Journal article Open Access

Estrogen accelerates the resolution of inflammation in macrophagic cells.

Villa, Alessandro; Rizzi, Nicoletta; Vegeto, Elisabetta; Ciana, Paolo; Maggi, Adriana

Although 17β-estradiol (E2) anti-inflammatory activity has been well described, very little is known about the effects of this hormone on the resolution phase of the inflammatory process. Here, we identified a previously unreported ERα-mediated effect of E2 on the inflammatory machinery. The study showed that the activation of the intracellular estrogen receptor shortens the LPS-induced pro-inflammatory phase and, by influencing the intrinsic and extrinsic programs, triggers the resolution of inflammation in RAW 264.7 cells. Through the regulation of the SOCS3 and STAT3 signaling pathways, E2 facilitates the progression of the inflammatory process toward the IL10-dependent "acquired deactivation" phenotype, which is responsible for tissue remodeling and the restoration of homeostatic conditions. The present study may provide an explanation for increased susceptibility to chronic inflammatory diseases in women after menopause, and it suggests novel anti-inflammatory treatments for such disorders.

Files (1.3 MB)
Name Size
Villa_SciRep_2015-P02.pdf
md5:0008eb21ef9a919f0b83b0d8991f492c
1.3 MB Download
24
29
views
downloads
Views 24
Downloads 29
Data volume 37.2 MB
Unique views 23
Unique downloads 29

Share

Cite as