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Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems

Stamenković-Radak Marina; Andjelković Marko


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    "description": "<p><br />\nTo gain more information on biological effects of plants, particularly herbs used in human medicine<br />\nand diet, in vitro and in vivo methods have been developed to predict their genotoxicity and/<br />\nor antigenotoxicity in various test systems. The sex-linked recessive lethal (SLRL) and somatic<br />\nmutations and recombination (SMART) tests are in vivo assays on D. melanogaster that have been<br />\nused to test both mutagenic and antigenotoxic effects of extracts from numerous plant species<br />\nused worldwide. The similarity of metabolic pathways between Drosophila and mammals and the<br />\nability to activate promutagens make the results of these tests widely applicable. Besides, Drosophila<br />\npresents significant orthology with human genes that control cancers, which makes the assays on<br />\nDrosophila reliable and informative for extrapolations onto humans.</p>\n\n<p>&nbsp;</p>", 
    "license": {
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    "title": "Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems", 
    "journal": {
      "volume": "40", 
      "year": "2016", 
      "issue": "1", 
      "pages": " 21-28", 
      "title": "Botanica Serbica"
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    "keywords": [
      "plant extracts", 
      "medicinal herbs", 
      "Drosophila", 
      "genotoxicity", 
      "antimutagenicity", 
      "diet"
    ], 
    "publication_date": "2016-04-04", 
    "creators": [
      {
        "affiliation": "Faculty of Biology, University of Belgrade, Studentski trg 3, Belgrade, Serbia", 
        "name": " Stamenkovi\u0107-Radak Marina"
      }, 
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        "affiliation": "Serbian Academy of Sciences and Arts, Knez Mihailova 35, Belgrade, Serbia", 
        "name": "Andjelkovi\u0107 Marko "
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