Journal article Open Access

Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems

Stamenković-Radak Marina; Andjelković Marko


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.48854", 
  "container_title": "Botanica Serbica", 
  "title": "Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems", 
  "issued": {
    "date-parts": [
      [
        2016, 
        4, 
        4
      ]
    ]
  }, 
  "abstract": "<p><br />\nTo gain more information on biological effects of plants, particularly herbs used in human medicine<br />\nand diet, in vitro and in vivo methods have been developed to predict their genotoxicity and/<br />\nor antigenotoxicity in various test systems. The sex-linked recessive lethal (SLRL) and somatic<br />\nmutations and recombination (SMART) tests are in vivo assays on D. melanogaster that have been<br />\nused to test both mutagenic and antigenotoxic effects of extracts from numerous plant species<br />\nused worldwide. The similarity of metabolic pathways between Drosophila and mammals and the<br />\nability to activate promutagens make the results of these tests widely applicable. Besides, Drosophila<br />\npresents significant orthology with human genes that control cancers, which makes the assays on<br />\nDrosophila reliable and informative for extrapolations onto humans.</p>\n\n<p>&nbsp;</p>", 
  "author": [
    {
      "given": "", 
      "family": "Stamenkovi\u0107-Radak Marina"
    }, 
    {
      "given": "", 
      "family": "Andjelkovi\u0107 Marko"
    }
  ], 
  "page": " 21-28", 
  "volume": "40", 
  "type": "article-journal", 
  "issue": "1", 
  "id": "48854"
}
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