Rodriguez-Vieitez, Elena
Carter, Stephen F
Chiotis, Konstantinos
Saint-Aubert, Laure
Leuzy, Antoine
Schöll, Michael
Almkvist, Ove
Wall, Anders
Langström, Bengt
Nordberg, Agneta
2016-02-16
<p>The PET tracer <sup>11</sup>C-deuterium-L-deprenyl (<sup>11</sup>C-DED) has been used to visualize activated astrocytes in vivo in patients with Alzheimer's disease (AD). In this multitracer PET study, early-phase <sup>11</sup>C-DED and <sup>11</sup>C-Pittsburgh compound-B (<sup>11</sup>C-PiB) (eDED and ePiB, respectively) were compared as surrogate markers of brain perfusion, and the extent to which <sup>11</sup>C-DED binding is influenced by brain perfusion was investigated.</p>
<p>METHODS:<sup> 11</sup>C-DED, <sup>11</sup>C-PiB and <sup>18</sup>F-fluorodeoxyglucose (FDG) dynamic PET scans were performed in age-matched groups comprising AD patients (n = 8), patients with mild cognitive impairment (MCI, n = 17), and healthy controls (HC, n = 16). A modified-reference Patlak model was used to quantify <sup>11</sup>C-DED binding. A Simplified Reference Tissue Model was applied to both <sup>11</sup>C-DED and <sup>11</sup>C-PiB to measure brain perfusion relative to the cerebellar gray matter (GM) (R<sub>1</sub>) and binding potentials. <sup>11</sup>C-PiB retention and <sup>18</sup>F-FDG uptake were also quantified as target-to-pons standardized uptake value ratios in 12 regions of interest (ROIs).</p>
<p>RESULTS: The strongest within-subject correlations with the corresponding R<sub>1</sub> values (R<sub>1,DED</sub> and R<sub>1,PiB</sub>, respectively) and with <sup>18</sup>F-FDG uptake were obtained when the eDED and ePiB PET data were measured 1-4 min post-injection. The optimum eDED/ePiB intervals also showed strong, significant ROI-based inter-subject Pearson's correlations with R<sub>1,DED</sub>/R<sub>1,PiB</sub> and with <sup>18</sup>F-FDG uptake, while <sup>11</sup>C-DED binding was largely independent of brain perfusion, as measured by eDED. Corresponding voxelwise correlations confirmed the ROI-based results. Temporo-parietal eDED or ePiB brain perfusion measurements were highly discriminative between patient and control groups, with discriminative ability statistically comparable to that of temporo-parietal <sup>18</sup>F-FDG glucose metabolism. Hypometabolism extended over wider regions than hypoperfusion in patient groups compared to controls.</p>
<p>CONCLUSION: The 1-4 min early-frame intervals of <sup>11</sup>C-DED or <sup>11</sup>C-PiB are suitable surrogate measures for brain perfusion. <sup>11</sup>C-DED binding is independent of brain perfusion and thus <sup>11</sup>C-DED PET can provide information on both functional (brain perfusion) and pathological (astrocytosis) aspects from a single PET scan. In comparison with glucose metabolism, early-phase <sup>11</sup>C-DED and <sup>11</sup>C-PiB perfusion appear to provide complementary rather than redundant information.</p>
https://doi.org/10.2967/jnumed.115.168732
oai:zenodo.org:47502
Zenodo
https://zenodo.org/communities/inmind
https://zenodo.org/communities/eu
info:eu-repo/semantics/restrictedAccess
Journal of Nuclear Medecine, 57(7), 1071-7., (2016-02-16)
Amyloid
Astrocytosis
Brain perfusion
Early-Phase PET
Comparison of Early-Phase 11C-Deuterium-L-Deprenyl and 11C-PiB PET for Assessing Brain Perfusion in Alzheimer's Disease.
info:eu-repo/semantics/article