July 6, 2015 Journal article Open Access

M Rodríguez Sánchez; Bassi AP; Carvalho PS

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    "description": "<p>Bisphosphonates toxicological effect on alveolar bone could be associated to medication related osteonecrosis of the jaw.&nbsp;(MRONJ) Oral surgical procedures as; tooth extractions, implants placements or trauma are suggested risk factors. The aim&nbsp;of this paper is to describe a case of MRONJ and recurrence after the first right mandibular molar extraction. A 54 years&nbsp;old man was referred to the Department of Surgery and Integrated Clinic of Aracatuba Dental School, Univ. Estadual&nbsp;Paulista - UNESP with a medical history of myeloma multiple and treated with zoledronic acid during 3 years. Her dental&nbsp;history consisted of a mandibular molar extraction 3 years after having finished zoledronic acid intake. After the dental&nbsp;extraction the patient developed a clinical features of MRONJ that was treated with antibiotics, sequestrectomy, hyperbaric&nbsp;oxygen, with apparently total resolution for about five month. The post-operative 6th month the patient complained of&nbsp;recurrent pain, exudates and swelling. Antibiotic were prescribed in addition to surgical debridement. Even though mucosal<br />\ncoverage was achieved during the second surgical procedures, healing occurred without signs of infection but without&nbsp;complete gingival coverage until the second year postoperative. MRONJ is a challenge complication and there is not a gold<br />\nstandard treatment.</p>", 
    "license": {
      "id": "CC-BY-4.0"
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    "title": "The Challenge Treatment of Medication Related Osteonecrosis of the Jaw: A Case Report", 
    "journal": {
      "volume": "2", 
      "year": "2015", 
      "issue": "7", 
      "pages": "102-105", 
      "title": "International Journal of Dentistry and Oral Science (IJDOS)"
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    "keywords": [
      "Osteonecrosis of the Jaw", 
      "Oral Surgery", 
      "Tooth Extraction", 
      "Bisphosphonates"
    ], 
    "publication_date": "2015-07-06", 
    "creators": [
      {
        "affiliation": "Postgraduate Student, Department of Surgery and Integrated Clinics, Aracatuba Dental School, Sao Paulo State University, Brazil", 
        "name": "M Rodr\u00edguez S\u00e1nchez"
      }, 
      {
        "affiliation": "Professor at Aracatuba Dental School, Department of Surgery and Integrated Clinics, Sao Paulo State University, Aracatuba SP, Brazil", 
        "name": "Bassi AP"
      }, 
      {
        "affiliation": "Professor at Bauru Dental School, Department of Stomatology, Sao Paulo State University, Bauru SP, Brazil.", 
        "name": "Carvalho PS"
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