Journal article Open Access

The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development

Boix-Montesinos, Paz; Soriano-Teruel, Paula M; Armiñán, Ana; Orzáez, Mar; Vicent, María J


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            <foaf:name>Centro de Investigación Príncipe Felipe, Polymer Therapeutics Lab, Av. Eduardo Primo Yúfera 3, E-46012 Valencia, Spain</foaf:name>
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        <foaf:name>Soriano-Teruel, Paula M</foaf:name>
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            <foaf:name>Centro de Investigación Príncipe Felipe, Polymer Therapeutics Laboratory and Targeted Therapies on Cancer and Inflammation Laboratory, Av. Eduardo Primo Yúfera 3, E-46012 Valencia (Spain). Electronic address: psoriano@cipf.es.</foaf:name>
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            <foaf:name>Centro de Investigación Príncipe Felipe, Targeted Therapies on Cancer and Inflammation Laboratory, Av. Eduardo Primo Yúfera 3, E-46012 Valencia (Spain). Electronic address: morzaez@cipf.es.</foaf:name>
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        <foaf:name>Vicent, María J</foaf:name>
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    <dct:title>The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development</dct:title>
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        <foaf:name>European Commission</foaf:name>
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    <dct:description>&lt;p&gt;Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conventional&amp;nbsp;&lt;em&gt;in vitro&lt;/em&gt;&amp;nbsp;models include the lack of representation of the stromal population, the absence of a three-dimensional (3D) structure, and a poor representation of inter-tumor and intra-tumor heterogeneity. Herein, we review those cell culture strategies that aim to overcome these limitations, including cell co-cultures, advanced 3D cell cultures, patient-derived cells, bioprinting, and microfluidics systems. The&amp;nbsp;&lt;em&gt;in vivo&lt;/em&gt;&amp;nbsp;evaluation of nanomedicines must consider critical parameters that include the enhanced permeability and retention effect, the host&amp;#39;s immune status, and the site of tumor implantation. Here, we critically discuss the advantages and limitations of current&amp;nbsp;&lt;em&gt;in vivo&lt;/em&gt;&amp;nbsp;models and report how the improved selection and application of breast cancer models can improve the clinical translation of nanomedicines.&lt;/p&gt;</dct:description>
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    <dct:title>Towards the design of Personalised Polymer-based Combination Nanomedicines for Advanced Stage Breast Cancer Patients</dct:title>
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