Journal article Open Access
Hugenberg, Verena; Wagner, Stefan; Kopka, Klaus; Schäfers, Michael; Schuit, Robert C; Windhorst, Albert D; Hermann, Sven
<?xml version='1.0' encoding='utf-8'?> <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:adms="http://www.w3.org/ns/adms#" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dct="http://purl.org/dc/terms/" xmlns:dctype="http://purl.org/dc/dcmitype/" xmlns:dcat="http://www.w3.org/ns/dcat#" xmlns:duv="http://www.w3.org/ns/duv#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:frapo="http://purl.org/cerif/frapo/" xmlns:geo="http://www.w3.org/2003/01/geo/wgs84_pos#" xmlns:gsp="http://www.opengis.net/ont/geosparql#" xmlns:locn="http://www.w3.org/ns/locn#" xmlns:org="http://www.w3.org/ns/org#" xmlns:owl="http://www.w3.org/2002/07/owl#" xmlns:prov="http://www.w3.org/ns/prov#" xmlns:rdfs="http://www.w3.org/2000/01/rdf-schema#" xmlns:schema="http://schema.org/" xmlns:skos="http://www.w3.org/2004/02/skos/core#" xmlns:vcard="http://www.w3.org/2006/vcard/ns#" xmlns:wdrs="http://www.w3.org/2007/05/powder-s#"> <rdf:Description rdf:about="https://zenodo.org/record/478813"> <rdf:type rdf:resource="http://www.w3.org/ns/dcat#Dataset"/> <dct:type rdf:resource="http://purl.org/dc/dcmitype/Text"/> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/478813</dct:identifier> <foaf:page rdf:resource="https://zenodo.org/record/478813"/> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Hugenberg, Verena</foaf:name> <foaf:givenName>Verena</foaf:givenName> <foaf:familyName>Hugenberg</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>European Institute for Molecular Imaging, University of Münster, Waldeyerstr. 15, D-48149 Münster, Germany and Department of Nuclear Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, D-48149 Münster, Germany</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Wagner, Stefan</foaf:name> <foaf:givenName>Stefan</foaf:givenName> <foaf:familyName>Wagner</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Department of Nuclear Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, D-48149 Münster, Germany</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Kopka, Klaus</foaf:name> <foaf:givenName>Klaus</foaf:givenName> <foaf:familyName>Kopka</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Department of Nuclear Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, D-48149 Münster, Germany</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Schäfers, Michael</foaf:name> <foaf:givenName>Michael</foaf:givenName> <foaf:familyName>Schäfers</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>European Institute for Molecular Imaging, University of Münster, Waldeyerstr. 15, D-48149 Münster, Germany; Department of Nuclear Medicine, University Hospital Münster, Albert-Schweitzer-Campus 1, Building A1, D-48149 Münster, Germany and DFG EXC 1003 Cluster of Excellence 'Cells in Motion', University of Münster, D-48149 Münster, Germany</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Schuit, Robert C</foaf:name> <foaf:givenName>Robert C</foaf:givenName> <foaf:familyName>Schuit</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Department of Radiology & Nuclear Medicine, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Windhorst, Albert D</foaf:name> <foaf:givenName>Albert D</foaf:givenName> <foaf:familyName>Windhorst</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>Department of Radiology & Nuclear Medicine, VU University Medical Center Amsterdam, De Boelelaan 1117, 1081 HZ Amsterdam, The Netherlands</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:creator> <rdf:Description> <rdf:type rdf:resource="http://xmlns.com/foaf/0.1/Agent"/> <foaf:name>Hermann, Sven</foaf:name> <foaf:givenName>Sven</foaf:givenName> <foaf:familyName>Hermann</foaf:familyName> <org:memberOf> <foaf:Organization> <foaf:name>European Institute for Molecular Imaging, University of Münster, Waldeyerstr. 15, D-48149 Münster, Germany and DFG EXC 1003 Cluster of Excellence 'Cells in Motion', University of Münster, D-48149 Münster, Germany</foaf:name> </foaf:Organization> </org:memberOf> </rdf:Description> </dct:creator> <dct:title>Radiolabeled Selective Matrix Metalloproteinase 13 (MMP-13) Inhibitors: (Radio)Syntheses and in Vitro and First in Vivo Evaluation.</dct:title> <dct:publisher> <foaf:Agent> <foaf:name>Zenodo</foaf:name> </foaf:Agent> </dct:publisher> <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#gYear">2017</dct:issued> <dcat:keyword>Selective matrix metalloproteinase inhibitors</dcat:keyword> <dcat:keyword>selective MMP-13 inhibitors</dcat:keyword> <dcat:keyword>positron emission tomography</dcat:keyword> <dcat:keyword>radiotracer</dcat:keyword> <frapo:isFundedBy rdf:resource="info:eu-repo/grantAgreement/EC/FP7/278850/"/> <schema:funder> <foaf:Organization> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100000780</dct:identifier> <foaf:name>European Commission</foaf:name> </foaf:Organization> </schema:funder> <dct:issued rdf:datatype="http://www.w3.org/2001/XMLSchema#date">2017-01-12</dct:issued> <owl:sameAs rdf:resource="https://zenodo.org/record/478813"/> <adms:identifier> <adms:Identifier> <skos:notation rdf:datatype="http://www.w3.org/2001/XMLSchema#anyURI">https://zenodo.org/record/478813</skos:notation> <adms:schemeAgency>url</adms:schemeAgency> </adms:Identifier> </adms:identifier> <owl:sameAs rdf:resource="https://doi.org/10.1021/acs.jmedchem.6b01284"/> <dct:isPartOf rdf:resource="https://zenodo.org/communities/ecfunded"/> <dct:isPartOf rdf:resource="https://zenodo.org/communities/inmind"/> <dct:description><p>The noninvasive imaging of MMP activity in vivo could have a<br> high impact in basic research as well as in clinical applications. This approach<br> can be established using radiolabeled MMP inhibitors (MMPIs) as tracers for<br> the detection of activated MMPs by means of PET. However, the complexity of<br> diseases associated with dysregulated MMP expression necessitates the imaging<br> of distinct MMPs or MMP subgroups to distinguish their individual role in<br> specific diseases. To this end, selective and potent MMP-13 inhibitors based on<br> a N,N′-bis(benzyl)pyrimidine-4,6-dicarboxamide core have been synthesized<br> and successfully radiolabeled with carbon-11, fluorine-18, and gallium-68.<br> Selected radiolabeled candidates were evaluated in vitro and in vivo regarding<br> their pharmacokinetic properties and metabolic stability.</p></dct:description> <dct:accessRights rdf:resource="http://publications.europa.eu/resource/authority/access-right/PUBLIC"/> <dct:accessRights> <dct:RightsStatement rdf:about="info:eu-repo/semantics/openAccess"> <rdfs:label>Open Access</rdfs:label> </dct:RightsStatement> </dct:accessRights> <dcat:distribution> <dcat:Distribution> <dct:license rdf:resource="https://creativecommons.org/licenses/by/4.0/legalcode"/> <dcat:accessURL rdf:resource="https://zenodo.org/record/478813"/> </dcat:Distribution> </dcat:distribution> <dcat:distribution> <dcat:Distribution> <dcat:accessURL>https://doi.org/10.1021/acs.jmedchem.6b01284</dcat:accessURL> <dcat:byteSize>1961061</dcat:byteSize> <dcat:downloadURL>https://zenodo.org/record/478813/files/Hugenberg_JMedChem_2017-P01-AAM.pdf</dcat:downloadURL> <dcat:mediaType>application/pdf</dcat:mediaType> </dcat:Distribution> </dcat:distribution> </rdf:Description> <foaf:Project rdf:about="info:eu-repo/grantAgreement/EC/FP7/278850/"> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">278850</dct:identifier> <dct:title>Imaging of Neuroinflammation in Neurodegenerative Diseases</dct:title> <frapo:isAwardedBy> <foaf:Organization> <dct:identifier rdf:datatype="http://www.w3.org/2001/XMLSchema#string">10.13039/501100000780</dct:identifier> <foaf:name>European Commission</foaf:name> </foaf:Organization> </frapo:isAwardedBy> </foaf:Project> </rdf:RDF>
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