Journal article Open Access

Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems

Stamenković-Radak Marina; Andjelković Marko


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  <identifier identifierType="DOI">10.5281/zenodo.48854</identifier>
  <creators>
    <creator>
      <creatorName> Stamenković-Radak Marina</creatorName>
      <affiliation>Faculty of Biology, University of Belgrade, Studentski trg 3, Belgrade, Serbia</affiliation>
    </creator>
    <creator>
      <creatorName>Andjelković Marko </creatorName>
      <affiliation>Serbian Academy of Sciences and Arts, Knez Mihailova 35, Belgrade, Serbia</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2016</publicationYear>
  <subjects>
    <subject>plant extracts</subject>
    <subject>medicinal herbs</subject>
    <subject>Drosophila</subject>
    <subject>genotoxicity</subject>
    <subject>antimutagenicity</subject>
    <subject>diet</subject>
  </subjects>
  <dates>
    <date dateType="Issued">2016-04-04</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/48854</alternateIdentifier>
  </alternateIdentifiers>
  <rightsList>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;&lt;br /&gt;
To gain more information on biological effects of plants, particularly herbs used in human medicine&lt;br /&gt;
and diet, in vitro and in vivo methods have been developed to predict their genotoxicity and/&lt;br /&gt;
or antigenotoxicity in various test systems. The sex-linked recessive lethal (SLRL) and somatic&lt;br /&gt;
mutations and recombination (SMART) tests are in vivo assays on D. melanogaster that have been&lt;br /&gt;
used to test both mutagenic and antigenotoxic effects of extracts from numerous plant species&lt;br /&gt;
used worldwide. The similarity of metabolic pathways between Drosophila and mammals and the&lt;br /&gt;
ability to activate promutagens make the results of these tests widely applicable. Besides, Drosophila&lt;br /&gt;
presents significant orthology with human genes that control cancers, which makes the assays on&lt;br /&gt;
Drosophila reliable and informative for extrapolations onto humans.&lt;/p&gt;

&lt;p&gt;&amp;nbsp;&lt;/p&gt;</description>
  </descriptions>
</resource>
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