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Karin", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Forsberg", "given_name": "Anton", "name": "Forsberg, Anton", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Schain", "given_name": "Martin", "name": "Schain, Martin", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Arakawa", "given_name": "Ryosuke", "name": "Arakawa, Ryosuke", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Jucaite", "given_name": "Aurelija", "name": "Jucaite, Aurelija", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden and Stress Research Institute, Stockholm University, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Lekander", "given_name": "Mats", "name": "Lekander, Mats", "type": "personal" } }, { "affiliations": [ { "name": "Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden and Department of Medicine Solna and CMM, Karolinska Institutet and Karolinska University Hospital Solna, Stockholm, Sweden" } ], "person_or_org": { "family_name": "H\u00f6glund", "given_name": "Caroline Olgart", "name": "H\u00f6glund, Caroline Olgart", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Osher Center for Integrative Medicine, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Kosek", "given_name": "Eva", "name": "Kosek, Eva", "type": "personal" } }, { "affiliations": [ { "name": "Department of Medicine, Rheumatology Unit, Center of Molecular Medicine (CMM), Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Lampa", "given_name": "Jon", "name": "Lampa, Jon", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Halldin", "given_name": "Christer", "name": "Halldin, Christer", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Farde", "given_name": "Lars", "name": "Farde, Lars", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Varrone", "given_name": "Andrea", "name": "Varrone, Andrea", "type": "personal" } }, { "affiliations": [ { "name": "Department of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet, Stockholm, Sweden" } ], "person_or_org": { "family_name": "Cervenka", "given_name": "Simon", "name": "Cervenka, Simon", "type": "personal" } } ], "description": "
Microglia, the resident macrophages in the central nervous system, are thought to be maintained by a local self-renewal mechanism. Although preclinical and in vitro studies have suggested that the brain may contain immune cells also from peripheral origin, the functional association between immune cells in the periphery and brain at physiological conditions is poorly understood. We examined 32 healthy individuals using positron emission tomography (PET) and [11C]PBR28, a radioligand for the 18-kDa translocator protein (TSPO) which is expressed both in brain microglia and blood immune cells. In 26 individuals, two measurements were performed with varying time intervals. In a subgroup of 19 individuals, of which 12 had repeat examinations, leukocyte numbers in blood was measured on each day of PET measurements. All individuals were genotyped for TSPO polymorphism and categorized as high, mixed, and low affinity binders. We assessed TSPO binding expressed as total distribution volume of [11C]PBR28 in brain and in blood cells. TSPO binding in brain was strongly and positively correlated to binding in blood cells both at baseline and when analyzing change between two PET examinations. Furthermore, there was a significant correlation between change of leukocyte numbers and change in TSPO binding in brain, and a trend-level correlation to change in TSPO binding in blood cells. These in vivo findings indicate an association between immunological cells in blood and brain via intact BBB, suggesting a functional interaction between these two compartments, such as interchange of peripherally derived cells or a common regulatory mechanism. Measurement of radioligand binding in blood cells may be a way to control for peripheral immune function in PET studies using TSPO as a marker of brain immune activation.
", "funding": [ { "award": { "acronym": "INMIND", "id": "00k4n6c32::278850", "identifiers": [ { "identifier": "https://cordis.europa.eu/projects/278850", "scheme": "url" } ], "number": "278850", "program": "FP7", "title": { "en": "Imaging of Neuroinflammation in Neurodegenerative Diseases" } }, "funder": { "id": "00k4n6c32", "name": "European Commission" } } ], "publication_date": "2016-01-25", "publisher": "Zenodo", "resource_type": { "id": "publication-article", "title": { "de": "Zeitschriftenartikel", "en": "Journal article" } }, "rights": [ { "description": { "en": "The Creative Commons Attribution license allows re-distribution and re-use of a licensed work on the condition that the creator is appropriately credited." }, "icon": "cc-by-icon", "id": "cc-by-4.0", "props": { "scheme": "spdx", "url": "https://creativecommons.org/licenses/by/4.0/legalcode" }, "title": { "en": "Creative Commons Attribution 4.0 International" } } ], "subjects": [ { "subject": "PET" }, { "subject": "[11C]PBR28" }, { "subject": "Translocator protein" }, { "subject": "Microglia" }, { "subject": "Blood immune cells" } ], "title": "In vivo evidence of a functional association between immune cells in blood and brain in healthy human subjects." }, "parent": { "access": { "owned_by": { "user": 1964 } }, "communities": { "default": "724cc757-0e37-4b01-a81f-b8aa5f1d7b44", "entries": [ { "access": { "member_policy": "open", "members_visibility": "public", "record_policy": "open", "review_policy": "open", "visibility": "public" }, "children": { "allow": false }, "created": "2014-01-06T13:42:25+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "724cc757-0e37-4b01-a81f-b8aa5f1d7b44", "links": {}, "metadata": { "curation_policy": "all uploads acknowledging the INMiND project are accepted", "page": "The goal of the EC FP7 Collaborative Project INMiND (GA 278850) is to carry out collaborative research on molecular mechanisms that link neuroinflammation with neurodegeneration in order to identify novel biological targets for activated microglia, which may serve for both diagnostic and therapeutic purposes, and to translate this knowledge into clinical application and patient benefit.
\r\n\r\n\r\n\r\n
The general objectives of INMiND are:
\r\n\r\n(i) to identify novel mechanisms of regulation and function of microglia under various conditions (inflammatory stimuli; neurodegenerative and -regenerative model systems);
\r\n\r\n(ii) to identify and implement new targets for activated microglia, which may serve for diagnostic (imaging) and therapeutic purposes;
\r\n\r\n(iii) to design new molecular probes (tracers) for these novel targets and to implement and validate them in in vivo innovative model systems and in patients;
\r\n\r\n(iv) to image and quantify modulated microglia activity in patients undergoing immune therapy for cognitive impairment, and to relate the findings to clinical outcome.
\r\n\r\nThe INMiND projects brings together a group of excellent basic scientists and clinicians with a proven background in efficiently accomplishing common scientific goals (FP6 DiMI, www.dimi.eu), who belong to highly complementary fields of research (from genome-oriented to imaging scientists and clinicians), and who are dedicated to formulate novel image-guided therapeutic strategies for neuroinflammation-related neurodegenerative diseases.
\r\n\r\nThe strength of the project is that, across Europe, it coordinates research and training activities related to neuroinflammation, neurodegeneration, neuroregeneration, and imaging with special emphasis on translating basic mechanisms into clinical applications that shall provide health benefits for our aging population.
\r\n\r\nWith its intellectual excellence and its crucial mass the INMiND consortium is playing a major role in the European Research Area and will gain European leadership in the creation of new image-guided diagnosis and therapy paradigms in patients with neurodegenerative diseases.
", "title": "INMiND - Imaging of Neuroinflammation in Neurodegenerative Diseases" }, "revision_id": 0, "slug": "inmind", "updated": "2016-09-28T07:01:51.111318+00:00" }, { "access": { "member_policy": "open", "members_visibility": "restricted", "record_policy": "open", "review_policy": "closed", "visibility": "public" }, "children": { "allow": true }, "created": "2022-11-23T15:53:29.436323+00:00", "custom_fields": {}, "deletion_status": { "is_deleted": false, "status": "P" }, "id": "f0a8b890-f97a-4eb2-9eac-8b8a712d3a6c", "links": {}, "metadata": { "curation_policy": "The EU Open Research Repository serves as a repository for research outputs (data, software, posters, presentations, publications, etc) which have been funded under an EU research funding programme such as Horizon Europe, Euratom or earlier Framework Programmes.
\nThe community is managed by CERN on behalf of the European Commission.
\nZenodo’s general policies and Terms of Use apply to all content.
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", "description": "Open repository for EU-funded research outputs from Horizon Europe, Euratom and earlier Framework Programmes.", "organizations": [ { "id": "00k4n6c32" } ], "page": "The EU Open Research Repository is a Zenodo-community dedicated to fostering open science and enhancing the visibility and accessibility of research outputs funded by the European Union. The community is managed by CERN on behalf of the European Commission.
\nThe mission of the repository is to support the implementation of the EU's open science policy, providing a trusted and comprehensive space for researchers to share their research outputs such as data, software, reports, presentations, posters and more. The EU Open Research Repository simplifies the process of complying with open science requirements, ensuring that research outputs from Horizon Europe, Euratom, and earlier Framework Programmes are freely accessible, thereby accelerating scientific discovery and innovation.
\nThe EU Open Research Repository serves as a complementary platform to the Open Research Europe (ORE) publishing platform. Open Research Europe focuses on providing a publishing venue for peer-reviewed articles, ensuring that research meets rigorous academic standards. The EU Open Research Repository provides a space for all the other research outputs including data sets, software, posters, and presentations that are out of scope for ORE. This holistic approach enables researchers to not only publish their findings but also share the underlying data and materials that support their work, fostering transparency and reproducibility in the scientific process.
\nCurrently in its pilot phase and set to be fully operational during autumn 2024, the EU Open Research Repository is constantly evolving. Efforts are committed to integrating cutting-edge features, including automated curation checks and FAIR (Findable, Accessible, Interoperable, and Reusable) assistance, to further support the research community. The goal is to provide researchers with a simple goto solution for making their publicly funded research open and as FAIR as possible.
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