Journal article Open Access

The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development

Boix-Montesinos, Paz; Soriano-Teruel, Paula M; Armiñán, Ana; Orzáez, Mar; Vicent, María J


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{
  "DOI": "10.1016/j.addr.2021.03.018", 
  "author": [
    {
      "family": "Boix-Montesinos, Paz"
    }, 
    {
      "family": "Soriano-Teruel, Paula M"
    }, 
    {
      "family": "Armi\u00f1\u00e1n, Ana"
    }, 
    {
      "family": "Orz\u00e1ez, Mar"
    }, 
    {
      "family": "Vicent, Mar\u00eda J"
    }
  ], 
  "issued": {
    "date-parts": [
      [
        2021, 
        3, 
        31
      ]
    ]
  }, 
  "abstract": "<p>Even given recent advances in nanomedicine development of breast cancer treatment in recent years and promising results in pre-clinical models, cancer nanomedicines often fail at the clinical trial stage. Limitations of conventional&nbsp;<em>in vitro</em>&nbsp;models include the lack of representation of the stromal population, the absence of a three-dimensional (3D) structure, and a poor representation of inter-tumor and intra-tumor heterogeneity. Herein, we review those cell culture strategies that aim to overcome these limitations, including cell co-cultures, advanced 3D cell cultures, patient-derived cells, bioprinting, and microfluidics systems. The&nbsp;<em>in vivo</em>&nbsp;evaluation of nanomedicines must consider critical parameters that include the enhanced permeability and retention effect, the host&#39;s immune status, and the site of tumor implantation. Here, we critically discuss the advantages and limitations of current&nbsp;<em>in vivo</em>&nbsp;models and report how the improved selection and application of breast cancer models can improve the clinical translation of nanomedicines.</p>", 
  "title": "The Past, Present, and Future of Breast Cancer Models for Nanomedicine Development", 
  "type": "article-journal", 
  "id": "4663679"
}
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