Project milestone Open Access

Identifying new ligands for the SARS-CoV-2 Macrodomain by Fragment Screening and Multi-temperature Crystallography

James S Fraser


JSON Export

{
  "files": [
    {
      "links": {
        "self": "https://zenodo.org/api/files/96426839-280e-4d79-83c9-15b0d09cb655/macrodomain.zip"
      }, 
      "checksum": "md5:7e114a9038057f2ced57ecdabb1a769a", 
      "bucket": "96426839-280e-4d79-83c9-15b0d09cb655", 
      "key": "macrodomain.zip", 
      "type": "zip", 
      "size": 1638175
    }, 
    {
      "links": {
        "self": "https://zenodo.org/api/files/96426839-280e-4d79-83c9-15b0d09cb655/ucsf_nsp3_mac1_C2.zip"
      }, 
      "checksum": "md5:5b53f87e16588241f36f2e53414a8d80", 
      "bucket": "96426839-280e-4d79-83c9-15b0d09cb655", 
      "key": "ucsf_nsp3_mac1_C2.zip", 
      "type": "zip", 
      "size": 631111212
    }
  ], 
  "owners": [
    110313
  ], 
  "doi": "10.5281/zenodo.4716363", 
  "stats": {
    "version_unique_downloads": 99.0, 
    "unique_views": 481.0, 
    "views": 557.0, 
    "version_views": 1439.0, 
    "unique_downloads": 27.0, 
    "version_unique_views": 1287.0, 
    "volume": 7607736219.0, 
    "version_downloads": 246.0, 
    "downloads": 33.0, 
    "version_volume": 42061940860.0
  }, 
  "links": {
    "doi": "https://doi.org/10.5281/zenodo.4716363", 
    "conceptdoi": "https://doi.org/10.5281/zenodo.3932379", 
    "bucket": "https://zenodo.org/api/files/96426839-280e-4d79-83c9-15b0d09cb655", 
    "conceptbadge": "https://zenodo.org/badge/doi/10.5281/zenodo.3932379.svg", 
    "html": "https://zenodo.org/record/4716363", 
    "latest_html": "https://zenodo.org/record/4716363", 
    "badge": "https://zenodo.org/badge/doi/10.5281/zenodo.4716363.svg", 
    "latest": "https://zenodo.org/api/records/4716363"
  }, 
  "conceptdoi": "10.5281/zenodo.3932379", 
  "created": "2021-04-23T17:50:35.371499+00:00", 
  "updated": "2021-04-24T00:27:29.310970+00:00", 
  "conceptrecid": "3932379", 
  "revision": 2, 
  "id": 4716363, 
  "metadata": {
    "access_right_category": "success", 
    "doi": "10.5281/zenodo.4716363", 
    "description": "<p>Macrodomain is a compelling target for SARS-CoV-2, but there are no inhibitors (or even starting points for inhibitors). The QCRG Structural Biology Consortium performed a crystallographic fragments screen, identifying a few small molecules to kick-start our work to develop an inhibitor. Our friends in the UK, Ivan Ahel&rsquo;s lab and X-Chem,&nbsp;<a href=\"https://www.diamond.ac.uk/covid-19/for-scientists/SARS-CoV-2-macrodomain.html\">did something similar</a>&nbsp;and found even more fragment starting points. We are releasing&nbsp;<a href=\"https://fragalysis.diamond.ac.uk/viewer/react/preview/target/mArh\">the data together</a>!</p>\n\n<p>This record (see README file) has the data available here:&nbsp;<a href=\"https://fraserlab.com/macrodomain/\">https://fraserlab.com/macrodomain/</a>&nbsp;and published here:&nbsp;https://pubmed.ncbi.nlm.nih.gov/33853786/&nbsp;</p>", 
    "contributors": [
      {
        "affiliation": "UCSF", 
        "type": "ResearchGroup", 
        "name": "QBI Coronavirus Research Group Structural Biology Consortium"
      }
    ], 
    "title": "Identifying new ligands for the SARS-CoV-2 Macrodomain by Fragment Screening and Multi-temperature Crystallography", 
    "language": "eng", 
    "relations": {
      "version": [
        {
          "count": 2, 
          "index": 1, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "3932379"
          }, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "4716363"
          }
        }
      ]
    }, 
    "access_right": "open", 
    "communities": [
      {
        "id": "covid-19"
      }, 
      {
        "id": "zenodo"
      }
    ], 
    "version": "2.0", 
    "keywords": [
      "coronavirus", 
      "macrodomain", 
      "fragment screening", 
      "X-ray crystallography"
    ], 
    "publication_date": "2021-04-23", 
    "creators": [
      {
        "orcid": "0000-0002-5080-2859", 
        "affiliation": "UCSF/QCRG", 
        "name": "James S Fraser"
      }
    ], 
    "license": {
      "id": "CC-BY-4.0"
    }, 
    "resource_type": {
      "subtype": "milestone", 
      "type": "publication", 
      "title": "Project milestone"
    }, 
    "related_identifiers": [
      {
        "scheme": "url", 
        "identifier": "https://fraserlab.com/macrodomain/", 
        "relation": "isDerivedFrom"
      }, 
      {
        "scheme": "url", 
        "identifier": "https://github.com/fraser-lab/fraser-lab.github.io/tree/master/macrodomain", 
        "relation": "isDerivedFrom"
      }, 
      {
        "scheme": "doi", 
        "identifier": "10.5281/zenodo.3932379", 
        "relation": "isVersionOf"
      }
    ]
  }
}
1,439
246
views
downloads
All versions This version
Views 1,439557
Downloads 24633
Data volume 42.1 GB7.6 GB
Unique views 1,287481
Unique downloads 9927

Share

Cite as