Journal article Open Access
Stamenković-Radak Marina; Andjelković Marko
{ "publisher": "Zenodo", "DOI": "10.5281/zenodo.48854", "container_title": "Botanica Serbica", "title": "Studying genotoxic and antimutagenic effects of plant extracts in Drosophila test systems", "issued": { "date-parts": [ [ 2016, 4, 4 ] ] }, "abstract": "<p><br />\nTo gain more information on biological effects of plants, particularly herbs used in human medicine<br />\nand diet, in vitro and in vivo methods have been developed to predict their genotoxicity and/<br />\nor antigenotoxicity in various test systems. The sex-linked recessive lethal (SLRL) and somatic<br />\nmutations and recombination (SMART) tests are in vivo assays on D. melanogaster that have been<br />\nused to test both mutagenic and antigenotoxic effects of extracts from numerous plant species<br />\nused worldwide. The similarity of metabolic pathways between Drosophila and mammals and the<br />\nability to activate promutagens make the results of these tests widely applicable. Besides, Drosophila<br />\npresents significant orthology with human genes that control cancers, which makes the assays on<br />\nDrosophila reliable and informative for extrapolations onto humans.</p>\n\n<p> </p>", "author": [ { "given": "", "family": "Stamenkovi\u0107-Radak Marina" }, { "given": "", "family": "Andjelkovi\u0107 Marko" } ], "page": " 21-28", "volume": "40", "type": "article-journal", "issue": "1", "id": "48854" }
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