AN OVERVIEW ON IN-SITU GELLING SYSTEM

In recent times in-situ gel systems have emerged as an alternative approach to conventional drug delivery systems.  These systems release the drug in a controlled manner by its special feature of ‘Sol to Gel’ transition. Further, this in-situ gelling system will stay as a solution before administering into the body and convert into a gel post administering into the body due to various physiological conditions. The drawbacks associated with conventional systems of both solutions and gels, such as accurate dosing, ease of administration overcome by using in situ gelling systems. The current review is mainly focused on giving a special emphasis on types, advantages, disadvantages, polymers used in the formulation, preparation of an in-situ gel, approaches, evaluations, and biomedical applications.

Keywords: In-situ gel; Polymers; Controlled Release; Drug delivery; Gelling Mechanism