Journal article Open Access

The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development

Boix-Montesinos, Paz; Soriano-Teruel, Paula M; Armiñán, Ana; Orzáez, Mar; Vicent, María J


MARC21 XML Export

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="u">https://creativecommons.org/licenses/by/4.0/legalcode</subfield>
    <subfield code="a">Creative Commons Attribution 4.0 International</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2021-03-31</subfield>
  </datafield>
  <controlfield tag="005">20210406122719.0</controlfield>
  <controlfield tag="001">4663679</controlfield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">openaire</subfield>
    <subfield code="o">oai:zenodo.org:4663679</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">&lt;p&gt;Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conventional&amp;nbsp;&lt;em&gt;in vitro&lt;/em&gt;&amp;nbsp;models include the lack of representation of the stromal population, the absence of a three-dimensional (3D) structure, and a poor representation of inter-tumor and intra-tumor heterogeneity. Herein, we review those cell culture strategies that aim to overcome these limitations, including cell co-cultures, advanced 3D cell cultures, patient-derived cells, bioprinting, and microfluidics systems. The&amp;nbsp;&lt;em&gt;in vivo&lt;/em&gt;&amp;nbsp;evaluation of nanomedicines must consider critical parameters that include the enhanced permeability and retention effect, the host&amp;#39;s immune status, and the site of tumor implantation. Here, we critically discuss the advantages and limitations of current&amp;nbsp;&lt;em&gt;in vivo&lt;/em&gt;&amp;nbsp;models and report how the improved selection and application of breast cancer models can improve the clinical translation of nanomedicines.&lt;/p&gt;</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Centro de Investigación Príncipe Felipe, Polymer Therapeutics Laboratory and Targeted Therapies on Cancer and Inflammation Laboratory, Av. Eduardo Primo Yúfera 3, E-46012 Valencia (Spain). Electronic address: psoriano@cipf.es.</subfield>
    <subfield code="a">Soriano-Teruel, Paula M</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Centro de Investigación Príncipe Felipe, Polymer Therapeutics Lab, Av. Eduardo Primo Yúfera 3, E-46012 Valencia, Spain</subfield>
    <subfield code="a">Armiñán, Ana</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Centro de Investigación Príncipe Felipe, Targeted Therapies on Cancer and Inflammation Laboratory, Av. Eduardo Primo Yúfera 3, E-46012 Valencia (Spain). Electronic address: morzaez@cipf.es.</subfield>
    <subfield code="a">Orzáez, Mar</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="u">Centro de Investigación Príncipe Felipe, Polymer Therapeutics Lab, Av. Eduardo Primo Yúfera 3, E-46012 Valencia, Spain</subfield>
    <subfield code="a">Vicent, María J</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="s">2353425</subfield>
    <subfield code="z">md5:9628f588b87e17f14ce36fc31c51d2a1</subfield>
    <subfield code="u">https://zenodo.org/record/4663679/files/Breast Cancer Review Proof.pdf</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="u">Centro de Investigación Príncipe Felipe, Polymer Therapeutics Lab, Av. Eduardo Primo Yúfera 3, E-46012 Valencia, Spain</subfield>
    <subfield code="a">Boix-Montesinos, Paz</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1016/j.addr.2021.03.018</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development</subfield>
  </datafield>
  <datafield tag="536" ind1=" " ind2=" ">
    <subfield code="c">648831</subfield>
    <subfield code="a">Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
</record>
9
12
views
downloads
Views 9
Downloads 12
Data volume 28.2 MB
Unique views 9
Unique downloads 12

Share

Cite as