Preprint Open Access

Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders

Arumugham, Vinu


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    <subfield code="a">Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders</subfield>
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    <subfield code="a">&lt;p&gt;SARS-CoV-2 mRNA vaccines and a viral vector based vaccine have been authorized for use in the US.&lt;br&gt;
AstraZeneca&amp;rsquo;s viral vector based vaccines have been authorized for use in many European countries.&lt;br&gt;
Numerous cases of bleeding disorders have been reported following SARS-CoV-2 vaccine&lt;br&gt;
administration. Vaccine Adverse Event Reporting System (VAERS) in the US shows 200 cases of&lt;br&gt;
platelet disorders following the vaccines. Such cases have also been investigated in Europe following&lt;br&gt;
AstraZeneca vaccine administration. Prof. P&amp;aring;l Andre Holme of the Oslo University Hospital and Prof.&lt;br&gt;
Andreas Greinacher at the University of Greifswald have independently found evidence for this being a&lt;br&gt;
vaccine induced autoimmune disorder. Greinacher and others identified platelet factor 4 (PF4) as the&lt;br&gt;
target of autoantibodies induced by the vaccine. Greinacher&amp;rsquo;s team have named it vaccine-induced&lt;br&gt;
prothrombotic immune thrombocytopenia (VIPIT).&lt;br&gt;
Animal/plant/fungal/viral protein contamination of vaccines and the risk of them inducing autoimmune&lt;br&gt;
diseases was predicted and world vaccine regulatory bodies were all repeatedly warned of the dangers.&lt;br&gt;
Safety engineering processes such as design Failure Modes and Effects Analysis (FMEA) are still being&lt;br&gt;
ignored in the vaccine industry ten years after the Pandemrix induced narcolepsy disaster.&lt;br&gt;
We show plant proteins that contaminate the vaccines have high protein sequence homology to epitopes&lt;br&gt;
known to be involved in thrombocytopenia, using Immune Epitope Database (IEDB) data and&lt;br&gt;
BLASTP bioinformatics analysis. BLASTP match score range is 27.8-19.6. The score for the epitope&lt;br&gt;
involved in Pandemrix induced narcolepsy was 19.7, in comparison. The conditions required for&lt;br&gt;
inducing autoimmunity are immunization using homologous xeneogeneic antigens that are similar to&lt;br&gt;
self antigens (plant proteins in this case) and costimulation of the innate immune system either by the&lt;br&gt;
adenovirus, lipid-in-water emulsion or the mRNA in the vaccines acting as adjuvants.&lt;br&gt;
Bleeding disorders are just the latest of numerous vaccine-induced diseases. For every individual&lt;br&gt;
diagnosed with VIPIT, thousands will develop subclinical disease. Of course, VIPIT is not the only&lt;br&gt;
autoimmune disorder induced by these contaminants.&lt;br&gt;
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