4808223
doi
10.1109/LCSYS.2020.3000954
oai:zenodo.org:4808223
user-cosy-bio
user-eu
Salzano, Davide
University of Naples Federico II, Naples, Italy
Cristòbal-Cóppulo, Enric
Department of Mathematics and Institute of Industrial and Control Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain
Olm, Josep M.
Department of Mathematics and Institute of Industrial and Control Engineering, Universitat Politècnica de Catalunya, Barcelona, Spain
di Bernardo, Mario
University of Naples Federico II, Naples, Italy University of Bristol, University Walk, Bristol, U.K.
Multicellular feedback control of a genetic toggle-switch in microbial consortia
Fiore, Davide
University of Naples Federico II, Naples, Italy
info:eu-repo/semantics/openAccess
Creative Commons Attribution 4.0 International
https://creativecommons.org/licenses/by/4.0/legalcode
<p><strong>Abstract</strong></p>
<p>We describe a multicellular approach to control a target cell population endowed with a bistable toggle-switch. The idea is to engineer a synthetic microbial consortium consisting of three different cell populations. In such a consortium, two populations, the Togglers, responding to some reference input, can induce the switch of a bistable memory mechanism in a third population, the Targets, so as to activate or deactivate some additional functionalities in the cells. Communication among the three populations is established by orthogonal quorum sensing molecules that are used to close a feedback control loop across the populations. The control design is validated via in-silico experiments in BSim, a realistic agent-based simulator of bacterial populations.</p>
Zenodo
2020-06-09
info:eu-repo/semantics/preprint
4808222
user-cosy-bio
user-eu
award_title=Control Engineering of Biological Systems for Reliable Synthetic Biology Applications; award_number=766840; award_identifiers_scheme=url; award_identifiers_identifier=https://cordis.europa.eu/projects/766840; funder_id=00k4n6c32; funder_name=European Commission;
1622114197.764572
1971679
md5:06dfd0ec8a7a7987a9833b8cece4ceb5
https://zenodo.org/records/4808223/files/Fiore et al IEEE 2020.pdf
public
IEEE Control Systems Letters
5
1
151 - 156
2020-06-09