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Abstract
\n\nChronic Hepatitis B virus (HBV) infection is a chronic viral illness that affects millions of people around the world and can cause serious consequences such as hepatic failure and hepatocellular carcinoma. Entecavir, a guanosine nucleoside analog (NA), is a commonly used and generally safe therapeutic agent in HBV infection. In this paper, we aimed to present a case of chronic HBV that developed severe myopathy as an extremely rare side effect after the use of entecavir. Patients receiving entecavir therapy for chronic HBV should be closely monitored for the development of myopathy as well as other known and common side effects.
\n\nÖzet
\n\nKronik Hepatit B virusu (HBV) enfeksiyonu, dünya çap\u0131nda milyonlarca insan\u0131 etkileyen ve karaci\u011fer yetmezli\u011fi ve hepatoselüler karsinoma gibi ciddi sonuçlara neden olabilen kronik viral bir hastal\u0131kt\u0131r. Bir guanozin nükleozit analo\u011fu (NA) olan entekavir, HBV enfeksiyonunda yayg\u0131n olarak kullan\u0131lan ve genellikle güvenli bir terapötik ajand\u0131r. Bu yaz\u0131da, entekavir kullan\u0131m\u0131ndan sonra son derece nadir bir yan etki olarak \u015fiddetli miyopati geli\u015fen bir kronik HBV olgusunu sunmay\u0131 amaçlad\u0131k. Kronik HBV için entekavir tedavisi alan hastalar, miyopati geli\u015fimi ve di\u011fer bilinen ve yayg\u0131n yan etkiler aç\u0131s\u0131ndan yak\u0131ndan izlenmelidir.
", "languages": [ { "id": "eng", "title": { "en": "English" } } ], "publication_date": "2021-04-07", "publisher": "Zenodo", "references": [ { "reference": "1. Wilkins T, Sams R, Carpenter M. Hepatitis B: Screening, Prevention, Diagnosis, and Treatment. Am Fam Physician 2019; 99(5): 314-23." }, { "reference": "2. Karagoz E, Tanoglu A. Clinical Usefulness of HBsAg Quantification in Patients with Chronic Hepatitis B Infection. Hepat Mon 2017; 17(4): e12293." }, { "reference": "3. Koklu S, Gulsen MT, Tuna Y, Koklu H, Yuksel O, Demir M, et al. Differences in nephrotoxicity risk and renal effects among anti-viral therapies against hepatitis B. Aliment Pharmacol Ther 2015; 41(3): 310-9." }, { "reference": "4. Tu T, Douglas MW. Hepatitis B Virus Infection: From Diagnostics to Treatments. Viruses 2020; 12(12): 1366." }, { "reference": "5. Findlay AR, Goyal NA, Mozaffar T. An overview of polymyositis and dermatomyositis. Muscle Nerve 2015; 51(5): 638-56." }, { "reference": "6. Chang TT, Gish RG, de Man R, Gadano A, Sollano J, Chao YC, et al; BEHoLD AI463022 Study Group. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 2006; 354(10): 1001-10." }, { "reference": "7. Zou XJ, Jiang XQ, Tian DY. Clinical features and risk factors of creatine kinase elevations and myopathy associated with telbivudine. J Viral Hepat 2011; 18(12): 892-6." }, { "reference": "8. Yuan K, Guochun W, Huang Z, Lin B, Zhou H, Lu X. Entecavir-associated myopathy: a case report and literature review. Muscle Nerve 2014; 49(4): 610-4." }, { "reference": "9. Dolce V, Fiermonte G, Runswick MJ, Palmieri F, Walker JE. The human mitochondrial deoxynucleotide carrier and its role in the toxicity of nucleoside antivirals. Proc Natl Acad Sci U S A 2001; 98(5): 2284-8." }, { "reference": "10. Bridges EG, Jiang Z, Cheng YC. Characterization of a dCTP transport activity reconstituted from human mitochondria. J Biol Chem 1999; 274(8): 4620-5." } ], "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "Hepatitis B" }, { "subject": "Antiviral therapy" }, { "subject": "Nucleoside analog" }, { "subject": "Hepatit B" }, { "subject": "Antiviral tedavi" }, { "subject": "N\u00fckleozit analo\u011fu" } ], "title": "Entecavir Induced Severe Myopathy: An Uncommon Side Effect" }, "parent": { "access": { "owned_by": { "user": 197681 } }, "communities": {}, "id": "4782422", "pids": {} }, "pids": { "doi": { "identifier": "10.46683/jmvi.2021.26", "provider": "external" }, "oai": { "identifier": "oai:zenodo.org:4782423", "provider": "oai" } }, "revision_id": 6, "stats": { "all_versions": { "data_volume": 11899896.0, "downloads": 68, "unique_downloads": 65, "unique_views": 74, "views": 82 }, "this_version": { "data_volume": 11899896.0, "downloads": 68, "unique_downloads": 65, "unique_views": 74, "views": 82 } }, "status": "published", "updated": "2023-01-12T16:42:17.455347+00:00", "versions": { "index": 1, "is_latest": true } }