Journal article Open Access

Self-adaptive biosystems through tunable genetic parts and circuits

Bartoli, Vittorio; di Bernardo, Mario; Gorochowski, Thomas E.

Abstract

Biological systems often need to operate in complex environments where conditions can rapidly change. This is possible because of their inherent ability to sense changes and adapt their behavior in response. Here, we detail recent advances in the creation of synthetic genetic parts and circuits whose behaviors can be dynamically tuned through a variety of intracellular and extracellular signals. We show how this capability lays the foundation for implementing control engineering schemes in living cells and allows for the creation of biological systems that are able to self-adapt, ensuring their functionality is maintained in the face of varying environmental and physiological conditions. We end by discussing some of the broader implications of this technology for the safe deployment of synthetic biology.

 

Files (1.2 MB)
Name Size
Bartoli et al 2020 .pdf
md5:ab85efa294ea0b23b9f9d2f5003a2bdb
1.2 MB Download
5
26
views
downloads
Views 5
Downloads 26
Data volume 30.3 MB
Unique views 4
Unique downloads 25

Share

Cite as