Journal article Open Access
Santosh Kumar Singh*, Prabhat Sinha, N.N. Singh, Nagendra Kumar
In this research the concept of design and analysis, silicon and stainless steel based on hollow micro-needles for transdermal drug delivery(TDD) have been evaluated by Using ANSYS & computational fluid dynamic (CFD), structural. Micro fluidic analysis has performed to ensure the micro-needles design suitability for Drug delivery. The effect of axial and transverse load on single and micro-needle array has investigated with the mechanical properties of micro-needle. The analysis predicted that the resultant stresses due to applied bending and axial loads were in the desired range. In computational fluid dynamic (CFD) static analysis, the fluid flow rate through micro-needle array has investigated by applying the pressure the inlet to ensure that the micro-needles were capable for flow of drug up to the desired range. Towards achieving painless injections and other micro fluidic applications, the main aim to focus on the conically tapered hollow needles of micron dimensions. The relationship between pressure drop and flow rate through micro-needles was experimentally quantified as a function of fluid viscosity, micro-needle length, diameter, and cone half-angle. The dimensionless pressure drop sharply decreased as increased the indicating role of viscous forces on the boundaries of the micro-needles. The flow was in viscid, indicates that the effect of pressure drop, numerical simulations shows that the flow through conically tapered micro-needles was mainly controlled by the diameter with taper angle of the micro-needle tip. In this research the hollow out-of-plane micro-needle of micron sized devices for drug delivery applications were obtained.