Journal article Open Access

The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development

Boix-Montesinos, Paz; Soriano-Teruel, Paula M; Armiñán, Ana; Orzáez, Mar; Vicent, María J


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{
  "description": "<p>Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conventional&nbsp;<em>in vitro</em>&nbsp;models include the lack of representation of the stromal population, the absence of a three-dimensional (3D) structure, and a poor representation of inter-tumor and intra-tumor heterogeneity. Herein, we review those cell culture strategies that aim to overcome these limitations, including cell co-cultures, advanced 3D cell cultures, patient-derived cells, bioprinting, and microfluidics systems. The&nbsp;<em>in vivo</em>&nbsp;evaluation of nanomedicines must consider critical parameters that include the enhanced permeability and retention effect, the host&#39;s immune status, and the site of tumor implantation. Here, we critically discuss the advantages and limitations of current&nbsp;<em>in vivo</em>&nbsp;models and report how the improved selection and application of breast cancer models can improve the clinical translation of nanomedicines.</p>", 
  "license": "https://creativecommons.org/licenses/by/4.0/legalcode", 
  "creator": [
    {
      "affiliation": "Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Polymer Therapeutics Lab, Av. Eduardo Primo Y\u00fafera 3, E-46012 Valencia, Spain", 
      "@type": "Person", 
      "name": "Boix-Montesinos, Paz"
    }, 
    {
      "affiliation": "Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Polymer Therapeutics Laboratory and Targeted Therapies on Cancer and Inflammation Laboratory, Av. Eduardo Primo Y\u00fafera 3, E-46012 Valencia (Spain). Electronic address: psoriano@cipf.es.", 
      "@type": "Person", 
      "name": "Soriano-Teruel, Paula M"
    }, 
    {
      "affiliation": "Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Polymer Therapeutics Lab, Av. Eduardo Primo Y\u00fafera 3, E-46012 Valencia, Spain", 
      "@type": "Person", 
      "name": "Armi\u00f1\u00e1n, Ana"
    }, 
    {
      "affiliation": "Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Targeted Therapies on Cancer and Inflammation Laboratory, Av. Eduardo Primo Y\u00fafera 3, E-46012 Valencia (Spain). Electronic address: morzaez@cipf.es.", 
      "@type": "Person", 
      "name": "Orz\u00e1ez, Mar"
    }, 
    {
      "affiliation": "Centro de Investigaci\u00f3n Pr\u00edncipe Felipe, Polymer Therapeutics Lab, Av. Eduardo Primo Y\u00fafera 3, E-46012 Valencia, Spain", 
      "@type": "Person", 
      "name": "Vicent, Mar\u00eda J"
    }
  ], 
  "headline": "The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development", 
  "image": "https://zenodo.org/static/img/logos/zenodo-gradient-round.svg", 
  "datePublished": "2021-03-31", 
  "url": "https://zenodo.org/record/4663679", 
  "keywords": [], 
  "@context": "https://schema.org/", 
  "identifier": "https://doi.org/10.1016/j.addr.2021.03.018", 
  "@id": "https://doi.org/10.1016/j.addr.2021.03.018", 
  "@type": "ScholarlyArticle", 
  "name": "The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development"
}
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