Project milestone Open Access

Identifying new ligands for the SARS-CoV-2 Macrodomain by Fragment Screening and Multi-temperature Crystallography

James S Fraser


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{
  "publisher": "Zenodo", 
  "DOI": "10.5281/zenodo.4716363", 
  "language": "eng", 
  "title": "Identifying new ligands for the SARS-CoV-2 Macrodomain by Fragment Screening and Multi-temperature Crystallography", 
  "issued": {
    "date-parts": [
      [
        2021, 
        4, 
        23
      ]
    ]
  }, 
  "abstract": "<p>Macrodomain is a compelling target for SARS-CoV-2, but there are no inhibitors (or even starting points for inhibitors). The QCRG Structural Biology Consortium performed a crystallographic fragments screen, identifying a few small molecules to kick-start our work to develop an inhibitor. Our friends in the UK, Ivan Ahel&rsquo;s lab and X-Chem,&nbsp;<a href=\"https://www.diamond.ac.uk/covid-19/for-scientists/SARS-CoV-2-macrodomain.html\">did something similar</a>&nbsp;and found even more fragment starting points. We are releasing&nbsp;<a href=\"https://fragalysis.diamond.ac.uk/viewer/react/preview/target/mArh\">the data together</a>!</p>\n\n<p>This record (see README file) has the data available here:&nbsp;<a href=\"https://fraserlab.com/macrodomain/\">https://fraserlab.com/macrodomain/</a>&nbsp;and published here:&nbsp;https://pubmed.ncbi.nlm.nih.gov/33853786/&nbsp;</p>", 
  "author": [
    {
      "family": "James S Fraser"
    }
  ], 
  "version": "2.0", 
  "type": "report", 
  "id": "4716363"
}
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