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Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders

Arumugham, Vinu


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  <dc:creator>Arumugham, Vinu</dc:creator>
  <dc:date>2021-03-27</dc:date>
  <dc:description>SARS-CoV-2 mRNA vaccines and a viral vector based vaccine have been authorized for use in the US.
AstraZeneca’s viral vector based vaccines have been authorized for use in many European countries.
Numerous cases of bleeding disorders have been reported following SARS-CoV-2 vaccine
administration. Vaccine Adverse Event Reporting System (VAERS) in the US shows 200 cases of
platelet disorders following the vaccines. Such cases have also been investigated in Europe following
AstraZeneca vaccine administration. Prof. Pål Andre Holme of the Oslo University Hospital and Prof.
Andreas Greinacher at the University of Greifswald have independently found evidence for this being a
vaccine induced autoimmune disorder. Greinacher and others identified platelet factor 4 (PF4) as the
target of autoantibodies induced by the vaccine. Greinacher’s team have named it vaccine-induced
prothrombotic immune thrombocytopenia (VIPIT).
Animal/plant/fungal/viral protein contamination of vaccines and the risk of them inducing autoimmune
diseases was predicted and world vaccine regulatory bodies were all repeatedly warned of the dangers.
Safety engineering processes such as design Failure Modes and Effects Analysis (FMEA) are still being
ignored in the vaccine industry ten years after the Pandemrix induced narcolepsy disaster.
We show plant proteins that contaminate the vaccines have high protein sequence homology to epitopes
known to be involved in thrombocytopenia, using Immune Epitope Database (IEDB) data and
BLASTP bioinformatics analysis. BLASTP match score range is 27.8-19.6. The score for the epitope
involved in Pandemrix induced narcolepsy was 19.7, in comparison. The conditions required for
inducing autoimmunity are immunization using homologous xeneogeneic antigens that are similar to
self antigens (plant proteins in this case) and costimulation of the innate immune system either by the
adenovirus, lipid-in-water emulsion or the mRNA in the vaccines acting as adjuvants.
Bleeding disorders are just the latest of numerous vaccine-induced diseases. For every individual
diagnosed with VIPIT, thousands will develop subclinical disease. Of course, VIPIT is not the only
autoimmune disorder induced by these contaminants.
 </dc:description>
  <dc:identifier>https://zenodo.org/record/4641693</dc:identifier>
  <dc:identifier>10.5281/zenodo.4641693</dc:identifier>
  <dc:identifier>oai:zenodo.org:4641693</dc:identifier>
  <dc:relation>doi:10.5281/zenodo.4641692</dc:relation>
  <dc:rights>info:eu-repo/semantics/openAccess</dc:rights>
  <dc:rights>https://creativecommons.org/licenses/by/4.0/legalcode</dc:rights>
  <dc:subject>Thrombocytopenia</dc:subject>
  <dc:subject>SARS-CoV-2</dc:subject>
  <dc:subject>mRNA</dc:subject>
  <dc:subject>AstraZeneca</dc:subject>
  <dc:subject>VIPIT</dc:subject>
  <dc:subject>viral vector</dc:subject>
  <dc:subject>vaccine</dc:subject>
  <dc:subject>platelet</dc:subject>
  <dc:subject>platelet factor 4</dc:subject>
  <dc:subject>narcolepsy</dc:subject>
  <dc:subject>Pandemrix</dc:subject>
  <dc:subject>Immune Epitope DataBase</dc:subject>
  <dc:subject>adjuvant</dc:subject>
  <dc:subject>autoimmunity</dc:subject>
  <dc:subject>xenogeneic antigen</dc:subject>
  <dc:subject>adenovirus</dc:subject>
  <dc:subject>lipid</dc:subject>
  <dc:subject>FMEA</dc:subject>
  <dc:title>Plant proteins that contaminate SARS-CoV-2 vaccines, excipients have high protein sequence homology to IEDB listed thrombocytopenia related platelet factor 4 epitopes thus explaining induction of autoimmune bleeding disorders</dc:title>
  <dc:type>info:eu-repo/semantics/preprint</dc:type>
  <dc:type>publication-preprint</dc:type>
</oai_dc:dc>
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