Preprint Open Access

A low-cost, open-source Turbidostat design for in-vivo control experiments in Synthetic Biology

Guarino, Agostino; Shannon, Barbara; Marucci, Lucia; Grierson, Claire; Savery, Nigel


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  <identifier identifierType="URL">https://zenodo.org/record/4808581</identifier>
  <creators>
    <creator>
      <creatorName>Guarino, Agostino</creatorName>
      <givenName>Agostino</givenName>
      <familyName>Guarino</familyName>
      <affiliation>Dipartimento di Ingegneria Elettrica e Tecnologie dell'Informazione, University of Naples Federico II, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Shannon, Barbara</creatorName>
      <givenName>Barbara</givenName>
      <familyName>Shannon</familyName>
      <affiliation>Departement of Engineering Mathematics, University of Bristol, U.K.</affiliation>
    </creator>
    <creator>
      <creatorName>Marucci, Lucia</creatorName>
      <givenName>Lucia</givenName>
      <familyName>Marucci</familyName>
      <affiliation>Departement of Engineering Mathematics, University of Bristol, U.K.</affiliation>
    </creator>
    <creator>
      <creatorName>Grierson, Claire</creatorName>
      <givenName>Claire</givenName>
      <familyName>Grierson</familyName>
      <affiliation>School of Biological Sciences, University of Bristol, UK</affiliation>
    </creator>
    <creator>
      <creatorName>Savery, Nigel</creatorName>
      <givenName>Nigel</givenName>
      <familyName>Savery</familyName>
      <affiliation>School of Biochemistry, University of Bristol, UK</affiliation>
    </creator>
  </creators>
  <titles>
    <title>A low-cost, open-source Turbidostat design for in-vivo control experiments in Synthetic Biology</title>
  </titles>
  <publisher>Zenodo</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-12-26</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Preprint</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://zenodo.org/record/4808581</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ifacol.2019.12.265</relatedIdentifier>
    <relatedIdentifier relatedIdentifierType="URL" relationType="IsPartOf">https://zenodo.org/communities/cosy-bio</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="https://creativecommons.org/licenses/by/4.0/legalcode">Creative Commons Attribution 4.0 International</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">&lt;p&gt;Abstract&lt;/p&gt;

&lt;p&gt;Continuous culture platforms are required to characterise the dynamics of new engineered systems in synthetic biology. In this paper, we review existing turbidostat platforms before describing the design and implementation of our new flexible and low-cost turbidostat for&amp;nbsp;&lt;em&gt;in-vivo&lt;/em&gt;control experiments. We provide preliminary experimental results on controlling the optical density of a bacterial culture. We also discuss the potential extensions to our design for the development of&amp;nbsp;&lt;em&gt;in-vivo&lt;/em&gt;multicellular control experiments.&lt;/p&gt;</description>
  </descriptions>
  <fundingReferences>
    <fundingReference>
      <funderName>European Commission</funderName>
      <funderIdentifier funderIdentifierType="Crossref Funder ID">10.13039/501100000780</funderIdentifier>
      <awardNumber awardURI="info:eu-repo/grantAgreement/EC/H2020/766840/">766840</awardNumber>
      <awardTitle>Control Engineering of Biological Systems for Reliable Synthetic Biology Applications</awardTitle>
    </fundingReference>
  </fundingReferences>
</resource>
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