Sci Inform"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"subject":["General Earth and Planetary Sciences"],"type":"journal-article","issued":{"date-parts":[[2021,3,11]]},"funder":[{"doi-asserted-by":"publisher","award":["LQ1602"],"DOI":"10.13039/501100001823","name":"Ministerstvo Školství, Mládeže a Tělovýchovy"}],"publisher":"Springer Science and Business Media LLC","id":"024tqkcf","reference-count":48,"pmcid":"PMC7951942","has_valid_oa_url":true,"deposited":{"timestamp":1615496921000,"date-time":"2021-03-11T21:08:41Z","date-parts":[[2021,3,11]]},"indexed":{"timestamp":1618020451039,"date-time":"2021-04-10T02:07:31Z","date-parts":[[2021,4,10]]},"is-referenced-by-count":1,"title":["A comprehensive social media data processing and analytics architecture by using big data platforms: a case study of twitter flood-risk messages"],"prefix":"10.1007","published-online":{"date-parts":[[2021,3,11]]},"has_valid_thumbnail":false,"references-count":48,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/ef/fb/PMC7951942.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s12145-021-00601-w","short-title":[],"issn-type":[{"value":"1865-0473","type":"print"},{"value":"1865-0481","type":"electronic"}],"container-title":["Earth Science Informatics"],"score":1,"has_valid_ref_annotation":false,"member":"297","abstract":"The main objective of the article is to propose an advanced architecture and workflow based on Apache Hadoop and Apache Spark big data platforms. The primary purpose of the presented architecture is collecting, storing, processing, and analysing intensive data from social media streams. This paper presents how the proposed architecture and data workflow can be applied to analyse Tweets with a specific flood topic. The secondary objective, trying to describe the flood alert situation by using only Tweet messages and exploring the informative potential of such data is demonstrated as well. The predictive machine learning approach based on Bayes Theorem was utilized to classify flood and no flood messages. For this study, approximately 100,000 Twitter messages were processed and analysed. Messages were related to the flooding domain and collected over a period of 5 days (14 May – 18 May 2018). Spark application was developed to run data processing commands automatically and to generate the appropriate output data. Results confirmed the advantages of many well-known features of Spark and Hadoop in social media data processing. It was noted that such technologies are prepared to deal with social media data streams, but there are still challenges that one has to take into account. Based on the flood tweet analysis, it was observed that Twitter messages with some considerations are informative enough to be used to estimate general flood alert situations in particular regions. Text analysis techniques proved that Twitter messages contain valuable flood-spatial information.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Michal","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8405-6658","family":"Podhoranyi","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s12145-021-00601-w.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s12145-021-00601-w/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s12145-021-00601-w.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1615492960000,"date-time":"2021-03-11T20:02:40Z","date-parts":[[2021,3,11]]},"ISSN":["1865-0473","1865-0481"],"assertion":[{"order":1,"value":"18 December 2020","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"1 March 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"11 March 2021","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"group":{"label":"Declarations","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The authors declare that they have no competing interests.","group":{"label":"Conflicts of interest/competing interests","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"cdcb0c56209a1b4588e3aa15397bdce973b5d425"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":23390},
  {"_key":"60c20cfb7723bebd86645629","_id":"documents/60c20cfb7723bebd86645629","_rev":"_cfFhBWq---","file_name":"025ab2mp.pdf","md5":"D306659C6FFFF62AA352A419D45F5576","id":"025ab2mp","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/5a/b2/mp/025ab2mp/025ab2mp.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["S0968090X20308524"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1614556800000,"date-time":"2021-03-01T00:00:00Z","date-parts":[[2021,3,1]]}}],"article-number":"102955","language":"en","volume":"124","pmid":"33456212","has_valid_tei":false,"DOI":"10.1016/j.trc.2020.102955","original-title":[],"published-print":{"date-parts":[[2021,3]]},"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","page":"102955","issued":{"date-parts":[[2021,3]]},"funder":[{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100000140","name":"U.S. Department of Transportation"}],"publisher":"Elsevier BV","id":"025ab2mp","reference-count":50,"title":["A big-data driven approach to analyzing and modeling human mobility trend under non-pharmaceutical interventions during COVID-19 pandemic"],"pmcid":"PMC7796660","has_valid_oa_url":true,"deposited":{"timestamp":1613850463000,"date-time":"2021-02-20T19:47:43Z","date-parts":[[2021,2,20]]},"indexed":{"timestamp":1613852307192,"date-time":"2021-02-20T20:18:27Z","date-parts":[[2021,2,20]]},"is-referenced-by-count":0,"short-container-title":["Transportation Research Part C: Emerging Technologies"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/cc/7e/PMC7796660.tar.gz","has_valid_thumbnail":false,"ISSN":["0968-090X"],"references-count":50,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.trc.2020.102955","short-title":[],"issn-type":[{"value":"0968-090X","type":"print"}],"container-title":["Transportation Research Part C: Emerging Technologies"],"score":1,"has_valid_ref_annotation":false,"member":"78","abstract":"During the unprecedented coronavirus disease 2019 (COVID-19) challenge, non-pharmaceutical interventions became a widely adopted strategy to limit physical movements and interactions to mitigate virus transmissions. For situational awareness and decision-support, quickly available yet accurate big-data analytics about human mobility and social distancing is invaluable to agencies and decision-makers. This paper presents a big-data-driven analytical framework that ingests terabytes of data on a daily basis and quantitatively assesses the human mobility trend during COVID-19. Using mobile device location data of over 150 million monthly active samples in the United States (U.S.), the study successfully measures human mobility with three main metrics at the county level: daily average number of trips per person; daily average person-miles traveled; and daily percentage of residents staying home. A set of generalized additive mixed models is employed to disentangle the policy effect on human mobility from other confounding effects including virus effect, socio-demographic effect, weather effect, industry effect, and spatiotemporal autocorrelation. Results reveal the policy plays a limited, time-decreasing, and region-specific effect on human movement. The stay-at-home orders only contribute to a 3.5%-7.9% decrease in human mobility, while the reopening guidelines lead to a 1.6%-5.2% mobility increase. Results also indicate a reasonable spatial heterogeneity among the U.S. counties, wherein the number of confirmed COVID-19 cases, income levels, industry structure, age and racial distribution play important roles. The data informatics generated by the framework are made available to the public for a timely understanding of mobility trends and policy effects, as well as for time-sensitive decision support to further contain the spread of the virus.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Hu","given":"Songhua","affiliation":[]},{"sequence":"additional","family":"Xiong","given":"Chenfeng","affiliation":[]},{"sequence":"additional","family":"Yang","given":"Mofeng","affiliation":[]},{"sequence":"additional","family":"Younes","given":"Hannah","affiliation":[]},{"sequence":"additional","family":"Luo","given":"Weiyu","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Lei","affiliation":[]}],"subject":["Automotive Engineering","Transportation","Computer Science Applications"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0968090X20308524?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0968090X20308524?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1610429700000,"date-time":"2021-01-12T05:35:00Z","date-parts":[[2021,1,12]]},"type":"journal-article","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"A big-data driven approach to analyzing and modeling human mobility trend under non-pharmaceutical interventions during COVID-19 pandemic","label":"Article Title","name":"articletitle"},{"value":"Transportation Research Part C: Emerging Technologies","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.trc.2020.102955","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2021 Elsevier Ltd. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"aea02d890a7e020cf6cd01ffb1540841a40b22f2"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":742.677,"page_height":544.252},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677},{"page_width":544.252,"page_height":742.677}],"runtime":18373},
  {"_key":"60c20cfc7723bebd86645632","_id":"documents/60c20cfc7723bebd86645632","_rev":"_cfFhBW2---","file_name":"025v6mh6.pdf","md5":"DD8465597AF65326683E8F7A0D64FE7F","id":"025v6mh6","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/5v/6m/h6/025v6mh6/025v6mh6.pdf","date":"2021-06-10T13:00+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2021,2,23]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2021.02.22.21252241","group-title":"Infectious Diseases (except HIV/AIDS)","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2021/02/23/2021.02.22.21252241.full.pdf","original-title":[],"title":["COVID-19 Spreading Dynamics in an Age-Structured Population with Selective Relaxation of Restrictions for Vaccinated Individuals : a Mathematical Modeling Study"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":37,"short-title":[],"issued":{"date-parts":[[2021,2,23]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2021,2,23]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Background. COVID-19 vaccination of healthcare and other essential workers is underway in many countries while immunization of the general public is expected to begin in the next several weeks. We consider the question of whether people who have received the vaccine can be selectively and immediately permitted to return to normal activities. Methods. We use a delay differential equation model to calculate the effects of vaccinee ``immunity passports'' on the epidemic spreading trajectories. The model incorporates age-structuring to account for children who are ineligible for vaccination, and senior citizens who are especially vulnerable to the disease. We consider consensus strains of virus as well as high-transmissibility variants such as B1.1.7 and B1.351 in our analysis. Results. We find that with high vaccine efficacy of 80 percent or greater, unrestricted vaccinee--vaccinee interactions do not derail the epidemic from a path towards elimination. Vaccinee--non-vaccinee interactions should however be treated with far more caution. At current vaccine administration rates, it may be the better part of a year before COVID-19 transmission is significantly reduced or ceased. With lower vaccine efficacy of approximately 60 percent, restrictions for vaccinees may need to remain in place until the elimination of the disease is achieved. In all cases, the death tolls can be reduced by vaccinating the vulnerable population first. Conclusions. Designing high-efficacy vaccines with easily scalable manufacturing and distribution capacity should remain on the priority list in academic as well as industrial circles. Performance of all vaccines should continue to be monitored in real time during vaccination drives with a view to analysing socio-demographic determinants of efficacy, if any, and optimizing distribution accordingly. A speedy and efficacious vaccination drive augmented with selective relaxations for vaccinees will provide the smoothest path out of the pandemic with the least additional caseloads, death tolls and socio-economic cost.","deposited":{"timestamp":1614353827000,"date-time":"2021-02-26T15:37:07Z","date-parts":[[2021,2,26]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"B","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2502-2268","family":"Shayak","affiliation":[]},{"sequence":"additional","given":"Mohit M","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-0091-5510","family":"Sharma","affiliation":[]},{"sequence":"additional","family":"Mishra","given":"Anand K","affiliation":[]}],"DOI":"10.1101/2021.02.22.21252241","reference-count":37,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2021.02.22.21252241","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1614113358000,"date-time":"2021-02-23T20:49:18Z","date-parts":[[2021,2,23]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"025v6mh6","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1614356114300,"date-time":"2021-02-26T16:15:14Z","date-parts":[[2021,2,26]]},"cord_sha":"e51399c0b2e25e5093ea18e87e70e172e6312c96"},"application":"software-mentions","pages":[{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92}],"runtime":17917},
  {"_key":"60c20d017723bebd86645634","_id":"documents/60c20d017723bebd86645634","_rev":"_cfFhBXC---","file_name":"0262bm3z.pdf","md5":"03D2BDE0D46BECDED4C9679532D4B2AE","id":"0262bm3z","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/62/bm/3z/0262bm3z/0262bm3z.pdf","date":"2021-06-10T13:00+0000","metadata":{"is-referenced-by-count":1,"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1167609600000,"date-time":"2007-01-01T00:00:00Z","date-parts":[[2007,1,1]]}}],"prefix":"10.1016","pmcid":"PMC7158280","subtitle":[],"license-simplified":"els-covid","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1016/b978-044453077-6/50008-9","references-count":65,"id":"0262bm3z","original-title":[],"short-container-title":[],"content-domain":{"domain":[],"crossmark-restriction":false},"page":"167-192","short-title":[],"issued":{"date-parts":[[2007]]},"container-title":["Lectins"],"has_valid_oa_url":true,"has_valid_ref_annotation":false,"publisher":"Elsevier","member":"78","abstract":"Publisher Summary Lectins can also be classified according to their binding specificity or selectivity with carbohydrates. This type of classification is helpful for selection of lectins as structural probes in biomedical applications. This chapter summarizes the concept and the updated information regarding the specificity-based lectin classification. Lectins are functionally classified based on their relative binding reactivities with the structural units of carbohydrate or glyco-epitopes. They are grouped according to their monosaccharide specificities and then further sub-grouped based on their reactivities with more complex structures. Carbohydrate specificities of biomedically important lectins are classified into six groups according to their specificities to monosaccharides. The chapter introduces a practical platform of carbohydrate microarrays that is useful for lectin characterization and classification. Finally, the chapter discusses a few examples to illustrate the application of this technology in lectin-related experimental investigations.","deposited":{"timestamp":1558430068000,"date-time":"2019-05-21T09:14:28Z","date-parts":[[2019,5,21]]},"published-print":{"date-parts":[[2007]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Wang","given":"Denong","affiliation":[]},{"sequence":"additional","family":"Wu","given":"Albert M.","affiliation":[]}],"DOI":"10.1016/b978-044453077-6/50008-9","reference-count":65,"title":["Carbohydrate Microarrays for Lectin Characterization and Glyco-Epitope Identification"],"ISBN":["9780444530776"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:B9780444530776500089?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:B9780444530776500089?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1247059870000,"date-time":"2009-07-08T13:31:10Z","date-parts":[[2009,7,8]]},"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/fe/73/PMC7158280.tar.gz","isbn-type":[{"value":"9780444530776","type":"print"}],"type":"book-chapter","score":1,"source":"Crossref","indexed":{"timestamp":1586833625449,"date-time":"2020-04-14T03:07:05Z","date-parts":[[2020,4,14]]},"cord_sha":"22ad89ce56ad3854bd07b0e695723b4f194581d9"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":680,"page_height":467},{"page_width":680,"page_height":467},{"page_width":680,"page_height":467},{"page_width":680,"page_height":467},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680},{"page_width":467,"page_height":680}],"runtime":11940},
  {"_key":"60c20d037723bebd8664563a","_id":"documents/60c20d037723bebd8664563a","_rev":"_cfFhBXO---","file_name":"0267pz15.pdf","md5":"7E8873479D00A8F3552FB8D8B7F0B4B2","id":"0267pz15","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/67/pz/15/0267pz15/0267pz15.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["S0022399907003091"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1201824000000,"date-time":"2008-02-01T00:00:00Z","date-parts":[[2008,2,1]]}}],"volume":"64","pmid":"18222131","has_valid_tei":false,"DOI":"10.1016/j.jpsychores.2007.07.015","original-title":[],"short-container-title":["Journal of Psychosomatic Research"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":41,"page":"177-183","type":"journal-article","issued":{"date-parts":[[2008,2]]},"publisher":"Elsevier BV","id":"0267pz15","short-title":[],"pmcid":"PMC7094601","has_valid_oa_url":true,"deposited":{"timestamp":1557229650000,"date-time":"2019-05-07T11:47:30Z","date-parts":[[2019,5,7]]},"indexed":{"timestamp":1618287131637,"date-time":"2021-04-13T04:12:11Z","date-parts":[[2021,4,13]]},"is-referenced-by-count":105,"title":["Impact on health care workers employed in high-risk areas during the Toronto SARS outbreak"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a4/dd/PMC7094601.tar.gz","has_valid_thumbnail":false,"ISSN":["0022-3999"],"references-count":41,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.jpsychores.2007.07.015","journal-issue":{"published-print":{"date-parts":[[2008,2]]},"issue":"2"},"issn-type":[{"value":"0022-3999","type":"print"}],"container-title":["Journal of Psychosomatic Research"],"has_valid_ref_annotation":false,"issue":"2","member":"78","abstract":"Abstract Background A number of publications focusing on health care workers (HCWs) during a severe acute respiratory syndrome (SARS) outbreak have suggested that HCWs experienced psychological distress, particularly increased levels of posttraumatic stress symptomatology (PTSS). Factors contributing to increased distress in HCWs working in high-risk areas treating patients with SARS have not been fully elucidated. The goal of this study was to quantify the psychological effects of working in a high-risk unit during the SARS outbreak. Methods HCWs in a Toronto hospital who worked in high-risk areas completed a questionnaire regarding their attitude toward the SARS crisis along with the Impact of Event Scale—Revised, which screens for PTSS. The comparison group consisted of clinical units that had no contact with patients infected with SARS. Results Factors that were identified to cause distress in the 248 respondent HCWs were the following: (a) perception of risk to themselves, (b) impact of the SARS crisis on their work life, (c) depressive affect, and (d) working in a high-risk unit. In addition, HCWs who cared for only one SARS patient in comparison to those caring for multiple SARS patients experienced more PTSS. Conclusions As expected, HCWs who were working in high-risk units experienced greater distress. Contrary to expectations, HCWs who experienced greater contact with SARS patients while working in the high-risk units were less distressed. This suggests that HCW experience in treating patients infected with SARS may be a mediating factor that could be amenable to intervention in future outbreaks.","published-print":{"date-parts":[[2008,2]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Styra","given":"Rima","affiliation":[]},{"sequence":"additional","family":"Hawryluck","given":"Laura","affiliation":[]},{"sequence":"additional","family":"Robinson","given":"Susan","affiliation":[]},{"sequence":"additional","family":"Kasapinovic","given":"Sonja","affiliation":[]},{"sequence":"additional","family":"Fones","given":"Calvin","affiliation":[]},{"sequence":"additional","family":"Gold","given":"Wayne L.","affiliation":[]}],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0022399907003091?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0022399907003091?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1201397501000,"date-time":"2008-01-27T01:31:41Z","date-parts":[[2008,1,27]]},"language":"en","score":1,"source":"Crossref","cord_sha":"4696f5b67a3c721e099958094a85220c09095b69"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":593.972,"page_height":792},{"page_width":593.972,"page_height":792},{"page_width":593.972,"page_height":792},{"page_width":593.972,"page_height":792},{"page_width":593.972,"page_height":792},{"page_width":593.972,"page_height":792},{"page_width":593.972,"page_height":792}],"runtime":7428},
  {"_key":"60c20d057723bebd8664563c","_id":"documents/60c20d057723bebd8664563c","_rev":"_cfFhBXa---","file_name":"026cf7v9.pdf","md5":"6830496A8927D1C222E82B72E88ED1D2","id":"026cf7v9","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/6c/f7/v9/026cf7v9/026cf7v9.pdf","date":"2021-06-10T13:00+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2021,1,19]]},"license-simplified":"biorxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2021.01.18.427217","group-title":"Neuroscience","oaLink":"https://www.biorxiv.org/content/biorxiv/early/2021/01/19/2021.01.18.427217.full.pdf","original-title":[],"title":["Autism Spectrum Disorder is a Risk Factor for PTSD-like Memory Formation"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":27,"short-title":[],"issued":{"date-parts":[[2021,1,19]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2021,1,19]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"The predisposition of Autism Spectrum Disorder (ASD) to Post-Traumatic Stress Disorder (PTSD) remained to be established. Here, we show that exposure to a single mild stressful event induces maladaptive memory, which recapitulates all features of PTSD, and is associated with the broad dysfunction of the prefrontal-hippocampo-amygdalar network. Using optogenetics, we demonstrate that prefrontal cortex hyperactivation triggers this PTSD-like memory. Finally, we show that recontextualization of the traumatic event normalizes maladaptive memory in ASD conditions. Overall, this study provides the first direct demonstration that ASD represents a risk factor for PTSD and uncovers new mechanisms that underlie pathological memory formation.","deposited":{"timestamp":1611248037000,"date-time":"2021-01-21T16:53:57Z","date-parts":[[2021,1,21]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"A.S.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6091-810X","family":"Al Abed","affiliation":[]},{"sequence":"additional","family":"Sellami","given":"A.","affiliation":[]},{"sequence":"additional","given":"A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-8893-278X","family":"Marighetto","affiliation":[]},{"sequence":"additional","given":"A.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1179-7161","family":"Desmedt","affiliation":[]},{"sequence":"additional","given":"N.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-7599-2866","family":"Dehorter","affiliation":[]}],"DOI":"10.1101/2021.01.18.427217","reference-count":27,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2021.01.18.427217","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1611118520000,"date-time":"2021-01-20T04:55:20Z","date-parts":[[2021,1,20]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"bioRxiv"},"id":"026cf7v9","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1611294097593,"date-time":"2021-01-22T05:41:37Z","date-parts":[[2021,1,22]]},"cord_sha":"eb269589033188907f7aaa96c6792ed6c3afc2c1"},"application":"software-mentions","pages":[{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92}],"runtime":8419},
  {"_key":"60c20d077723bebd8664563f","_id":"documents/60c20d077723bebd8664563f","_rev":"_cfFhBXm---","file_name":"026ujyk6.pdf","md5":"A352C980D102BA19F108D9AF30FCD260","id":"026ujyk6","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/6u/jy/k6/026ujyk6/026ujyk6.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["7"],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1122854400000,"date-time":"2005-08-01T00:00:00Z","date-parts":[[2005,8,1]]}}],"language":"en","volume":"10","pmid":"16091935","has_valid_tei":false,"DOI":"10.1007/s00775-005-0007-3","license-simplified":"no-cc","original-title":[],"short-container-title":["J Biol Inorg Chem"],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":67,"page":"529-538","type":"journal-article","issued":{"date-parts":[[2005,8]]},"publisher":"Springer Science and Business Media LLC","id":"026ujyk6","short-title":[],"pmcid":"PMC7087908","has_valid_oa_url":true,"deposited":{"timestamp":1584479923000,"date-time":"2020-03-17T21:18:43Z","date-parts":[[2020,3,17]]},"indexed":{"timestamp":1608642255287,"date-time":"2020-12-22T13:04:15Z","date-parts":[[2020,12,22]]},"is-referenced-by-count":65,"title":["Biophysical studies of a ruthenium(II) polypyridyl complex binding to DNA and RNA prove that nucleic acid structure has significant effects on binding behaviors"],"prefix":"10.1007","published-online":{"date-parts":[[2005,8,10]]},"has_valid_thumbnail":false,"references-count":67,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a9/e9/PMC7087908.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.1007/s00775-005-0007-3","ISSN":["0949-8257","1432-1327"],"issn-type":[{"value":"0949-8257","type":"print"},{"value":"1432-1327","type":"electronic"}],"subject":["Inorganic Chemistry","Biochemistry"],"container-title":["JBIC Journal of Biological Inorganic Chemistry"],"score":1,"has_valid_ref_annotation":false,"issue":"5","member":"297","abstract":"The interactions of a metal complex [Ru(phen)(2)PMIP](2+) {Ru=ruthenium, phen=1,10-phenanthroline, PMIP=2-(4-methylphenyl)imidazo[4,5-f]1,10-phenanthroline} with yeast tRNA and calf thymus DNA (CT DNA) have been investigated comparatively by UV-vis spectroscopy, fluorescence spectroscopy, viscosity measurements, isothermal titration calorimetry (ITC), as well as equilibrium dialysis and circular dichroism (CD). Spectroscopic studies together with ITC and viscosity measurements indicate that both binding modes of the Ru(II) polypyridyl complex to yeast tRNA and CT DNA are intercalation and yeast tRNA binding of the complex is stronger than CT DNA binding. ITC experiments show that the interaction of the complex with yeast tRNA is driven by a moderately favorable enthalpy decrease in combination with a moderately favorable entropy increase, while the binding of the complex to CT DNA is driven by a large favorable enthalpy decrease with a less favorable entropy increase. The results from equilibrium dialysis and CD suggest that both interactions are enantioselective and the Δ enantiomer of the complex may bind more favorably to both yeast tRNA and CT DNA than the Λ enantiomer does, and that the complex is a better candidate for an enantioselective binder to yeast tRNA than to CT DNA. Taken together, these results indicate that the structures of nucleic acids have significant effects on the binding behaviors of metal complexes.","published-print":{"date-parts":[[2005,8]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Xu","given":"Hong","affiliation":[]},{"sequence":"additional","family":"Liang","given":"Yi","affiliation":[]},{"sequence":"additional","family":"Zhang","given":"Peng","affiliation":[]},{"sequence":"additional","family":"Du","given":"Fen","affiliation":[]},{"sequence":"additional","family":"Zhou","given":"Bing-Rui","affiliation":[]},{"sequence":"additional","family":"Wu","given":"Jun","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Jian-Hong","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Zhi-Gang","affiliation":[]},{"sequence":"additional","family":"Ji","given":"Liang-Nian","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s00775-005-0007-3.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s00775-005-0007-3/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00775-005-0007-3","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00775-005-0007-3.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1123585655000,"date-time":"2005-08-09T11:07:35Z","date-parts":[[2005,8,9]]},"journal-issue":{"published-print":{"date-parts":[[2005,8]]},"issue":"5"},"assertion":[{"order":1,"value":"21 January 2005","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"3 July 2005","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"10 August 2005","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785},{"page_width":595,"page_height":785}],"runtime":10073},
  {"_key":"60c20d0b7723bebd86645641","_id":"documents/60c20d0b7723bebd86645641","_rev":"_cfFhBXy---","file_name":"027twgah.pdf","md5":"B9917D84E00CD5DEFE41EBE3B3A46690","id":"027twgah","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/7t/wg/ah/027twgah/027twgah.pdf","date":"2021-06-10T13:00+0000","metadata":{"alternative-id":["S019096222030517X"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1598918400000,"date-time":"2020-09-01T00:00:00Z","date-parts":[[2020,9,1]]}}],"language":"en","volume":"83","pmid":"32277971","has_valid_tei":false,"created":{"timestamp":1586360198000,"date-time":"2020-04-08T15:36:38Z","date-parts":[[2020,4,8]]},"DOI":"10.1016/j.jaad.2020.03.094","original-title":[],"short-container-title":["Journal of the American Academy of Dermatology"],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","jaad.org","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Dermatology"],"page":"854-859","type":"journal-article","issued":{"date-parts":[[2020,9]]},"publisher":"Elsevier BV","id":"027twgah","short-title":[],"pmcid":"PMC7141633","has_valid_oa_url":true,"deposited":{"timestamp":1597829336000,"date-time":"2020-08-19T09:28:56Z","date-parts":[[2020,8,19]]},"indexed":{"timestamp":1611284650749,"date-time":"2021-01-22T03:04:10Z","date-parts":[[2021,1,22]]},"is-referenced-by-count":4,"title":["Racial differences in time to treatment for melanoma"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/e7/c6/PMC7141633.tar.gz","has_valid_thumbnail":false,"references-count":25,"license-simplified":"els-covid","subtitle":[],"reference-count":25,"ISSN":["0190-9622"],"issn-type":[{"value":"0190-9622","type":"print"}],"container-title":["Journal of the American Academy of Dermatology"],"score":1,"has_valid_ref_annotation":false,"issue":"3","member":"78","abstract":"Abstract Background Longer time from diagnosis to definitive surgery (TTDS) is associated with increased melanoma-specific mortality. Although Black patients present with later stage melanoma and have worse survival than non-Hispanic white (NHW) patients, the association between race and TTDS is unknown. Objective To investigate racial differences in time to melanoma treatment. Methods Retrospective review of the National Cancer Database (2004-2015). Multivariable logistic regression was used to evaluate the association of race with TTDS controlling for sociodemographic/disease characteristics. Results Of the 233,982 melanoma patients identified, 1,221 (0.52%) were Black. Black patients had longer TTDS for stage I-III melanoma (p<0.001) and time to immunotherapy (p=0.01), but not for TTDS for stage IV melanoma or time to chemotherapy (p>0.05 for both). Controlling for sociodemographic characteristics, Black patients had over twice the odds of having TTDS between 41-60 days, over three times the odds of having TTDS between 61-90 days, and over five times the odds of having TTDS over 90 days. Racial differences in TTDS persisted within each insurance type. Patients with Medicaid had the longest TTDS (mean 60.4 days), and those with private insurance had the shortest TTDS (mean 44.6 days; p<0.001 for both). Conclusions Targeted approaches to improve TTDS for Black patients are integral in reducing racial disparities in melanoma outcomes.","published-print":{"date-parts":[[2020,9]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Tripathi","given":"Raghav","affiliation":[]},{"sequence":"additional","family":"Archibald","given":"Laura K.","affiliation":[]},{"sequence":"additional","family":"Mazmudar","given":"Rishabh S.","affiliation":[]},{"sequence":"additional","family":"Conic","given":"Rosalynn R.Z.","affiliation":[]},{"sequence":"additional","family":"Rothermel","given":"Luke D.","affiliation":[]},{"sequence":"additional","family":"Scott","given":"Jeffrey F.","affiliation":[]},{"sequence":"additional","family":"Bordeaux","given":"Jeremy S.","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S019096222030517X?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S019096222030517X?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1016/j.jaad.2020.03.094","journal-issue":{"published-print":{"date-parts":[[2020,9]]},"issue":"3"},"assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Racial differences in time to treatment for melanoma","label":"Article Title","name":"articletitle"},{"value":"Journal of the American Academy of Dermatology","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.jaad.2020.03.094","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 by the American Academy of Dermatology, Inc.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"3028e5ac8d6858dd81cf20fae61fbe38a4dc5e37"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986},{"page_width":584.957,"page_height":782.986}],"runtime":7953},
  {"_key":"60c20d0f7723bebd86645642","_id":"documents/60c20d0f7723bebd86645642","_rev":"_cfFhBY----","file_name":"027ya5ky.pdf","md5":"B5FBEB2F30AFDC0D136A7F83207E3AB1","id":"027ya5ky","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/7y/a5/ky/027ya5ky/027ya5ky.pdf","date":"2021-06-10T13:01+0000","metadata":{"is-referenced-by-count":0,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,9,9]]},"license-simplified":"biorxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.09.09.290247","group-title":"Bioinformatics","oaLink":"https://www.biorxiv.org/content/biorxiv/early/2020/09/10/2020.09.09.290247.full.pdf","original-title":[],"title":["rSWeeP: A R/Bioconductor package deal with SWeeP sequences representation"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":9,"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,9,10]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"The rSWeeP package is an R implementation of the SWeeP model, designed to handle Big Data. rSweeP meets to the growing demand for efficient methods of heuristic representation in the field of Bioinformatics, on platforms accessible to the entire scientific community. We explored the implementation of rSWeeP using a dataset containing 31,386 viral proteomes, performing phylogenetic and principal component analysis. As a case study we analyze the viral strains closest to the SARS-CoV, responsible for the current pandemic of COVID-19, confirming that rSWeeP can accurately classify organisms taxonomically. rSWeeP package is freely available at https://bioconductor.org/packages/release/bioc/html/rSWeeP.html.","deposited":{"timestamp":1599939920000,"date-time":"2020-09-12T19:45:20Z","date-parts":[[2020,9,12]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Fernandes","given":"Danrley","affiliation":[]},{"sequence":"additional","family":"Kulik","given":"Mariane G.","affiliation":[]},{"sequence":"additional","family":"Machado","given":"Diogo J. S.","affiliation":[]},{"sequence":"additional","given":"Jeroniza N.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-5176-7055","family":"Marchaukoski","affiliation":[]},{"sequence":"additional","given":"Fabio O.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3711-969X","family":"Pedrosa","affiliation":[]},{"sequence":"additional","given":"Camilla R.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6114-1734","family":"De Pierri","affiliation":[]},{"sequence":"additional","given":"Roberto T.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-5271-991X","family":"Raittz","affiliation":[]}],"DOI":"10.1101/2020.09.09.290247","reference-count":9,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.09.09.290247","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1599760510000,"date-time":"2020-09-10T17:55:10Z","date-parts":[[2020,9,10]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"bioRxiv"},"id":"027ya5ky","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1599941516721,"date-time":"2020-09-12T20:11:56Z","date-parts":[[2020,9,12]]},"cord_sha":"4b3443fe3689e65a637843c68864136834c6317f"},"application":"software-mentions","pages":[{"page_width":468,"page_height":720},{"page_width":468,"page_height":720},{"page_width":468,"page_height":720},{"page_width":468,"page_height":720},{"page_width":468,"page_height":720},{"page_width":468,"page_height":720},{"page_width":468,"page_height":720},{"page_width":2049.67,"page_height":1243.4}],"runtime":11787},
  {"_key":"60c20d157723bebd8664565a","_id":"documents/60c20d157723bebd8664565a","_rev":"_cfFhBYG---","file_name":"029hqc82.pdf","md5":"EA990626B9434B3C67EC158AEEC373A3","id":"029hqc82","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/9h/qc/82/029hqc82/029hqc82.pdf","date":"2021-06-10T13:01+0000","metadata":{"published-print":{"date-parts":[[2015]]},"language":"en","volume":"77","pmid":"25716289","author":[{"sequence":"first","family":"ALFRED","given":"Niyokwishimira","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"LIU","given":"Huan","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"LI","given":"Mu Lan","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"HONG","given":"Shao Feng","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"TANG","given":"Hai Bo","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"WEI","given":"Zu Zhang","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"CHEN","given":"Ying","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"LI","given":"Fa Kai","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"ZHONG","given":"Yi Zhi","affiliation":[{"name":"State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]},{"sequence":"additional","family":"HUANG","given":"Wei Jian","affiliation":[{"name":"Laboratory of Animal Infectious Diseases Prevention and Molecular Immunology, Guangxi University, Daxue Road 100, Nanning, Guangxi 530004, China"}]}],"DOI":"10.1292/jvms.14-0252","original-title":[],"short-container-title":["The Journal of Veterinary Medical Science","J. Vet. Med. Sci."],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":28,"page":"643-651","type":"journal-article","issued":{"date-parts":[[2015]]},"publisher":"Japanese Society of Veterinary Science","id":"029hqc82","short-title":[],"pmcid":"PMC4488400","has_valid_oa_url":true,"deposited":{"timestamp":1598745048000,"date-time":"2020-08-29T23:50:48Z","date-parts":[[2020,8,29]]},"indexed":{"timestamp":1598746220817,"date-time":"2020-08-30T00:10:20Z","date-parts":[[2020,8,30]]},"is-referenced-by-count":9,"title":["Molecular epidemiology and phylogenetic analysis of diverse bovine astroviruses associated with diarrhea in cattle and water buffalo calves in China"],"prefix":"10.1292","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/38/14/PMC4488400.tar.gz","has_valid_thumbnail":false,"references-count":28,"license-simplified":"cc-by-nc-nd","subtitle":[],"URL":"http://dx.doi.org/10.1292/jvms.14-0252","ISSN":["0916-7250","1347-7439"],"issn-type":[{"value":"0916-7250","type":"print"},{"value":"1347-7439","type":"electronic"}],"container-title":["Journal of Veterinary Medical Science"],"has_valid_ref_annotation":false,"issue":"6","member":"122","abstract":"Astroviruses are the principal causative agents of gastroenteritis in humans and have been associated with diarrhea in other mammals as well as birds. However, astroviral infection of animals had been poorly studied. In the present study, 211 rectal swabs collected from cattle and water buffalo calves with mild to severe diarrhea were tested for bovine astrovirus (BAstV) by RT-PCR. Results: 92/211 (43.6%) samples were positive for BAstV, at a rate of 46.10% (71/154) in cattle and 36.84% (21/57) in water buffalo. Phylogenetic analysis based on the partial and full-length of 25 ORF2 amino acid sequences obtained in this study classified the Guangxi BAstVs isolates into five subgroups under the genus of Mamastrovirus, genotype MAstV33, which suggested that the water buffalo was a new host of this genogroup that previously included only cattle and roe deer. Despite the origin of the host, the Guangxi BAstV isolates were closely related to the BAstV Hong Kong isolates (B18/HK and B76-2/HK), but highly divergent from the BAstV NeuroS1 isolate previously associated with neurologic disease in cattle in the U.S.A. Nucleotide sequence-based characterization of the ORF1b/ORF2 junction and corresponding overlapping regions showed distinctive properties, which may be common to BAstVs. Our results suggested that cattle and water buffalo are prone to infection of closely related astroviruses, which probably evolved from the same ancestor. The current study described astroviruses in water buffalo for the first time and is thus far among the largest epidemiological investigations of BAstV infection in cattle conducted in China.","has_valid_pdf":true,"has_valid_tei":false,"subject":["General Veterinary"],"relation":{},"created":{"timestamp":1423778589000,"date-time":"2015-02-12T22:03:09Z","date-parts":[[2015,2,12]]},"journal-issue":{"published-print":{"date-parts":[[2015]]},"issue":"6"},"score":1,"source":"Crossref","cord_sha":"0a296d80d8a8c0408c1ea9559c0f0589fb35cb03"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":10727},
  {"_key":"60c20d177723bebd86645662","_id":"documents/60c20d177723bebd86645662","_rev":"_cfFhBYS---","file_name":"029u9uwm.pdf","md5":"37A4D1C5DD313E91BC955848A68DC1D9","id":"029u9uwm","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/9u/9u/wm/029u9uwm/029u9uwm.pdf","date":"2021-06-10T13:01+0000","metadata":{"license":[{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1524614400000,"date-time":"2018-04-25T00:00:00Z","date-parts":[[2018,4,25]]}},{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","content-version":"vor","delay-in-days":0,"start":{"timestamp":1524614400000,"date-time":"2018-04-25T00:00:00Z","date-parts":[[2018,4,25]]}}],"volume":"31","pmid":"29696697","journal-issue":{"published-print":{"date-parts":[[2018,10]]},"issue":"5"},"has_valid_tei":false,"URL":"http://dx.doi.org/10.1111/joic.12513","id":"029u9uwm","original-title":[],"short-container-title":["J Interven Cardiol"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":10,"page":"685-692","type":"journal-article","issued":{"date-parts":[[2018,4,25]]},"publisher":"Wiley","DOI":"10.1111/joic.12513","short-title":[],"oaLink":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/joic.12513","has_valid_oa_url":true,"deposited":{"timestamp":1537781866000,"date-time":"2018-09-24T09:37:46Z","date-parts":[[2018,9,24]]},"indexed":{"timestamp":1594320222742,"date-time":"2020-07-09T18:43:42Z","date-parts":[[2020,7,9]]},"is-referenced-by-count":3,"title":["A novel double snare technique to retrieve embolized septal and left atrial appendage occluders"],"prefix":"10.1111","license-simplified":"cc-by-nc-nd","has_valid_thumbnail":false,"references-count":10,"published-online":{"date-parts":[[2018,4,25]]},"subtitle":[],"has_valid_ref_annotation":false,"ISSN":["0896-4327"],"issn-type":[{"value":"0896-4327","type":"print"}],"container-title":["Journal of Interventional Cardiology"],"archive":["Portico"],"issue":"5","member":"311","abstract":"BACKGROUND Device embolization is the most frequent procedural complication during transcatheter closure of congenital cardiac defects. Retrieval of an embolized device may often be complicated by failure to introduce the right atrial (RA) disk hub into the sheath or difficulty in securely grasping the hub pin of RA disk. We aimed to evaluate the efficiency and success rate of device retrieval using a novel double snare technique. METHODS We reviewed retrieval procedures of embolized atrial septal defect (ASD) or left atrial appendage (LAA) occluder using double snare technique reported from five tertiary referral centers in Korea, Japan, and Uzbekistan. A total of 16 retrieval procedures in 15 patients were reported, including 14 patients who were planned for ASD device closure while 1 patient was planned for LA appendage occlusion. RESULTS Retrieved devices included 15 ASD occluders from six different manufacturers and one Amplantzer cardiac plug. Success rate of retrieval procedure was 100% using the double snare technique. There were no complications related to device retrieval. Most (15/16, 93.8%) of these devices could be retrieved through their original delivery sheaths. In six patients for whom retrieval was unsuccessful with conventional single snare technique and switched to double snare technique, the retrieval time was shortened significantly (P = 0.004*) by using the double snare technique. CONCLUSIONS The double snare technique enables effective retrieval of various embolized devices. It abolishes the need of changing the sheath to a larger one in most patients.","published-print":{"date-parts":[[2018,10]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Kee Soo","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6753-5411","family":"Ha","affiliation":[{"name":"Department of Pediatrics; College of Medicine; Korea University; Seoul Republic of Korea"}]},{"sequence":"additional","given":"Jae Young","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1247-6669","family":"Choi","affiliation":[{"name":"Division of Pediatric Cardiology; Severance Cardiovascular Hospital; Yonsei University College of Medicine; Seoul Republic of Korea"}]},{"sequence":"additional","family":"Jung","given":"Se Yong","affiliation":[{"name":"Division of Pediatric Cardiology; Severance Cardiovascular Hospital; Yonsei University College of Medicine; Seoul Republic of Korea"}]},{"sequence":"additional","family":"Kim","given":"Jung-Sun","affiliation":[{"name":"Division of Cardiology; Severance Cardiovascular Hospital; Yonsei University College of Medicine; Seoul Republic of Korea"}]},{"sequence":"additional","family":"Byun","given":"Ki Hyun","affiliation":[{"name":"Division of Cardiology; Good Morning General Hospital; Pyungtaek Gyeonggi-do Republic of Korea"}]},{"sequence":"additional","family":"Akagi","given":"Teiji","affiliation":[{"name":"Adult Congenital Heart Disease Center; Okayama University Hospital; Okayama Japan"}]},{"sequence":"additional","family":"Zufarov","given":"Mirjamol M.","affiliation":[{"name":"Department of Interventional Cardiology and Cardiac Arrhythmias; Republican Specialized Center of Surgery Named After V. Vakhidov; Tashkent Republic of Uzbekistan"}]}],"link":[{"URL":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fjoic.12513","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://onlinelibrary.wiley.com/wol1/doi/10.1111/joic.12513/fullpdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1524712605000,"date-time":"2018-04-26T03:16:45Z","date-parts":[[2018,4,26]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362},{"page_width":595.276,"page_height":782.362}],"runtime":7988},
  {"_key":"60c20d197723bebd86645664","_id":"documents/60c20d197723bebd86645664","_rev":"_cfFhBYi---","file_name":"029tipqh.pdf","md5":"04F01BB95CC7515CC63CCA4362A10202","id":"029tipqh","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/9t/ip/qh/029tipqh/029tipqh.pdf","date":"2021-06-10T13:01+0000","metadata":{"alternative-id":["S0148296320303222"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1596240000000,"date-time":"2020-08-01T00:00:00Z","date-parts":[[2020,8,1]]}}],"volume":"116","pmid":"32501306","has_valid_tei":false,"DOI":"10.1016/j.jbusres.2020.05.025","short-title":[],"original-title":[],"published-print":{"date-parts":[[2020,8]]},"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"subject":["Marketing"],"page":"199-208","issued":{"date-parts":[[2020,8]]},"publisher":"Elsevier BV","id":"029tipqh","reference-count":89,"title":["Masters of disasters? Challenges and opportunities for SMEs in times of crisis"],"pmcid":"PMC7247971","has_valid_oa_url":true,"deposited":{"timestamp":1592340149000,"date-time":"2020-06-16T20:42:29Z","date-parts":[[2020,6,16]]},"indexed":{"timestamp":1617955994725,"date-time":"2021-04-09T08:13:14Z","date-parts":[[2021,4,9]]},"is-referenced-by-count":39,"short-container-title":["Journal of Business Research"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/cb/5e/PMC7247971.tar.gz","has_valid_thumbnail":false,"ISSN":["0148-2963"],"references-count":89,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.jbusres.2020.05.025","type":"journal-article","issn-type":[{"value":"0148-2963","type":"print"}],"container-title":["Journal of Business Research"],"score":1,"has_valid_ref_annotation":false,"member":"78","abstract":"Small and medium-sized enterprises (SMEs) are the backbone of every economy. So, when an external crisis jeopardizes markets, such as the recent COVID-19 outbreak, SMEs are hit with great force. Their so-called liability of smallness, a lack of resources that would shield them from outside shocks, worsens the situation. This manuscript conducts a literature study on 69 manuscripts that studied SMEs in previous crises and proposes ways to overcome economic downturns in the areas of finance, strategy and the institutional environment. The paper finds a “strategy/funding chicken-and-egg-problem” and proposes an effectual world view when dealing with situations of great uncertainty.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Eggers","given":"Fabian","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1016/elsevier_cm_policy","link":[{"URL":"https://api.elsevier.com/content/article/PII:S0148296320303222?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0148296320303222?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1590463841000,"date-time":"2020-05-26T03:30:41Z","date-parts":[[2020,5,26]]},"language":"en","assertion":[{"value":"Elsevier","label":"This article is maintained by","name":"publisher"},{"value":"Masters of disasters? Challenges and opportunities for SMEs in times of crisis","label":"Article Title","name":"articletitle"},{"value":"Journal of Business Research","label":"Journal Title","name":"journaltitle"},{"value":"https://doi.org/10.1016/j.jbusres.2020.05.025","label":"CrossRef DOI link to publisher maintained version","name":"articlelink"},{"value":"article","label":"Content Type","name":"content_type"},{"value":"© 2020 Elsevier Inc. All rights reserved.","label":"Copyright","name":"copyright"}],"source":"Crossref","cord_sha":"e959a9ca78f768f4dea79d408ed638afce4fb861"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":10199},
  {"_key":"60c20d1b7723bebd86645666","_id":"documents/60c20d1b7723bebd86645666","_rev":"_cfFhBYu---","file_name":"02a1hekf.pdf","md5":"42721CFC861A115035715354E9ECF67E","id":"02a1hekf","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/a1/he/kf/02a1hekf/02a1hekf.pdf","date":"2021-06-10T13:01+0000","metadata":{"alternative-id":["1774"],"published-print":{"date-parts":[[2018,12]]},"article-number":"201","language":"en","volume":"18","pmid":"29914413","journal-issue":{"published-print":{"date-parts":[[2018,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1186/s12888-018-1774-z","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1529280000000,"date-time":"2018-06-18T00:00:00Z","date-parts":[[2018,6,18]]}},{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1529280000000,"date-time":"2018-06-18T00:00:00Z","date-parts":[[2018,6,18]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","type":"journal-article","issued":{"date-parts":[[2018,6,18]]},"funder":[{"doi-asserted-by":"crossref","award":[],"DOI":"10.13039/100004441","name":"Styrelsen för Internationellt Utvecklingssamarbete"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100000278","name":"Department for International Development, UK Government"},{"doi-asserted-by":"crossref","award":[],"DOI":"10.13039/501100000780","name":"European Commission"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100009099","name":"Irish Aid"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100000009","name":"Foundation for the National Institutes of Health"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100009131","name":"Direktion für Entwicklung und Zusammenarbeit"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100000200","name":"United States Agency for International Development"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100000778","name":"U.S. Department of Labor"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/100006641","name":"UNICEF"},{"award":[],"name":"3ie-International Initiative for Impact Evaluation"},{"award":[],"name":"KfW Development Bank"},{"award":[],"name":"American World Jewish Services"}],"publisher":"Springer Science and Business Media LLC","id":"02a1hekf","reference-count":50,"title":["Examination of performance of the Center for Epidemiologic Studies Depression Scale Short Form 10 among African youth in poor, rural households"],"oaLink":"https://bmcpsychiatry.biomedcentral.com/track/pdf/10.1186/s12888-018-1774-z","has_valid_oa_url":true,"deposited":{"timestamp":1589475363000,"date-time":"2020-05-14T16:56:03Z","date-parts":[[2020,5,14]]},"indexed":{"timestamp":1617090349421,"date-time":"2021-03-30T07:45:49Z","date-parts":[[2021,3,30]]},"is-referenced-by-count":23,"short-container-title":["BMC Psychiatry"],"prefix":"10.1186","published-online":{"date-parts":[[2018,6,18]]},"has_valid_thumbnail":false,"references-count":50,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s12888-018-1774-z","short-title":[],"issn-type":[{"value":"1471-244X","type":"electronic"}],"container-title":["BMC Psychiatry"],"score":1,"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND Youth mental health has emerged as a pressing global issue. However, to advance research gaps in low-income settings, we need valid measures of common mental health disorders. Using primary data collected in five countries (Kenya, Malawi, Tanzania, Zambia, and Zimbabwe), this study aims to assess the psychometric properties of the commonly used 10-item Center for Epidemiological Studies Depression (CES-D 10) scale among poor, disadvantaged youth populations in sub-Saharan African (SSA). METHODS Youth samples from each country (sample sizes ranging from 651 to 2098) come from large household surveys with youth modules, collected for impact evaluations of cash transfer programs targeted to poor families. For each sample, we assessed internal consistency (alpha), conducted factor analysis, and then examined construct validity and measurement invariance. We performed both exploratory (EFA) and confirmatory factor analysis (CFA) to examine and confirm the structure of the CES-D 10 for each country and then used multigroup CFA to assess measurement invariance across gender and age. Multivariate analyses were conducted to assess construct validity via test of the relationship between CES-D 10 and background characteristics. RESULTS Results show the CES-D 10 had strong psychometric properties and was a reliable measure of depressive symptoms among disadvantaged youth in SSA. Across countries, there was high internal consistency (Cronbach alphas = 0.70-0.76) and the traditional two-factor solution showed good model fit. Full measurement invariance of the CES-D 10 was supported across gender. Consistent with previous literature on risk factors for depressive symptoms, the CES-D 10 was associated with increasing age, and female gender and being out of school in some locations. CONCLUSIONS Results from this study support broad use of the CES-D 10 among poor youth populations in SSA. Between one-third and two-thirds of our samples demonstrated depressive symptoms as classified by recommended cut-offs for the CES-D 10, indicating a high burden of mental illness in disadvantaged youth populations. This tool can be used in future efforts to study prevalence and dynamics of depressive symptoms in this population, as well as effectiveness of policies and interventions to improve the mental health of youth in SSA.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Kelly","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-3069-3958","family":"Kilburn","affiliation":[]},{"sequence":"additional","family":"Prencipe","given":"Leah","affiliation":[]},{"sequence":"additional","family":"Hjelm","given":"Lisa","affiliation":[]},{"sequence":"additional","family":"Peterman","given":"Amber","affiliation":[]},{"sequence":"additional","family":"Handa","given":"Sudhanshu","affiliation":[]},{"sequence":"additional","family":"Palermo","given":"Tia","affiliation":[]}],"subject":["Psychiatry and Mental health"],"link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s12888-018-1774-z.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s12888-018-1774-z/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s12888-018-1774-z.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1529329074000,"date-time":"2018-06-18T13:37:54Z","date-parts":[[2018,6,18]]},"ISSN":["1471-244X"],"assertion":[{"order":1,"value":"2 October 2017","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"5 June 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"18 June 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"All studies were submitted to local institutional review board (IRB) for ethical clearance.Kenya: The University of North Carolina at Chapel Hill IRB and the Kenya Medical Research Institute Ethics Review Committee.Malawi: The University of North Carolina at Chapel Hill IRB, Malawi’s National Commission for Science and Technology (NCST), and National Committee for Research in Social Sciences and Humanities.Tanzania: Tanzania’s Commission for Science and Technology (COSTECH).Zambia: American Institute for Research IRB and the University of Zambia’s Research Ethics Committee.Zimbabwe: American Institute for Research IRB and the Medical Research Council of Zimbabwe.Written consent to participate was obtained in Kenya and Tanzania and verbal consent in Malawi, Zambia, and Zimbabwe where enumerators signed forms documenting that consent was asked and received. Verbal consent was given ethical approval in these settings as available data indicated that a large proportion of our main respondent sample would be illiterate and thus unable to read and sign a consent form.","group":{"label":"Ethics approval and consent to participate","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The authors declare that they have no competing interests.","group":{"label":"Competing interests","name":"EthicsHeading"},"name":"Ethics"},{"order":3,"value":"Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.","group":{"label":"Publisher’s Note","name":"EthicsHeading"},"name":"Ethics"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":11850},
  {"_key":"60c20d217723bebd86645668","_id":"documents/60c20d217723bebd86645668","_rev":"_cfFhBY2---","file_name":"02b714lm.pdf","md5":"D2CA1F53733A10EB3CC7EBEDB31C8DFC","id":"02b714lm","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/b7/14/lm/02b714lm/02b714lm.pdf","date":"2021-06-10T13:01+0000","metadata":{"alternative-id":["10.1080/15459624.2017.1358817"],"published-print":{"date-parts":[[2017,12,2]]},"volume":"14","pmid":"28763290","has_valid_tei":false,"DOI":"10.1080/15459624.2017.1358817","short-title":[],"original-title":[],"title":["Powered air-purifying respirator use in healthcare: Effects on thermal sensations and comfort"],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.1080/tandf_crossmark_01","page":"947-954","type":"journal-article","issued":{"date-parts":[[2017,8]]},"publisher":"Informa UK Limited","id":"02b714lm","reference-count":22,"has_valid_oa_url":true,"deposited":{"timestamp":1512581678000,"date-time":"2017-12-06T17:34:38Z","date-parts":[[2017,12,6]]},"indexed":{"timestamp":1613953439360,"date-time":"2021-02-22T00:23:59Z","date-parts":[[2021,2,22]]},"is-referenced-by-count":17,"published-online":{"date-parts":[[2017,8]]},"short-container-title":["Journal of Occupational and Environmental Hygiene"],"prefix":"10.1080","oaLink":"http://europepmc.org/articles/pmc6198805?pdf=render","has_valid_thumbnail":false,"ISSN":["1545-9624","1545-9632"],"references-count":22,"license-simplified":"unk","subtitle":[],"URL":"http://dx.doi.org/10.1080/15459624.2017.1358817","journal-issue":{"published-print":{"date-parts":[[2017,12,2]]},"issue":"12","published-online":{"date-parts":[[2017,8]]}},"issn-type":[{"value":"1545-9624","type":"print"},{"value":"1545-9632","type":"electronic"}],"container-title":["Journal of Occupational and Environmental Hygiene"],"score":1,"has_valid_ref_annotation":false,"issue":"12","member":"301","abstract":"Twelve subjects wore an N95 filtering facepiece respirator (N95 FFR), one tight-fitting full facepiece powered air-purifying respirator (PAPR), two loose-fitting PAPRs, and one elastomeric/PAPR hybrid for 1 hr each during treadmill walking at 5.6 km/hr while undergoing physiological and subjective response monitoring. No significant interaction (p ≥ .05) was noted between the five respirators in heart rate, respiratory rate, oxygen saturation, transcutaneous carbon dioxide, and perceptions of breathing effort or discomfort, exertion, facial heat, and overall body heat. Respirator deadspace heat/humidity were significantly greater for the N95 FFR, whereas tympanic forehead skin temperatures were significantly greater for the hybrid PAPR. Temperature of the facial skin covered by the respirator was equivalent for the N95 FFR and hybrid PAPR, and both were significantly higher than for the other three PAPRs. Perception of eye dryness was significantly greater for a tight-fitting full facepiece PAPR than the N95 FFR and hybrid PAPR. At a low-moderate work rate over 1 hr, effects on cardiopulmonary variables, breathing perceptions, and facial and overall body heat perceptions did not differ significantly between the four PAPRs and a N95 FFR, but the tight-fitting, full facepiece PAPR increased perceptions of eye dryness. The two loose-fitting PAPRs and the full facepiece tight-fitting PAPR ameliorated exercise-induced increases in facial temperature, but this did not translate to improved perception of facial heat and overall body heat.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Powell","given":"Jeffrey B.","affiliation":[{"name":"National Institute for Occupational Safety and Health/National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania"}]},{"sequence":"additional","family":"Kim","given":"Jung-Hyun","affiliation":[{"name":"National Institute for Occupational Safety and Health/National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania"}]},{"sequence":"additional","family":"Roberge","given":"Raymond J.","affiliation":[{"name":"National Institute for Occupational Safety and Health/National Personal Protective Technology Laboratory, Pittsburgh, Pennsylvania"}]}],"subject":["Public Health, Environmental and Occupational Health"],"link":[{"URL":"https://www.tandfonline.com/doi/pdf/10.1080/15459624.2017.1358817","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1501616305000,"date-time":"2017-08-01T19:38:25Z","date-parts":[[2017,8,1]]},"language":"en","assertion":[{"order":1,"value":"The publishing and review policy for this title is described in its Aims & Scope.","label":"Peer Review Statement","name":"peerreview_statement"},{"order":2,"URL":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=uoeh20","value":"http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=uoeh20","label":"Aim & Scope","name":"aims_and_scope_url"}],"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":7971},
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  {"_key":"60c20d3a7723bebd8664567f","_id":"documents/60c20d3a7723bebd8664567f","_rev":"_cfFhBZa---","file_name":"02bwyi1w.pdf","md5":"E4F5835B1CD2AD5A62C4A796C953EB2C","id":"02bwyi1w","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/bw/yi/1w/02bwyi1w/02bwyi1w.pdf","date":"2021-06-10T13:01+0000","metadata":{"is-referenced-by-count":2,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,7,15]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.07.13.20152959","group-title":"Epidemiology","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/07/15/2020.07.13.20152959.full.pdf","original-title":[],"title":["Dissemination and co-circulation of SARS-CoV2 subclades exhibiting enhanced transmission associated with increased mortality in Western Europe and the United States"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":24,"short-title":[],"issued":{"date-parts":[[2020,7,15]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,7,15]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Mechanisms underlying the acute respiratory distress syndrome (ARDS)-like clinical manifestations leading to deaths in patients who develop COVID-19 remain uncharacterized. While multiple factors could influence these clinical outcomes, we explored if differences in transmissibility and pathogenicity of SARS-CoV2 variants could contribute to these terminal clinical consequences of COVID-19. We analyzed 34,412 SARS-CoV2 sequences deposited in the Global Initiative for Sharing All Influenza Data (GISAID) SARS-CoV2 sequence database to determine if regional differences in circulating strain variants correlated with increased mortality in Europe, the United States, and California. We found two subclades descending from the Wuhan HU-1 strain that rapidly became dominant in Western Europe and the United States. These variants contained nonsynonymous nucleotide mutations in the Orf1ab segment encoding RNA-dependent RNA polymerase (C14408T), the spike protein gene (A23403G), and Orf1a (G25563T), which resulted in non-conservative amino acid substitutions P323L, D614G, and Q57H, respectively. In Western Europe, the A23403G-C14408T subclade dominated, while in the US, the A23403G-C14408T-G25563T mutant became the dominant strain in New York and parts of California. The high cumulative frequencies of both subclades showed inconsistent but significant association with high cumulative CFRs in some of the regions. When the frequencies of the subclades were analyzed by their 7-day moving averages across each epidemic, we found co-circulation of both subclades to temporally correlate with peak mortality periods. We postulate that in areas with high numbers of these co-circulating subclades, a person may get serially infected. The second infection may trigger a hyperinflammatory response similar to the antibody-dependent enhancement (ADE) response, which could explain the ARDS-like manifestations observed in people with co-morbidity, who may not mount sufficient levels of neutralizing antibodies against the first infection. Further studies are necessary but the implication of such a mechanism will need to be considered for all current COVID-19 vaccine designs.","deposited":{"timestamp":1610491909000,"date-time":"2021-01-12T22:51:49Z","date-parts":[[2021,1,12]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Hu","given":"Yuan","affiliation":[]},{"sequence":"additional","family":"Riley","given":"Lee W.","affiliation":[]}],"DOI":"10.1101/2020.07.13.20152959","reference-count":24,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.07.13.20152959","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1594831821000,"date-time":"2020-07-15T16:50:21Z","date-parts":[[2020,7,15]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"02bwyi1w","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1614246280376,"date-time":"2021-02-25T09:44:40Z","date-parts":[[2021,2,25]]},"cord_sha":"c832b068beb6645d83c981b9473af7b5872ec1bd"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":525,"page_height":324},{"page_width":525,"page_height":324},{"page_width":525,"page_height":324},{"page_width":525,"page_height":324}],"runtime":13751},
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  {"_key":"60c20d3e7723bebd8664568a","_id":"documents/60c20d3e7723bebd8664568a","_rev":"_cfFhBZu---","file_name":"02d35os2.pdf","md5":"F90CF62A7EEA5D3591DBC3BD535E64E2","id":"02d35os2","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/d3/5o/s2/02d35os2/02d35os2.pdf","date":"2021-06-10T13:01+0000","metadata":{"alternative-id":["10.3389/fbioe.2020.582953"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1610668800000,"date-time":"2021-01-15T00:00:00Z","date-parts":[[2021,1,15]]}}],"volume":"8","pmid":"33520952","author":[{"sequence":"first","family":"Morenikeji","given":"Olanrewaju B.","affiliation":[]},{"sequence":"additional","family":"Bernard","given":"Kahleel","affiliation":[]},{"sequence":"additional","family":"Strutton","given":"Ellis","affiliation":[]},{"sequence":"additional","family":"Wallace","given":"Madeleine","affiliation":[]},{"sequence":"additional","family":"Thomas","given":"Bolaji N.","affiliation":[]}],"DOI":"10.3389/fbioe.2020.582953","license-simplified":"cc-by","original-title":[],"short-container-title":["Front. Bioeng. Biotechnol."],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"update-policy":"http://dx.doi.org/10.3389/crossmark-policy","type":"journal-article","issued":{"date-parts":[[2021,1,15]]},"publisher":"Frontiers Media SA","id":"02d35os2","reference-count":91,"pmcid":"PMC7844208","has_valid_oa_url":true,"deposited":{"timestamp":1610690604000,"date-time":"2021-01-15T06:03:24Z","date-parts":[[2021,1,15]]},"indexed":{"timestamp":1610695963962,"date-time":"2021-01-15T07:32:43Z","date-parts":[[2021,1,15]]},"is-referenced-by-count":0,"title":["Evolutionarily Conserved Long Non-coding RNA Regulates Gene Expression in Cytokine Storm During COVID-19"],"prefix":"10.3389","published-online":{"date-parts":[[2021,1,15]]},"has_valid_thumbnail":false,"references-count":91,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/06/e0/PMC7844208.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.3389/fbioe.2020.582953","short-title":[],"issn-type":[{"value":"2296-4185","type":"electronic"}],"container-title":["Frontiers in Bioengineering and Biotechnology"],"has_valid_ref_annotation":false,"member":"1965","abstract":"Coronavirus is a family of viruses including alpha-, beta-, gamma-, delta-coronaviruses. Only alpha- and betacoronaviruses have been observed to infect humans. Past outbreaks of SARS-CoV and MERS-CoV, both betacoronavirus, are the result of a spillover from animals. Recently, a new strain termed SARS-CoV-2 emerged in December 2019 in Wuhan, China. Severe cases of COVID-19, the disease caused by SARS-CoV-2, lead to acute respiratory distress syndrome (ARDS). One contributor to the development of ARDS is cytokine storm, an overwhelming inflammatory immune response. Long non-coding RNAs (lncRNAs) are genetic regulatory elements that, among many functions, alter gene expression and cellular processes. lncRNAs identified to be pertinent in COVID-19 cytokine storm have the potential to serve as disease markers or drug targets. This project aims to computationally identify conserved lncRNAs potentially regulating gene expression in cytokine storm during COVID-19. We found 22 lncRNAs that can target 10 cytokines overexpressed in COVID-19 cytokine storm, 8 of which targeted two or more cytokine storm cytokines. In particular, the lncRNA non-coding RNA activated by DNA damage (NORAD), targeted five out of the ten identified cytokine storm cytokines, and is evolutionarily conserved across multiple species. These lncRNAs are ideal candidates for further in vitro and in vivo analysis.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Biotechnology","Bioengineering","Histology","Biomedical Engineering"],"link":[{"URL":"https://www.frontiersin.org/articles/10.3389/fbioe.2020.582953/full","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1610690602000,"date-time":"2021-01-15T06:03:22Z","date-parts":[[2021,1,15]]},"ISSN":["2296-4185"],"score":1,"source":"Crossref","cord_sha":"33656a747e6e78452937222bd59ee6422a7d8702"},"application":"software-mentions","pages":[{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52}],"runtime":14854},
  {"_key":"60c20d427723bebd8664569f","_id":"documents/60c20d427723bebd8664569f","_rev":"_cfFhBZ6---","file_name":"02fa1hxy.pdf","md5":"3DF124AF0D7011A748B6244BC9987A72","id":"02fa1hxy","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/fa/1h/xy/02fa1hxy/02fa1hxy.pdf","date":"2021-06-10T13:01+0000","metadata":{"is-referenced-by-count":1,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,5,10]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.05.06.20093351","group-title":"Infectious Diseases (except HIV/AIDS)","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/05/14/2020.05.06.20093351.full.pdf","original-title":[],"title":["Age-adjusted associations between comorbidity and outcomes of COVID-19: a review of the evidence"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":37,"short-title":[],"issued":{"date-parts":[[2020,5,10]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,5,10]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"Background: Current evidence suggests that older people and people with underlying comorbidities are at increased risk of severe disease and death following hospitalisation with COVID-19. As comorbidity increases with age, it is necessary to understand the age-adjusted relationship between comorbidity and COVID-19 outcomes, in order to enhance planning capabilities and our understanding of COVID-19. Methods: We conducted a rapid, comprehensive review of the literature up to 10 April 2020, to assess the international empirical evidence on the association between comorbidities and severe or critical care outcomes of COVID-19, after accounting for age, among hospitalised patients with COVID-19. Results: After screening 579 studies, we identified seven studies eligible for inclusion and these were synthesised narratively. All were from China. The emerging evidence base mostly indicates that after adjustment for age (and in some cases other potential confounders), obesity, hypertension, diabetes mellitus, chronic obstructive airways disease (COPD), and cancer are all associated with worse outcomes. The largest study, using a large nationwide sample of COVID-19 patients in China, found that those with multiple comorbidities had more than twice the risk of a severe outcome or death compared with patients with no comorbidities, after adjusting for age and smoking (HR=2.59, 95% CI 1.61, 4.17). Conclusions: This review summarises for clinicians, policymakers, and academics the most robust evidence to date on this topic, to inform the management of patients and control measures for tackling the pandemic. Given the intersection of comorbidity with ethnicity and social disadvantage, these findings also have important implications for health inequalities. As the pandemic develops, further research should confirm these trends in other settings outside China and explore mechanisms by which various underlying health conditions increase risk of severe COVID-19.","deposited":{"timestamp":1607677223000,"date-time":"2020-12-11T09:00:23Z","date-parts":[[2020,12,11]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Kate E.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5020-5256","family":"Mason","affiliation":[]},{"sequence":"additional","family":"McHale","given":"Philip","affiliation":[]},{"sequence":"additional","family":"Pennington","given":"Andy","affiliation":[]},{"sequence":"additional","family":"Maudsley","given":"Gillian","affiliation":[]},{"sequence":"additional","family":"Day","given":"Jennifer","affiliation":[]},{"sequence":"additional","family":"Barr","given":"Ben","affiliation":[]}],"DOI":"10.1101/2020.05.06.20093351","reference-count":37,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.05.06.20093351","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1589120967000,"date-time":"2020-05-10T14:29:27Z","date-parts":[[2020,5,10]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"02fa1hxy","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1609010616298,"date-time":"2020-12-26T19:23:36Z","date-parts":[[2020,12,26]]},"cord_sha":"687fec04ac33c91790ef56acf1f00d53f2b91d1d"},"application":"software-mentions","pages":[{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":841.92,"page_height":595.32},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92},{"page_width":595.32,"page_height":841.92}],"runtime":7956},
  {"_key":"60c20d447723bebd866456a1","_id":"documents/60c20d447723bebd866456a1","_rev":"_cfFhBaG---","file_name":"02fsiayg.pdf","md5":"FB68B386947CC5A8CF793604E756F082","id":"02fsiayg","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/fs/ia/yg/02fsiayg/02fsiayg.pdf","date":"2021-06-10T13:01+0000","metadata":{"alternative-id":["4867"],"published-print":{"date-parts":[[2020,2]]},"volume":"28","pmid":"31144173","journal-issue":{"published-print":{"date-parts":[[2020,2]]},"issue":"2"},"author":[{"sequence":"first","given":"Steven H.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-5587-7844","family":"Hsu","affiliation":[]},{"sequence":"additional","family":"Campbell","given":"Claudine","affiliation":[]},{"sequence":"additional","family":"Weeks","given":"Amanda K.","affiliation":[]},{"sequence":"additional","family":"Herklotz","given":"Maryann","affiliation":[]},{"sequence":"additional","family":"Kostelecky","given":"Natalie","affiliation":[]},{"sequence":"additional","family":"Pastores","given":"Stephen M.","affiliation":[]},{"sequence":"additional","family":"Halpern","given":"Neil A.","affiliation":[]},{"sequence":"additional","family":"Voigt","given":"Louis P.","affiliation":[]}],"DOI":"10.1007/s00520-019-04867-1","original-title":[],"license":[{"URL":"http://www.springer.com/tdm","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1559088000000,"date-time":"2019-05-29T00:00:00Z","date-parts":[[2019,5,29]]}},{"URL":"http://www.springer.com/tdm","content-version":"vor","delay-in-days":0,"start":{"timestamp":1559088000000,"date-time":"2019-05-29T00:00:00Z","date-parts":[[2019,5,29]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":25,"page":"747-753","type":"journal-article","issued":{"date-parts":[[2019,5,29]]},"funder":[{"doi-asserted-by":"publisher","award":["P30 CA008748"],"DOI":"10.13039/100000054","name":"National Cancer Institute"}],"publisher":"Springer Science and Business Media LLC","id":"02fsiayg","short-title":[],"title":["A pilot survey of ventilated cancer patients’ perspectives and recollections of early mobility in the intensive care unit"],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/a0/18/PMC7223790.tar.gz","pmcid":"PMC7223790","has_valid_oa_url":true,"deposited":{"timestamp":1590621444000,"date-time":"2020-05-27T23:17:24Z","date-parts":[[2020,5,27]]},"indexed":{"timestamp":1590622838953,"date-time":"2020-05-27T23:40:38Z","date-parts":[[2020,5,27]]},"is-referenced-by-count":0,"short-container-title":["Support Care Cancer"],"prefix":"10.1007","published-online":{"date-parts":[[2019,5,29]]},"has_valid_thumbnail":false,"references-count":25,"license-simplified":"no-cc","subtitle":[],"URL":"http://dx.doi.org/10.1007/s00520-019-04867-1","ISSN":["0941-4355","1433-7339"],"issn-type":[{"value":"0941-4355","type":"print"},{"value":"1433-7339","type":"electronic"}],"subject":["Oncology"],"container-title":["Supportive Care in Cancer"],"score":1,"has_valid_ref_annotation":false,"issue":"2","member":"297","abstract":"PURPOSE: To determine the level of recall, satisfaction, and perceived benefits of early mobility (EM) among ventilated cancer patients after extubation in the intensive care unit (ICU). METHODS: A survey of patients’ perceptions and recollections of EM was administered within 72 h of extubation. Data on recall of EM participation, activities achieved, adequacy of staffing and rest periods, strength to participate, activity level of difficulty, satisfaction with staff instructions, breathing management, and overall rating of the experience were analyzed. The Confusion Assessment Method for ICU (CAM-ICU) was used for delirium screening. RESULTS: Fifty-four patients comprised the study group. Nearly 90% reported satisfaction with instructions, staffing, rest periods, and breathing management during EM. Participants indicated that EM maintained their strength (67%) and gave them control over their recovery (61%); a minority felt optimistic (37%) and safe (22%). Patients who achieved more sessions and “out-of-bed” exercises had better recall of actual activities compared with those who exercised in bed. Overall, patients with CAM-ICU-positive results (33%) performed less physical and occupational therapy exercises. CONCLUSIONS: Ventilated cancer patients reported an overall positive EM experience, but factual memory impairment of EM activities was common. These findings highlight the needs and the importance of shaping strategies to deliver a more patient focused EM experience. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00520-019-04867-1) contains supplementary material, which is available to authorized users.","has_valid_pdf":true,"has_valid_tei":false,"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1007/s00520-019-04867-1.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1007/s00520-019-04867-1/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1007/s00520-019-04867-1.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1559154454000,"date-time":"2019-05-29T18:27:34Z","date-parts":[[2019,5,29]]},"language":"en","assertion":[{"order":1,"value":"12 November 2018","group":{"label":"Article History","name":"ArticleHistory"},"label":"Received","name":"received"},{"order":2,"value":"9 May 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"Accepted","name":"accepted"},{"order":3,"value":"29 May 2019","group":{"label":"Article History","name":"ArticleHistory"},"label":"First Online","name":"first_online"},{"order":1,"value":"Recommendations from the pilot were incorporated into the final version of the survey, which was approved by the Institutional Review Board (IRB). Informed consent was obtained from all study patients.","group":{"label":"Compliance with ethical standards","name":"EthicsHeading"},"name":"Ethics"},{"order":2,"value":"The authors declare that they have no conflict of interest.","group":{"label":"Conflict of interest","name":"EthicsHeading"},"name":"Ethics"},{"value":"This content has been made available to all.","label":"Free to read","name":"free"}],"source":"Crossref","cord_sha":"eae9b40e9e7d33009f48997306137c21f48d5fce"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866},{"page_width":595.276,"page_height":790.866}],"runtime":8757},
  {"_key":"60c20d487723bebd866456a3","_id":"documents/60c20d487723bebd866456a3","_rev":"_cfFhBaS---","file_name":"02go3t4p.pdf","md5":"2B7FEAF30C7DCB3BD998534FEA46AC44","id":"02go3t4p","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/go/3t/4p/02go3t4p/02go3t4p.pdf","date":"2021-06-10T13:02+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1600387200000,"date-time":"2020-09-18T00:00:00Z","date-parts":[[2020,9,18]]}}],"volume":"15","pmid":"32946463","journal-issue":{"issue":"9","published-online":{"date-parts":[[2020,9,18]]}},"has_valid_tei":false,"arxiv_id":"2003.13983","created":{"timestamp":1600450235000,"date-time":"2020-09-18T17:30:35Z","date-parts":[[2020,9,18]]},"DOI":"10.1371/journal.pone.0239113","original-title":[],"short-container-title":["PLoS ONE"],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"update-policy":"http://dx.doi.org/10.1371/journal.pone.corrections_policy","page":"e0239113","type":"journal-article","issued":{"date-parts":[[2020,9,18]]},"publisher":"Public Library of Science (PLoS)","id":"02go3t4p","short-title":[],"editor":[{"sequence":"first","family":"Angeli","given":"Federica","affiliation":[]}],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/37/a9/PMC7500649.tar.gz","pmcid":"PMC7500649","has_valid_oa_url":true,"deposited":{"timestamp":1600450259000,"date-time":"2020-09-18T17:30:59Z","date-parts":[[2020,9,18]]},"indexed":{"timestamp":1618916205191,"date-time":"2021-04-20T10:56:45Z","date-parts":[[2021,4,20]]},"is-referenced-by-count":14,"title":["Business disruptions from social distancing"],"prefix":"10.1371","published-online":{"date-parts":[[2020,9,18]]},"has_valid_thumbnail":false,"references-count":43,"license-simplified":"cc-by","subtitle":[],"reference-count":43,"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"container-title":["PLOS ONE"],"has_valid_ref_annotation":false,"issue":"9","member":"340","abstract":"Social distancing interventions can be effective against epidemics but are potentially detrimental for the economy. Businesses that rely heavily on face-to-face communication or close physical proximity when producing a product or providing a service are particularly vulnerable. There is, however, no systematic evidence about the role of human interactions across different lines of business and about which will be the most limited by social distancing. Here we provide theory-based measures of the reliance of U.S. businesses on human interaction, detailed by industry and geographic location. We find that, before the pandemic hit, 43 million workers worked in occupations that rely heavily on face-to-face communication or require close physical proximity to other workers. Many of these workers lost their jobs since. Consistently with our model, employment losses have been largest in sectors that rely heavily on customer contact and where these contacts dropped the most: retail, hotels and restaurants, arts and entertainment and schools. Our results can help quantify the economic costs of social distancing.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Miklós","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-4495-7560","family":"Koren","affiliation":[]},{"sequence":"additional","family":"Pető","given":"Rita","affiliation":[]}],"subject":["General Biochemistry, Genetics and Molecular Biology","General Agricultural and Biological Sciences","General Medicine"],"link":[{"URL":"https://dx.plos.org/10.1371/journal.pone.0239113","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"URL":"http://dx.doi.org/10.1371/journal.pone.0239113","language":"en","score":1,"source":"Crossref","cord_sha":"e89cab8cf55117c67e6ab4f359a469094f3e49e9"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":8843},
  {"_key":"60c20d4b7723bebd866456a8","_id":"documents/60c20d4b7723bebd866456a8","_rev":"_cfFhBae---","file_name":"02gozhvq.pdf","md5":"9913C34DE26C0DDF9DBBC605A2BBC1B0","id":"02gozhvq","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/go/zh/vq/02gozhvq/02gozhvq.pdf","date":"2021-06-10T13:02+0000","metadata":{"is-referenced-by-count":0,"alternative-id":["10.3389/fvets.2021.637716"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1614902400000,"date-time":"2021-03-05T00:00:00Z","date-parts":[[2021,3,5]]}}],"prefix":"10.3389","volume":"8","subtitle":[],"type":"journal-article","license-simplified":"cc-by","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.3389/fvets.2021.637716","references-count":45,"published-online":{"date-parts":[[2021,3,5]]},"original-title":[],"title":["Alpha-2-Macroglobulin as a New Promising Biomarker Improving the Diagnostic Sensitivity of Bovine Paratuberculosis"],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"reference-count":45,"short-title":[],"issued":{"date-parts":[[2021,3,5]]},"issn-type":[{"value":"2297-1769","type":"electronic"}],"container-title":["Frontiers in Veterinary Science"],"has_valid_oa_url":true,"has_valid_ref_annotation":false,"publisher":"Frontiers Media SA","member":"1965","short-container-title":["Front. Vet. Sci."],"deposited":{"timestamp":1614918518000,"date-time":"2021-03-05T04:28:38Z","date-parts":[[2021,3,5]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Park","given":"Hyun-Eui","affiliation":[]},{"sequence":"additional","family":"Park","given":"Jin-Sik","affiliation":[]},{"sequence":"additional","family":"Park","given":"Hong-Tae","affiliation":[]},{"sequence":"additional","family":"Choi","given":"Jeong-Gyu","affiliation":[]},{"sequence":"additional","family":"Shin","given":"Jeong-Ih","affiliation":[]},{"sequence":"additional","family":"Jung","given":"Myunghwan","affiliation":[]},{"sequence":"additional","family":"Kang","given":"Hyung-Lyun","affiliation":[]},{"sequence":"additional","family":"Baik","given":"Seung-Chul","affiliation":[]},{"sequence":"additional","family":"Lee","given":"Woo-Kon","affiliation":[]},{"sequence":"additional","family":"Kim","given":"Donghyuk","affiliation":[]},{"sequence":"additional","family":"Yoo","given":"Han Sang","affiliation":[]},{"sequence":"additional","family":"Shin","given":"Min-Kyoung","affiliation":[]}],"DOI":"10.3389/fvets.2021.637716","update-policy":"http://dx.doi.org/10.3389/crossmark-policy","abstract":"Johne's disease (JD) is a chronic granulomatous enteritis of ruminants caused by Mycobacterium avium subsp. paratuberculosis (MAP), which induces persistent diarrhea and cachexia. JD causes huge economic losses to the dairy industry due to reduced milk production and premature culling. Infected animals excrete MAP via feces during the prolonged subclinical stage without exhibiting any clinical signs. Therefore, accurate detection of subclinical stage animals is crucial for successful eradication of JD in the herd. In the current study, we analyzed serum samples of MAP-infected and non-infected cattle to identify potential biomarker candidates. First, we identified 12 differentially expressed serum proteins in subclinical and clinical shedder groups compared to the healthy control group. Second, we conducted ELISA for three selected biomarkers (alpha-2-macroglobulin (A2M), alpha-1-beta glycoprotein, and transthyretin) and compared their diagnostic performance with that of two commercial ELISA diagnostic kits. Serum A2M levels were significantly higher in the MAP-exposed, subclinical shedder, subclinical non-shedder, and clinical shedder groups than in the healthy control group, suggesting its possible use as a diagnostic biomarker for MAP infection. Furthermore, A2M demonstrated a sensitivity of 90.4%, and a specificity of 100% while the two commercial ELISA kits demonstrated a sensitivity of 67.83 and 73.04% and a specificity of 100%, respectively. In conclusion, our results suggest that measuring A2M by ELISA can be used as a diagnostic tool to detect MAP infection, considerably improving the detection rate of subclinical shedders and MAP-exposed animals that are undetectable using current diagnostic tools.","link":[{"URL":"https://www.frontiersin.org/articles/10.3389/fvets.2021.637716/full","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"pmcid":"PMC7973028","created":{"timestamp":1614918514000,"date-time":"2021-03-05T04:28:34Z","date-parts":[[2021,3,5]]},"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/77/d9/PMC7973028.tar.gz","id":"02gozhvq","ISSN":["2297-1769"],"score":1,"source":"Crossref","indexed":{"timestamp":1615054306728,"date-time":"2021-03-06T18:11:46Z","date-parts":[[2021,3,6]]},"cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52},{"page_width":595.26,"page_height":779.52}],"runtime":8330},
  {"_key":"60c20d4b7723bebd866456ad","_id":"documents/60c20d4b7723bebd866456ad","_rev":"_cfFhBaq---","file_name":"02gyapoe.pdf","md5":"BEC15D7E4BE8F94FF32B9A4E30312E6D","id":"02gyapoe","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/gy/ap/oe/02gyapoe/02gyapoe.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["10.1111/his.14249"],"published-print":{"date-parts":[[2021,3]]},"volume":"78","pmid":"32926596","journal-issue":{"published-print":{"date-parts":[[2021,3]]},"issue":"4"},"has_valid_tei":false,"URL":"http://dx.doi.org/10.1111/his.14249","id":"02gyapoe","original-title":[],"license":[{"URL":"http://onlinelibrary.wiley.com/termsAndConditions#vor","content-version":"vor","delay-in-days":0,"start":{"timestamp":1605052800000,"date-time":"2020-11-11T00:00:00Z","date-parts":[[2020,11,11]]}},{"URL":"http://doi.wiley.com/10.1002/tdm_license_1.1","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1605052800000,"date-time":"2020-11-11T00:00:00Z","date-parts":[[2020,11,11]]}}],"content-domain":{"domain":[],"crossmark-restriction":false},"page":"542-555","type":"journal-article","issued":{"date-parts":[[2020,11,11]]},"funder":[{"doi-asserted-by":"publisher","award":["81773022"],"DOI":"10.13039/501100001809","name":"National Natural Science Foundation of China"},{"doi-asserted-by":"publisher","award":["2020YFC0845700"],"DOI":"10.13039/100007225","name":"Ministry of Science and Technology"},{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100003397","name":"Huazhong University of Science and Technology"}],"publisher":"Wiley","DOI":"10.1111/his.14249","reference-count":70,"title":["Progression to fibrosing diffuse alveolar damage in a series of 30 minimally invasive autopsies with COVID‐19 pneumonia in Wuhan, China"],"oaLink":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/his.14249","has_valid_oa_url":true,"deposited":{"timestamp":1613647918000,"date-time":"2021-02-18T11:31:58Z","date-parts":[[2021,2,18]]},"indexed":{"timestamp":1615554234350,"date-time":"2021-03-12T13:03:54Z","date-parts":[[2021,3,12]]},"is-referenced-by-count":10,"short-container-title":["Histopathology"],"prefix":"10.1111","license-simplified":"unk","has_valid_thumbnail":false,"ISSN":["0309-0167","1365-2559"],"references-count":70,"published-online":{"date-parts":[[2020,11,11]]},"subtitle":[],"archive":["Portico"],"short-title":[],"issn-type":[{"value":"0309-0167","type":"print"},{"value":"1365-2559","type":"electronic"}],"container-title":["Histopathology"],"has_valid_ref_annotation":false,"issue":"4","has_valid_pdf":true,"abstract":"AIMS Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) infection has been deemed as a global pandemic by World Health Organization. While diffuse alveolar damage (DAD) is recognized to be the primary manifestation COVID-19 pneumonia, there has been little emphasis on the progression to the fibrosing phase of DAD. This topic is of great interest due to growing concerns regarding the potential long-term complications in prolonged survivors. METHODS Here we report a detailed histopathologic study of thirty autopsy cases with COVID-19 virus infection, based on minimally invasive autopsies performed between February to March, 2020. RESULTS The mean age was 69 years, with twenty (67%) males and 10 (33%) females and frequent (70.0%) underlying comorbidities. The duration of illness ranged from 16 to 82 (median=42) days. Histologically, the most common manifestation was diffuse alveolar damage (DAD) in 28 (93.3%) cases which showed predominantly acute (32%), organizing (25%), and/or fibrosing (43%) patterns. Patients with fibrosing DAD were one decade younger (p=0.034) and they had a longer duration of illness (p=0.033), hospitalization (p=0.037) and mechanical ventilation (p=0.014) compared to those with acute DAD. Patients with organizing DAD had a longer duration of illness (p=0.032) and hospitalization (p=0.023) compared to those with acute DAD. CONCLUSIONS COVID-19 pneumonia patients who develop DAD can progress to the fibrosing pattern. While we observed fibrosing DAD in fatal cases, whether surviving patients are at risk for developing pulmonary fibrosis and the frequency of this complication will require further clinical and radiologic follow-up studies.","member":"311","author":[{"sequence":"first","family":"Li","given":"Yan","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Wu","given":"Junhua","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Wang","given":"Sihua","affiliation":[{"name":"Department of Thoracic Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Li","given":"Xiang","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Zhou","given":"Junjie","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Huang","given":"Bo","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Luo","given":"Danju","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Cao","given":"Qin","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Chen","given":"Yajun","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Chen","given":"Shuo","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Ma","given":"Lin","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Peng","given":"Li","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","family":"Pan","given":"Huaxiong","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]},{"sequence":"additional","given":"William D.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-3160-6729","family":"Travis","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York NY USA"}]},{"sequence":"additional","family":"Nie","given":"Xiu","affiliation":[{"name":"Department of Pathology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology Wuhan China"}]}],"subject":["Pathology and Forensic Medicine","Histology","General Medicine"],"link":[{"URL":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fhis.14249","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/his.14249","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"https://onlinelibrary.wiley.com/doi/full-xml/10.1111/his.14249","content-version":"vor","intended-application":"text-mining","content-type":"application/xml"},{"URL":"https://onlinelibrary.wiley.com/doi/pdf/10.1111/his.14249","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1600413713000,"date-time":"2020-09-18T07:21:53Z","date-parts":[[2020,9,18]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":7107},
  {"_key":"60c20d527723bebd866456af","_id":"documents/60c20d527723bebd866456af","_rev":"_cfFhBa2---","file_name":"02ie6wqq.pdf","md5":"F36AA10298E7462A1547C7039B6007EC","id":"02ie6wqq","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/ie/6w/qq/02ie6wqq/02ie6wqq.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["ijerph18030973"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1611273600000,"date-time":"2021-01-22T00:00:00Z","date-parts":[[2021,1,22]]}}],"volume":"18","pmid":"33499343","journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,2]]}},"has_valid_tei":false,"DOI":"10.3390/ijerph18030973","original-title":[],"title":["Risk of Amyotrophic Lateral Sclerosis and Exposure to Particulate Matter from Vehicular Traffic: A Case-Control Study"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":70,"page":"973","type":"journal-article","issued":{"date-parts":[[2021,1,22]]},"funder":[{"doi-asserted-by":"publisher","award":["not applicable"],"DOI":"10.13039/501100003407","name":"Ministero dell’Istruzione, dell’Università e della Ricerca"}],"publisher":"MDPI AG","id":"02ie6wqq","short-title":[],"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/36/c7/PMC7908475.tar.gz","pmcid":"PMC7908475","has_valid_oa_url":true,"deposited":{"timestamp":1611334411000,"date-time":"2021-01-22T16:53:31Z","date-parts":[[2021,1,22]]},"indexed":{"timestamp":1611335666349,"date-time":"2021-01-22T17:14:26Z","date-parts":[[2021,1,22]]},"is-referenced-by-count":0,"short-container-title":["IJERPH"],"prefix":"10.3390","published-online":{"date-parts":[[2021,1,22]]},"has_valid_thumbnail":false,"references-count":70,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.3390/ijerph18030973","ISSN":["1660-4601"],"issn-type":[{"value":"1660-4601","type":"electronic"}],"container-title":["International Journal of Environmental Research and Public Health"],"has_valid_ref_annotation":false,"issue":"3","member":"1968","abstract":"(1) Background: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with still unknown etiology. Some occupational and environmental risk factors have been suggested, including long-term air pollutant exposure. We carried out a pilot case-control study in order to evaluate ALS risk due to particulate matter with a diameter of ≤10 µm (PM(10)) as a proxy of vehicular traffic exposure. (2) Methods: We recruited ALS patients and controls referred to the Modena Neurology ALS Care Center between 1994 and 2015. Using a geographical information system, we modeled PM(10) concentrations due to traffic emissions at the geocoded residence address at the date of case diagnosis. We computed the odds ratio (OR) and 95% confidence interval (CI) of ALS according to increasing PM(10) exposure, using an unconditional logistic regression model adjusted for age and sex. (3) Results: For the 132 study participants (52 cases and 80 controls), the average of annual median and maximum PM(10) concentrations were 5.2 and 38.6 µg/m(3), respectively. Using fixed cutpoints at 5, 10, and 20 of the annual median PM(10) levels, and compared with exposure <5 µg/m(3), we found no excess ALS risk at 5–10 µg/m(3) (OR 0.87, 95% CI 0.39–1.96), 10–20 µg/m(3) (0.94, 95% CI 0.24–3.70), and ≥20 µg/m(3) (0.87, 95% CI 0.05–15.01). Based on maximum PM(10) concentrations, we found a statistically unstable excess ALS risk for subjects exposed at 10–20 µg/m(3) (OR 4.27, 95% CI 0.69–26.51) compared with those exposed <10 µg/m(3). However, risk decreased at 20–50 µg/m(3) (OR 1.49, 95% CI 0.39–5.75) and ≥50 µg/m(3) (1.16, 95% CI 0.28–4.82). ALS risk in increasing tertiles of exposure showed a similar null association, while comparison between the highest and the three lowest quartiles lumped together showed little evidence for an excess risk at PM(10) concentrations (OR 1.13, 95% CI 0.50–2.55). After restricting the analysis to subjects with stable residence, we found substantially similar results. (4) Conclusions: In this pilot study, we found limited evidence of an increased ALS risk due to long-term exposure at high PM(10) concentration, though the high statistical imprecision of the risk estimates, due to the small sample size, particularly in some exposure categories, limited our capacity to detect small increases in risk, and further larger studies are needed to assess this relation.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Tommaso","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2100-0344","family":"Filippini","affiliation":[]},{"sequence":"additional","given":"Jessica","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-9244-9782","family":"Mandrioli","affiliation":[]},{"sequence":"additional","family":"Malagoli","given":"Carlotta","affiliation":[]},{"sequence":"additional","given":"Sofia","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2227-622X","family":"Costanzini","affiliation":[]},{"sequence":"additional","family":"Cherubini","given":"Andrea","affiliation":[]},{"sequence":"additional","family":"Maffeis","given":"Giuseppe","affiliation":[]},{"sequence":"additional","given":"Marco","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-0551-2473","family":"Vinceti","affiliation":[]}],"link":[{"URL":"https://www.mdpi.com/1660-4601/18/3/973/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1611332033000,"date-time":"2021-01-22T16:13:53Z","date-parts":[[2021,1,22]]},"language":"en","score":1,"source":"Crossref","cord_sha":"d8c8e313d377d2a51970d6d3761a63643f7a86dd"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":6790},
  {"_key":"60c20d5c7723bebd866456b4","_id":"documents/60c20d5c7723bebd866456b4","_rev":"_cfFhBbC---","file_name":"02jevl2y.pdf","md5":"8D6BF759BFE780428E31134D6DD90E22","id":"02jevl2y","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/je/vl/2y/02jevl2y/02jevl2y.pdf","date":"2021-06-10T13:02+0000","metadata":{"is-referenced-by-count":1,"short-container-title":[],"prefix":"10.1101","subtitle":[],"accepted":{"date-parts":[[2020,12,14]]},"license-simplified":"medrxiv","has_valid_tei":false,"has_valid_thumbnail":false,"URL":"http://dx.doi.org/10.1101/2020.12.11.20247825","group-title":"Public and Global Health","oaLink":"https://www.medrxiv.org/content/medrxiv/early/2020/12/14/2020.12.11.20247825.full.pdf","original-title":[],"title":["Identifying Synergistic Interventions to Address COVID-19 Using a Large Scale Agent-Based Model"],"content-domain":{"domain":[],"crossmark-restriction":false},"references-count":66,"short-title":[],"issued":{"date-parts":[[2020,12,14]]},"subtype":"preprint","container-title":[],"posted":{"date-parts":[[2020,12,14]]},"has_valid_ref_annotation":false,"publisher":"Cold Spring Harbor Laboratory","member":"246","abstract":"There is a range of public health tools and interventions to address the global pandemic of COVID-19. Although it is essential for public health efforts to comprehensively identify which interventions have the largest impact on preventing new cases, most of the modeling studies that support such decision-making efforts have only considered a very small set of interventions. In addition, previous studies predominantly considered interventions as independent or examined a single scenario in which every possible intervention was applied. Reality has been more nuanced, as a subset of all possible interventions may be in effect for a given time period, in a given place. In this paper, we use cloud-based simulations and a previously published Agent-Based Model of COVID-19 (Covasim) to measure the individual and interacting contribution of interventions on reducing new infections in the US over 6 months. Simulated interventions include face masks, working remotely, stay-at-home orders, testing, contact tracing, and quarantining. Through a factorial design of experiments, we find that mask wearing together with transitioning to remote work/schooling has the largest impact. Having sufficient capacity to immediately and effectively perform contact tracing has a smaller contribution, primarily via interacting effects.","deposited":{"timestamp":1610620980000,"date-time":"2021-01-14T10:43:00Z","date-parts":[[2021,1,14]]},"has_valid_pdf":true,"author":[{"sequence":"first","given":"Junjiang","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-4144-106X","family":"Li","affiliation":[]},{"sequence":"additional","given":"Philippe J.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-6816-355X","family":"Giabbanelli","affiliation":[]}],"DOI":"10.1101/2020.12.11.20247825","reference-count":66,"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1101/2020.12.11.20247825","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1608187698000,"date-time":"2020-12-17T06:48:18Z","date-parts":[[2020,12,17]]},"has_valid_oa_url":true,"institution":{"place":["-"],"acronym":["-"],"name":"medRxiv"},"id":"02jevl2y","type":"posted-content","score":1,"source":"Crossref","indexed":{"timestamp":1612295118876,"date-time":"2021-02-02T19:45:18Z","date-parts":[[2021,2,2]]},"cord_sha":"b5309ace95b5997d4c9c385380be760cc1f1b6df"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":10757},
  {"_key":"60c20d5e7723bebd866456ba","_id":"documents/60c20d5e7723bebd866456ba","_rev":"_cfFhBbO---","file_name":"02jzaos4.pdf","md5":"AADA74D4A43DFC88C39F826BE778DEC5","id":"02jzaos4","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/jz/ao/s4/02jzaos4/02jzaos4.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["5302910","5302910"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1606262400000,"date-time":"2020-11-25T00:00:00Z","date-parts":[[2020,11,25]]}}],"volume":"2020","pmid":"33282951","has_valid_tei":false,"DOI":"10.1155/2020/5302910","original-title":[],"published-print":{"date-parts":[[2020,11,25]]},"content-domain":{"domain":[],"crossmark-restriction":false},"page":"1-5","type":"journal-article","issued":{"date-parts":[[2020,11,25]]},"funder":[{"award":["cstc2019jscx-msxmX0200","cstc2017shms-kjfp0339"],"name":"Social enterprise and people’s livelihood protection science and technology innovation in Chongqing"}],"publisher":"Hindawi Limited","id":"02jzaos4","reference-count":26,"title":["Effects of Different Methods of Air Disinfection of Computed Tomography Rooms Dedicated to COVID-19 Cases"],"editor":[{"sequence":"additional","family":"Cordier","given":"Reinie","affiliation":[]}],"pmcid":"PMC7686846","has_valid_oa_url":true,"deposited":{"timestamp":1607745638000,"date-time":"2020-12-12T04:00:38Z","date-parts":[[2020,12,12]]},"indexed":{"timestamp":1609377829849,"date-time":"2020-12-31T01:23:49Z","date-parts":[[2020,12,31]]},"is-referenced-by-count":1,"short-container-title":["BioMed Research International"],"prefix":"10.1155","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/13/0e/PMC7686846.tar.gz","has_valid_thumbnail":false,"ISSN":["2314-6141","2314-6133"],"references-count":26,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1155/2020/5302910","short-title":[],"issn-type":[{"value":"2314-6133","type":"print"},{"value":"2314-6141","type":"electronic"}],"container-title":["BioMed Research International"],"has_valid_ref_annotation":false,"member":"98","abstract":"OBJECTIVE: To monitor the number of bacterial colonies in the air of computed tomography (CT) room for COVID-19 using different disinfection methods and to identify the most effective method for disinfection and protection of equipment. METHODS: Three methods for disinfection using ultraviolet germicidal irradiation (group A), plasma circulation air sterilizer (group B), and ultraviolet germicidal irradiation plus plasma circulation air sterilizer (group C) were utilized to sanitize the air in the CT room dedicated to COVID-19 cases. Single-factor ANOVA was used to evaluate and compare the disinfection effect of the three air disinfection methods; an air microbial sampler was used to sample and measure the number of bacteria in the air of the machine room. RESULTS: The number of bacteria in the air immediately after disinfection was significantly lower than before disinfection (p < 0.01). All three disinfection methods met the disinfection requirement. No significant differences in the number of air bacteria in the machine room immediately after disinfection were observed among the three methods (p > 0.05). In addition, the effect of disinfection after 2 h was compared, and the number of bacteria in group C after 2 h was significantly lower than that in group A and group B. CONCLUSIONS: All three disinfection methods have significant disinfection effects. In addition, using ultraviolet disinfection lamps combined with a plasma air disinfection machine to sterilize the air in CT machine room has the best disinfection effect for the longest duration. Therefore, we recommend the combined disinfection method (ultraviolet disinfection lamps plus plasma air disinfection), as well as formulating relevant disinfection management norms, which should thus be the method to use during pandemics.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Cheng","given":"Yilian","affiliation":[{"name":"Department of Radiology, Southwest Hospital, Third Millitary Medical University (Army Medical University), Chongqing, 400038, China"}]},{"sequence":"additional","family":"Hu","given":"Jing","affiliation":[{"name":"Department of Radiology, Southwest Hospital, Third Millitary Medical University (Army Medical University), Chongqing, 400038, China"}]},{"sequence":"additional","family":"Chen","given":"Hui","affiliation":[{"name":"Department of Radiology, Southwest Hospital, Third Millitary Medical University (Army Medical University), Chongqing, 400038, China"}]},{"sequence":"additional","family":"Wu","given":"Liu","affiliation":[{"name":"Infection Control Department, Southwest Hospital, Third Millitary Medical University (Army Medical University), Chongqing, 400038, China"}]},{"sequence":"additional","given":"Jianmei","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-5619-6423","family":"Liao","affiliation":[{"name":"Nursing Department, Southwest Hospital, Third Millitary Medical University (Army Medical University), Chongqing, 400038, China"}]},{"sequence":"additional","given":"Lin","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-4258-9194","family":"Cheng","affiliation":[{"name":"Department of Radiology, Southwest Hospital, Third Millitary Medical University (Army Medical University), Chongqing, 400038, China"}]}],"subject":["General Biochemistry, Genetics and Molecular Biology","General Immunology and Microbiology","General Medicine"],"link":[{"URL":"http://downloads.hindawi.com/journals/bmri/2020/5302910.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://downloads.hindawi.com/journals/bmri/2020/5302910.xml","content-version":"vor","intended-application":"text-mining","content-type":"application/xml"},{"URL":"http://downloads.hindawi.com/journals/bmri/2020/5302910.pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1606323080000,"date-time":"2020-11-25T16:51:20Z","date-parts":[[2020,11,25]]},"language":"en","score":1,"source":"Crossref","cord_sha":"5d3dc74f85430ab94220620ba67be462f659143d"},"application":"software-mentions","pages":[{"page_width":599.981,"page_height":799.994},{"page_width":599.981,"page_height":799.994},{"page_width":599.981,"page_height":799.994},{"page_width":599.981,"page_height":799.994},{"page_width":599.981,"page_height":799.994}],"runtime":9755},
  {"_key":"60c20d617723bebd866456bd","_id":"documents/60c20d617723bebd866456bd","_rev":"_cfFhBbW---","file_name":"02ktsgy5.pdf","md5":"507F335C339FA7B03759C6EA1BDAFE92","id":"02ktsgy5","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/kt/sg/y5/02ktsgy5/02ktsgy5.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["ijerph18020815"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1611014400000,"date-time":"2021-01-19T00:00:00Z","date-parts":[[2021,1,19]]}}],"volume":"18","pmid":"33477880","has_valid_tei":false,"URL":"http://dx.doi.org/10.3390/ijerph18020815","DOI":"10.3390/ijerph18020815","original-title":[],"title":["The Role of Coping in the Wellbeing and Work-Related Quality of Life of UK Health and Social Care Workers during COVID-19"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":64,"page":"815","type":"journal-article","issued":{"date-parts":[[2021,1,19]]},"publisher":"MDPI AG","id":"02ktsgy5","short-title":[],"pmcid":"PMC7832874","has_valid_oa_url":true,"deposited":{"timestamp":1611057514000,"date-time":"2021-01-19T11:58:34Z","date-parts":[[2021,1,19]]},"indexed":{"timestamp":1611060363724,"date-time":"2021-01-19T12:46:03Z","date-parts":[[2021,1,19]]},"is-referenced-by-count":0,"short-container-title":["IJERPH"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/b2/67/PMC7832874.tar.gz","has_valid_thumbnail":false,"ISSN":["1660-4601"],"references-count":64,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,1]]}},"issn-type":[{"value":"1660-4601","type":"electronic"}],"container-title":["International Journal of Environmental Research and Public Health"],"published-online":{"date-parts":[[2021,1,19]]},"issue":"2","member":"1968","abstract":"The coronavirus disease 2019 (COVID-19) was declared a global pandemic in early 2020. Due to the rapid spread of the virus and limited availability of effective treatments, health and social care systems worldwide quickly became overwhelmed. Such stressful circumstances are likely to have negative impacts on health and social care workers’ wellbeing. The current study examined the relationship between coping strategies and wellbeing and quality of working life in nurses, midwives, allied health professionals, social care workers and social workers who worked in health and social care in the UK during its first wave of COVID-19. Data were collected using an anonymous online survey (N = 3425), and regression analyses were used to examine the associations of coping strategies and demographic characteristics with staff wellbeing and quality of working life. The results showed that positive coping strategies, particularly active coping and help-seeking, were associated with higher wellbeing and better quality of working life. Negative coping strategies, such as avoidance, were risk factors for low wellbeing and worse quality of working life. The results point to the importance of organizational and management support during stressful times, which could include psycho-education and training about active coping and might take the form of workshops designed to equip staff with better coping skills.","has_valid_pdf":true,"author":[{"sequence":"first","given":"Paula","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-6025-5107","family":"McFadden","affiliation":[]},{"sequence":"additional","given":"Jana","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2794-1268","family":"Ross","affiliation":[]},{"sequence":"additional","given":"John","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-8280-973X","family":"Moriarty","affiliation":[]},{"sequence":"additional","given":"John","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-7539-3329","family":"Mallett","affiliation":[]},{"sequence":"additional","given":"Heike","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-8973-7954","family":"Schroder","affiliation":[]},{"sequence":"additional","given":"Jermaine","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-8418-4841","family":"Ravalier","affiliation":[]},{"sequence":"additional","given":"Jill","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9006-1410","family":"Manthorpe","affiliation":[]},{"sequence":"additional","given":"Denise","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0003-2002-0407","family":"Currie","affiliation":[]},{"sequence":"additional","family":"Harron","given":"Jaclyn","affiliation":[]},{"sequence":"additional","family":"Gillen","given":"Patricia","affiliation":[]}],"link":[{"URL":"https://www.mdpi.com/1660-4601/18/2/815/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1611050131000,"date-time":"2021-01-19T09:55:31Z","date-parts":[[2021,1,19]]},"language":"en","score":1,"source":"Crossref","cord_sha":"868a1a00db56c10aefa6e895cdeb25926e8926cc"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":9448},
  {"_key":"60c20d6a7723bebd866456bf","_id":"documents/60c20d6a7723bebd866456bf","_rev":"_cfFhBbi---","file_name":"02o93wlh.pdf","md5":"BFC2940CA878DF04C0D721041D48DFDF","id":"02o93wlh","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/o9/3w/lh/02o93wlh/02o93wlh.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["S0006291X05002640"],"license":[{"URL":"https://www.elsevier.com/tdm/userlicense/1.0/","content-version":"tdm","delay-in-days":0,"start":{"timestamp":1112313600000,"date-time":"2005-04-01T00:00:00Z","date-parts":[[2005,4,1]]}}],"volume":"329","pmid":"15752746","has_valid_tei":false,"DOI":"10.1016/j.bbrc.2005.02.061","original-title":[],"short-container-title":["Biochemical and Biophysical Research Communications"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":20,"page":"934-940","type":"journal-article","issued":{"date-parts":[[2005,4]]},"publisher":"Elsevier BV","id":"02o93wlh","short-title":[],"pmcid":"PMC7092912","has_valid_oa_url":true,"deposited":{"timestamp":1586120511000,"date-time":"2020-04-05T21:01:51Z","date-parts":[[2020,4,5]]},"indexed":{"timestamp":1614068634031,"date-time":"2021-02-23T08:23:54Z","date-parts":[[2021,2,23]]},"is-referenced-by-count":40,"title":["The substrate specificity of SARS coronavirus 3C-like proteinase"],"prefix":"10.1016","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/4a/5e/PMC7092912.tar.gz","has_valid_thumbnail":false,"ISSN":["0006-291X"],"references-count":20,"license-simplified":"els-covid","subtitle":[],"URL":"http://dx.doi.org/10.1016/j.bbrc.2005.02.061","journal-issue":{"published-print":{"date-parts":[[2005,4]]},"issue":"3"},"issn-type":[{"value":"0006-291X","type":"print"}],"container-title":["Biochemical and Biophysical Research Communications"],"has_valid_ref_annotation":false,"issue":"3","member":"78","abstract":"Abstract The 3C-like proteinase of severe acute respiratory syndrome coronavirus (SARS) has been proposed to be a key target for structural based drug design against SARS. We have designed and synthesized 34 peptide substrates and determined their hydrolysis activities. The conserved core sequence of the native cleavage site is optimized for high hydrolysis activity. Residues at position P4, P3, and P3′ are critical for substrate recognition and binding, and increment of β-sheet conformation tendency is also helpful. A comparative molecular field analysis (CoMFA) model was constructed. Based on the mutation data and CoMFA model, a multiply mutated octapeptide S24 was designed for higher activity. The experimentally determined hydrolysis activity of S24 is the highest in all designed substrates and is close to that predicted by CoMFA. These results offer helpful information for the research on the mechanism of substrate recognition of coronavirus 3C-like proteinase.","published-print":{"date-parts":[[2005,4]]},"has_valid_pdf":true,"author":[{"sequence":"first","family":"Fan","given":"Keqiang","affiliation":[]},{"sequence":"additional","family":"Ma","given":"Liang","affiliation":[]},{"sequence":"additional","family":"Han","given":"Xiaofeng","affiliation":[]},{"sequence":"additional","family":"Liang","given":"Huanhuan","affiliation":[]},{"sequence":"additional","family":"Wei","given":"Ping","affiliation":[]},{"sequence":"additional","family":"Liu","given":"Ying","affiliation":[]},{"sequence":"additional","family":"Lai","given":"Luhua","affiliation":[]}],"subject":["Biophysics","Cell Biology","Biochemistry","Molecular Biology"],"link":[{"URL":"https://api.elsevier.com/content/article/PII:S0006291X05002640?httpAccept=text/xml","content-version":"vor","intended-application":"text-mining","content-type":"text/xml"},{"URL":"https://api.elsevier.com/content/article/PII:S0006291X05002640?httpAccept=text/plain","content-version":"vor","intended-application":"text-mining","content-type":"text/plain"}],"relation":{"cites":[]},"created":{"timestamp":1108731048000,"date-time":"2005-02-18T12:50:48Z","date-parts":[[2005,2,18]]},"language":"en","score":1,"source":"Crossref","cord_sha":"c349bed6fd4c66467200b8203614248da0038224"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794},{"page_width":595,"page_height":794}],"runtime":3927},
  {"_key":"60c20d717723bebd866456c3","_id":"documents/60c20d717723bebd866456c3","_rev":"_cfFhBbu---","file_name":"02n30zc5.pdf","md5":"EF5F572A157BD150E2CBF4EB58312395","id":"02n30zc5","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/n3/0z/c5/02n30zc5/02n30zc5.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["10.1128/AAC.03011-14"],"published-print":{"date-parts":[[2014,8]]},"volume":"58","pmid":"24841269","journal-issue":{"published-print":{"date-parts":[[2014,8]]},"issue":"8","published-online":{"date-parts":[[2014,7,15]]}},"has_valid_tei":false,"DOI":"10.1128/aac.03011-14","license-simplified":"unk","original-title":[],"title":["Screening of an FDA-Approved Compound Library Identifies Four Small-Molecule Inhibitors of Middle East Respiratory Syndrome Coronavirus Replication in Cell Culture"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":85,"page":"4875-4884","type":"journal-article","issued":{"date-parts":[[2014,5,19]]},"publisher":"American Society for Microbiology","id":"02n30zc5","short-title":[],"has_valid_oa_url":true,"deposited":{"timestamp":1589384542000,"date-time":"2020-05-13T15:42:22Z","date-parts":[[2020,5,13]]},"indexed":{"timestamp":1616995430779,"date-time":"2021-03-29T05:23:50Z","date-parts":[[2021,3,29]]},"is-referenced-by-count":385,"short-container-title":["Antimicrob. Agents Chemother."],"prefix":"10.1128","oaLink":"https://aac.asm.org/content/aac/58/8/4875.full.pdf","has_valid_thumbnail":false,"references-count":85,"published-online":{"date-parts":[[2014,5,19]]},"subtitle":[],"URL":"http://dx.doi.org/10.1128/aac.03011-14","ISSN":["0066-4804","1098-6596"],"issn-type":[{"value":"0066-4804","type":"print"},{"value":"1098-6596","type":"electronic"}],"container-title":["Antimicrobial Agents and Chemotherapy"],"has_valid_ref_annotation":false,"issue":"8","member":"235","abstract":"Coronaviruses can cause respiratory and enteric disease in a wide variety of human and animal hosts. The 2003 outbreak of severe acute respiratory syndrome (SARS) first demonstrated the potentially lethal consequences of zoonotic coronavirus infections in humans. In 2012, a similar previously unknown coronavirus emerged, Middle East respiratory syndrome coronavirus (MERS-CoV), thus far causing over 650 laboratory-confirmed infections, with an unexplained steep rise in the number of cases being recorded over recent months. The human MERS fatality rate of ∼ 30% is alarmingly high, even though many deaths were associated with underlying medical conditions. Registered therapeutics for the treatment of coronavirus infections are not available. Moreover, the pace of drug development and registration for human use is generally incompatible with strategies to combat emerging infectious diseases. Therefore, we have screened a library of 348 FDA-approved drugs for anti-MERS-CoV activity in cell culture. If such compounds proved sufficiently potent, their efficacy might be directly assessed in MERS patients. We identified four compounds (chloroquine, chlorpromazine, loperamide, and lopinavir) inhibiting MERS-CoV replication in the low-micromolar range (50% effective concentrations [EC(50)s], 3 to 8 μM). Moreover, these compounds also inhibit the replication of SARS coronavirus and human coronavirus 229E. Although their protective activity (alone or in combination) remains to be assessed in animal models, our findings may offer a starting point for treatment of patients infected with zoonotic coronaviruses like MERS-CoV. Although they may not necessarily reduce viral replication to very low levels, a moderate viral load reduction may create a window during which to mount a protective immune response.","has_valid_pdf":true,"author":[{"sequence":"first","family":"de Wilde","given":"Adriaan H.","affiliation":[]},{"sequence":"additional","family":"Jochmans","given":"Dirk","affiliation":[]},{"sequence":"additional","family":"Posthuma","given":"Clara C.","affiliation":[]},{"sequence":"additional","family":"Zevenhoven-Dobbe","given":"Jessika C.","affiliation":[]},{"sequence":"additional","family":"van Nieuwkoop","given":"Stefan","affiliation":[]},{"sequence":"additional","family":"Bestebroer","given":"Theo M.","affiliation":[]},{"sequence":"additional","family":"van den Hoogen","given":"Bernadette G.","affiliation":[]},{"sequence":"additional","family":"Neyts","given":"Johan","affiliation":[]},{"sequence":"additional","family":"Snijder","given":"Eric J.","affiliation":[]}],"subject":["Pharmacology (medical)","Pharmacology","Infectious Diseases"],"link":[{"URL":"https://syndication.highwire.org/content/doi/10.1128/AAC.03011-14","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1400562287000,"date-time":"2014-05-20T05:04:47Z","date-parts":[[2014,5,20]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783},{"page_width":585,"page_height":783}],"runtime":11041},
  {"_key":"60c20d727723bebd866456c5","_id":"documents/60c20d727723bebd866456c5","_rev":"_cfFhBb6---","file_name":"02o9ik36.pdf","md5":"F1ABE186193CFAA8D0C59AF78E6AE38D","id":"02o9ik36","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/o9/ik/36/02o9ik36/02o9ik36.pdf","date":"2021-06-10T13:02+0000","metadata":{"license":[{"URL":"http://creativecommons.org/licenses/by/4.0/","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1598918400000,"date-time":"2020-09-01T00:00:00Z","date-parts":[[2020,9,1]]}}],"volume":"Volume 13","pmid":"33061709","author":[{"sequence":"first","given":"Mahmoud A","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0003-3605-5946","family":"Alomari","affiliation":[]},{"sequence":"additional","given":"Omar F","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-3006-3104","family":"Khabour","affiliation":[]},{"sequence":"additional","given":"Karem H","authenticated-orcid":true,"ORCID":"http://orcid.org/0000-0002-2808-5099","family":"Alzoubi","affiliation":[]}],"DOI":"10.2147/rmhp.s268320","license-simplified":"cc-by","original-title":[],"language":"en","content-domain":{"domain":[],"crossmark-restriction":false},"page":"1757-1764","type":"journal-article","issued":{"date-parts":[[2020,9]]},"publisher":"Informa UK Limited","id":"02o9ik36","reference-count":46,"title":["<p>Changes in Physical Activity and Sedentary Behavior Amid Confinement: The BKSQ-COVID-19 Project</p>"],"pmcid":"PMC7526007","has_valid_oa_url":true,"deposited":{"timestamp":1600981083000,"date-time":"2020-09-24T20:58:03Z","date-parts":[[2020,9,24]]},"indexed":{"timestamp":1618292647754,"date-time":"2021-04-13T05:44:07Z","date-parts":[[2021,4,13]]},"is-referenced-by-count":12,"short-container-title":["RMHP"],"prefix":"10.2147","published-online":{"date-parts":[[2020,9]]},"has_valid_thumbnail":false,"references-count":46,"oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/41/59/PMC7526007.tar.gz","subtitle":[],"URL":"http://dx.doi.org/10.2147/rmhp.s268320","short-title":[],"issn-type":[{"value":"1179-1594","type":"electronic"}],"container-title":["Risk Management and Healthcare Policy"],"has_valid_ref_annotation":false,"member":"301","abstract":"BACKGROUND: Coronavirus disease 19 (COVID-19) has compelled implementing confinement measure across the globe. These measures can potentially lead to many changes in lifestyle. However, no studies examined the effect of COVID-19-induced confinement on physical activity (PA) and sedentary behavior (SB). METHODS: During April and May of 2020, the current study surveyed changes in PA and SB induced by COVID-19 confinement. RESULTS: The participants of the study were 1844. Among the participants who were regularly involved in PA, the majority (41.8–42.2%) of the participants reported a “decrease” (p<0.05) in walking, jogging, and sports while the majority (46.3–53.1%) reported a “no change” (p<0.05) in swimming, cycling, and weight lifting. With regard to the SB, most of the participants reported an “increase” in watching TV (72.3%), using electronics (82.7%), and logging to social media (81.9%). Additionally, gender, job type, obesity, and being worried to contract the disease were associated (p<0.05) with changes in PA. On the other hand, age, gender, obesity, job type and income were related (p<0.05) to changes in SB. CONCLUSION: Results of the current study might enhance knowledge about the impact of COVID-19 on lifestyle, particularly PA and SB. Subsequently, it can also be used to establish strategies to enhance engagement in activities during the current and future pandemics.","has_valid_pdf":true,"has_valid_tei":false,"subject":["Public Health, Environmental and Occupational Health","Health Policy"],"link":[{"URL":"https://www.dovepress.com/getfile.php?fileID=61794","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"https://www.dovepress.com/getfile.php?fileID=61794","content-version":"vor","intended-application":"similarity-checking","content-type":"application/pdf"}],"relation":{"cites":[]},"created":{"timestamp":1600981075000,"date-time":"2020-09-24T20:57:55Z","date-parts":[[2020,9,24]]},"ISSN":["1179-1594"],"score":1,"source":"Crossref","cord_sha":"fd4b116a9540d6d9d4dd349f10ebdaecfac55674"},"application":"software-mentions","pages":[{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792},{"page_width":612,"page_height":792}],"runtime":10145},
  {"_key":"60c20d787723bebd866456c7","_id":"documents/60c20d787723bebd866456c7","_rev":"_cfFhBcG---","file_name":"02oe3a3y.pdf","md5":"603BF2B6C02700F90B12163933D62ABE","id":"02oe3a3y","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/oe/3a/3y/02oe3a3y/02oe3a3y.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["ijerph17238865"],"license":[{"URL":"https://creativecommons.org/licenses/by/4.0/","content-version":"vor","delay-in-days":0,"start":{"timestamp":1606521600000,"date-time":"2020-11-28T00:00:00Z","date-parts":[[2020,11,28]]}}],"volume":"17","pmid":"33260570","has_valid_tei":false,"URL":"http://dx.doi.org/10.3390/ijerph17238865","DOI":"10.3390/ijerph17238865","original-title":[],"title":["What Motivates Smokers to Switch to ENDS? A Qualitative Study of Perceptions and Use"],"content-domain":{"domain":[],"crossmark-restriction":false},"reference-count":30,"page":"8865","type":"journal-article","issued":{"date-parts":[[2020,11,28]]},"publisher":"MDPI AG","id":"02oe3a3y","short-title":[],"pmcid":"PMC7729446","has_valid_oa_url":true,"deposited":{"timestamp":1606755297000,"date-time":"2020-11-30T16:54:57Z","date-parts":[[2020,11,30]]},"indexed":{"timestamp":1606756358251,"date-time":"2020-11-30T17:12:38Z","date-parts":[[2020,11,30]]},"is-referenced-by-count":0,"short-container-title":["IJERPH"],"prefix":"10.3390","oaLink":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_package/5d/46/PMC7729446.tar.gz","has_valid_thumbnail":false,"ISSN":["1660-4601"],"references-count":30,"license-simplified":"cc-by","subtitle":[],"has_valid_ref_annotation":false,"journal-issue":{"issue":"23","published-online":{"date-parts":[[2020,12]]}},"issn-type":[{"value":"1660-4601","type":"electronic"}],"container-title":["International Journal of Environmental Research and Public Health"],"published-online":{"date-parts":[[2020,11,28]]},"issue":"23","member":"1968","abstract":"Switching completely from cigarettes to electronic nicotine delivery systems (ENDS) may reduce health risks for addicted smokers. This paper provides information about perceptions and other factors that may influence smokers’ ENDS use and substitution for cigarettes. We conducted 12 online focus groups (N = 61) among smokers who had never tried using ENDS (Never Users, N = 11), currently used both cigarettes and ENDS (Dual Users, N = 21), used but discontinued ENDS (Rejectors, N = 14), and switched completely to ENDS use (Switchers, N = 15). Thematic analysis was used to interpret the transcripts. Participants described initial interest in trying ENDS in hopes of quitting smoking and because of convenience (i.e., due to rules, regulations, or social norms). Risk perceptions and higher prices relative to cigarettes were reported as disadvantages of ENDS that discouraged initiation. Dual Users and Rejectors reported product problems (e.g., products breaking) and dissatisfaction (i.e., inability to satisfy cravings for cigarettes) as factors that lowered their substitutability for cigarettes or led to discontinuing ENDS use. Switchers indicated that satisfaction, lack of product problems, and perceived safety facilitated successfully switching from cigarette smoking to exclusive ENDS use. However, Switchers reported trying many products before they found ones that satisfied their needs. We recommend that policymakers consider the potential impact of tobacco control policies on smokers’ motivation and ability to switch completely from cigarettes to ENDS.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Evans","given":"Abigail T.","affiliation":[]},{"sequence":"additional","given":"Katherine C.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0001-9905-8648","family":"Henderson","affiliation":[]},{"sequence":"additional","family":"Geier","given":"Anna","affiliation":[]},{"sequence":"additional","family":"Weaver","given":"Scott R.","affiliation":[]},{"sequence":"additional","family":"Spears","given":"Claire Adams","affiliation":[]},{"sequence":"additional","given":"David L.","authenticated-orcid":false,"ORCID":"http://orcid.org/0000-0002-1060-5893","family":"Ashley","affiliation":[]},{"sequence":"additional","family":"Fritz","given":"Meredith","affiliation":[]},{"sequence":"additional","family":"John","given":"Lisa","affiliation":[]},{"sequence":"additional","family":"Pechacek","given":"Terry F.","affiliation":[]}],"link":[{"URL":"https://www.mdpi.com/1660-4601/17/23/8865/pdf","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1606701657000,"date-time":"2020-11-30T02:00:57Z","date-parts":[[2020,11,30]]},"language":"en","score":1,"source":"Crossref","cord_sha":"c158a97ef6159d22b9d28e0f96c48051ec3f4860"},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89},{"page_width":595.276,"page_height":841.89}],"runtime":12310},
  {"_key":"60c20d7a7723bebd866456ca","_id":"documents/60c20d7a7723bebd866456ca","_rev":"_cfFhBcS---","file_name":"02o0i1je.pdf","md5":"4CFB6D3BA03E48C1A16F6EF9F256C264","id":"02o0i1je","version":"0.7.0-SNAPSHOT","original_file_path":"/media/lopez/store/cord-19/data/02/o0/i1/je/02o0i1je/02o0i1je.pdf","date":"2021-06-10T13:02+0000","metadata":{"alternative-id":["131"],"published-print":{"date-parts":[[2016,12]]},"article-number":"30","volume":"6","pmid":"27076185","journal-issue":{"published-print":{"date-parts":[[2016,12]]},"issue":"1"},"has_valid_tei":false,"DOI":"10.1186/s13613-016-0131-y","original-title":[],"license":[{"URL":"http://creativecommons.org/licenses/by/4.0","content-version":"unspecified","delay-in-days":0,"start":{"timestamp":1460592000000,"date-time":"2016-04-14T00:00:00Z","date-parts":[[2016,4,14]]}}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"reference-count":16,"type":"journal-article","issued":{"date-parts":[[2016,4,14]]},"funder":[{"doi-asserted-by":"publisher","award":[],"DOI":"10.13039/501100002736","name":"Covidien"},{"award":[],"name":"Angers University Hospital, France"},{"award":[],"name":"Faculty of Medicine Siriraj Hospital, Bangkok, Thailand"}],"publisher":"Springer Science and Business Media LLC","id":"02o0i1je","short-title":[],"title":["Accuracy of delivered airway pressure and work of breathing estimation during proportional assist ventilation: a bench study"],"oaLink":"https://annalsofintensivecare.springeropen.com/track/pdf/10.1186/s13613-016-0131-y","has_valid_oa_url":true,"deposited":{"timestamp":1553616518000,"date-time":"2019-03-26T16:08:38Z","date-parts":[[2019,3,26]]},"indexed":{"timestamp":1597144304358,"date-time":"2020-08-11T11:11:44Z","date-parts":[[2020,8,11]]},"is-referenced-by-count":7,"short-container-title":["Ann. Intensive Care"],"prefix":"10.1186","published-online":{"date-parts":[[2016,4,14]]},"has_valid_thumbnail":false,"references-count":16,"license-simplified":"cc-by","subtitle":[],"URL":"http://dx.doi.org/10.1186/s13613-016-0131-y","ISSN":["2110-5820"],"issn-type":[{"value":"2110-5820","type":"electronic"}],"container-title":["Annals of Intensive Care"],"has_valid_ref_annotation":false,"issue":"1","member":"297","abstract":"BACKGROUND Proportional assist ventilation+ (PAV+) delivers airway pressure (P aw) in proportion to patient effort (P mus) by using the equation of motion of the respiratory system. PAV+ calculates automatically respiratory mechanics (elastance and resistance); the work of breathing (WOB) is estimated by the ventilator. The accuracy of P mus estimation and hence accuracy of the delivered P aw and WOB calculation have not been assessed. This study aimed at assessing the accuracy of delivered P aw and calculated WOB by PAV+ and examining the factors influencing this accuracy. METHODS Using an active lung model with different respiratory mechanics, we compared (1) the actual delivered P aw by the ventilator to the theoretical P aw as defined by the equation of motion and (2) the WOB value displayed by the ventilator to the WOB measured from a Campbell diagram. RESULTS Irrespective of respiratory mechanics and gain, the ventilator provided a P aw approximately 25 % lower than expected. This underassistance was greatest at the beginning of the inspiration. Intrinsic PEEP (PEEPi), associated with an increase in trigger delay, was a major factor affecting PAV+ accuracy. The absolute value of total WOB displayed by the ventilator was underestimated, but the changes in WOB were accurately detected by the ventilator. CONCLUSION The assistance provided by PAV+ well follows P mus but with a constant underassistance. This is associated with an underestimation by the ventilator of the WOB. PEEPi can be a major factor contributing to PAV+ inaccuracy. Clinical recommendations should include using a high trigger sensitivity and a careful PEEP titration.","has_valid_pdf":true,"author":[{"sequence":"first","family":"Beloncle","given":"Francois","affiliation":[]},{"sequence":"additional","family":"Akoumianaki","given":"Evangelia","affiliation":[]},{"sequence":"additional","family":"Rittayamai","given":"Nuttapol","affiliation":[]},{"sequence":"additional","family":"Lyazidi","given":"Aissam","affiliation":[]},{"sequence":"additional","family":"Brochard","given":"Laurent","affiliation":[]}],"update-policy":"http://dx.doi.org/10.1007/springer_crossmark_policy","link":[{"URL":"http://link.springer.com/content/pdf/10.1186/s13613-016-0131-y.pdf","content-version":"vor","intended-application":"text-mining","content-type":"application/pdf"},{"URL":"http://link.springer.com/article/10.1186/s13613-016-0131-y/fulltext.html","content-version":"vor","intended-application":"text-mining","content-type":"text/html"},{"URL":"http://link.springer.com/content/pdf/10.1186/s13613-016-0131-y","content-version":"vor","intended-application":"similarity-checking","content-type":"unspecified"}],"relation":{"cites":[]},"created":{"timestamp":1460620773000,"date-time":"2016-04-14T07:59:33Z","date-parts":[[2016,4,14]]},"language":"en","score":1,"source":"Crossref","cord_sha":""},"application":"software-mentions","pages":[{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701},{"page_width":595.276,"page_height":793.701}],"runtime":19972},
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