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Published November 28, 2015 | Version v1
Journal article Open

Imaging of Neuroinflammation in Alzheimer's Disease, Multiple Sclerosis and Stroke: Recent Developments in Positron Emission Tomography.

  • 1. Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands
  • 2. Department of Radiology & Nuclear Medicine, VU University Medical Center, Amsterdam, the Netherlands and BV Cyclotron VU, Amsterdam, the Netherlands
  • 3. BV Cyclotron VU, Amsterdam, the Netherlands

Description

Neuroinflammation is thought to play a pivotal role in many diseases affecting the brain, including Alzheimer’s disease, multiple sclerosis and stroke. Neuroinflammation is characterised predominantly by microglial activation, which can be visualised using positron emission tomography (PET). Traditionally, translocator protein 18 kDa (TSPO) is the target for imaging of neuroinflammation using PET. In this review, recent preclinical and clinical research using PET in Alzheimer’s disease, multiple sclerosis and stroke is summarised. In addition, new molecular targets
for imaging of neuroinflammation, such as monoamine oxidases, adenosine receptors and cannabinoid receptor type 2, are discussed.

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Additional details

Funding

INMIND – Imaging of Neuroinflammation in Neurodegenerative Diseases 278850
European Commission