Journal article Open Access

The Challenge Treatment of Medication Related Osteonecrosis of the Jaw: A Case Report

M Rodríguez Sánchez; Bassi AP; Carvalho PS

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  "DOI": "10.19070/2377-8075-1500022", 
  "container_title": "International Journal of Dentistry and Oral Science (IJDOS)", 
  "title": "The Challenge Treatment of Medication Related Osteonecrosis of the Jaw: A Case Report", 
  "issued": {
    "date-parts": [
  "abstract": "<p>Bisphosphonates toxicological effect on alveolar bone could be associated to medication related osteonecrosis of the jaw.&nbsp;(MRONJ) Oral surgical procedures as; tooth extractions, implants placements or trauma are suggested risk factors. The aim&nbsp;of this paper is to describe a case of MRONJ and recurrence after the first right mandibular molar extraction. A 54 years&nbsp;old man was referred to the Department of Surgery and Integrated Clinic of Aracatuba Dental School, Univ. Estadual&nbsp;Paulista - UNESP with a medical history of myeloma multiple and treated with zoledronic acid during 3 years. Her dental&nbsp;history consisted of a mandibular molar extraction 3 years after having finished zoledronic acid intake. After the dental&nbsp;extraction the patient developed a clinical features of MRONJ that was treated with antibiotics, sequestrectomy, hyperbaric&nbsp;oxygen, with apparently total resolution for about five month. The post-operative 6th month the patient complained of&nbsp;recurrent pain, exudates and swelling. Antibiotic were prescribed in addition to surgical debridement. Even though mucosal<br />\ncoverage was achieved during the second surgical procedures, healing occurred without signs of infection but without&nbsp;complete gingival coverage until the second year postoperative. MRONJ is a challenge complication and there is not a gold<br />\nstandard treatment.</p>", 
  "author": [
      "given": "", 
      "family": "M Rodr\u00edguez S\u00e1nchez"
      "given": "", 
      "family": "Bassi AP"
      "given": "", 
      "family": "Carvalho PS"
  "page": "102-105", 
  "volume": "2", 
  "type": "article-journal", 
  "issue": "7", 
  "id": "47167"
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