10.1364/BOE.417357
https://zenodo.org/records/4742300
oai:zenodo.org:4742300
Amendola, Caterina
Caterina
Amendola
Spinelli, Lorenzo
Lorenzo
Spinelli
Contini, Davide
Davide
Contini
De Carli, Agnese
Agnese
De Carli
Martinelli, Cesare
Cesare
Martinelli
Fumagalli, Monica
Monica
Fumagalli
Torricelli, Alessandro
Alessandro
Torricelli
Accuracy of homogeneous models for photon diffusion in estimating neonatal cerebral hemodynamics by TD-NIRS
Zenodo
2021
2021-04-01
https://zenodo.org/communities/perinatal-life-support
https://zenodo.org/communities/eu
Creative Commons Attribution 4.0 International
Abstract: We assessed the accuracy of homogenous (semi-infinite, spherical) photon diffusion models in estimating absolute hemodynamic parameters of the neonatal brain in realistic scenarios (ischemia, hyperoxygenation, and hypoventilation) from 1.5 cm interfiber distance TD NIRS measurements. Time-point-spread-functions in 29- and 44-weeks postmenstrual age head meshes were simulated by the Monte Carlo method, convoluted with a real instrument response function, and then fitted with photon diffusion models. The results show good accuracy in retrieving brain oxygen saturation, and severe underestimation of total cerebral hemoglobin, suggesting the need for more complex models of analysis or of larger interfiber distances to precisely monitor all hemodynamic parameters
European Commission
10.13039/501100000780
863087
Perinatal Life Support System: Integration of Enabling Technologies for Clinical Translation