Journal article Open Access

Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems

Stamenković-Radak Marina; Andjelković Marko


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{
  "description": "<p><br />\nTo gain more information on biological effects of plants, particularly herbs used in human medicine<br />\nand diet, in vitro and in vivo methods have been developed to predict their genotoxicity and/<br />\nor antigenotoxicity in various test systems. The sex-linked recessive lethal (SLRL) and somatic<br />\nmutations and recombination (SMART) tests are in vivo assays on D. melanogaster that have been<br />\nused to test both mutagenic and antigenotoxic effects of extracts from numerous plant species<br />\nused worldwide. The similarity of metabolic pathways between Drosophila and mammals and the<br />\nability to activate promutagens make the results of these tests widely applicable. Besides, Drosophila<br />\npresents significant orthology with human genes that control cancers, which makes the assays on<br />\nDrosophila reliable and informative for extrapolations onto humans.</p>\n\n<p>&nbsp;</p>", 
  "license": "", 
  "creator": [
    {
      "affiliation": "Faculty of Biology, University of Belgrade, Studentski trg 3, Belgrade, Serbia", 
      "@type": "Person", 
      "name": " Stamenkovi\u0107-Radak Marina"
    }, 
    {
      "affiliation": "Serbian Academy of Sciences and Arts, Knez Mihailova 35, Belgrade, Serbia", 
      "@type": "Person", 
      "name": "Andjelkovi\u0107 Marko "
    }
  ], 
  "headline": "Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2016-04-04", 
  "url": "https://zenodo.org/record/48854", 
  "keywords": [
    "plant extracts", 
    "medicinal herbs", 
    "Drosophila", 
    "genotoxicity", 
    "antimutagenicity", 
    "diet"
  ], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.5281/zenodo.48854", 
  "@id": "https://doi.org/10.5281/zenodo.48854", 
  "@type": "ScholarlyArticle", 
  "name": "Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems"
}
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