Journal article Open Access

Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems

Stamenković-Radak Marina; Andjelković Marko


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    <subfield code="a">&lt;p&gt;&lt;br /&gt;
To gain more information on biological effects of plants, particularly herbs used in human medicine&lt;br /&gt;
and diet, in vitro and in vivo methods have been developed to predict their genotoxicity and/&lt;br /&gt;
or antigenotoxicity in various test systems. The sex-linked recessive lethal (SLRL) and somatic&lt;br /&gt;
mutations and recombination (SMART) tests are in vivo assays on D. melanogaster that have been&lt;br /&gt;
used to test both mutagenic and antigenotoxic effects of extracts from numerous plant species&lt;br /&gt;
used worldwide. The similarity of metabolic pathways between Drosophila and mammals and the&lt;br /&gt;
ability to activate promutagens make the results of these tests widely applicable. Besides, Drosophila&lt;br /&gt;
presents significant orthology with human genes that control cancers, which makes the assays on&lt;br /&gt;
Drosophila reliable and informative for extrapolations onto humans.&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;</subfield>
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